HUP0102773A3 - Tetrahydronaphthyridinil-carboxamides having anti-convulsant activity, process for their preparation and pharmaceutical compositions containing the same - Google Patents

Tetrahydronaphthyridinil-carboxamides having anti-convulsant activity, process for their preparation and pharmaceutical compositions containing the same

Info

Publication number: HUP0102773A3
Authority: HU; Hungary
Prior art keywords: tetrahydronaphthyridinil; carboxamides; preparation; pharmaceutical compositions; same
Prior art date: 1998-06-12

Application number

HU0102773A

Other languages

English (en)

Original Assignee

Smithkline Beecham Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-06-12

Filing date

1999-06-09

Publication date

2002-09-30

1999-06-09 Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc

2002-01-28 Publication of HUP0102773A2 publication Critical patent/HUP0102773A2/hu

2002-09-30 Publication of HUP0102773A3 publication Critical patent/HUP0102773A3/hu

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Addiction (AREA)
Pain & Pain Management (AREA)
Psychology (AREA)
Physical Education & Sports Medicine (AREA)
Virology (AREA)
Orthopedic Medicine & Surgery (AREA)
Tropical Medicine & Parasitology (AREA)
Oncology (AREA)
AIDS & HIV (AREA)
Hospice & Palliative Care (AREA)
Anesthesiology (AREA)
Immunology (AREA)
Molecular Biology (AREA)
Rheumatology (AREA)
Communicable Diseases (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

HU0102773A 1998-06-12 1999-06-09 Tetrahydronaphthyridinil-carboxamides having anti-convulsant activity, process for their preparation and pharmaceutical compositions containing the same HUP0102773A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9812683.2A GB9812683D0 (en)	1998-06-12	1998-06-12	Novel compounds
PCT/GB1999/001826 WO1999065903A1 (en)	1998-06-12	1999-06-09	Tetrahydronaphthyridinyl-carboxamides having anti-convulsant activity

Publications (2)

Publication Number	Publication Date
HUP0102773A2 HUP0102773A2 (hu)	2002-01-28
HUP0102773A3 true HUP0102773A3 (en)	2002-09-30

Family

ID=10833636

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HU0102773A HUP0102773A3 (en)	1998-06-12	1999-06-09	Tetrahydronaphthyridinil-carboxamides having anti-convulsant activity, process for their preparation and pharmaceutical compositions containing the same

Country Status (31)

Country	Link
US (2)	US6410555B1 (hu)
EP (1)	EP1084122B1 (hu)
JP (1)	JP2002518390A (hu)
KR (1)	KR20010052792A (hu)
CN (1)	CN1311789A (hu)
AP (1)	AP2000002009A0 (hu)
AR (1)	AR018656A1 (hu)
AT (1)	ATE252579T1 (hu)
AU (1)	AU750470B2 (hu)
BG (1)	BG105126A (hu)
BR (1)	BR9911110A (hu)
CA (1)	CA2334900A1 (hu)
CO (1)	CO5040081A1 (hu)
CZ (1)	CZ293010B6 (hu)
DE (1)	DE69912278T2 (hu)
EA (1)	EA200100033A1 (hu)
ES (1)	ES2209524T3 (hu)
GB (1)	GB9812683D0 (hu)
HU (1)	HUP0102773A3 (hu)
ID (1)	ID27593A (hu)
IL (1)	IL140171A0 (hu)
MA (1)	MA26646A1 (hu)
NO (1)	NO20006269L (hu)
NZ (1)	NZ508799A (hu)
PE (1)	PE20000727A1 (hu)
PL (1)	PL344791A1 (hu)
SK (1)	SK18962000A3 (hu)
TR (1)	TR200003694T2 (hu)
TW (1)	TW495510B (hu)
WO (1)	WO1999065903A1 (hu)
ZA (1)	ZA200007397B (hu)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9812683D0 (en) *	1998-06-12	1998-08-12	Smithkline Beecham Plc	Novel compounds
DK1243263T3 (da) *	2001-03-21	2003-03-17	Sanol Arznei Schwarz Gmbh	Hidtil ukendt anvendelse af en klasse af peptidforbindelser til behandling af allodyni eller andre forskellige typer af kronisk- eller fantomsmerte
JP2009514846A (ja) *	2005-11-04	2009-04-09	ファイザー・リミテッド	テトラヒドロナフチリジン誘導体
KR20150047597A (ko) *	2012-08-27	2015-05-04	어레이 바이오파마 인크.	과증식성 질환의 치료를 위한 세린/트레오닌 키나아제 억제제

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9112721D0 (en)	1991-06-13	1991-07-31	Smithkline Beecham Plc	Novel treatment
CZ416498A3 (cs) *	1996-06-17	1999-06-16	Smithkline Beecham Plc	Substituovaný benzamidový derivát a jeho použití jako antikonvulsantu
GB9711257D0 (en) *	1997-05-30	1997-07-30	Smithkline Beecham Plc	Novel compounds
GB9812683D0 (en) *	1998-06-12	1998-08-12	Smithkline Beecham Plc	Novel compounds

1998
- 1998-06-12 GB GBGB9812683.2A patent/GB9812683D0/en not_active Ceased
1999
- 1999-06-09 KR KR1020007014099A patent/KR20010052792A/ko not_active Application Discontinuation
- 1999-06-09 ID IDW20002580A patent/ID27593A/id unknown
- 1999-06-09 TR TR2000/03694T patent/TR200003694T2/xx unknown
- 1999-06-09 CN CN99809413A patent/CN1311789A/zh active Pending
- 1999-06-09 CZ CZ20004611A patent/CZ293010B6/cs not_active IP Right Cessation
- 1999-06-09 JP JP2000554728A patent/JP2002518390A/ja active Pending
- 1999-06-09 EP EP99957056A patent/EP1084122B1/en not_active Expired - Lifetime
- 1999-06-09 DE DE69912278T patent/DE69912278T2/de not_active Expired - Fee Related
- 1999-06-09 ES ES99957056T patent/ES2209524T3/es not_active Expired - Lifetime
- 1999-06-09 AP APAP/P/2000/002009A patent/AP2000002009A0/en unknown
- 1999-06-09 NZ NZ508799A patent/NZ508799A/en unknown
- 1999-06-09 PL PL99344791A patent/PL344791A1/xx not_active Application Discontinuation
- 1999-06-09 AT AT99957056T patent/ATE252579T1/de not_active IP Right Cessation
- 1999-06-09 AU AU42800/99A patent/AU750470B2/en not_active Ceased
- 1999-06-09 HU HU0102773A patent/HUP0102773A3/hu unknown
- 1999-06-09 WO PCT/GB1999/001826 patent/WO1999065903A1/en not_active Application Discontinuation
- 1999-06-09 IL IL14017199A patent/IL140171A0/xx unknown
- 1999-06-09 EA EA200100033A patent/EA200100033A1/ru unknown
- 1999-06-09 CA CA002334900A patent/CA2334900A1/en not_active Abandoned
- 1999-06-09 BR BR9911110-1A patent/BR9911110A/pt not_active IP Right Cessation
- 1999-06-09 SK SK1896-2000A patent/SK18962000A3/sk unknown
- 1999-06-09 US US09/719,335 patent/US6410555B1/en not_active Expired - Fee Related
- 1999-06-10 AR ARP990102772A patent/AR018656A1/es not_active Application Discontinuation
- 1999-06-10 MA MA25618A patent/MA26646A1/fr unknown
- 1999-06-11 TW TW088109749A patent/TW495510B/zh active
- 1999-06-11 PE PE1999000519A patent/PE20000727A1/es not_active Application Discontinuation
- 1999-06-11 CO CO99036865A patent/CO5040081A1/es unknown
2000
- 2000-12-11 NO NO20006269A patent/NO20006269L/no not_active Application Discontinuation
- 2000-12-12 ZA ZA200007397A patent/ZA200007397B/xx unknown
2001
- 2001-01-08 BG BG105126A patent/BG105126A/xx unknown
2002
- 2002-05-23 US US10/154,997 patent/US6762192B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
PE20000727A1 (es)	2000-09-28
CZ293010B6 (cs)	2004-01-14
BR9911110A (pt)	2001-10-30
SK18962000A3 (sk)	2001-08-06
CN1311789A (zh)	2001-09-05
CZ20004611A3 (en)	2001-06-13
AU750470B2 (en)	2002-07-18
EP1084122B1 (en)	2003-10-22
KR20010052792A (ko)	2001-06-25
CO5040081A1 (es)	2001-05-29
EA200100033A1 (ru)	2001-06-25
US6762192B2 (en)	2004-07-13
ZA200007397B (en)	2002-02-27
CA2334900A1 (en)	1999-12-23
DE69912278T2 (de)	2004-08-12
AP2000002009A0 (en)	2000-12-31
ES2209524T3 (es)	2004-06-16
TR200003694T2 (tr)	2001-06-21
AU4280099A (en)	2000-01-05
EP1084122A1 (en)	2001-03-21
IL140171A0 (en)	2002-02-10
DE69912278D1 (en)	2003-11-27
TW495510B (en)	2002-07-21
AR018656A1 (es)	2001-11-28
BG105126A (en)	2001-11-30
NZ508799A (en)	2003-08-29
JP2002518390A (ja)	2002-06-25
WO1999065903A1 (en)	1999-12-23
GB9812683D0 (en)	1998-08-12
PL344791A1 (en)	2001-11-19
US6410555B1 (en)	2002-06-25
HUP0102773A2 (hu)	2002-01-28
US20020143029A1 (en)	2002-10-03
NO20006269D0 (no)	2000-12-11
ID27593A (id)	2001-04-12
NO20006269L (no)	2001-02-07
ATE252579T1 (de)	2003-11-15
MA26646A1 (fr)	2004-12-20

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