ATE275402T1 - Arzneimittel zur behandlung von darmverstopfung und reizkolon - Google Patents
Arzneimittel zur behandlung von darmverstopfung und reizkolonInfo
- Publication number
- ATE275402T1 ATE275402T1 AT00971617T AT00971617T ATE275402T1 AT E275402 T1 ATE275402 T1 AT E275402T1 AT 00971617 T AT00971617 T AT 00971617T AT 00971617 T AT00971617 T AT 00971617T AT E275402 T1 ATE275402 T1 AT E275402T1
- Authority
- AT
- Austria
- Prior art keywords
- intestinal
- constitution
- treatment
- medicinal products
- irritable colon
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4891—Coated capsules; Multilayered drug free capsule shells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Emergency Medicine (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9925872A GB9925872D0 (en) | 1999-11-01 | 1999-11-01 | Composition for relief of constipation |
GB9928314A GB9928314D0 (en) | 1999-11-30 | 1999-11-30 | Composition for the treatment of irritable bowel syndrome |
PCT/GB2000/004167 WO2001032180A2 (en) | 1999-11-01 | 2000-10-30 | Composition for treatment of constipation and irritable bowel syndrome |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE275402T1 true ATE275402T1 (de) | 2004-09-15 |
Family
ID=26316047
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT00971617T ATE275402T1 (de) | 1999-11-01 | 2000-10-30 | Arzneimittel zur behandlung von darmverstopfung und reizkolon |
Country Status (14)
Country | Link |
---|---|
US (1) | US6734188B1 (de) |
EP (1) | EP1225897B1 (de) |
JP (1) | JP2003513045A (de) |
AT (1) | ATE275402T1 (de) |
AU (1) | AU776567B2 (de) |
CA (1) | CA2389650C (de) |
CZ (1) | CZ299726B6 (de) |
DE (1) | DE60013630T2 (de) |
DK (1) | DK1225897T3 (de) |
ES (1) | ES2226933T3 (de) |
HK (1) | HK1048595A1 (de) |
IL (2) | IL149378A0 (de) |
PT (1) | PT1225897E (de) |
WO (1) | WO2001032180A2 (de) |
Families Citing this family (75)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2266564B1 (de) | 1997-12-22 | 2013-03-13 | Euro-Celtique S.A. | Peroral zu verabreichende Arzneiform enthaltend eine Kombination von einem opioid Agonisten und einem opioid Antagonisten |
ATE275402T1 (de) | 1999-11-01 | 2004-09-15 | John Rhodes | Arzneimittel zur behandlung von darmverstopfung und reizkolon |
NZ520554A (en) | 2000-02-08 | 2005-08-26 | Euro Celtique S | Tamper-resistant oral opioid agonist formulations |
JP4522652B2 (ja) | 2001-05-11 | 2010-08-11 | エンドー ファーマシューティカルズ, インコーポレイティド | 乱用防止制御放出オピオイド投薬形態 |
PT1416842E (pt) | 2001-07-18 | 2009-03-31 | Euro Celtique Sa | Composições farmacêuticas de oxicodona e naloxona |
RS12104A (en) | 2001-08-06 | 2007-04-10 | Euroceltique S.A., | Opioid agonist formulations with releasable and sequestered antagonist |
AU2002324624A1 (en) | 2001-08-06 | 2003-02-24 | Euro-Celtique S.A. | Sequestered antagonist formulations |
KR100717591B1 (ko) | 2002-04-05 | 2007-05-15 | 유로-셀띠끄 소시에떼 아노님 | 활성 화합물의 지속적, 불변적 및 독립적 방출용 매트릭스 |
US7501433B2 (en) * | 2002-05-17 | 2009-03-10 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
PT1551372T (pt) | 2002-09-20 | 2018-07-23 | Alpharma Pharmaceuticals Llc | Subunidade de sequestração e composições e métodos relacionados |
US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
DK1911763T3 (da) | 2003-01-28 | 2010-11-15 | Ironwood Pharmaceuticals Inc | Sammensætninger til behandling af mavetarmsygdomme |
CN1767830A (zh) * | 2003-04-08 | 2006-05-03 | 普罗热尼奇制药公司 | 外周阿片拮抗剂具体是甲基纳曲酮治疗肠易激综合征的用途 |
US20040202717A1 (en) | 2003-04-08 | 2004-10-14 | Mehta Atul M. | Abuse-resistant oral dosage forms and method of use thereof |
CA2811272C (en) | 2003-04-08 | 2016-12-20 | Progenics Pharmaceuticals, Inc. | Pharmaceutical formulations containing methylnaltrexone |
MY135852A (en) | 2003-04-21 | 2008-07-31 | Euro Celtique Sa | Pharmaceutical products |
US8017622B2 (en) * | 2003-05-16 | 2011-09-13 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
CN1933850B (zh) * | 2004-03-22 | 2011-01-12 | 索尔瓦药物有限公司 | 含表面活性剂的、含脂肪酶产品尤其是胰酶的口服药物组合物 |
EP1844792A4 (de) * | 2004-12-14 | 2008-05-21 | Shionogi & Co | Therapeutisches mittel gegen obstipation |
EP1702558A1 (de) | 2005-02-28 | 2006-09-20 | Euro-Celtique S.A. | Verfahren und Vorrichtung zur Darmtätigkeitserfassung |
US8524731B2 (en) | 2005-03-07 | 2013-09-03 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
BRPI0608818A2 (pt) | 2005-03-07 | 2010-01-26 | Univ Chicago | uso de antagonista opióides para atenuação de proliferação e migração de células endoteliais |
US9662325B2 (en) | 2005-03-07 | 2017-05-30 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
US8518962B2 (en) | 2005-03-07 | 2013-08-27 | The University Of Chicago | Use of opioid antagonists |
AR057035A1 (es) | 2005-05-25 | 2007-11-14 | Progenics Pharm Inc | SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS |
AR057325A1 (es) | 2005-05-25 | 2007-11-28 | Progenics Pharm Inc | Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos |
HUE034739T2 (en) | 2005-07-29 | 2018-02-28 | Abbott Laboratories Gmbh | Reduced viral pancreatin |
US11266607B2 (en) * | 2005-08-15 | 2022-03-08 | AbbVie Pharmaceuticals GmbH | Process for the manufacture and use of pancreatin micropellet cores |
US9198871B2 (en) * | 2005-08-15 | 2015-12-01 | Abbott Products Gmbh | Delayed release pancreatin compositions |
US20070185145A1 (en) * | 2006-02-03 | 2007-08-09 | Royds Robert B | Pharmaceutical composition containing a central opioid agonist, a central opioid antagonist, and a peripheral opioid antagonist, and method for making the same |
JP2009534384A (ja) * | 2006-04-19 | 2009-09-24 | ジル・ピー・スミス | オピオイドアンタゴニストによる炎症性および潰瘍性腸疾患の治療 |
US10072256B2 (en) * | 2006-05-22 | 2018-09-11 | Abbott Products Gmbh | Process for separating and determining the viral load in a pancreatin sample |
PL2034975T3 (pl) | 2006-06-19 | 2012-09-28 | Alpharma Pharmaceuticals Llc | Kompozycje farmaceutyczne |
TW200817048A (en) * | 2006-09-08 | 2008-04-16 | Wyeth Corp | Dry powder compound formulations and uses thereof |
WO2008033124A1 (en) * | 2006-09-13 | 2008-03-20 | The Procter & Gamble Company | Methods of treatment for ulcerative colitis |
MX2009002786A (es) * | 2006-09-13 | 2009-03-30 | Procter & Gamble | Metodos de tratamiento para colitis ulcerante que utiliza aminosalicilato. |
EP2137191B8 (de) | 2007-03-29 | 2016-06-08 | Progenics Pharmaceuticals, Inc. | Antagonisten der peripheren opioidrezeptoren und ihre verwendung |
CN102942572A (zh) | 2007-03-29 | 2013-02-27 | 普罗热尼奇制药公司 | (r)-n-溴化甲基纳曲酮的晶体形式及其用途 |
ES2493590T3 (es) | 2007-03-29 | 2014-09-12 | Wyeth Llc | Antagonistas de receptores opioides periféricos y usos de los mismos |
CA3089569C (en) | 2007-06-04 | 2023-12-05 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
CA2702680A1 (en) * | 2007-10-18 | 2009-04-23 | Aiko Biotechnology | Combination analgesic employing opioid and neutral antagonist |
US8748448B2 (en) | 2007-10-18 | 2014-06-10 | Aiko Biotechnology | Combination analgesic employing opioid agonist and neutral antagonist |
US20090130063A1 (en) * | 2007-11-15 | 2009-05-21 | Solvay Pharmaceuticals Gmbh | Process for separating and determining the viral load in a pancreatin sample |
US8623418B2 (en) | 2007-12-17 | 2014-01-07 | Alpharma Pharmaceuticals Llc | Pharmaceutical composition |
US8471022B2 (en) | 2008-02-06 | 2013-06-25 | Progenics Pharmaceuticals, Inc. | Preparation and use of (R),(R)-2,2′-bis-methylnaltrexone |
CA2719134C (en) | 2008-03-21 | 2015-06-30 | The University Of Chicago | Treatment with opioid antagonists and mtor inhibitors |
EP2300009A1 (de) * | 2008-05-07 | 2011-03-30 | Nektar Therapeutics | Orale verabreichung von peripher wirkenden opioid-antagonisten |
WO2009149279A2 (en) | 2008-06-04 | 2009-12-10 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
WO2010009319A2 (en) | 2008-07-16 | 2010-01-21 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
CA2676881C (en) | 2008-09-30 | 2017-04-25 | Wyeth | Peripheral opioid receptor antagonists and uses thereof |
EP3351248B1 (de) | 2008-12-31 | 2021-06-09 | Ardelyx, Inc. | Verbindungen und verfahren zur inhibierung des nhe-vermittelten antiports bei der behandlung von mit flüssigkeitsretention und salzüberlastung assoziierten erkrankungen und erkrankungen des magen-darm-trakts |
WO2018129556A1 (en) | 2017-01-09 | 2018-07-12 | Ardelyx, Inc. | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
RU2522212C2 (ru) | 2009-03-10 | 2014-07-10 | Еуро-Селтик С.А. | Фармацевтические композиции с мгновенным высвобождением, содержащие оксикодон и налоксон |
AU2010238925A1 (en) * | 2009-04-22 | 2011-12-15 | Phoeme Gmbh | Particulate pharmaceutical composition having an opioid and an opioid antagonist |
CN102695508A (zh) * | 2009-09-18 | 2012-09-26 | 阿得罗公司 | 阿片样受体拮抗剂用于胃肠道疾病的用途 |
BR112012028656A2 (pt) | 2010-05-10 | 2016-08-09 | Euro Celtique Sa | combinação de grânulos carregados ativos com ativos adicionais |
EP2568968B1 (de) | 2010-05-10 | 2017-07-12 | Euro-Celtique S.A. | Herstellung von Wirkstoff-freiem Granulat und dieses enthaltende Tabletten |
MX366293B (es) | 2012-08-21 | 2019-07-04 | Ardelyx Inc | Compuestos y metodos para inhibir al antipuerto mediado por nhe en el tratamiento de trastornos asociados con la retencion de fluidos o la sobrecarga de sal y trastornos del tracto gastrointestinal. |
US10376481B2 (en) | 2012-08-21 | 2019-08-13 | Ardelyx, Inc. | Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
BR112015004165A2 (pt) * | 2012-08-29 | 2017-07-04 | Salix Pharmaceuticals Inc | métodos e composições laxantes para o tratamento de constipação e condições e doenças gastrointestinais relacionadas |
JP2016514671A (ja) | 2013-03-15 | 2016-05-23 | シナジー ファーマシューティカルズ インコーポレイテッド | グアニル酸シクラーゼのアゴニストおよびその使用 |
WO2014151200A2 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
BR112015025805A2 (pt) | 2013-04-12 | 2017-07-25 | Ardelyx Inc | compostos de ligação de nh3 e métodos para inibir o transporte de fosfato |
KR20160034352A (ko) | 2013-07-23 | 2016-03-29 | 유로-셀티큐 에스.에이. | 장내 세균총이상을 초래하고/하거나 장내 박테리아 전위에 대한 위험을 증가시키는 질환과 통증으로 인해 고통받고 있는 환자에서 통증을 치료하는데 사용하기 위한 옥시코돈과 날록손의 조합물 |
US9814710B2 (en) | 2013-11-13 | 2017-11-14 | Euro-Celtique S.A. | Hydromorphone and naloxone for treatment of pain and opioid bowel dysfunction syndrome |
WO2016091805A2 (de) * | 2014-12-08 | 2016-06-16 | Develco Pharma Schweiz Ag | Naloxon-monopräparat und mehrschichttablette |
US20160256451A1 (en) * | 2015-03-06 | 2016-09-08 | Develco Pharma Schweiz Ag | Dosage of naloxone |
WO2016193456A2 (en) * | 2015-06-03 | 2016-12-08 | Develco Pharma Schweiz Ag | Opioid receptor antagonist for use in treating patients with severe constipation |
US9861629B1 (en) | 2015-10-07 | 2018-01-09 | Banner Life Sciences Llc | Opioid abuse deterrent dosage forms |
US10335405B1 (en) | 2016-05-04 | 2019-07-02 | Patheon Softgels, Inc. | Non-burst releasing pharmaceutical composition |
WO2018129552A1 (en) | 2017-01-09 | 2018-07-12 | Ardelyx, Inc. | Compounds useful for treating gastrointestinal tract disorders |
CN110291082A (zh) | 2017-01-09 | 2019-09-27 | 阿德利克斯股份有限公司 | Nhe介导的反向转运的抑制剂 |
US10335375B2 (en) | 2017-05-30 | 2019-07-02 | Patheon Softgels, Inc. | Anti-overingestion abuse deterrent compositions |
WO2023102491A1 (en) * | 2021-12-01 | 2023-06-08 | Invea Therapeutics, Inc. | Methods for treating gastrointestinal inflammatory disease |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4987136A (en) | 1982-03-16 | 1991-01-22 | The Rockefeller University | Method for controlling gastrointestinal dysmotility |
WO1983003197A1 (en) * | 1982-03-16 | 1983-09-29 | Univ Rockefeller | Method for controlling gastrointestinal dysmotility |
IT1188550B (it) * | 1986-02-07 | 1988-01-14 | Sclavo Spa | Peptide sintetico ad attivita' interleukina 1 umana |
US4774230A (en) | 1988-03-26 | 1988-09-27 | Ivax Laboratories, Inc. | Glucuronic acid derivatives of opioid antagonists |
EP0647448A1 (de) * | 1993-10-07 | 1995-04-12 | Euroceltique S.A. | Oral verabreichbare, Opioid-Analgetika enthaltende Arzneimittel mit verlängerter Wirkung |
US5846983A (en) * | 1996-02-09 | 1998-12-08 | Mayo Foundation For Medical Education And Research | Colonic delivery of nicotine to treat inflammatory bowel disease |
GB9614902D0 (en) * | 1996-07-16 | 1996-09-04 | Rhodes John | Sustained release composition |
GB9720797D0 (en) * | 1997-09-30 | 1997-12-03 | Rhodes John | Pharmaceutical composition for the treatment of inflammatory bowel disease and irritable bowel syndrome |
US6274591B1 (en) | 1997-11-03 | 2001-08-14 | Joseph F. Foss | Use of methylnaltrexone and related compounds |
IT1298575B1 (it) * | 1998-02-06 | 2000-01-12 | Vectorpharma Int | Composizioni farmaceutiche in forma di nanoparticelle comprendenti sostanze lipidiche e sostanze antifiliche e relativo processo di |
ES2325141T3 (es) | 1998-07-17 | 2009-08-26 | Pacira Pharmaceuticals, Inc. | Composiciones biodegradables para la liberacion controlada de sustancias encapsuladas. |
ATE275402T1 (de) | 1999-11-01 | 2004-09-15 | John Rhodes | Arzneimittel zur behandlung von darmverstopfung und reizkolon |
-
2000
- 2000-10-30 AT AT00971617T patent/ATE275402T1/de active
- 2000-10-30 WO PCT/GB2000/004167 patent/WO2001032180A2/en active Search and Examination
- 2000-10-30 CA CA002389650A patent/CA2389650C/en not_active Expired - Fee Related
- 2000-10-30 CZ CZ20021536A patent/CZ299726B6/cs not_active IP Right Cessation
- 2000-10-30 JP JP2001534385A patent/JP2003513045A/ja active Pending
- 2000-10-30 IL IL14937800A patent/IL149378A0/xx active IP Right Grant
- 2000-10-30 PT PT00971617T patent/PT1225897E/pt unknown
- 2000-10-30 DE DE60013630T patent/DE60013630T2/de not_active Expired - Lifetime
- 2000-10-30 EP EP00971617A patent/EP1225897B1/de not_active Expired - Lifetime
- 2000-10-30 DK DK00971617T patent/DK1225897T3/da active
- 2000-10-30 US US10/111,850 patent/US6734188B1/en not_active Expired - Fee Related
- 2000-10-30 ES ES00971617T patent/ES2226933T3/es not_active Expired - Lifetime
- 2000-10-30 AU AU10447/01A patent/AU776567B2/en not_active Ceased
-
2002
- 2002-04-28 IL IL149378A patent/IL149378A/en not_active IP Right Cessation
-
2003
- 2003-02-04 HK HK03100799A patent/HK1048595A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CZ20021536A3 (cs) | 2003-02-12 |
CA2389650C (en) | 2008-12-09 |
WO2001032180A2 (en) | 2001-05-10 |
AU1044701A (en) | 2001-05-14 |
IL149378A (en) | 2006-12-31 |
WO2001032180A3 (en) | 2001-09-20 |
EP1225897A2 (de) | 2002-07-31 |
CZ299726B6 (cs) | 2008-11-05 |
DK1225897T3 (da) | 2005-01-10 |
PT1225897E (pt) | 2005-01-31 |
DE60013630D1 (de) | 2004-10-14 |
US6734188B1 (en) | 2004-05-11 |
AU776567B2 (en) | 2004-09-16 |
IL149378A0 (en) | 2002-11-10 |
HK1048595A1 (en) | 2003-04-11 |
JP2003513045A (ja) | 2003-04-08 |
CA2389650A1 (en) | 2001-05-10 |
DE60013630T2 (de) | 2005-09-15 |
ES2226933T3 (es) | 2005-04-01 |
EP1225897B1 (de) | 2004-09-08 |
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