ATE252579T1 - Tetrahydronaphthyridinyl-carboxamide mit anticonvulsiver wirkung - Google Patents

Tetrahydronaphthyridinyl-carboxamide mit anticonvulsiver wirkung

Info

Publication number: ATE252579T1
Authority: AT; Austria
Prior art keywords: tetrahydronaphthyridinyl; carboxamide; anticonvulsive effect; anticonvulsive; effect
Prior art date: 1998-06-12

Application number

AT99957056T

Other languages

German (de)

English (en)

Inventor

John David Harling

Frank Peter Harrington

Mervyn Thompson

Original Assignee

Smithkline Beecham Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-06-12

Filing date

1999-06-09

Publication date

2003-11-15

1999-06-09 Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc

2003-11-15 Application granted granted Critical

2003-11-15 Publication of ATE252579T1 publication Critical patent/ATE252579T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Addiction (AREA)
Pain & Pain Management (AREA)
Psychology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Virology (AREA)
Immunology (AREA)
Oncology (AREA)
Hospice & Palliative Care (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Communicable Diseases (AREA)
Anesthesiology (AREA)
Rheumatology (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT99957056T 1998-06-12 1999-06-09 Tetrahydronaphthyridinyl-carboxamide mit anticonvulsiver wirkung ATE252579T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9812683.2A GB9812683D0 (en)	1998-06-12	1998-06-12	Novel compounds
PCT/GB1999/001826 WO1999065903A1 (fr)	1998-06-12	1999-06-09	Tetrahydronaphtyridinyl-carboxamides presentant une activite anti-convulsivante

Publications (1)

Publication Number	Publication Date
ATE252579T1 true ATE252579T1 (de)	2003-11-15

Family

ID=10833636

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99957056T ATE252579T1 (de)	1998-06-12	1999-06-09	Tetrahydronaphthyridinyl-carboxamide mit anticonvulsiver wirkung

Country Status (31)

Country	Link
US (2)	US6410555B1 (fr)
EP (1)	EP1084122B1 (fr)
JP (1)	JP2002518390A (fr)
KR (1)	KR20010052792A (fr)
CN (1)	CN1311789A (fr)
AP (1)	AP2000002009A0 (fr)
AR (1)	AR018656A1 (fr)
AT (1)	ATE252579T1 (fr)
AU (1)	AU750470B2 (fr)
BG (1)	BG105126A (fr)
BR (1)	BR9911110A (fr)
CA (1)	CA2334900A1 (fr)
CO (1)	CO5040081A1 (fr)
CZ (1)	CZ293010B6 (fr)
DE (1)	DE69912278T2 (fr)
EA (1)	EA200100033A1 (fr)
ES (1)	ES2209524T3 (fr)
GB (1)	GB9812683D0 (fr)
HU (1)	HUP0102773A3 (fr)
ID (1)	ID27593A (fr)
IL (1)	IL140171A0 (fr)
MA (1)	MA26646A1 (fr)
NO (1)	NO20006269L (fr)
NZ (1)	NZ508799A (fr)
PE (1)	PE20000727A1 (fr)
PL (1)	PL344791A1 (fr)
SK (1)	SK18962000A3 (fr)
TR (1)	TR200003694T2 (fr)
TW (1)	TW495510B (fr)
WO (1)	WO1999065903A1 (fr)
ZA (1)	ZA200007397B (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9812683D0 (en) *	1998-06-12	1998-08-12	Smithkline Beecham Plc	Novel compounds
DE60100055T2 (de) *	2001-03-21	2003-07-24	Schwarz Pharma Ag	Neue Verwendung einer Klasse von Peptidverbindungen zur Behandlung von Allodynie oder andere Arten von chronischen oder Phantomschmerzen
EP1945639A1 (fr) *	2005-11-04	2008-07-23	Pfizer Limited	Dérivé de tétrahydronaphtyridine
MX369989B (es) *	2012-08-27	2019-11-27	Array Biopharma Inc	Inhibidores de serina/treonina cinasa para el tratamiento de enfermedades hiperproliferativas.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9112721D0 (en)	1991-06-13	1991-07-31	Smithkline Beecham Plc	Novel treatment
BR9709906A (pt) *	1996-06-17	1999-08-10	Smithkline Beecham Plc	Derivados de benzamida substituídos e o uso dos mesmos como anticonvulsivantes
GB9711257D0 (en) *	1997-05-30	1997-07-30	Smithkline Beecham Plc	Novel compounds
GB9812683D0 (en) *	1998-06-12	1998-08-12	Smithkline Beecham Plc	Novel compounds

1998
- 1998-06-12 GB GBGB9812683.2A patent/GB9812683D0/en not_active Ceased
1999
- 1999-06-09 PL PL99344791A patent/PL344791A1/xx not_active Application Discontinuation
- 1999-06-09 AU AU42800/99A patent/AU750470B2/en not_active Ceased
- 1999-06-09 NZ NZ508799A patent/NZ508799A/en unknown
- 1999-06-09 EP EP99957056A patent/EP1084122B1/fr not_active Expired - Lifetime
- 1999-06-09 JP JP2000554728A patent/JP2002518390A/ja active Pending
- 1999-06-09 ES ES99957056T patent/ES2209524T3/es not_active Expired - Lifetime
- 1999-06-09 CZ CZ20004611A patent/CZ293010B6/cs not_active IP Right Cessation
- 1999-06-09 ID IDW20002580A patent/ID27593A/id unknown
- 1999-06-09 IL IL14017199A patent/IL140171A0/xx unknown
- 1999-06-09 CN CN99809413A patent/CN1311789A/zh active Pending
- 1999-06-09 KR KR1020007014099A patent/KR20010052792A/ko not_active Application Discontinuation
- 1999-06-09 TR TR2000/03694T patent/TR200003694T2/xx unknown
- 1999-06-09 WO PCT/GB1999/001826 patent/WO1999065903A1/fr not_active Application Discontinuation
- 1999-06-09 EA EA200100033A patent/EA200100033A1/ru unknown
- 1999-06-09 AT AT99957056T patent/ATE252579T1/de not_active IP Right Cessation
- 1999-06-09 CA CA002334900A patent/CA2334900A1/fr not_active Abandoned
- 1999-06-09 HU HU0102773A patent/HUP0102773A3/hu unknown
- 1999-06-09 BR BR9911110-1A patent/BR9911110A/pt not_active IP Right Cessation
- 1999-06-09 SK SK1896-2000A patent/SK18962000A3/sk unknown
- 1999-06-09 DE DE69912278T patent/DE69912278T2/de not_active Expired - Fee Related
- 1999-06-09 US US09/719,335 patent/US6410555B1/en not_active Expired - Fee Related
- 1999-06-09 AP APAP/P/2000/002009A patent/AP2000002009A0/en unknown
- 1999-06-10 AR ARP990102772A patent/AR018656A1/es not_active Application Discontinuation
- 1999-06-10 MA MA25618A patent/MA26646A1/fr unknown
- 1999-06-11 CO CO99036865A patent/CO5040081A1/es unknown
- 1999-06-11 TW TW088109749A patent/TW495510B/zh active
- 1999-06-11 PE PE1999000519A patent/PE20000727A1/es not_active Application Discontinuation
2000
- 2000-12-11 NO NO20006269A patent/NO20006269L/no not_active Application Discontinuation
- 2000-12-12 ZA ZA200007397A patent/ZA200007397B/xx unknown
2001
- 2001-01-08 BG BG105126A patent/BG105126A/xx unknown
2002
- 2002-05-23 US US10/154,997 patent/US6762192B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JP2002518390A (ja)	2002-06-25
SK18962000A3 (sk)	2001-08-06
PL344791A1 (en)	2001-11-19
BG105126A (en)	2001-11-30
PE20000727A1 (es)	2000-09-28
WO1999065903A1 (fr)	1999-12-23
TW495510B (en)	2002-07-21
CZ293010B6 (cs)	2004-01-14
AU750470B2 (en)	2002-07-18
DE69912278D1 (en)	2003-11-27
AU4280099A (en)	2000-01-05
AP2000002009A0 (en)	2000-12-31
NO20006269D0 (no)	2000-12-11
DE69912278T2 (de)	2004-08-12
GB9812683D0 (en)	1998-08-12
TR200003694T2 (tr)	2001-06-21
AR018656A1 (es)	2001-11-28
US6410555B1 (en)	2002-06-25
US20020143029A1 (en)	2002-10-03
NZ508799A (en)	2003-08-29
ID27593A (id)	2001-04-12
CO5040081A1 (es)	2001-05-29
EP1084122A1 (fr)	2001-03-21
HUP0102773A2 (hu)	2002-01-28
IL140171A0 (en)	2002-02-10
NO20006269L (no)	2001-02-07
EA200100033A1 (ru)	2001-06-25
EP1084122B1 (fr)	2003-10-22
US6762192B2 (en)	2004-07-13
CA2334900A1 (fr)	1999-12-23
MA26646A1 (fr)	2004-12-20
CZ20004611A3 (en)	2001-06-13
KR20010052792A (ko)	2001-06-25
BR9911110A (pt)	2001-10-30
ES2209524T3 (es)	2004-06-16
HUP0102773A3 (en)	2002-09-30
ZA200007397B (en)	2002-02-27
CN1311789A (zh)	2001-09-05

Publication	Publication Date	Title
ID30132A (id)	2001-11-08	Turunan-turunan pirazol trisiklik
DK1080275T4 (da)	2007-02-19	Syntetisk græstörv
DE59910140D1 (de)	2004-09-09	Gleitschalungsfertiger
DE69934805D1 (de)	2007-02-22	Substituierte imidazole mit cytokin-inhibierender wirkung
IS5699A (is)	2000-11-01	Ný notkun
ID26162A (id)	2000-11-30	Turunan-turunan benzilbifenil biosida
DE69737411D1 (de)	2007-04-12	Induktor mit verbesserten Q-Wert
DE59708160D1 (de)	2002-10-17	1-Dimethylaminomethyl-2-phenyl-cycloalk-2-enverbindungen mit analgetischer Wirkung
ID23287A (id)	2000-04-05	Trisiklik tersubstitusi
NO994626D0 (no)	1999-09-23	Substituerte benzamider
DE69908262D1 (de)	2003-07-03	Sprühbehälter
NO20010333L (no)	2001-01-19	Bifenylderivater
DE59901964D1 (de)	2002-08-08	Wendestangenanordnung
ID23219A (id)	2000-03-30	Trisiklik tersubstitusi
PT1135381E (pt)	2004-10-29	Mono-hidrato de hidrobrometo de eletriptano
DE59811628D1 (de)	2004-08-05	Rollenumlenkung
NO20005857L (no)	2000-11-21	Nye blandinger
DE69908863D1 (de)	2003-07-24	Einspritzventil
FI980759A0 (fi)	1998-04-02	Taetningskonstruktion foer suglaodan i en sugvals
NO20005435D0 (no)	2000-10-27	Bifenylderivater
ATE252579T1 (de)	2003-11-15	Tetrahydronaphthyridinyl-carboxamide mit anticonvulsiver wirkung
DE69907561D1 (de)	2003-06-12	Titanatverbindungen
ATE237615T1 (de)	2003-05-15	Tricyclische carboxamide
DE59911610D1 (de)	2005-03-17	Substituierte benzoylcyclohexandione
DE59911463D1 (de)	2005-02-24	Fahrzeugleitvorrichtung mit Fahrstreckenabtastung

Legal Events

Date	Code	Title	Description
2004-04-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties