ATE239019T1 - Pyrido(2,3-b)indolizinderivate und aza analoge: crf1 spezifische liganden - Google Patents
Pyrido(2,3-b)indolizinderivate und aza analoge: crf1 spezifische ligandenInfo
- Publication number
- ATE239019T1 ATE239019T1 AT99928519T AT99928519T ATE239019T1 AT E239019 T1 ATE239019 T1 AT E239019T1 AT 99928519 T AT99928519 T AT 99928519T AT 99928519 T AT99928519 T AT 99928519T AT E239019 T1 ATE239019 T1 AT E239019T1
- Authority
- AT
- Austria
- Prior art keywords
- pyrido
- specific ligands
- indolizine derivatives
- crf1
- aza analogue
- Prior art date
Links
- 102100038018 Corticotropin-releasing factor receptor 1 Human genes 0.000 title 1
- 101000878678 Homo sapiens Corticotropin-releasing factor receptor 1 Proteins 0.000 title 1
- 101000948733 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) Probable phospholipid translocase non-catalytic subunit CRF1 Proteins 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- ZQKPWOFYWBQDCR-UHFFFAOYSA-N pyrido[2,3-b]indolizine Chemical class C1=CC=CC2=CC3=NC=CC=C3N21 ZQKPWOFYWBQDCR-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000028173 post-traumatic stress disease Diseases 0.000 abstract 2
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 108091005471 CRHR1 Proteins 0.000 abstract 1
- 206010019233 Headaches Diseases 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 231100000869 headache Toxicity 0.000 abstract 1
- 239000004031 partial agonist Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/12—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/57—Nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8880898P | 1998-06-09 | 1998-06-09 | |
| PCT/US1999/012990 WO1999064422A1 (en) | 1998-06-09 | 1999-06-08 | Pyrido[2,3-b]indolizine derivatives and aza analogues thereof; crf1 specific ligands |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE239019T1 true ATE239019T1 (de) | 2003-05-15 |
Family
ID=22213614
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99928519T ATE239019T1 (de) | 1998-06-09 | 1999-06-08 | Pyrido(2,3-b)indolizinderivate und aza analoge: crf1 spezifische liganden |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US6194574B1 (de) |
| EP (1) | EP1086103B1 (de) |
| JP (1) | JP2002517501A (de) |
| AT (1) | ATE239019T1 (de) |
| AU (1) | AU4556999A (de) |
| CA (1) | CA2334671A1 (de) |
| DE (1) | DE69907448T2 (de) |
| ES (1) | ES2196820T3 (de) |
| WO (1) | WO1999064422A1 (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1303487A4 (de) | 2000-07-21 | 2005-11-23 | Schering Corp | Neue peptide als ns3-serin protease inhibitoren des hepatitis c virus |
| PT1354884E (pt) | 2000-12-28 | 2007-12-24 | Ono Pharmaceutical Co | Composto de ciclopenta (d) pirazolo [1,5-a] piramida como antagonista de receptor de crf |
| ATE478873T1 (de) | 2003-06-25 | 2010-09-15 | Ono Pharmaceutical Co | Methansulfonsäuresalz einer pyrazolopyrimidinverbindung, kristall davon und verfahren zu deren herstellung |
| KR102571296B1 (ko) | 2016-09-07 | 2023-08-28 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | P-tau를 감소시키고 인지를 개선하는 알로스테릭 코르티코트로핀-방출 인자 수용체 1 (crfr1) 길항제 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3932431A (en) * | 1970-06-24 | 1976-01-13 | Schering Corporation | Certain 2-[α(2-pyridyl)-benzyl] imidazolines and derivatives thereof |
| US3988338A (en) | 1974-04-24 | 1976-10-26 | Wisconsin Alumni Research Foundation | 4-Substituted amino-2-substituted thio-pyrrolo-[2,3-d]pyrimidine derivatives |
| US4605642A (en) | 1984-02-23 | 1986-08-12 | The Salk Institute For Biological Studies | CRF antagonists |
| EP0239191A3 (de) | 1986-01-30 | 1988-07-20 | Beecham Group Plc | Pyrazolo[4,3-b]pyridinderivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen |
| JP2541702B2 (ja) | 1989-10-11 | 1996-10-09 | 帝人株式会社 | 二環性ピリミジン誘導体、その製造方法およびそれを有効成分とする医薬製剤 |
| US5063245A (en) | 1990-03-28 | 1991-11-05 | Nova Pharmaceutical Corporation | Corticotropin-releasing factor antagonism compounds |
| US5244896A (en) | 1990-09-14 | 1993-09-14 | Marion Merrell Dow Inc. | Carbocyclic adenosine analogs useful as immunosuppressants |
| DK0674641T3 (da) | 1992-12-17 | 1999-09-27 | Pfizer | Pyrrolopyrimidiner som CRF-antagonister |
| JP3398152B2 (ja) | 1993-10-12 | 2003-04-21 | ブリストル‐マイヤーズ・スクイブ・ファーマ・カンパニー | １ｎ−アルキル−ｎ−アリールピリミジンアミンおよびその誘導体 |
| DE69603240T2 (de) | 1995-05-12 | 2000-01-05 | Neurogen Corp., Branford | Neue deazapurinderivate; eine neue klasse von crf1-spezifischen liganden |
| US5644057A (en) | 1995-05-12 | 1997-07-01 | Neurogen Corporation | Deazapurine derivatives; a new class of CRF1 specific ligands |
| US5804685A (en) | 1995-06-07 | 1998-09-08 | Neurogen Corporation | Deazapurine derivatives: a new class of CRF1 specific ligands |
| JPH10114744A (ja) * | 1996-08-22 | 1998-05-06 | Takeda Chem Ind Ltd | アミノグアニジンヒドラゾン誘導体、その製法及び剤 |
| ATE340176T1 (de) * | 1996-08-28 | 2006-10-15 | Pfizer | Substituierte 6,5-heterobicyclische-derivate |
-
1999
- 1999-06-08 AU AU45569/99A patent/AU4556999A/en not_active Abandoned
- 1999-06-08 JP JP2000553431A patent/JP2002517501A/ja active Pending
- 1999-06-08 US US09/328,179 patent/US6194574B1/en not_active Expired - Fee Related
- 1999-06-08 DE DE69907448T patent/DE69907448T2/de not_active Expired - Fee Related
- 1999-06-08 EP EP99928519A patent/EP1086103B1/de not_active Expired - Lifetime
- 1999-06-08 AT AT99928519T patent/ATE239019T1/de not_active IP Right Cessation
- 1999-06-08 CA CA002334671A patent/CA2334671A1/en not_active Abandoned
- 1999-06-08 WO PCT/US1999/012990 patent/WO1999064422A1/en active IP Right Grant
- 1999-06-08 ES ES99928519T patent/ES2196820T3/es not_active Expired - Lifetime
-
2001
- 2001-02-23 US US09/791,370 patent/US6495686B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE69907448D1 (de) | 2003-06-05 |
| DE69907448T2 (de) | 2004-03-18 |
| WO1999064422A1 (en) | 1999-12-16 |
| JP2002517501A (ja) | 2002-06-18 |
| CA2334671A1 (en) | 1999-12-16 |
| EP1086103A1 (de) | 2001-03-28 |
| AU4556999A (en) | 1999-12-30 |
| EP1086103B1 (de) | 2003-05-02 |
| US6194574B1 (en) | 2001-02-27 |
| US6495686B2 (en) | 2002-12-17 |
| US20020019525A1 (en) | 2002-02-14 |
| ES2196820T3 (es) | 2003-12-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |