[go: up one dir, main page]

ATE288478T1 - Herstellung von dreidimensionalem vaskularisierten gewebe mittels der verwendung von zweidimensionalen mikrohergestellten formen - Google Patents

Herstellung von dreidimensionalem vaskularisierten gewebe mittels der verwendung von zweidimensionalen mikrohergestellten formen

Info

Publication number
ATE288478T1
ATE288478T1 AT00930192T AT00930192T ATE288478T1 AT E288478 T1 ATE288478 T1 AT E288478T1 AT 00930192 T AT00930192 T AT 00930192T AT 00930192 T AT00930192 T AT 00930192T AT E288478 T1 ATE288478 T1 AT E288478T1
Authority
AT
Austria
Prior art keywords
tissue
mold
dimensional
etched
living
Prior art date
Application number
AT00930192T
Other languages
English (en)
Inventor
Joseph P Vacanti
Jeffrey T Borenstein
Homer Dr Pien
Brian T Cunnungham
Original Assignee
Massachusetts Gen Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Gen Hospital filed Critical Massachusetts Gen Hospital
Application granted granted Critical
Publication of ATE288478T1 publication Critical patent/ATE288478T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/44—Vessels; Vascular smooth muscle cells; Endothelial cells; Endothelial progenitor cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3886—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells comprising two or more cell types
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3895—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells using specific culture conditions, e.g. stimulating differentiation of stem cells, pulsatile flow conditions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y70/00—Materials specially adapted for additive manufacturing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C12N5/0671—Three-dimensional culture, tissue culture or organ culture; Encapsulated cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/14—Coculture with; Conditioned medium produced by hepatocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/28—Vascular endothelial cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2535/00—Supports or coatings for cell culture characterised by topography
    • C12N2535/10—Patterned coating

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Materials Engineering (AREA)
  • Molecular Biology (AREA)
  • Manufacturing & Machinery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Prostheses (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Materials For Medical Uses (AREA)
  • Laser Surgery Devices (AREA)
AT00930192T 1999-04-30 2000-04-28 Herstellung von dreidimensionalem vaskularisierten gewebe mittels der verwendung von zweidimensionalen mikrohergestellten formen ATE288478T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13193099P 1999-04-30 1999-04-30
US16532999P 1999-11-12 1999-11-12
PCT/US2000/011407 WO2000066036A2 (en) 1999-04-30 2000-04-28 Fabrication of vascularized tissue using microfabricated two-dimensional molds

Publications (1)

Publication Number Publication Date
ATE288478T1 true ATE288478T1 (de) 2005-02-15

Family

ID=26829934

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00930192T ATE288478T1 (de) 1999-04-30 2000-04-28 Herstellung von dreidimensionalem vaskularisierten gewebe mittels der verwendung von zweidimensionalen mikrohergestellten formen

Country Status (8)

Country Link
US (3) US6455311B1 (de)
EP (1) EP1187909B1 (de)
JP (1) JP2002542883A (de)
AT (1) ATE288478T1 (de)
AU (1) AU772484B2 (de)
CA (1) CA2370781A1 (de)
DE (1) DE60017900T2 (de)
WO (1) WO2000066036A2 (de)

Families Citing this family (122)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE288478T1 (de) * 1999-04-30 2005-02-15 Massachusetts Gen Hospital Herstellung von dreidimensionalem vaskularisierten gewebe mittels der verwendung von zweidimensionalen mikrohergestellten formen
US7759113B2 (en) * 1999-04-30 2010-07-20 The General Hospital Corporation Fabrication of tissue lamina using microfabricated two-dimensional molds
US7371400B2 (en) * 2001-01-02 2008-05-13 The General Hospital Corporation Multilayer device for tissue engineering
US6793677B2 (en) * 1999-08-13 2004-09-21 Bret A. Ferree Method of providing cells and other biologic materials for transplantation
US6503273B1 (en) * 1999-11-22 2003-01-07 Cyograft Tissue Engineering, Inc. Tissue engineered blood vessels and methods and apparatus for their manufacture
US6576265B1 (en) * 1999-12-22 2003-06-10 Acell, Inc. Tissue regenerative composition, method of making, and method of use thereof
US20040043006A1 (en) * 2002-08-27 2004-03-04 Badylak Stephen F. Tissue regenerative composition
US7776021B2 (en) * 2000-04-28 2010-08-17 The Charles Stark Draper Laboratory Micromachined bilayer unit for filtration of small molecules
WO2002078439A2 (en) * 2001-03-30 2002-10-10 The Arizona Board Of Regents On Behalf Of The University Of Arizona Prevascularized constructs for implantation to provide blood perfusion
GB0114399D0 (en) * 2001-06-13 2001-08-08 Univ Liverpool Substrates, biomaterials and methods
WO2003004254A1 (en) * 2001-07-03 2003-01-16 The Regents Of The University Of California Microfabricated biopolymer scaffolds and method of making same
DE10146903C1 (de) * 2001-09-24 2002-11-14 Cytonet Gmbh & Co Kg Verfahren zur Herstellung von in vitro-Hohlorganen
JP2005509495A (ja) * 2001-11-16 2005-04-14 チルドレンズ メディカル センター コーポレーション 臓器の機能の増強
US20050019488A1 (en) * 2001-11-30 2005-01-27 Cambridge Polymer Group, Inc., Boston, Ma Layered aligned polymer structures and methods of making same
US7048963B2 (en) * 2001-11-30 2006-05-23 Cambridge Polymers Group, Inc. Layered aligned polymer structures and methods of making same
WO2003050266A2 (en) * 2001-12-11 2003-06-19 Cytograft Tissue Engineering, Inc. Tissue engineered cellular sheets, methods of making and use thereof
US7622299B2 (en) * 2002-02-22 2009-11-24 University Of Washington Bioengineered tissue substitutes
AU2003222697A1 (en) * 2002-04-24 2003-11-10 Biogentis Inc. Method for preparing tissue constructs
CA2389394A1 (en) * 2002-06-05 2003-12-05 Michael V. Sefton Modular assembly of tissue engineered constructs
FR2843386B1 (fr) 2002-08-12 2007-02-16 Pentax Corp Procede pour la production d'un comprime fritte, comprime fritte produit par ce procede, et base de culture cellulaire a partir de ce comprime fritte
EP1589814B1 (de) * 2003-01-16 2009-08-12 The General Hospital Corporation Verwendung von dreidimensionalen, mikrogefertigten, mittels gewebetechnologie hergestellten systemen für pharmakologische anwendungen
US7517453B2 (en) 2003-03-01 2009-04-14 The Trustees Of Boston University Microvascular network device
US8828226B2 (en) 2003-03-01 2014-09-09 The Trustees Of Boston University System for assessing the efficacy of stored red blood cells using microvascular networks
US20040175366A1 (en) * 2003-03-07 2004-09-09 Acell, Inc. Scaffold for cell growth and differentiation
US20040176855A1 (en) * 2003-03-07 2004-09-09 Acell, Inc. Decellularized liver for repair of tissue and treatment of organ deficiency
JP4247737B2 (ja) * 2003-03-11 2009-04-02 ウシオ電機株式会社 細胞固定用基板の製造方法および細胞固定用基板
GB2401612A (en) * 2003-05-13 2004-11-17 Univ Manchester Method and device for culturing tissue
WO2005034624A2 (en) 2003-05-21 2005-04-21 The General Hospital Corporation Microfabricated compositions and processes for engineering tissues containing multiple cell types
US7051654B2 (en) * 2003-05-30 2006-05-30 Clemson University Ink-jet printing of viable cells
AU2004253508A1 (en) * 2003-06-25 2005-01-13 Acell, Inc. Conditioned matrix compositions for tissue restoration
US20050014364A1 (en) * 2003-07-18 2005-01-20 Infineon Technologies North America Corp. Method of suppressing the effect of shining spots present at the edge of a wafer
EP1668117A4 (de) * 2003-08-18 2006-12-13 Gen Hospital Corp Nanotopographische zusammensetzungen und verfahren zur zellulären organisation in geweberekonstruktionsstrukturen
US8043614B2 (en) * 2004-03-09 2011-10-25 Ahlfors Jan-Eric W Autogenic living scaffolds and living tissue matrices: methods and uses thereof
JP4247231B2 (ja) * 2003-10-17 2009-04-02 育男 森田 人工細胞組織の作成方法、及びそのための基材
US7919305B2 (en) 2004-02-19 2011-04-05 Dai Nippon Printing Co., Ltd. Method for manufacturing cell culture substrate
JP4456393B2 (ja) 2004-03-26 2010-04-28 大日本印刷株式会社 細胞培養基板の製造方法および細胞培養基板製造装置
JP4585790B2 (ja) * 2004-03-27 2010-11-24 独立行政法人科学技術振興機構 細胞培養足場および細胞培養方法
JP4422719B2 (ja) * 2004-04-12 2010-02-24 大日本印刷株式会社 人工組織およびその製造方法
JP4303643B2 (ja) 2004-06-01 2009-07-29 育男 森田 人工組織体およびその製造方法
WO2006028274A1 (ja) * 2004-09-08 2006-03-16 National University Corporation Nagoya University 細胞培養物の生産と該生産に用いる材料
US9427496B2 (en) 2005-02-18 2016-08-30 Drexel University Method for creating an internal transport system within tissue scaffolds using computer-aided tissue engineering
US9249386B2 (en) 2005-06-06 2016-02-02 Dai Nippon Printing Co., Ltd. Substrate for cell transfer
US7790028B1 (en) * 2005-09-28 2010-09-07 The Charles Stark Draper Laboratory, Inc. Systems, methods, and devices relating to a cellularized nephron unit
DK1948259T3 (en) * 2005-10-26 2017-04-10 Genesis Tech Ltd ACELLULAR BIOabsorbable Tissue Regeneration Matrices Produced by Incubation of ACELLULAR BLOOD PRODUCTS
US20080159604A1 (en) * 2005-12-30 2008-07-03 Allan Wang Method and system for imaging to identify vascularization
WO2007080990A1 (ja) * 2006-01-12 2007-07-19 Kazuo Ohashi 肝組織細胞機能の長期維持方法
US20100273667A1 (en) * 2006-02-10 2010-10-28 The Regents Of The University Of Michigan Cell culture well-plates having inverted colloidal crystal scaffolds
US20090041825A1 (en) * 2006-02-10 2009-02-12 Kotov Nicholas A Cell culture well-plates having inverted colloidal crystal scaffolds
US7854505B2 (en) * 2006-03-15 2010-12-21 The Board Of Trustees Of The University Of Illinois Passive and active photonic crystal structures and devices
US20090169596A1 (en) * 2006-03-29 2009-07-02 Mikael Svensson Device for spinal cord nerve regeneration
US20090239303A1 (en) * 2006-04-24 2009-09-24 Rhoades Lawrence J Ultrasonic Machining Fabrication of Guided Tissue Generation Surfaces and Tissue Scaffolds
JP4821466B2 (ja) * 2006-07-03 2011-11-24 富士ゼロックス株式会社 液滴吐出ヘッド
JP4934360B2 (ja) * 2006-07-05 2012-05-16 学校法人東京女子医科大学 細胞培養支持体
US20100189712A1 (en) * 2006-11-17 2010-07-29 Cytograft Tissue Engineering, Inc. Preparation And Use Of Cell-Synthesized Threads
DE102007014158A1 (de) * 2007-03-21 2008-09-25 Matthias Schreiber Verfahren zur Herstellung einer 3D Gefäßmatrix und Zellträgermatrix und In-vitro-Verfahren und Vorrichtung zur Inkubaktion
ES2859575T3 (es) 2007-04-12 2021-10-04 Massachusetts Gen Hospital Red vascular biomimética
US9580688B2 (en) 2007-06-08 2017-02-28 Wake Forest University Health Sciences Kidney structures and methods of forming the same
CN103865871A (zh) 2007-06-08 2014-06-18 韦克福里斯特大学健康科学院 治疗肾功能衰竭的选择性细胞疗法
WO2009039378A2 (en) 2007-09-19 2009-03-26 The Charles Stark Draper Laboratory, Inc. Microfluidic structures for biomedical applications
US20110033887A1 (en) * 2007-09-24 2011-02-10 Fang Nicholas X Three-Dimensional Microfabricated Bioreactors with Embedded Capillary Network
US20090234332A1 (en) * 2008-03-17 2009-09-17 The Charles Stark Draper Laboratory, Inc Artificial microvascular device and methods for manufacturing and using the same
DE102008015633B4 (de) * 2008-03-25 2010-07-01 Nova Tissue Gmbh Perfundierbarer Bioreaktor zur Herstellung und/oder Kultivierung eines menschlichen oder tierischen Blutgefäßes und/oder eines menschlichen oder tierischen Gewebes
US20110091926A1 (en) * 2008-03-25 2011-04-21 Novatissue Gmbh Perfusable bioreactor for the production of human or animal tissues
WO2010005753A1 (en) * 2008-06-16 2010-01-14 Cytograft Tissue Engineering, Inc. Arterial implants
US9242027B2 (en) 2008-07-18 2016-01-26 Cornell University Fabrication of a vascular system using sacrificial structures
WO2010057013A1 (en) 2008-11-14 2010-05-20 Wake Forest University Health Sciences Selective cell therapy for the treatment of renal failure
JP2012527931A (ja) * 2009-05-26 2012-11-12 デバイオテック・ソシエテ・アノニム 異方性コーティングにおける多孔性の制御
WO2011002926A2 (en) 2009-07-01 2011-01-06 The General Hospital Corporation Isolated adult cells, artificial organs,rehabilitated organs, research rools, organ encasements, organ perfusion systems, and methods for preparing and utilizing the same
US8298586B2 (en) * 2009-07-22 2012-10-30 Acell Inc Variable density tissue graft composition
US8652500B2 (en) * 2009-07-22 2014-02-18 Acell, Inc. Particulate tissue graft with components of differing density and methods of making and using the same
US20110082563A1 (en) * 2009-10-05 2011-04-07 The Charles Stark Draper Laboratory, Inc. Microscale multiple-fluid-stream bioreactor for cell culture
US20110186165A1 (en) * 2009-10-05 2011-08-04 Borenstein Jeffrey T Three-dimensional microfluidic platforms and methods of use and manufacture thereof
CA2781874A1 (en) 2009-10-12 2011-04-21 New Health Sciences, Inc. Oxygen depletion devices and methods for removing oxygen from red blood cells
CA2781866C (en) 2009-10-12 2019-12-03 New Health Sciences, Inc. Blood storage bag system and depletion devices with oxygen and carbon dioxide depletion capabilities
US11284616B2 (en) 2010-05-05 2022-03-29 Hemanext Inc. Irradiation of red blood cells and anaerobic storage
US9199016B2 (en) 2009-10-12 2015-12-01 New Health Sciences, Inc. System for extended storage of red blood cells and methods of use
US12089589B2 (en) 2009-10-12 2024-09-17 Hemanext Inc. Irradiation of red blood cells and anaerobic storage
JP5879267B2 (ja) * 2009-10-29 2016-03-08 ザ・チャールズ・スターク・ドレイパ・ラボラトリー・インコーポレイテッド 血液透析用マイクロ流体装置
CN111281890A (zh) * 2010-05-07 2020-06-16 北卡罗来纳大学查伯山分校 移植来自实体组织的细胞的方法
US9506024B2 (en) 2010-08-06 2016-11-29 Tissuse Gmbh Circulation system
ES2959120T3 (es) 2010-08-25 2024-02-20 Hemanext Inc Método para potenciar la calidad y la supervivencia de glóbulos rojos durante el almacenamiento
US20120089238A1 (en) 2010-10-06 2012-04-12 Hyun-Wook Kang Integrated organ and tissue printing methods, system and apparatus
PT3539381T (pt) 2010-11-05 2023-09-26 Hemanext Inc Irradiação de glóbulos vermelhos e armazenamento anaeróbico
US9067004B2 (en) 2011-03-28 2015-06-30 New Health Sciences, Inc. Method and system for removing oxygen and carbon dioxide during red cell blood processing using an inert carrier gas and manifold assembly
CA2839435C (en) 2011-06-15 2021-05-11 The Charles Stark Draper Laboratory, Inc. Systems, methods, and devices relating to a biomimetic cellularized nephron unit
US8703216B2 (en) 2011-07-26 2014-04-22 The Curators Of The University Of Missouri Engineered comestible meat
AU2012294269B2 (en) 2011-08-10 2016-11-24 Hemanext Inc. Integrated leukocyte, oxygen and/or CO2 depletion, and plasma separation filter device
US8414654B1 (en) * 2011-11-23 2013-04-09 Amendia, Inc. Bone implants and method of manufacture
US20140308688A1 (en) 2011-12-08 2014-10-16 Research Triangle Institute Human emulated response with microfluidic enhanced systems
WO2013116834A2 (en) 2012-02-03 2013-08-08 The Charles Stark Draper Laboratory, Inc. Microfluidic device for generating neural cells to simulate post-stroke conditions
EP4108331A1 (de) 2012-05-22 2022-12-28 Hemanext Inc. Kapillare netzwerkvorrichtungen
JP6270856B2 (ja) * 2012-10-05 2018-01-31 マテリアライズ エン．フェー． カスタマイズされた大動脈ステントデバイスおよびそれを作製する方法
WO2014134503A1 (en) 2013-02-28 2014-09-04 New Health Sciences, Inc. Gas depletion and gas addition devices for blood treatment
WO2014159722A1 (en) * 2013-03-12 2014-10-02 Carol Livermore-Clifford Deterministic manufacturing process for creating 3d living tissues based on 2d directed assembly and origami techniques
DE102013108616A1 (de) * 2013-08-09 2015-02-12 Karlsruher Institut für Technologie Bioreaktor, Verfahren und seine Verwendung zur Gewinnung von Zellmetaboliten
WO2015038988A1 (en) 2013-09-13 2015-03-19 Modern Meadow, Inc. Edible and animal-product-free microcarriers for engineered meat
CN103767804A (zh) * 2014-01-20 2014-05-07 清华大学 一种具有微流体通道的血管化组织结构及其制备方法
JP2017505138A (ja) 2014-02-05 2017-02-16 モダン メドー インコーポレイテッド 培養筋細胞から形成される乾燥食品
TWI568849B (zh) * 2014-08-15 2017-02-01 國防醫學院 一種製造用於重建神經血管組織之細胞層片結構物的方法
WO2016145210A1 (en) 2015-03-10 2016-09-15 New Health Sciences, Inc. Oxygen reduction disposable kits, devices and methods of use thereof
KR102661405B1 (ko) 2015-04-23 2024-04-25 헤마넥스트 인코포레이티드 혐기성 혈액 저장 용기
WO2016179242A1 (en) * 2015-05-05 2016-11-10 President And Fellows Of Harvard College Tubular tissue construct and a method of printing
MX2017014812A (es) 2015-05-18 2018-05-11 New Health Sciences Inc Metodos para el almacenamiento de sangre completa y composiciones de esta.
WO2017030762A1 (en) 2015-08-14 2017-02-23 The General Hospital Corporation Systems for and methods for using biomimetic structures providing communication in living tissue
DK3341465T3 (da) 2015-08-26 2023-11-20 Emulate Inc Perfusionsfordeleranordning
CN109414527B (zh) * 2015-09-17 2022-07-26 博纳斯治疗公司 基于微毛细管网络的支架
EP3337923B2 (de) 2015-09-21 2023-01-04 Modern Meadow, Inc. Faserverstärkte gewebeverbundwerkstoffe
US11530304B2 (en) 2016-02-15 2022-12-20 Modern Meadow, Inc. Biofabricated material containing collagen fibrils
WO2017205590A2 (en) 2016-05-27 2017-11-30 New Health Sciences, Inc. Anaerobic blood storage and pathogen inactivation method
US10767164B2 (en) 2017-03-30 2020-09-08 The Research Foundation For The State University Of New York Microenvironments for self-assembly of islet organoids from stem cells differentiation
AU2018253595A1 (en) 2017-11-13 2019-05-30 Modern Meadow, Inc. Biofabricated leather articles having zonal properties
US10398795B2 (en) * 2017-12-29 2019-09-03 Tomi Environmental Solutions, Inc. Decontamination device and method using ultrasonic cavitation
US10073440B1 (en) * 2018-02-13 2018-09-11 University Of Central Florida Research Foundation, Inc. Method for the design and manufacture of composites having tunable physical properties
CN117752862A (zh) * 2018-05-25 2024-03-26 通用医疗公司 复杂可植入维生装置的增材制造
CN110607271B (zh) * 2018-06-14 2023-01-20 中国科学院大连化学物理研究所 一种基于微加工技术的体外血管化3d组织的制备方法
EP3704202A4 (de) 2019-01-17 2020-12-16 Modern Meadow, Inc. Geschichtete kollagenmaterialien und verfahren zu ihrer herstellung
JP2022553206A (ja) * 2019-10-16 2022-12-22 ウィスコンシン・アルムナイ・リサーチ・ファウンデーション 光受容細胞および網膜色素上皮の移植治療のための機械的に安定な高細胞密度の蜂巣状網膜足場設計
CN111921016B (zh) * 2020-07-20 2022-04-26 中国医科大学 一种人工器官制造模具及人工器官制造方法
CN113081397A (zh) * 2021-03-10 2021-07-09 浙江工业大学 具有血管微循环通道和引导骨生长的下颌骨植入体制作方法及植入体
US11819415B2 (en) 2021-04-02 2023-11-21 Arthrex, Inc. Orthopaedic implant systems including internal networks and methods of repair
CN113229993A (zh) * 2021-05-10 2021-08-10 中国医科大学 可拆卸式组合模具及其制备带多分支通道复杂器官的方法
CN115503268A (zh) * 2022-09-05 2022-12-23 重庆三大伟业制药有限公司 一种用于血液循环的集装盒的制作方法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5266480A (en) * 1986-04-18 1993-11-30 Advanced Tissue Sciences, Inc. Three-dimensional skin culture system
US4996154A (en) * 1989-05-04 1991-02-26 Millipore Corporation Method for growing cellular tissue
US5204055A (en) 1989-12-08 1993-04-20 Massachusetts Institute Of Technology Three-dimensional printing techniques
US5061620A (en) * 1990-03-30 1991-10-29 Systemix, Inc. Human hematopoietic stem cell
JP2609556B2 (ja) * 1990-06-08 1997-05-14 株式会社バイオマテリアル研究所 神経細胞の培養に用いる基質
US5486359A (en) * 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
US5549674A (en) 1992-03-02 1996-08-27 The Regents Of The University Of Michigan Methods and compositions of a bioartificial kidney suitable for use in vivo or ex vivo
US5849553A (en) * 1992-07-27 1998-12-15 California Institute Of Technology Mammalian multipotent neural stem cells
CA2119064A1 (en) * 1993-03-17 1994-09-18 Richard A. Berg Dermal-epidermal in vitro test system
US6200802B1 (en) * 1993-10-08 2001-03-13 Arch Development Corporation Human peroxisome proliferator activated receptor gamma: compositions and methods
US6176874B1 (en) 1993-10-18 2001-01-23 Masschusetts Institute Of Technology Vascularized tissue regeneration matrices formed by solid free form fabrication techniques
US5843480A (en) * 1994-03-14 1998-12-01 Euro-Celtique, S.A. Controlled release diamorphine formulation
JP2570621B2 (ja) * 1994-06-27 1997-01-08 日本電気株式会社 細胞培養用基板とその作製方法および細胞配列形成方法
AT405288B (de) 1994-09-21 1999-06-25 Chemie Linz Gmbh Flammfeste, glasfaserverstärkte polyamidharzmasse mit melamin- oder melem-phosphorsäure-umsetzungsprodukten als flammhemmer
JP2609073B2 (ja) * 1994-10-26 1997-05-14 鐘淵化学工業株式会社 細胞の配列制御用具および細胞の配列制御法
US5843780A (en) * 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
US5869243A (en) * 1996-03-05 1999-02-09 Rhode Island Hospital Immortalized hepatocytes
US5817343A (en) * 1996-05-14 1998-10-06 Alkermes, Inc. Method for fabricating polymer-based controlled-release devices
US6331406B1 (en) * 1997-03-31 2001-12-18 The John Hopkins University School Of Medicine Human enbryonic germ cell and methods of use
ATE227338T1 (de) * 1998-03-18 2002-11-15 Massachusetts Inst Technology Vaskularisierte perfundierte anordnungen für mikrogewebe und mikroorgane
US6143293A (en) * 1998-03-26 2000-11-07 Carnegie Mellon Assembled scaffolds for three dimensional cell culturing and tissue generation
CA2330104A1 (en) 1998-04-09 1999-10-21 Charlotte-Mecklenberg Hospital Authority Creation of three-dimensional tissues
ATE288478T1 (de) * 1999-04-30 2005-02-15 Massachusetts Gen Hospital Herstellung von dreidimensionalem vaskularisierten gewebe mittels der verwendung von zweidimensionalen mikrohergestellten formen
US7371400B2 (en) * 2001-01-02 2008-05-13 The General Hospital Corporation Multilayer device for tissue engineering

Also Published As

Publication number Publication date
US6455311B1 (en) 2002-09-24
DE60017900D1 (de) 2005-03-10
WO2000066036A3 (en) 2001-02-08
CA2370781A1 (en) 2000-11-09
EP1187909A2 (de) 2002-03-20
US20030003575A1 (en) 2003-01-02
EP1187909B1 (de) 2005-02-02
DE60017900T2 (de) 2006-04-06
WO2000066036A2 (en) 2000-11-09
US20070148139A1 (en) 2007-06-28
AU772484B2 (en) 2004-04-29
AU4805500A (en) 2000-11-17
JP2002542883A (ja) 2002-12-17

Similar Documents

Publication Publication Date Title
ATE288478T1 (de) Herstellung von dreidimensionalem vaskularisierten gewebe mittels der verwendung von zweidimensionalen mikrohergestellten formen
Zhao et al. Review on the vascularization of organoids and organoids-on-a-C hip
Kitsara et al. Heart on a chip: micro-nanofabrication and microfluidics steering the future of cardiac tissue engineering
CN112280678B (zh) 一种可拆卸、可重复使用的疏水或超疏水微流控器官芯片
CN103981096B (zh) 一种两层细胞培养体系器官芯片及其制备方法
CN107312713A (zh) 一种微流控芯片及其应用
Gwyther et al. Directed cellular self-assembly to fabricate cell-derived tissue rings for biomechanical analysis and tissue engineering
EP3383997A1 (de) Oben offene mikrofluidische vorrichtung mit strukturellem anker
CN112143642B (zh) 用于体外培养的血管化肿瘤微流控器官芯片及其制备方法
AVCI et al. Recent advances in organ-on-a-chip technologies and future challenges: a review
Tabatabaei Rezaei et al. Recent advances in organ‐on‐chips integrated with bioprinting technologies for drug screening
US12029832B2 (en) Three-dimensional bioprinting of cardiac patch with anisotropic and perfusable architecture
Chen et al. Engineering Cardiac Tissue for Advanced Heart‐On‐A‐Chip Platforms
Kashte et al. Bioinspired engineering for liver tissue regeneration and development of bioartificial liver: a review
Tien et al. Microstructured extracellular matrices in tissue engineering and development: an update
Khanna et al. Cardiovascular human organ‐on‐a‐chip platform for disease modeling, drug development, and personalized therapy
EP3138904A1 (de) Vorrichtung und verfahren für gewebekultur mit hermetisch verschlossener blutzirkulation
Sree et al. Nature-inspired vascularised materials and devices for biomedical engineering
Bhumiratana et al. Principles of bioreactor design for tissue engineering
CN116640666A (zh) 用于药物筛选的高通量气体暴露仿生肺微流控芯片装置及其应用
JP2002542817A (ja) 三次元的な細胞増殖のためのモジュール状の細胞キャリヤー系
JP2005305177A (ja) 組織付属器官様構造体を含む人工組織およびその製造方法
CN108407156A (zh) 组织工程人工肝样组织构建模具和制造该模具的注塑模具的方法
CN114774278A (zh) 一种3d心脏瓣膜类器官培育器及其使用方法
Dermenoudis et al. Bioreactors in tissue engineering

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties