ATE238761T1 - Mundwasser mit kalzium- und phosphationen in einer übersättigten lösung - Google Patents
Mundwasser mit kalzium- und phosphationen in einer übersättigten lösungInfo
- Publication number
- ATE238761T1 ATE238761T1 AT97941536T AT97941536T ATE238761T1 AT E238761 T1 ATE238761 T1 AT E238761T1 AT 97941536 T AT97941536 T AT 97941536T AT 97941536 T AT97941536 T AT 97941536T AT E238761 T1 ATE238761 T1 AT E238761T1
- Authority
- AT
- Austria
- Prior art keywords
- calcium
- mouthwash
- supersaturated solution
- phosphations
- supersaturated
- Prior art date
Links
- 239000000243 solution Substances 0.000 title abstract 3
- 239000002324 mouth wash Substances 0.000 title abstract 2
- 229940051866 mouthwash Drugs 0.000 title abstract 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 title 1
- 229910052791 calcium Inorganic materials 0.000 title 1
- 239000011575 calcium Substances 0.000 title 1
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 229910001424 calcium ion Inorganic materials 0.000 abstract 1
- 229910000389 calcium phosphate Inorganic materials 0.000 abstract 1
- 239000001506 calcium phosphate Substances 0.000 abstract 1
- 235000011010 calcium phosphates Nutrition 0.000 abstract 1
- 208000002925 dental caries Diseases 0.000 abstract 1
- 210000000214 mouth Anatomy 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 239000003381 stabilizer Substances 0.000 abstract 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Molecular Biology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Neurosurgery (AREA)
- AIDS & HIV (AREA)
- Biomedical Technology (AREA)
- Nutrition Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Biotechnology (AREA)
- Surgery (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2657896P | 1996-09-18 | 1996-09-18 | |
| GBGB9619464.2A GB9619464D0 (en) | 1996-09-18 | 1996-09-18 | Compositions |
| PCT/US1997/016125 WO1998011866A1 (en) | 1996-09-18 | 1997-09-18 | Mouthwash comprising calcium and phosphate ions in supersaturated solution |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE238761T1 true ATE238761T1 (de) | 2003-05-15 |
Family
ID=26310059
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97941536T ATE238761T1 (de) | 1996-09-18 | 1997-09-18 | Mundwasser mit kalzium- und phosphationen in einer übersättigten lösung |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US5993785A (de) |
| EP (1) | EP0939613B1 (de) |
| JP (2) | JP3895388B2 (de) |
| AT (1) | ATE238761T1 (de) |
| AU (1) | AU4342497A (de) |
| CA (1) | CA2266409C (de) |
| DE (1) | DE69721556T2 (de) |
| DK (1) | DK0939613T3 (de) |
| ES (1) | ES2197364T3 (de) |
| GB (1) | GB2318977B (de) |
| NO (1) | NO313367B1 (de) |
| PT (1) | PT939613E (de) |
| WO (1) | WO1998011866A1 (de) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITFI980051A1 (it) * | 1998-03-06 | 1999-09-06 | Italmed Di Galli Giovanna E Pa | Composizione ad uso odontoiatrico per la desensibilizzazione della dentina esposta |
| NL1018208C2 (nl) * | 2001-06-05 | 2002-12-10 | Calcio B V | Tandpasta. |
| US20030175220A1 (en) * | 2001-12-11 | 2003-09-18 | Wang Xiao Bing | Effect of electrolyzed solutions on acidogenesis of plaque |
| EP1607005B1 (de) * | 2001-12-11 | 2008-10-08 | Xiao Bing Wang | Die Wirkung eines Puffers auf die Säurebildung durch Plaque |
| TWI231182B (en) * | 2001-12-11 | 2005-04-21 | Shinkatsu Morisawa | The effect of a buffering agent on acidogenesis of plaque |
| US6610275B1 (en) * | 2002-02-13 | 2003-08-26 | Joseph L. Owades | Device for treating drinking water to make it hostile to dental plaque |
| RU2316242C2 (ru) * | 2002-10-04 | 2008-02-10 | Дзе Проктер Энд Гэмбл Компани | Составы для рта и их использование |
| US9011823B2 (en) | 2005-02-01 | 2015-04-21 | Ada Foundation | Enhanced anti-carious dentifrices, rinses, lozenges, candies and chewing gums and methods of using same |
| US20080299182A1 (en) * | 2007-03-01 | 2008-12-04 | Shuyuan Zhang | Methods and formulations for topical gene therapy |
| EP2164512A2 (de) * | 2007-06-20 | 2010-03-24 | Actogenix N.V. | Verfahren und zusammensetzungen zur behandlung von mucositis |
| WO2009146104A1 (en) * | 2008-04-02 | 2009-12-03 | Accentia Biopharmaceuticals, Inc. | Formulations, devices and methods for treating and preventing mucositis |
| US20110086108A1 (en) * | 2009-10-12 | 2011-04-14 | Bartholomew Weldon | Dissolving powders that can be mixed with water and used as an oral rinse |
| WO2011109919A1 (en) | 2010-03-09 | 2011-09-15 | Unilever Plc | Stable oral care compositions |
| WO2012135426A2 (en) * | 2011-03-29 | 2012-10-04 | New York University | Anti-bacterial and mineralizing calcium phosphate compositions |
| WO2012156502A2 (en) * | 2011-05-18 | 2012-11-22 | Arcoral Pharma As | Two component mouth rinse preparation |
| WO2012164083A1 (en) | 2011-06-01 | 2012-12-06 | Actogenix N.V. | Polycistronic expression system for bacteria |
| EP2919744B1 (de) * | 2012-11-16 | 2020-09-02 | EUSA Pharma (UK) Ltd | Brausetablette |
| WO2015013549A1 (en) | 2013-07-25 | 2015-01-29 | Invado Pharmaceuticals, LLC | Treating oral inflammation, injury or pain |
| JP5764712B1 (ja) * | 2014-12-16 | 2015-08-19 | 株式会社松風 | 歯質再生剤 |
| US11590165B2 (en) | 2014-12-17 | 2023-02-28 | Bausch Health Companies Inc. | Formulations of calcium and phosphate for oral inflammation |
| KR102813956B1 (ko) * | 2015-10-26 | 2025-05-28 | 바스프 에스이 | 구강세정제 제품 및 방법 |
| BR112018010091A2 (pt) | 2015-11-19 | 2019-02-05 | Fantarella & Harewood LLC | colutório não alcoólico e método para inibir o crescimento de células de bactérias na boca |
| CN108883140A (zh) | 2016-01-14 | 2018-11-23 | 英特瑞克斯顿阿克图比奥帝克斯有限公司 | 治疗1型糖尿病的组合物和方法 |
| CN109310587A (zh) * | 2016-04-28 | 2019-02-05 | 加利福尼亚大学董事会 | 用于控制菌斑形成的组合物 |
| EP3506932B1 (de) | 2016-09-02 | 2025-06-25 | Intrexon Actobiotics NV | Gentechnisch veränderte bakterien mit stabiler expression von il-10 und insulin |
| US10808014B2 (en) | 2016-09-13 | 2020-10-20 | Intrexon Actobiotics N.V. | Mucoadhesive microorganism |
| KR20200012855A (ko) * | 2017-04-25 | 2020-02-05 | 뉴트레코 아이피 애셋츠 비.브이. | 사산을 방지하는 데 사용하기 위한 칼슘 결합제 |
| AU2019209400B2 (en) * | 2018-01-17 | 2022-02-24 | The Procter & Gamble Company | Methods and compositions to increase the hardness and resistance of enamel |
| US11642199B2 (en) * | 2018-09-24 | 2023-05-09 | 3M Innovative Properties Company | Dental appliance with cosmetic therapeutic aqueous solution |
| EP4034144A1 (de) | 2019-09-27 | 2022-08-03 | Intrexon Actobiotics NV d/b/a Precigen Actobio | Behandlung von zöliakie |
| US11903992B2 (en) * | 2021-01-23 | 2024-02-20 | Cellix Bio Private Limited | Composition comprising lidocaine, l-carnosine and dexpanthenol |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1492247A1 (de) * | 1964-03-20 | 1969-11-06 | Warner Lambert Pharmaceutical | Verfahren zum Wiederverhaerten von Zahnschmelz und dafuer geeignetes Zahnpflegemittel |
| US3679360A (en) * | 1970-06-26 | 1972-07-25 | Nasa | Process for the preparation of brushite crystals |
| GB1408922A (en) * | 1972-02-02 | 1975-10-08 | Blendax Werke Schneider Co | Process and composition for the remineralisation and prevention of demineralisation of human teeth |
| US4048300A (en) * | 1973-01-11 | 1977-09-13 | Colgate-Palmolive Company | Dental preparation containing materials having calcium and phosphate components |
| US4108980A (en) * | 1973-01-11 | 1978-08-22 | Colgate-Palmolive Company | Process of preparing materials having calcium and phosphate components |
| DE2452969A1 (de) * | 1973-11-13 | 1975-05-15 | Procter & Gamble | Mittel zum remineralisieren von zahnschmelz |
| US4080440A (en) * | 1974-12-13 | 1978-03-21 | The Procter & Gamble Company | Method for remineralizing tooth enamel |
| US4097588A (en) * | 1975-03-11 | 1978-06-27 | National Research Development Corporation | Mineralizing dental mouthrinse |
| US4083955A (en) * | 1975-04-02 | 1978-04-11 | The Procter & Gamble Company | Processes and compositions for remineralization of dental enamel |
| GB1509977A (en) * | 1975-10-31 | 1978-05-10 | Nat Res Dev | Remineralising composition |
| US4097935A (en) * | 1976-07-21 | 1978-07-04 | Sterling Drug Inc. | Hydroxylapatite ceramic |
| US4183915A (en) * | 1978-10-13 | 1980-01-15 | Colgate-Palmolive Company | Stable solution for dental remineralization |
| US4177258A (en) * | 1978-10-13 | 1979-12-04 | Colgate Palmolive Company | Dentifrice for dental remineralization |
| US4348381A (en) * | 1981-05-06 | 1982-09-07 | Colgate-Palmolive Company | Dental remineralization composition |
| US4606912A (en) * | 1981-07-22 | 1986-08-19 | Caries Research Group Of Rochester, Inc. | Method of making a clear, stable aqueous mouthwash solution and the solution made by that method for the enhancement of cells of the oral cavity and the remineralization of teeth |
| US4532124A (en) * | 1981-08-19 | 1985-07-30 | Development Finance Corporation Of New Zealand | Dental rinse |
| US5037639A (en) * | 1989-05-24 | 1991-08-06 | American Dental Association Health Foundation | Methods and compositions for mineralizing calcified tissues |
| US5460803A (en) * | 1989-05-24 | 1995-10-24 | American Dental Association Health Foundation | Methods and compositions for mineralizing and fluoridating calcified tissues |
| US5427768A (en) * | 1993-06-23 | 1995-06-27 | American Dental Association Health Foundation | Carbonated solutions for treating, mineralizing and fluoridating calcified tissues and methods for their use |
| US5658554A (en) | 1995-06-01 | 1997-08-19 | Colgate-Palmolive Company | Mouth moistener for the relief of dry mouth condition |
| US5605675A (en) * | 1995-06-06 | 1997-02-25 | Enamelon Inc. | Processes and compositions for remineralization and prevention of demineralization of dental enamel |
| US5603922A (en) * | 1995-08-08 | 1997-02-18 | Enamelon Inc. | Processes and compositions for the remineralization of teeth |
| US5571502A (en) * | 1995-08-08 | 1996-11-05 | Enamelon Research | Stable single-part compositions and the use thereof for remineralization of lesions in teeth |
-
1997
- 1997-09-18 DK DK97941536T patent/DK0939613T3/da active
- 1997-09-18 AU AU43424/97A patent/AU4342497A/en not_active Abandoned
- 1997-09-18 DE DE69721556T patent/DE69721556T2/de not_active Expired - Lifetime
- 1997-09-18 PT PT97941536T patent/PT939613E/pt unknown
- 1997-09-18 EP EP97941536A patent/EP0939613B1/de not_active Expired - Lifetime
- 1997-09-18 GB GB9719780A patent/GB2318977B/en not_active Expired - Lifetime
- 1997-09-18 WO PCT/US1997/016125 patent/WO1998011866A1/en not_active Ceased
- 1997-09-18 JP JP51475898A patent/JP3895388B2/ja not_active Expired - Lifetime
- 1997-09-18 AT AT97941536T patent/ATE238761T1/de active
- 1997-09-18 US US08/933,481 patent/US5993785A/en not_active Expired - Lifetime
- 1997-09-18 ES ES97941536T patent/ES2197364T3/es not_active Expired - Lifetime
- 1997-09-18 CA CA002266409A patent/CA2266409C/en not_active Expired - Lifetime
-
1999
- 1999-03-17 NO NO19991302A patent/NO313367B1/no not_active IP Right Cessation
- 1999-07-09 US US09/350,965 patent/US6387352B1/en not_active Expired - Lifetime
-
2002
- 2002-05-14 US US10/146,500 patent/US20030152530A1/en not_active Abandoned
-
2006
- 2006-02-21 JP JP2006043285A patent/JP4746441B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US20020044910A1 (en) | 2002-04-18 |
| DE69721556D1 (de) | 2003-06-05 |
| US20030152530A1 (en) | 2003-08-14 |
| DK0939613T3 (da) | 2003-07-14 |
| JP2006199702A (ja) | 2006-08-03 |
| GB2318977B (en) | 1999-07-21 |
| NO991302L (no) | 1999-03-17 |
| CA2266409A1 (en) | 1998-03-26 |
| EP0939613B1 (de) | 2003-05-02 |
| US6387352B1 (en) | 2002-05-14 |
| NO991302D0 (no) | 1999-03-17 |
| AU4342497A (en) | 1998-04-14 |
| CA2266409C (en) | 2009-01-06 |
| ES2197364T3 (es) | 2004-01-01 |
| GB2318977A (en) | 1998-05-13 |
| DE69721556T2 (de) | 2004-03-04 |
| JP4746441B2 (ja) | 2011-08-10 |
| EP0939613A1 (de) | 1999-09-08 |
| JP3895388B2 (ja) | 2007-03-22 |
| NO313367B1 (no) | 2002-09-23 |
| JP2001500874A (ja) | 2001-01-23 |
| US5993785A (en) | 1999-11-30 |
| GB9719780D0 (en) | 1997-11-19 |
| WO1998011866A1 (en) | 1998-03-26 |
| PT939613E (pt) | 2003-07-31 |
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