ATE251624T1 - Granulatimide-derivate zur behandlung von krebs - Google Patents

Granulatimide-derivate zur behandlung von krebs

Info

Publication number: ATE251624T1
Authority: AT; Austria
Prior art keywords: granulatimide; cancer; derivatives; treatment; iii
Prior art date: 1998-03-13

Application number

AT99908706T

Other languages

English (en)

Inventor

Raymond J Andersen

Michel Roberge

Jasbinder Sanghera

Danny Leung

Roberto G S Berlinck

Sao Paulo De

Edward Piers

Robert Britton

Original Assignee

Univ British Columbia

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-03-13

Filing date

1999-03-11

Publication date

2003-10-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27170646&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE251624(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1998-03-13 Priority claimed from CA 2232074 external-priority patent/CA2232074A1/en

1998-08-14 Priority claimed from CA002245029A external-priority patent/CA2245029A1/en

1999-03-11 Application filed by Univ British Columbia filed Critical Univ British Columbia

2003-10-15 Application granted granted Critical

2003-10-15 Publication of ATE251624T1 publication Critical patent/ATE251624T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/044—Pyrrole radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
- C07H9/06—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing nitrogen as ring hetero atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Saccharide Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

AT99908706T 1998-03-13 1999-03-11 Granulatimide-derivate zur behandlung von krebs ATE251624T1 (de)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
CA 2232074 CA2232074A1 (en)	1998-03-13	1998-03-13	Granulatimide compounds as g2 checkpoint inhibitors
CA002245029A CA2245029A1 (en)	1998-03-13	1998-08-14	Granulatimide compounds as g2 checkpoint inhibitors
US09/258,991 US6291447B1 (en)	1998-03-13	1999-02-26	Granulatimide compounds and uses thereof
PCT/CA1999/000224 WO1999047522A1 (en)	1998-03-13	1999-03-11	Granulatimide derivatives for use in cancer treatment

Publications (1)

Publication Number	Publication Date
ATE251624T1 true ATE251624T1 (de)	2003-10-15

Family

ID=27170646

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99908706T ATE251624T1 (de)	1998-03-13	1999-03-11	Granulatimide-derivate zur behandlung von krebs

Country Status (6)

Country	Link
EP (1)	EP1070068B2 (de)
JP (1)	JP2002506868A (de)
AT (1)	ATE251624T1 (de)
AU (1)	AU758241B2 (de)
DE (1)	DE69911935T3 (de)
WO (1)	WO1999047522A1 (de)

Families Citing this family (20)

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NZ511024A (en)	1998-09-25	2003-10-31	Cephalon Inc	Methods for preventing/treating damage to sensory hair cells, loss of hearing and cochlear neurons using fused pyrrolocarbazoles
US6841567B1 (en)	1999-02-12	2005-01-11	Cephalon, Inc.	Cyclic substituted fused pyrrolocarbazoles and isoindolones
CA2395284A1 (en) *	1999-12-23	2001-07-05	The Ontario Cancer Institute	Inhibition of gsk-3.beta.
GB0008264D0 (en) *	2000-04-04	2000-05-24	Smithkline Beecham Plc	Novel method and compounds
US7122679B2 (en)	2000-05-09	2006-10-17	Cephalon, Inc.	Multicyclic compounds and the use thereof
US7129250B2 (en)	2000-05-19	2006-10-31	Aegera Therapeutics Inc.	Neuroprotective and anti-proliferative compounds
CA2308994A1 (en) *	2000-05-19	2001-11-19	Aegera Therapeutics Inc.	Neuroprotective compounds
AUPR500201A0 (en)	2001-05-14	2001-06-07	Commonwealth Scientific And Industrial Research Organisation	Recovery of minerals by flotation
EP1511713B8 (de) *	2002-06-06	2012-02-08	CanBas Co. Ltd.	Verbindungen, die den durch dna-schädigung induzierten g2-checkpoint des zellzyklus stilllegen und/oder die antikrebswirkung von dna-schädigenden behandlungen erhöhen
FR2845995A1 (fr) *	2002-10-16	2004-04-23	Servier Lab	Nouveaux derives de pyrrolo[3,4-c]carbazole et de pyrido[2,3-b]pyrrolo[3,4-e]indole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP1928437A2 (de)	2005-08-26	2008-06-11	Braincells, Inc.	Neurogenese mittels muscarinrezeptormodulation
EP2258359A3 (de)	2005-08-26	2011-04-06	Braincells, Inc.	Neurogenese durch Modulation des Muscarinrezeptors mit Sabcomelin
JP2009512711A (ja)	2005-10-21	2009-03-26	ブレインセルス，インコーポレイティド	Ｐｄｅ阻害による神経新生の調節
AU2006308889A1 (en)	2005-10-31	2007-05-10	Braincells, Inc.	GABA receptor mediated modulation of neurogenesis
US20100216734A1 (en)	2006-03-08	2010-08-26	Braincells, Inc.	Modulation of neurogenesis by nootropic agents
EP2021000A2 (de)	2006-05-09	2009-02-11	Braincells, Inc.	Neurogenese mittels angiotensin-modulation
US20100184806A1 (en)	2006-09-19	2010-07-22	Braincells, Inc.	Modulation of neurogenesis by ppar agents
WO2009127059A1 (en) *	2008-04-15	2009-10-22	Alethia Biotherapeutics Inc.	Complexes of isogranulatimide and granulatimide with a cyclodextrm, formulations and their use for the treatment of cancer
WO2010099217A1 (en)	2009-02-25	2010-09-02	Braincells, Inc.	Modulation of neurogenesis using d-cycloserine combinations
CN103864890B (zh) *	2012-12-12	2016-09-14	浙江医药股份有限公司新昌制药厂	咪唑异丙乙酰茶氨酸苄酯并吡啶并吲哚、其制备、纳米结构及应用

Family Cites Families (16)

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DE3835842A1 (de) *	1988-10-21	1990-04-26	Goedecke Ag	Indolocarbazol-derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel
DE3803620A1 (de) *	1988-02-06	1989-08-17	Goedecke Ag	Indolocarbazol-derivate, verfahren zu deren herstellung und diese enthaltende arzneimittel
WO1991009034A1 (en) *	1989-12-14	1991-06-27	Schering Corporation	Indolocarbazoles from saccharothrix aerocolonigenes subsp. copiosa subsp. nov. scc 1951 atcc 53856
DE3942296A1 (de) *	1989-12-21	1991-06-27	Goedecke Ag	Indolocarbazol-derivate, verfahren zu deren herstellung und deren verwendung
EP0655066A1 (de) *	1992-08-12	1995-05-31	PHARMACIA & UPJOHN COMPANY	Proteinkinase-inhibitoren und verwandte verbindungen kombiniert mit taxol
WO1994007895A1 (en) *	1992-09-25	1994-04-14	Schering Corporation	Diindolo compounds and pharmaceutical compositions containing them
US5624949A (en) *	1993-12-07	1997-04-29	Eli Lilly And Company	Protein kinase C inhibitors
ES2162843T3 (es) *	1993-12-07	2002-01-16	Lilly Co Eli	Inhibidores de la proteina quinasa c.
US5604219A (en) *	1994-03-18	1997-02-18	Kyowa Hakko Kogyo Co., Ltd.	Indolocarbazole derivatives that stimulate platelet production
JPH10501527A (ja) *	1994-06-01	1998-02-10	チバ−ガイギーアクチェンゲゼルシャフト	多重薬剤耐性細胞を抗腫瘍剤に対して感受性にするためのインドロカルバゾール誘導体
AU2565795A (en) *	1994-06-01	1995-12-21	Ciba-Geigy Ag	Carbazole derivatives as agents against multi-drug resistance
AU2565995A (en) *	1994-06-01	1995-12-21	Ciba-Geigy Ag	Polycyclic lactam derivatives for sensitizing multidrug-resistant cells to antitumour agents
US5705511A (en) *	1994-10-14	1998-01-06	Cephalon, Inc.	Fused pyrrolocarbazoles
JP3348859B2 (ja) *	1995-11-20	2002-11-20	イーライ・リリー・アンド・カンパニー	プロテインキナーゼｃインヒビター
TR199800876T2 (xx) *	1995-11-20	1998-08-21	Eli Lilly And Company	Yeni ara �r�nler ve bunlar�n N,N'-k�pr�l� bisindolilmaleimidlerin elde edilmesinde kullan�m�.
FR2755691B1 (fr) *	1996-11-08	1998-12-04	Adir	Nouveaux derives 7,12-dioxa-benzo[a]anthraceniques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

1999
- 1999-03-11 EP EP99908706A patent/EP1070068B2/de not_active Expired - Lifetime
- 1999-03-11 JP JP2000536717A patent/JP2002506868A/ja not_active Ceased
- 1999-03-11 AU AU28219/99A patent/AU758241B2/en not_active Ceased
- 1999-03-11 AT AT99908706T patent/ATE251624T1/de not_active IP Right Cessation
- 1999-03-11 WO PCT/CA1999/000224 patent/WO1999047522A1/en active IP Right Grant
- 1999-03-11 DE DE69911935T patent/DE69911935T3/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
AU2821999A (en)	1999-10-11
DE69911935T2 (de)	2004-09-09
EP1070068B2 (de)	2007-01-17
DE69911935T3 (de)	2008-02-07
AU758241B2 (en)	2003-03-20
EP1070068A1 (de)	2001-01-24
DE69911935D1 (de)	2003-11-13
EP1070068B1 (de)	2003-10-08
WO1999047522A1 (en)	1999-09-23
JP2002506868A (ja)	2002-03-05

Publication	Publication Date	Title
ATE251624T1 (de)	2003-10-15	Granulatimide-derivate zur behandlung von krebs
ATE264846T1 (de)	2004-05-15	Substituierte benzimidazol-derivaten und ihre verwendung zur behandlung retroviraler infektionen
ATE383339T1 (de)	2008-01-15	Amin-derivate zur behandlung von apoptosis
ATE296826T1 (de)	2005-06-15	Pyrazolo(1,5)pyridinderivate
BR9908332A (pt)	2000-11-07	Derivados de n-[carbonil(anel di ou triaza diinsaturado de cinco membros substituìdo)] derivados de guanidina para tratamento de esquemia
BR0007589A (pt)	2002-10-15	Inibidores da proliferação de células
TR199800924T2 (xx)	1998-08-21	Quinoline t�revleri.
DE59709414D1 (de)	2003-04-03	Oxyiminopregnancarbolactone
ATE227293T1 (de)	2002-11-15	2,3-disubstituierte-(5,6)-heteroarylkondensiert - pyrimidin-4-one
ES2243579T3 (es)	2005-12-01	Derivados de pirazolopirideno.
DE69330282D1 (de)	2001-07-05	Chinolon und acridinon derivate zur behandlung der harninkontinenz
EE03771B1 (et)	2002-06-17	Tetrahüdropüridoühendid, neid sisaldav ravim ja nende kasutamine
EA200000431A3 (ru)	2001-02-26	Новые замещенные димерные соединения, способ их получения и фармацевтические композиции, содержащие их
GR1001597B (el)	1994-06-30	Νέα βιολογικώς δραστικά παράγωγα εμπουρναμενίνης, φαρμακευτικές συν?έσεις οι οποίες περιέχουν αυτά και μέ?οδος δια την παρασκευή αυτών.
DE69813565D1 (de)	2003-05-22	Substituierte 3,3-diamino-2-propennitrile, ihre herstellung und verwendung
DE69127976D1 (de)	1997-11-20	Tropolonderivate und pharmazeutische zubereitungen davon zur vorbeugung und behandlung von ischämischen krankheiten
TR199802044T2 (xx)	1999-02-22	Yeni karbon asidi t�revleri, �retilmeleri ve kullan�mlar�.
ES2019840A6 (es)	1991-07-01	Procedimiento para preparar nuevos derivados de tieno-triazolo-diazepina.
EA199900534A1 (ru)	2000-02-28	Имидазопиридазины
ATE266029T1 (de)	2004-05-15	Substituierte pyrrolobenzimidazolderivate zur entzündungshemmung
ATE148109T1 (de)	1997-02-15	Hiv-proteaseinhibitoren und ihre verwendung zur behandlung von aids
SE9604582D0 (sv)	1996-12-13	Novel compounds
RU94014631A (ru)	1997-02-20	Производные 4-хиномиодигидропиридина, смесь их изомеров или отдельные изомеры и их соли
ES2104174T3 (es)	1997-10-01	Derivados de bencilamino, bencilamido y bencilimido ciclicos utilizados como agentes antipsicoticos.
ATE267018T1 (de)	2004-06-15	Verwendung von peptidverbindungen zur behandlung von sle

Legal Events

Date	Code	Title	Description
2004-04-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties