ATE280777T1 - Bradykinin-antagonist peptide mit n- substituierten glycinen - Google Patents

Bradykinin-antagonist peptide mit n- substituierten glycinen

Info

Publication number: ATE280777T1
Authority: AT; Austria
Prior art keywords: substituted glycines; bradykinin; antagonist peptides; bradykinin antagonist; glycines
Prior art date: 1994-03-09

Application number

AT95911948T

Other languages

English (en)

Inventor

Val S Goodfellow

Manoj V Marathe

Eric T Whalley

Timothy D Fitzpatrick

Karen G Kuhlman

Original Assignee

Cortech Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-03-09

Filing date

1995-03-07

Publication date

2004-11-15

1995-03-07 Application filed by Cortech Inc filed Critical Cortech Inc

2004-11-15 Application granted granted Critical

2004-11-15 Publication of ATE280777T1 publication Critical patent/ATE280777T1/de

Links

108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
108010049175 N-substituted Glycines Proteins 0.000 title abstract 2
UYRCOTSOPWOSJK-JXTBTVDRSA-N bradykinin antagonist Chemical compound C1C2=CC=CC=C2CC1[C@@H](NC(=O)C(CO)NC(=O)C(NC(=O)CNC(=O)[C@H]1N(C[C@H](O)C1)C(=O)C1N(CCC1)C(=O)C(CCCNC(N)=N)NC(=O)[C@@H](CCCNC(N)=N)NC(=N)CCCCCCC(=N)N[C@H](CCCNC(N)=N)C(=O)NC(CCCNC(N)=N)C(=O)N1C(CCC1)C(=O)N1[C@@H](C[C@@H](O)C1)C(=O)NCC(=O)NC(C1CC2=CC=CC=C2C1)C(=O)NC(CO)C(=O)N[C@H](C1CC2=CC=CC=C2C1)C(=O)N1C2CCCCC2CC1C(=O)NC(CCCNC(N)=N)C(O)=O)C1CC2=CC=CC=C2C1)C(=O)N1C2CCCCC2CC1C(=O)NC(CCCNC(=N)N)C(O)=O UYRCOTSOPWOSJK-JXTBTVDRSA-N 0.000 title abstract 2
239000003152 bradykinin antagonist Substances 0.000 title abstract 2
102400000967 Bradykinin Human genes 0.000 abstract 2
101800004538 Bradykinin Proteins 0.000 abstract 2
QXZGBUJJYSLZLT-UHFFFAOYSA-N H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH Natural products NC(N)=NCCCC(N)C(=O)N1CCCC1C(=O)N1C(C(=O)NCC(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CO)C(=O)N2C(CCC2)C(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CCCN=C(N)N)C(O)=O)CCC1 QXZGBUJJYSLZLT-UHFFFAOYSA-N 0.000 abstract 2
QXZGBUJJYSLZLT-FDISYFBBSA-N bradykinin Chemical compound NC(=N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(=O)NCC(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CO)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)CCC1 QXZGBUJJYSLZLT-FDISYFBBSA-N 0.000 abstract 2
206010061218 Inflammation Diseases 0.000 abstract 1
230000004054 inflammatory process Effects 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/18—Kallidins; Bradykinins; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biophysics (AREA)
Pain & Pain Management (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Biomedical Technology (AREA)
Heart & Thoracic Surgery (AREA)
Rheumatology (AREA)
Cardiology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Hematology (AREA)
Obesity (AREA)
Diabetes (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Pulmonology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT95911948T 1994-03-09 1995-03-07 Bradykinin-antagonist peptide mit n- substituierten glycinen ATE280777T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US20811594A	1994-03-09	1994-03-09
PCT/US1995/002399 WO1995024422A1 (en)	1994-03-09	1995-03-07	Bradykinin antagonist peptides incorporating n-substituted glycines

Publications (1)

Publication Number	Publication Date
ATE280777T1 true ATE280777T1 (de)	2004-11-15

Family

ID=22773240

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95911948T ATE280777T1 (de)	1994-03-09	1995-03-07	Bradykinin-antagonist peptide mit n- substituierten glycinen

Country Status (12)

Country	Link
US (1)	US5700779A (de)
EP (1)	EP0813544B1 (de)
JP (1)	JPH09511500A (de)
KR (1)	KR100360639B1 (de)
CN (1)	CN1150206C (de)
AT (1)	ATE280777T1 (de)
AU (1)	AU696429B2 (de)
CA (1)	CA2184824A1 (de)
DE (1)	DE69533704D1 (de)
TW (1)	TW408133B (de)
WO (1)	WO1995024422A1 (de)
ZA (1)	ZA951974B (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5648336A (en) *	1994-11-18	1997-07-15	University Of Colorado	Bradykinin antagonist peptides containing indane-substituted amino acids
WO1996039425A2 (en) *	1995-06-05	1996-12-12	Cortech, Inc.	Compounds having bradykinin antagonistic activity and mu-opioid agonistic activity
US5849863A (en) *	1995-09-08	1998-12-15	University Of Colorado	Cytolytic bradykinin antagonists
DE19612067A1 (de) *	1996-03-27	1997-10-02	Hoechst Ag	Verwendung von Bradykinin-Antagonisten zur Herstellung von Arzneimitteln zur Behandlung von chronisch fibrogenetischen Lebererkrankungen und akuten Lebererkrankungen
FR2756566B1 (fr) *	1996-12-04	1999-01-08	Fournier Ind & Sante	Peptides agonistes du recepteur b2 de la bradykinine, procede de preparation et utilisation en therapeutique
US7704958B1 (en)	1999-03-05	2010-04-27	Bio Holding, Inc.	Methods and compositions for inhibiting apoptosis using serine protease inhibitors
WO2000051625A1 (en) *	1999-03-05	2000-09-08	The Trustees Of University Technology Corporation	Inhibitors of serine protease activity, methods and compositions for treatment of herpes viruses
AU3511500A (en)	1999-03-05	2000-09-21	Trustees Of University Technology Corporation, The	Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide-induced clinical conditions
US6849605B1 (en)	1999-03-05	2005-02-01	The Trustees Of University Technology Corporation	Inhibitors of serine protease activity, methods and compositions for treatment of viral infections
US7105172B1 (en)	1999-11-18	2006-09-12	Bolla John D	Treatment of rosacea
US6699486B1 (en)	1999-11-18	2004-03-02	Bolla Corporation	Treatment or prevention of photoaging and skin cancer
US7211566B2 (en) *	2003-04-01	2007-05-01	Universite De Sherbrooke	Selective bradykinin (BK) B1 peptidic receptor antagonists and uses thereof
US20040220242A1 (en) *	2003-05-02	2004-11-04	Leland Shapiro	Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide induced clinical conditions
US7605120B2 (en) *	2003-10-22	2009-10-20	Amgen Inc.	Antagonists of the brandykinin B1 receptor
US7932228B2 (en) *	2004-08-19	2011-04-26	Societe de Commercialisation des Produits de la Recherche Applique Socpra Sciences Sante et Humaines S.E.C.	Method of treating bone or prostate cancer with selective bradykinin B1 receptor antagonists
EP1906929A2 (de) *	2005-04-25	2008-04-09	Amgen Inc.	Porogene enthaltende zusammensetzungen mit anhaltender freisetzung eines biologisch abbaubaren peptids
US7403325B2 (en) *	2006-05-19	2008-07-22	Xerox Corporation	Electrophoretic display device
US8476408B2 (en) *	2008-06-13	2013-07-02	Alize Pharma Sas	Unacylated ghrelin and analogs as therapeutic agents for vascular remodeling in diabetic patients and treatment of cardiovascular disease
FR2974182B1 (fr) *	2011-04-14	2013-04-26	Univ Grenoble 1	Diagnostic et traitement de l'angioedeme
CN102295711A (zh) *	2011-08-23	2011-12-28	湖北宝迪农业科技有限公司	从猪肺中提取肝素钠并联产多肽蛋白粉的工艺
WO2013043669A1 (en) *	2011-09-21	2013-03-28	The Board Of Regents Of The University Of Texas System	Peptoid compositions for the treatment of alzheimer's disease and polyglutamine expansion disorder
KR102686073B1 (ko)	2015-10-14	2024-07-17	엑스-써마 인코포레이티드	얼음 결정 형성을 감소시키기 위한 조성물 및 방법
CN116554267A (zh) *	2022-01-30	2023-08-08	江苏众红生物工程创药研究院有限公司	聚乙二醇修饰的激肽或其变体和药物应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2964956D1 (en) *	1978-07-18	1983-04-07	Kabi Ab	Bradykinin inhibiting tripeptide derivatives, process for their preparation and pharmaceutical preparations containing them
US4693993A (en) *	1985-06-13	1987-09-15	Stewart John M	Bradykinin antagonist peptides
IE63490B1 (en) *	1988-11-24	1995-05-03	Hoechst Ag	Peptides having bradykinin antagonist action
DE4013270A1 (de) *	1990-04-26	1991-10-31	Hoechst Ag	Peptide mit bradykinin-antagonistischer wirkung
JP3465000B2 (ja) *	1991-04-19	2003-11-10	シオス・ノヴァ・インコーポレイティット	ブラジキニン型ペプチド
EP0529499A1 (de) *	1991-08-22	1993-03-03	Hoechst Aktiengesellschaft	Pharmazeutische Zusammensetzungen enthaltend Bradykinin-Antagonisten zur lokalen Anwendung an Nase und Auge
WO1993011789A1 (en) *	1991-12-12	1993-06-24	Scios Nova Inc.	Modified position (7) bradykinin antagonist peptides
TW258739B (de) *	1992-04-04	1995-10-01	Hoechst Ag
ES2148347T3 (es) *	1993-09-09	2000-10-16	Scios Inc	Antagonistas del receptor de la bradiquinina pseudo y no peptidica.

1995
- 1995-03-07 AT AT95911948T patent/ATE280777T1/de not_active IP Right Cessation
- 1995-03-07 JP JP7523493A patent/JPH09511500A/ja not_active Ceased
- 1995-03-07 EP EP95911948A patent/EP0813544B1/de not_active Expired - Lifetime
- 1995-03-07 DE DE69533704T patent/DE69533704D1/de not_active Expired - Lifetime
- 1995-03-07 KR KR1019960704967A patent/KR100360639B1/ko not_active IP Right Cessation
- 1995-03-07 AU AU19325/95A patent/AU696429B2/en not_active Ceased
- 1995-03-07 CA CA002184824A patent/CA2184824A1/en not_active Abandoned
- 1995-03-07 WO PCT/US1995/002399 patent/WO1995024422A1/en active IP Right Grant
- 1995-03-07 CN CNB951930176A patent/CN1150206C/zh not_active Expired - Fee Related
- 1995-03-09 ZA ZA951974A patent/ZA951974B/xx unknown
- 1995-03-15 TW TW084102476A patent/TW408133B/zh not_active IP Right Cessation
1996
- 1996-06-20 US US08/668,100 patent/US5700779A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0813544A4 (de)	1998-01-07
EP0813544A1 (de)	1997-12-29
JPH09511500A (ja)	1997-11-18
WO1995024422A1 (en)	1995-09-14
CN1150206C (zh)	2004-05-19
AU696429B2 (en)	1998-09-10
AU1932595A (en)	1995-09-25
US5700779A (en)	1997-12-23
EP0813544B1 (de)	2004-10-27
CN1148393A (zh)	1997-04-23
CA2184824A1 (en)	1995-09-14
KR100360639B1 (ko)	2003-01-30
ZA951974B (en)	1995-12-11
DE69533704D1 (de)	2004-12-02
TW408133B (en)	2000-10-11

Publication	Publication Date	Title
DE69533704D1 (de)	2004-12-02	Bradykinin-antagonist peptide mit n-substituierten glycinen
DE122009000012I1 (de)	2011-12-01	Substituierte pyrazolyl-benzolsulfonamide zur behandlung von entzundungen.
ATE396205T1 (de)	2008-06-15	Die verwendung von peptiden von il-2 und peptid- derivaten als therapeutische wirkstoffe
DE69435105D1 (de)	2008-08-07	Derivate therapeutischer Peptide
PT705100E (pt)	2003-12-31	Guanidinas substituidas terapeuticas
PL328858A1 (en)	1999-03-01	Immunogenous peptides
DE69526216D1 (de)	2002-05-08	Antifungaleverfahren und mitteln
DE69905170T2 (de)	2004-01-15	Thiazolopyrimidinderivate
PT848720E (pt)	2004-05-31	Antagonistas da actividade oncogenica da proteina mdm2 e sua utilizacao no tratamento de cancros
DE69625506D1 (de)	2003-01-30	Schwefelsubstituierte peptide als inhibitoren für metalloproteinasen und der tnf-freisetzung
ATE398630T1 (de)	2008-07-15	Zyklische conotoxin-peptide
MXPA94009086A (es)	2006-02-14	Guanidinas sustituidas terapeuticas.
DE69711078D1 (de)	2002-04-18	Topische verwendung von kappa-opioidrezeptoragonisten zur behandlung von augenschmerz
DE69429101D1 (de)	2001-12-20	Verbindungen und zusammensetzungen zur behandlung von allergien und entzündungen
DE69330268D1 (de)	2001-07-05	Hämoregulierende peptide
DE69514928D1 (de)	2000-03-09	Gegen protozoen wirksamezyklische tetrapeptide
EA200001127A1 (ru)	2001-08-27	Бактериальные феромоны и их использование
EP0917535A4 (de)	2001-11-21	Neuroaktive peptide
TR199902866T2 (xx)	2000-02-21	Organo- koruyucu aktiviteye sahip yeni BPC peptid tuzlar�, haz�rlanmalar� ve terapide kullan�lmalar� i�in prosesler.
DK0952982T3 (da)	2004-03-29	Hidtil ukendte hepatitis B inhibitorer
DE69409961D1 (de)	1998-06-04	Triarylethylenderivate zur therapeutischen verwendung
IT1290910B1 (it)	1998-12-14	2-amminotetralina otticamente attiva, procedimento per la sua preparazione e composizioni farmaceutiche che la contengono, attive
NO982151L (no)	1998-07-03	Hemoregulatoriske forbindelser
DE69825307D1 (de)	2004-09-02	Verwendung von protein h als zytostattischer wirkstoff
ATE237345T1 (de)	2003-05-15	Verwendung von citrullin enthaltenden peptiden, die von filaggrin abstammen, zur behandlung von autoimmunkrankheiten

Legal Events

Date	Code	Title	Description
2005-04-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties