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ATE276247T1 - Benzo(5,6)cyclohepta(1,2b)pyridine derivate anwendbar als farnesyl protein transferase inhibitoren - Google Patents

Benzo(5,6)cyclohepta(1,2b)pyridine derivate anwendbar als farnesyl protein transferase inhibitoren

Info

Publication number
ATE276247T1
ATE276247T1 AT98926278T AT98926278T ATE276247T1 AT E276247 T1 ATE276247 T1 AT E276247T1 AT 98926278 T AT98926278 T AT 98926278T AT 98926278 T AT98926278 T AT 98926278T AT E276247 T1 ATE276247 T1 AT E276247T1
Authority
AT
Austria
Prior art keywords
aryl
alkyl
aralkyl
heteroaryl
protein transferase
Prior art date
Application number
AT98926278T
Other languages
English (en)
Inventor
Arthur G Taveras
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ATE276247T1 publication Critical patent/ATE276247T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT98926278T 1997-06-17 1998-06-15 Benzo(5,6)cyclohepta(1,2b)pyridine derivate anwendbar als farnesyl protein transferase inhibitoren ATE276247T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87767397A 1997-06-17 1997-06-17
PCT/US1998/011498 WO1998057962A1 (en) 1997-06-17 1998-06-15 Benzo(5,6)cyclohepta(1,2b)pyridine derivatives useful for inhibition of farnesyl protein transferase

Publications (1)

Publication Number Publication Date
ATE276247T1 true ATE276247T1 (de) 2004-10-15

Family

ID=25370476

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98926278T ATE276247T1 (de) 1997-06-17 1998-06-15 Benzo(5,6)cyclohepta(1,2b)pyridine derivate anwendbar als farnesyl protein transferase inhibitoren

Country Status (14)

Country Link
EP (1) EP0993460B1 (de)
JP (1) JP2002504147A (de)
KR (1) KR20010013828A (de)
CN (1) CN1172932C (de)
AT (1) ATE276247T1 (de)
AU (1) AU753533B2 (de)
CA (1) CA2293372C (de)
DE (1) DE69826281T2 (de)
ES (1) ES2226142T3 (de)
HK (1) HK1028238A1 (de)
HU (1) HUP0004806A3 (de)
IL (1) IL133390A0 (de)
NZ (1) NZ501615A (de)
WO (1) WO1998057962A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0317230A (pt) * 2002-12-13 2005-10-25 Smithkline Beecham Corp Composto, composição, métodos de antagonizar uma atividade do receptor de quimiocina ccr-5, e de tratar uma infecção viral em um paciente, e, uso de um composto
DE10334493B4 (de) * 2003-07-29 2006-01-05 Klingelnberg Gmbh Verfahren zum Fräsen von Spiralkegelrädern
WO2019142900A1 (ja) * 2018-01-19 2019-07-25 有機合成薬品工業株式会社 N-アルコキシカルボニルピペリジン誘導体の製造方法及びその中間体

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5089496A (en) * 1986-10-31 1992-02-18 Schering Corporation Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
KR950004004B1 (ko) * 1988-04-28 1995-04-22 쉐링코포레이션 신규한 벤조피리도 피페리딘, 피페리딜리덴 및 피페라진 화합물, 조성물, 제조방법 및 이용방법
US5719148A (en) * 1993-10-15 1998-02-17 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
IL111235A (en) * 1993-10-15 2001-03-19 Schering Plough Corp Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them

Also Published As

Publication number Publication date
CN1267298A (zh) 2000-09-20
KR20010013828A (ko) 2001-02-26
EP0993460A1 (de) 2000-04-19
EP0993460B1 (de) 2004-09-15
CA2293372A1 (en) 1998-12-23
AU7815398A (en) 1999-01-04
DE69826281T2 (de) 2005-11-17
WO1998057962A1 (en) 1998-12-23
IL133390A0 (en) 2001-04-30
NZ501615A (en) 2002-02-01
HUP0004806A3 (en) 2002-11-28
JP2002504147A (ja) 2002-02-05
CA2293372C (en) 2009-01-13
ES2226142T3 (es) 2005-03-16
HUP0004806A2 (hu) 2001-10-28
DE69826281D1 (de) 2004-10-21
CN1172932C (zh) 2004-10-27
HK1028238A1 (en) 2001-02-09
AU753533B2 (en) 2002-10-17

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties