DE69923906D1 - Verfahren zur Herstellung von Pyrazolo-(4,3-d)pyrimidin-7-ones und Zwischenprodukte davon - Google Patents

Verfahren zur Herstellung von Pyrazolo-(4,3-d)pyrimidin-7-ones und Zwischenprodukte davon

Info

Publication number: DE69923906D1
Authority: DE; Germany
Prior art keywords: pyrazolo; pyrimidin; intermediates; ones; preparation
Prior art date: 1998-10-12
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69923906T

Other languages

English (en)

Other versions

DE69923906T2 (de

Inventor

Peter James Dunn

Philip Charles Levett

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Pfizer Ireland Pharmaceuticals

Original Assignee

Pfizer Ireland Pharmaceuticals

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-10-12

Filing date

1999-10-11

Publication date

2005-04-07

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10840421&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69923906(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1999-10-11 Application filed by Pfizer Ireland Pharmaceuticals filed Critical Pfizer Ireland Pharmaceuticals

2005-04-07 Publication of DE69923906D1 publication Critical patent/DE69923906D1/de

2006-04-06 Application granted granted Critical

2006-04-06 Publication of DE69923906T2 publication Critical patent/DE69923906T2/de

2019-10-12 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/26—Sulfur atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Gynecology & Obstetrics (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

DE69923906T 1998-10-12 1999-10-11 Verfahren zur Herstellung von Pyrazolo-(4,3-d)pyrimidin-7-ones und Zwischenprodukte davon Expired - Lifetime DE69923906T2 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB9822238		1998-10-12
GBGB9822238.3A GB9822238D0 (en)	1998-10-12	1998-10-12	Process for preparation of pyrazolo[4,3-D]pyrimidin-7-ones and intermediates thereof

Publications (2)

Publication Number	Publication Date
DE69923906D1 true DE69923906D1 (de)	2005-04-07
DE69923906T2 DE69923906T2 (de)	2006-04-06

Family

ID=10840421

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69923906T Expired - Lifetime DE69923906T2 (de)	1998-10-12	1999-10-11	Verfahren zur Herstellung von Pyrazolo-(4,3-d)pyrimidin-7-ones und Zwischenprodukte davon

Country Status (49)

Country	Link
US (3)	US6207829B1 (de)
EP (1)	EP0994115B1 (de)
JP (1)	JP3721021B2 (de)
KR (1)	KR100380954B1 (de)
CN (2)	CN1207295C (de)
AP (1)	AP1233A (de)
AR (1)	AR019244A1 (de)
AT (1)	ATE290003T1 (de)
AU (1)	AU756463B2 (de)
BG (1)	BG63205B1 (de)
BR (1)	BR9905092A (de)
CA (1)	CA2285733C (de)
CO (1)	CO5150214A1 (de)
CR (1)	CR6118A (de)
CU (1)	CU22928A3 (de)
CZ (1)	CZ296816B6 (de)
DE (1)	DE69923906T2 (de)
DK (1)	DK0994115T3 (de)
DZ (1)	DZ2912A1 (de)
EA (1)	EA003774B1 (de)
EE (1)	EE04192B1 (de)
EG (1)	EG22630A (de)
ES (1)	ES2237049T3 (de)
GB (1)	GB9822238D0 (de)
GE (1)	GEP20022700B (de)
GT (1)	GT199900172A (de)
HK (1)	HK1027559A1 (de)
HR (1)	HRP990318B1 (de)
HU (1)	HU226162B1 (de)
ID (1)	ID23351A (de)
IL (11)	IL152924A (de)
IS (1)	IS1951B (de)
MA (1)	MA25007A1 (de)
MY (1)	MY124620A (de)
NO (1)	NO313700B1 (de)
OA (1)	OA11165A (de)
PE (1)	PE20001086A1 (de)
PL (1)	PL198150B1 (de)
PT (1)	PT994115E (de)
RS (1)	RS49762B (de)
SG (1)	SG118060A1 (de)
SI (1)	SI0994115T1 (de)
SK (1)	SK285215B6 (de)
TN (1)	TNSN99189A1 (de)
TR (1)	TR199902541A2 (de)
TW (1)	TW589314B (de)
UA (1)	UA66787C2 (de)
UY (1)	UY25750A1 (de)
ZA (1)	ZA996412B (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2000078760A1 (fr) *	1999-06-21	2000-12-28	The Biochemical Pharmaceutical Factory Of Zhuhai Sez	Procede de preparation de sildenafil, agent et procede d'obtention d'un comprime mixte a base de sildenafil et de chlorhydrate d'apomorphine
AP2001002194A0 (en) *	2000-06-22	2002-12-21	Pfizer	Novel process for the preparation of pyrazolopyrimidinones.
US6667398B2 (en)	2000-06-22	2003-12-23	Pfizer Inc	Process for the preparation of pyrazolopyrimidinones
US6407259B1 (en)	2000-07-28	2002-06-18	Pfizer Inc.	Process for the preparation of pyrazoles
YU51701A (sh) *	2000-07-28	2003-12-31	Pfizer Inc.	Postupak za dobijanje jedinjenja pirazola/4,3-d/ pirimidin-7-ona i njihovih derivata
EP1176142A1 (de) *	2000-07-28	2002-01-30	Pfizer Inc.	Verfahren zur Herstellung von Pyrazolen
PE20020394A1 (es)	2000-08-18	2002-06-21	Agouron Pharma	Compuestos de pirazol y composiciones farmaceuticas que los contienen, que modulan y/o inhiben la actividad de erab/hadh2
US7335680B2 (en) *	2001-12-20	2008-02-26	Laboratoires Serono Sa	Pyrrolidine derivatives as prostaglandin modulators
WO2003059258A2 (en) *	2001-12-21	2003-07-24	Cytokinetics, Inc.	Compositions and methods for treating heart failure
EP1719772A1 (de)	2002-05-31	2006-11-08	Schering Corporation	Verfahren zur Herstellung von Xanthin Phosphodiesterase v Inhibitoren und deren Vorstufen
WO2004072079A1 (en) *	2003-02-11	2004-08-26	Pfizer Limited	Hydrated and anhydrous sildenafil hemi-citrate compound
ES2378620T3 (es)	2003-03-27	2012-04-16	Cytokinetics, Inc.	Sulfonamidas para el tratamiento de insuficiencia cardiaca congestiva, sus composiciones y usos.
CN100360531C (zh) *	2003-12-18	2008-01-09	中国人民解放军军事医学科学院放射与辐射医学研究所	用于预防或治疗阳萎和性冷淡的新吡唑并嘧啶类化合物
US20070010525A1 (en) *	2005-06-27	2007-01-11	Meyer Jackson	Method and compositions for modulating neuropeptide hormone secretion
NL2000291C2 (nl) *	2005-11-10	2009-02-17	Pfizer Prod Inc	1-(1-(2-ethoxyethyl)-3-ethyl-7-(4-methylpyridin-2-ylamino)-1H- pyrazool(4,3-d)pyrimidine-5-yl)piperidine-4-carbonzuur en zouten daarvan.
EP2024369A4 (de) *	2006-06-05	2010-10-27	Matrix Lab Ltd	Neues verfahren zur herstellung von sildenafilcitrat
CZ308056B6 (cs) *	2015-07-20	2019-11-27	Ustav Experimentalni Botaniky Av Cr V V I	5-Substituované-7-[4-(substituované)benzyl]amino-3-isopropylpyrazolo[4,3-d]pyrimidiny, jejich použití jako antirevmatika, a farmaceutické přípravky
WO2017168174A1 (en)	2016-04-02	2017-10-05	N4 Pharma Uk Limited	New pharmaceutical forms of sildenafil
CN107759603B (zh) *	2016-08-18	2020-09-01	四川科伦药物研究院有限公司	一种杂环化合物的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3992441A (en) *	1972-12-26	1976-11-16	Pfizer Inc.	Sulfamylbenzoic acids
GB9013750D0 (en) *	1990-06-20	1990-08-08	Pfizer Ltd	Therapeutic agents
GB9612514D0 (en) *	1996-06-14	1996-08-14	Pfizer Ltd	Novel process
IL132276A0 (en) *	1997-04-25	2001-03-19	Pfizer	Pyrazolopyrimidinones which inhibit type 5 cyclic guanosine 3',5'-monophosphate phosphodiesterase (cgmp pde5) for the treatment of sexual dysfunction

1998
- 1998-10-12 GB GBGB9822238.3A patent/GB9822238D0/en not_active Ceased
1999
- 1999-09-22 CU CU1999142A patent/CU22928A3/es unknown
- 1999-09-22 TW TW088116306A patent/TW589314B/zh not_active IP Right Cessation
- 1999-09-27 RS YUP-489/99A patent/RS49762B/sr unknown
- 1999-10-05 GT GT199900172A patent/GT199900172A/es unknown
- 1999-10-06 CZ CZ0353299A patent/CZ296816B6/cs not_active IP Right Cessation
- 1999-10-07 IL IL15292499A patent/IL152924A/en not_active IP Right Cessation
- 1999-10-07 IL IL15292399A patent/IL152923A/en not_active IP Right Cessation
- 1999-10-07 IL IL152928A patent/IL152928A/en not_active IP Right Cessation
- 1999-10-07 IL IL13227399A patent/IL132273A/en not_active IP Right Cessation
- 1999-10-07 AP APAP/P/1999/001672A patent/AP1233A/en active
- 1999-10-07 PE PE1999001016A patent/PE20001086A1/es not_active Application Discontinuation
- 1999-10-07 IL IL15292799A patent/IL152927A/en not_active IP Right Cessation
- 1999-10-07 IL IL15292699A patent/IL152926A/en not_active IP Right Cessation
- 1999-10-07 CR CR6118A patent/CR6118A/es unknown
- 1999-10-08 US US09/415,440 patent/US6207829B1/en not_active Expired - Fee Related
- 1999-10-08 MY MYPI99004353A patent/MY124620A/en unknown
- 1999-10-08 SK SK1385-99A patent/SK285215B6/sk not_active IP Right Cessation
- 1999-10-08 IS IS5209A patent/IS1951B/is unknown
- 1999-10-08 AR ARP990105109A patent/AR019244A1/es active IP Right Grant
- 1999-10-08 UA UA99105491A patent/UA66787C2/xx unknown
- 1999-10-08 CA CA002285733A patent/CA2285733C/en not_active Expired - Lifetime
- 1999-10-08 OA OA9900224A patent/OA11165A/en unknown
- 1999-10-09 CN CNB991239180A patent/CN1207295C/zh not_active Expired - Fee Related
- 1999-10-09 CN CNA031427383A patent/CN1473831A/zh active Pending
- 1999-10-11 EG EG126999A patent/EG22630A/xx active
- 1999-10-11 AT AT99307996T patent/ATE290003T1/de active
- 1999-10-11 NO NO19994943A patent/NO313700B1/no not_active IP Right Cessation
- 1999-10-11 ES ES99307996T patent/ES2237049T3/es not_active Expired - Lifetime
- 1999-10-11 DZ DZ990212A patent/DZ2912A1/xx active
- 1999-10-11 DE DE69923906T patent/DE69923906T2/de not_active Expired - Lifetime
- 1999-10-11 ZA ZA9906412A patent/ZA996412B/xx unknown
- 1999-10-11 AU AU53581/99A patent/AU756463B2/en not_active Ceased
- 1999-10-11 EP EP99307996A patent/EP0994115B1/de not_active Expired - Lifetime
- 1999-10-11 TN TNTNSN99189A patent/TNSN99189A1/fr unknown
- 1999-10-11 PT PT99307996T patent/PT994115E/pt unknown
- 1999-10-11 SI SI9930773T patent/SI0994115T1/xx unknown
- 1999-10-11 EA EA199900822A patent/EA003774B1/ru not_active IP Right Cessation
- 1999-10-11 ID IDP990941A patent/ID23351A/id unknown
- 1999-10-11 KR KR10-1999-0043836A patent/KR100380954B1/ko not_active IP Right Cessation
- 1999-10-11 HU HU9903469A patent/HU226162B1/hu not_active IP Right Cessation
- 1999-10-11 DK DK99307996T patent/DK0994115T3/da active
- 1999-10-11 MA MA25812A patent/MA25007A1/fr unknown
- 1999-10-11 BG BG103794A patent/BG63205B1/bg unknown
- 1999-10-11 BR BR9905092-7A patent/BR9905092A/pt not_active IP Right Cessation
- 1999-10-12 CO CO99064776A patent/CO5150214A1/es unknown
- 1999-10-12 HR HR990318A patent/HRP990318B1/xx not_active IP Right Cessation
- 1999-10-12 JP JP29009999A patent/JP3721021B2/ja not_active Expired - Fee Related
- 1999-10-12 PL PL335959A patent/PL198150B1/pl not_active IP Right Cessation
- 1999-10-12 GE GEAP19995027A patent/GEP20022700B/en unknown
- 1999-10-12 EE EEP199900507A patent/EE04192B1/xx not_active IP Right Cessation
- 1999-10-12 TR TR1999/02541A patent/TR199902541A2/xx unknown
- 1999-10-12 UY UY25750A patent/UY25750A1/es not_active Application Discontinuation
- 1999-10-12 SG SG1999005097A patent/SG118060A1/en unknown
2000
- 2000-10-10 HK HK00106399A patent/HK1027559A1/xx not_active IP Right Cessation
2001
- 2001-01-16 US US09/761,376 patent/US20010009962A1/en not_active Abandoned
2002
- 2002-09-23 US US10/253,029 patent/US20030069422A1/en not_active Abandoned
- 2002-11-18 IL IL15292802A patent/IL152928A0/xx active IP Right Grant
- 2002-11-18 IL IL15292702A patent/IL152927A0/xx unknown
- 2002-11-18 IL IL15292402A patent/IL152924A0/xx unknown
- 2002-11-18 IL IL15292302A patent/IL152923A0/xx unknown
- 2002-11-18 IL IL15292602A patent/IL152926A0/xx unknown

Also Published As

Publication number	Publication date
IL152928A0 (en)	2003-06-24
IL152924A0 (en)	2003-06-24
PL335959A1 (en)	2000-04-25
IL152924A (en)	2004-02-19
GB9822238D0 (en)	1998-12-09
BG103794A (en)	2000-09-29
CZ296816B6 (cs)	2006-06-14
MA25007A1 (fr)	2000-07-01
ZA996412B (en)	2001-04-11
PT994115E (pt)	2005-06-30
TR199902541A2 (xx)	2000-07-21
DK0994115T3 (da)	2005-06-20
JP3721021B2 (ja)	2005-11-30
AU5358199A (en)	2000-04-13
EA199900822A3 (ru)	2000-08-28
GEP20022700B (en)	2002-05-27
EE9900507A (et)	2000-06-15
IS1951B (is)	2004-10-13
CN1255497A (zh)	2000-06-07
HRP990318B1 (en)	2004-06-30
IL152927A (en)	2004-06-01
AR019244A1 (es)	2001-12-26
UA66787C2 (en)	2004-06-15
NO994943L (no)	2000-04-13
ATE290003T1 (de)	2005-03-15
AU756463B2 (en)	2003-01-16
EP0994115A3 (de)	2000-05-24
CO5150214A1 (es)	2002-04-29
HRP990318A2 (en)	2000-06-30
IL152926A0 (en)	2003-06-24
SG118060A1 (en)	2006-01-27
AP9901672A0 (en)	1999-12-31
TW589314B (en)	2004-06-01
BR9905092A (pt)	2000-08-08
SI0994115T1 (de)	2005-08-31
DZ2912A1 (fr)	2004-03-01
IS5209A (is)	2000-04-13
NO994943D0 (no)	1999-10-11
PL198150B1 (pl)	2008-05-30
EA003774B1 (ru)	2003-08-28
IL152927A0 (en)	2003-06-24
IL152923A0 (en)	2003-06-24
ES2237049T3 (es)	2005-07-16
GT199900172A (es)	2001-03-28
TNSN99189A1 (fr)	2005-11-10
CA2285733A1 (en)	2000-04-12
NO313700B1 (no)	2002-11-18
HUP9903469A3 (en)	2000-10-30
EA199900822A2 (ru)	2000-04-24
ID23351A (id)	2000-04-13
SK138599A3 (en)	2000-05-16
CR6118A (es)	2005-09-16
CZ353299A3 (cs)	2000-05-17
IL132273A (en)	2004-06-20
HU9903469D0 (en)	1999-12-28
EP0994115A2 (de)	2000-04-19
US20010009962A1 (en)	2001-07-26
KR100380954B1 (ko)	2003-04-21
DE69923906T2 (de)	2006-04-06
US6207829B1 (en)	2001-03-27
HK1027559A1 (en)	2001-01-19
BG63205B1 (bg)	2001-06-29
CU22928A3 (es)	2004-02-20
OA11165A (en)	2003-04-22
IL132273A0 (en)	2001-03-19
SK285215B6 (sk)	2006-09-07
CA2285733C (en)	2004-08-24
EE04192B1 (et)	2003-12-15
MY124620A (en)	2006-06-30
AP1233A (en)	2003-12-18
IL152923A (en)	2004-02-08
HU226162B1 (en)	2008-05-28
HUP9903469A2 (hu)	2000-08-28
UY25750A1 (es)	2001-08-27
JP2000119273A (ja)	2000-04-25
RS49762B (sr)	2008-04-04
KR20000028987A (ko)	2000-05-25
EG22630A (en)	2003-05-31
CN1473831A (zh)	2004-02-11
EP0994115B1 (de)	2005-03-02
PE20001086A1 (es)	2000-10-18
IL152928A (en)	2007-07-04
CN1207295C (zh)	2005-06-22
IL152926A (en)	2004-02-19
YU48999A (sh)	2002-06-19
US20030069422A1 (en)	2003-04-10

Publication	Publication Date	Title
DE69801973D1 (de)	2001-11-15	Verfahren zur Herstellung von 1,1,1,3,3-Pentafluorpropan
DE69923906D1 (de)	2005-04-07	Verfahren zur Herstellung von Pyrazolo-(4,3-d)pyrimidin-7-ones und Zwischenprodukte davon
DE69534190D1 (de)	2005-06-09	Verfahren zur Herstellung von 1,2-Benzisothiazol-3-onen
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