ATE278673T1 - Disubstituierte pyrazoline und triazoline als faktor xa inhibitoren - Google Patents
Disubstituierte pyrazoline und triazoline als faktor xa inhibitorenInfo
- Publication number
- ATE278673T1 ATE278673T1 AT99912828T AT99912828T ATE278673T1 AT E278673 T1 ATE278673 T1 AT E278673T1 AT 99912828 T AT99912828 T AT 99912828T AT 99912828 T AT99912828 T AT 99912828T AT E278673 T1 ATE278673 T1 AT E278673T1
- Authority
- AT
- Austria
- Prior art keywords
- triazolines
- inhibitors
- factor
- disubstituted pyrazolines
- pyrazolines
- Prior art date
Links
- 150000003219 pyrazolines Chemical class 0.000 title abstract 2
- 229940123583 Factor Xa inhibitor Drugs 0.000 title 1
- 108010074860 Factor Xa Proteins 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 150000003839 salts Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Photoreceptors In Electrophotography (AREA)
- Manufacturing Of Printed Wiring (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7972598P | 1998-03-27 | 1998-03-27 | |
PCT/US1999/006310 WO1999050255A2 (en) | 1998-03-27 | 1999-03-23 | Disubstituted pyrazolines and triazolines as factor xa inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE278673T1 true ATE278673T1 (de) | 2004-10-15 |
Family
ID=22152402
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT99912828T ATE278673T1 (de) | 1998-03-27 | 1999-03-23 | Disubstituierte pyrazoline und triazoline als faktor xa inhibitoren |
Country Status (9)
Country | Link |
---|---|
US (3) | US6191159B1 (de) |
EP (1) | EP1064270B1 (de) |
JP (1) | JP2002509924A (de) |
AT (1) | ATE278673T1 (de) |
AU (1) | AU3110999A (de) |
CA (1) | CA2321538A1 (de) |
DE (1) | DE69920888T2 (de) |
ES (1) | ES2230841T3 (de) |
WO (1) | WO1999050255A2 (de) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69920888T2 (de) * | 1998-03-27 | 2006-02-02 | Bristol-Myers Squibb Pharma Co. | Disubstituierte pyrazoline und triazoline als faktor xa inhibitoren |
US6858616B2 (en) | 1998-12-23 | 2005-02-22 | Bristol-Myers Squibb Pharma Company | Nitrogen containing heterobicycles as factor Xa inhibitors |
WO2000039131A1 (en) * | 1998-12-23 | 2000-07-06 | Du Pont Pharmaceuticals Company | Nitrogen containing heterobicycles as factor xa inhibitors |
AU4307800A (en) * | 1999-04-30 | 2000-11-17 | Merab Lomia | New indication for use of antiepileptic agents and medicines |
US6329527B1 (en) | 1999-10-21 | 2001-12-11 | Bristol-Myers Squibb Pharma Company | Synthesis of 1,3,5-trisubstituted pyrazoles |
ATE373655T1 (de) | 2000-06-23 | 2007-10-15 | Bristol Myers Squibb Pharma Co | 1-(heteroaryl-phenyl)-kondensierte pyrazol- derivate als factor xa inhibitoren |
US6670362B2 (en) | 2000-09-20 | 2003-12-30 | Pfizer Inc. | Pyridazine endothelin antagonists |
US6982251B2 (en) * | 2000-12-20 | 2006-01-03 | Schering Corporation | Substituted 2-azetidinones useful as hypocholesterolemic agents |
US7071181B2 (en) | 2001-01-26 | 2006-07-04 | Schering Corporation | Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors |
MEP27808A (en) | 2001-01-26 | 2010-10-10 | Schering Corp | Combinations of peroxisome proliferator-activated receptor (ppar) activator(s) and sterol absorption inhibitor(s) and treatments for vascular indications |
US20060287254A1 (en) * | 2001-01-26 | 2006-12-21 | Schering Corporation | Use of substituted azetidinone compounds for the treatment of sitosterolemia |
EP1355644B1 (de) | 2001-01-26 | 2006-06-28 | Schering Corporation | Verwendung azetidinone-substituierter verbindungen zur behandlung der sitosterolhämie |
US7053080B2 (en) | 2001-09-21 | 2006-05-30 | Schering Corporation | Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors |
HRP20080382A2 (en) | 2001-09-21 | 2008-12-31 | Bristol-Myers Squibb Company A Delaware (Usa) Corporation | LACTAM-CONTAINING COMPOUNDS AND DERIVATIVES THEREOF AS FACTOR Xa INHIBITORS |
TWI331526B (en) | 2001-09-21 | 2010-10-11 | Bristol Myers Squibb Pharma Co | Lactam-containing compounds and derivatives thereof as factor xa inhibitors |
ATE345793T1 (de) * | 2001-09-21 | 2006-12-15 | Schering Corp | Behandlung von xanthom mittels azetidinon- derivate als hemmer der sterol absorption |
WO2003048081A2 (en) | 2001-12-04 | 2003-06-12 | Bristol-Myers Squibb Company | Glycinamides as factor xa inhibitors |
TW200302225A (en) | 2001-12-04 | 2003-08-01 | Bristol Myers Squibb Co | Substituted amino methyl factor Xa inhibitors |
EP1505966A4 (de) | 2002-05-10 | 2006-08-30 | Bristol Myers Squibb Co | 1,1-disubstituierte cycloalkyl-derivate als faktor xa hemmer |
US7589199B2 (en) * | 2002-06-12 | 2009-09-15 | Chemocentryx, Inc. | Substituted piperazines |
AU2003236500B9 (en) * | 2002-06-12 | 2009-07-02 | Chemocentryx, Inc. | 1-aryl-4-substituted piperazine derivatives for use as CCR1 antagonists for the treatment of inflammation and immune disorders |
US20050256130A1 (en) * | 2002-06-12 | 2005-11-17 | Chemocentryx, Inc. | Substituted piperazines |
US7842693B2 (en) * | 2002-06-12 | 2010-11-30 | Chemocentryx, Inc. | Substituted piperazines |
CA2504916A1 (en) | 2002-11-06 | 2004-05-27 | Schering Corporation | Cholesterol absorptions inhibitors for the treatment of autoimmune disorders |
SI1569912T1 (sl) | 2002-12-03 | 2015-09-30 | Pharmacyclics Llc | Derivati 2-(2-hidroksibifenil-3-il)-1h-benzoimidazol-5-karboksamidina kot inhibitorji faktorja viia |
ES2311806T3 (es) | 2003-03-07 | 2009-02-16 | Schering Corporation | Compuesto de azetidinona sustituidos, fornulaciones y usos de los mismos para el tratamiento de hipercolesterolemia. |
WO2004081004A1 (en) * | 2003-03-07 | 2004-09-23 | Schering Corporation | Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia |
US7459442B2 (en) * | 2003-03-07 | 2008-12-02 | Schering Corporation | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof |
WO2004081003A1 (en) * | 2003-03-07 | 2004-09-23 | Schering Corporation | Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholeterolemia |
US7122557B2 (en) | 2003-03-18 | 2006-10-17 | Bristol-Myers Squibb Company | Sulfonyl-amidino-containing and tetrahydropyrimidino-containing compounds as factor Xa inhibitors |
US7235662B2 (en) * | 2003-06-11 | 2007-06-26 | Bristol-Myers Squibb Company | Modulators of the glucocorticoid receptor and method |
EP1720545B1 (de) * | 2004-03-03 | 2014-10-29 | ChemoCentryx, Inc. | Bizyklische und überbrückte stickstoff-heterozyklen |
US7435831B2 (en) * | 2004-03-03 | 2008-10-14 | Chemocentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
TWI357901B (en) * | 2004-03-12 | 2012-02-11 | Lundbeck & Co As H | Substituted morpholine and thiomorpholine derivati |
KR101362024B1 (ko) | 2006-03-24 | 2014-02-11 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 트리아졸론 유도체 |
CN101405275B (zh) * | 2006-03-24 | 2011-11-09 | 卫材R&D管理有限公司 | 三唑酮衍生物 |
US7807690B2 (en) | 2007-09-21 | 2010-10-05 | Eisai R&D Management Co., Ltd. | 2,3-dihydro-iminoisoindole derivatives |
RU2557908C1 (ru) * | 2014-07-04 | 2015-07-27 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Кубанский государственный аграрный университет" | Способ инкубации куриных яиц |
EP3886854A4 (de) | 2018-11-30 | 2022-07-06 | Nuvation Bio Inc. | Pyrrol- und pyrazolverbindungen und verfahren zu deren verwendung |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4124942A1 (de) * | 1991-07-27 | 1993-01-28 | Thomae Gmbh Dr K | 5-gliedrige heterocyclen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
US5424334A (en) * | 1991-12-19 | 1995-06-13 | G. D. Searle & Co. | Peptide mimetic compounds useful as platelet aggregation inhibitors |
US5550147A (en) | 1992-02-05 | 1996-08-27 | Fujisawa Pharmaceutical Co., Ltd. | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same |
US5849736A (en) | 1993-11-24 | 1998-12-15 | The Dupont Merck Pharmaceutical Company | Isoxazoline and isoxazole fibrinogen receptor antagonists |
JPH09505589A (ja) * | 1993-11-24 | 1997-06-03 | ザ・デュポン・メルク・ファーマシュウティカル・カンパニー | フィブリノーゲン受容体アンタゴニストとして有用なイソオキサゾリン化合物 |
PT730590E (pt) * | 1993-11-24 | 2001-05-31 | Du Pont Pharm Co | Derivados de isoxazolina e isoxazole como antagonistas dos reciptores do fibrinogenio |
US5563158A (en) | 1993-12-28 | 1996-10-08 | The Dupont Merck Pharmaceutical Company | Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists |
US5616601A (en) | 1994-07-28 | 1997-04-01 | Gd Searle & Co | 1,2-aryl and heteroaryl substituted imidazolyl compounds for the treatment of inflammation |
ATE267011T1 (de) * | 1995-12-21 | 2004-06-15 | Bristol Myers Squibb Pharma Co | Isoxazolin, isothiazolin und pyrazolin als faktor xa inhibitoren |
WO1997030971A1 (en) * | 1996-02-22 | 1997-08-28 | The Du Pont Merck Pharmaceutical Company | M-AMIDINO PHENYL ANALOGS AS FACTOR Xa INHIBITORS |
WO1997047299A1 (en) * | 1996-06-12 | 1997-12-18 | 3-Dimensional Pharmaceuticals, Inc. | Amidino and guanidino heterocyclic protease inhibitors |
EA003056B1 (ru) * | 1996-12-23 | 2002-12-26 | Дюпон Фармасьютикалз Компани | АЗОТСОДЕРЖАЩИЕ ГЕТЕРОАРОМАТИЧЕСКИЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ ФАКТОРА Ха, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И СПОСОБ ЛЕЧЕНИЯ |
CA2293824A1 (en) * | 1997-06-19 | 1998-12-23 | Mimi Lifen Quan | (amidino)6-membered aromatics as factor xa inhibitors |
ZA985247B (en) * | 1997-06-19 | 1999-12-17 | Du Pont Merck Pharma | Guanidine mimics as factor Xa inhibitors. |
SK174699A3 (en) * | 1997-06-19 | 2000-08-14 | Du Pont Pharm Co | Inhibitors of factor xa with a neutral p1 specificity group |
DE69920888T2 (de) * | 1998-03-27 | 2006-02-02 | Bristol-Myers Squibb Pharma Co. | Disubstituierte pyrazoline und triazoline als faktor xa inhibitoren |
-
1999
- 1999-03-23 DE DE69920888T patent/DE69920888T2/de not_active Expired - Fee Related
- 1999-03-23 ES ES99912828T patent/ES2230841T3/es not_active Expired - Lifetime
- 1999-03-23 JP JP2000541159A patent/JP2002509924A/ja active Pending
- 1999-03-23 AU AU31109/99A patent/AU3110999A/en not_active Abandoned
- 1999-03-23 CA CA002321538A patent/CA2321538A1/en not_active Abandoned
- 1999-03-23 EP EP99912828A patent/EP1064270B1/de not_active Expired - Lifetime
- 1999-03-23 AT AT99912828T patent/ATE278673T1/de not_active IP Right Cessation
- 1999-03-23 WO PCT/US1999/006310 patent/WO1999050255A2/en active IP Right Grant
- 1999-03-26 US US09/276,960 patent/US6191159B1/en not_active Expired - Lifetime
-
2000
- 2000-12-01 US US09/728,695 patent/US6436985B2/en not_active Expired - Lifetime
-
2002
- 2002-06-26 US US10/180,812 patent/US6630468B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US20030105105A1 (en) | 2003-06-05 |
AU3110999A (en) | 1999-10-18 |
ES2230841T3 (es) | 2005-05-01 |
WO1999050255A2 (en) | 1999-10-07 |
US6191159B1 (en) | 2001-02-20 |
WO1999050255A3 (en) | 1999-11-18 |
US20010000179A1 (en) | 2001-04-05 |
US6436985B2 (en) | 2002-08-20 |
EP1064270B1 (de) | 2004-10-06 |
EP1064270A2 (de) | 2001-01-03 |
DE69920888D1 (de) | 2004-11-11 |
JP2002509924A (ja) | 2002-04-02 |
US6630468B2 (en) | 2003-10-07 |
DE69920888T2 (de) | 2006-02-02 |
CA2321538A1 (en) | 1999-10-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |