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ATE237362T1 - Thermostabilisiertes kontrastmittel - Google Patents

Thermostabilisiertes kontrastmittel

Info

Publication number
ATE237362T1
ATE237362T1 AT97903507T AT97903507T ATE237362T1 AT E237362 T1 ATE237362 T1 AT E237362T1 AT 97903507 T AT97903507 T AT 97903507T AT 97903507 T AT97903507 T AT 97903507T AT E237362 T1 ATE237362 T1 AT E237362T1
Authority
AT
Austria
Prior art keywords
contrast agent
thermostabilized
freeze
excess
temperatures
Prior art date
Application number
AT97903507T
Other languages
English (en)
Inventor
Marit Swaerd-Nordmo
Per Helge Gulliksen
Jorunn Undheim Braenden
Anne Kjersti Fahlvik
Original Assignee
Amersham Health As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9603466.5A external-priority patent/GB9603466D0/en
Priority claimed from GBGB9611894.8A external-priority patent/GB9611894D0/en
Priority claimed from GBGB9624919.8A external-priority patent/GB9624919D0/en
Application filed by Amersham Health As filed Critical Amersham Health As
Application granted granted Critical
Publication of ATE237362T1 publication Critical patent/ATE237362T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/227—Liposomes, lipoprotein vesicles, e.g. LDL or HDL lipoproteins, micelles, e.g. phospholipidic or polymeric

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Acoustics & Sound (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Light Receiving Elements (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
AT97903507T 1996-02-19 1997-02-19 Thermostabilisiertes kontrastmittel ATE237362T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9603466.5A GB9603466D0 (en) 1996-02-19 1996-02-19 Improvements in or relating to contrast agents
GBGB9611894.8A GB9611894D0 (en) 1996-06-07 1996-06-07 Improvements in or relating to contrast agents
GBGB9624919.8A GB9624919D0 (en) 1996-11-29 1996-11-29 Product
PCT/GB1997/000458 WO1997029782A1 (en) 1996-02-19 1997-02-19 Thermally stabilized contrast agent

Publications (1)

Publication Number Publication Date
ATE237362T1 true ATE237362T1 (de) 2003-05-15

Family

ID=27268136

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97903507T ATE237362T1 (de) 1996-02-19 1997-02-19 Thermostabilisiertes kontrastmittel

Country Status (18)

Country Link
EP (1) EP0885016B1 (de)
JP (1) JP4250747B2 (de)
KR (1) KR100501863B1 (de)
CN (1) CN1092988C (de)
AT (1) ATE237362T1 (de)
AU (1) AU722735B2 (de)
CA (1) CA2246778A1 (de)
CZ (1) CZ262698A3 (de)
DE (1) DE69720979T2 (de)
EA (1) EA000900B1 (de)
EE (1) EE9800248A (de)
ES (1) ES2197331T3 (de)
HU (1) HUP9900812A3 (de)
IL (1) IL125800A0 (de)
NO (1) NO313815B1 (de)
NZ (1) NZ331372A (de)
PL (1) PL328309A1 (de)
WO (1) WO1997029782A1 (de)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
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IL128345A0 (en) * 1996-08-02 2000-01-31 Nycomed Imaging As Improvements in or relating to contrast agents
GB9717542D0 (en) * 1997-08-19 1997-10-22 Nycomed Imaging As Process
KR20030023697A (ko) 2000-07-13 2003-03-19 다이이찌 세이야꾸 가부시기가이샤 Ｄｄｓ 화합물을 함유하는 의약 조성물
US6793626B2 (en) 2001-01-17 2004-09-21 Fuji Photo Film Co., Ltd. Ultrasonic scatterer, ultrasonic imaging method and ultrasonic imaging apparatus
DE60111917T2 (de) * 2001-01-31 2006-04-20 Bracco International B.V. Lyophilisierbares Kontrastmittel, gasgefüllte Mikrobläschen enthaltend
EP1572001A1 (de) 2002-11-29 2005-09-14 Amersham Health AS Ultraschallauflösende methode
EP1590006B1 (de) 2003-02-04 2010-09-08 Bracco Suisse SA Ultraschall kontrastmittel und verfahren zur erstellung
JP5513708B2 (ja) 2003-12-22 2014-06-04 ブラッコ・シュイス・ソシエテ・アノニム 造影イメージング用の気体封入マイクロベシクル・アセンブリー
EP1784228B1 (de) 2004-08-18 2016-10-05 Bracco Suisse SA Gasgefüllte mikrovesikelzusammensetzung für kontrastbilddarstellungen
WO2006076826A1 (fr) * 2005-01-18 2006-07-27 Institute Of Pharmacology Toxicology, Academy Of Military Medical Sciences Composition de contraste pour ultrasons utilisant un phospholipide filmogene et procede de preparation de celle-ci
US9446156B2 (en) 2006-09-05 2016-09-20 Bracco Suisse S.A. Gas-filled microvesicles with polymer-modified lipids
WO2008075192A2 (en) 2006-12-19 2008-06-26 Bracco International Bv Targeting and therapeutic compounds and gas-filled microvesicles comprising said com ounds
JP2010539038A (ja) 2007-09-11 2010-12-16 モンドバイオテック ラボラトリーズ アクチエンゲゼルシャフト 治療剤としてのＴｙｒ−Ｗ−ＭＩＦ−１およびウロコーチン２の使用
CA2699255A1 (en) 2007-09-11 2009-04-09 Mondobiotech Laboratories Ag Use of a peptide as a therapeutic agent
AU2008306272A1 (en) 2007-09-11 2009-04-09 Mondobiotech Laboratories Ag U e of urocortin and corticotropin-releasing fact r as therapeutic agents
EP2190535B1 (de) 2007-09-11 2012-08-08 Mondobiotech Laboratories AG Somatostatin-14 zur Verwendung bei der Vorbeugung und/oder Behandlung von HBV-Infektionen
AU2008303954A1 (en) 2007-09-11 2009-04-02 Mondobiotech Laboratories Ag Use of band 3 protein (824-829) and/or melanocyte-stimulating hormone release-inhibiting factor as a therapeutic agent in the treatment of Pseudomonas aeruginosa infection
KR20100063716A (ko) 2007-09-11 2010-06-11 몬도바이오테크 래보래토리즈 아게 치료제로서 사용하기 위한 아스트레신 및 베타-엔도르핀
US20100204107A1 (en) 2007-09-11 2010-08-12 Dorian Bevec Use of urodilatin as a therapeutic agent
WO2009043468A2 (en) 2007-09-11 2009-04-09 Mondobiotech Laboratories Ag Use of corticotropin-releasing factor as a therapeutic agent
CA2698745A1 (en) 2007-09-11 2009-03-19 Mondobiotech Laboratories Ag Use of a peptide as a therapeutic agent
US20100197599A1 (en) 2007-09-11 2010-08-05 Dorian Bevec Use of a peptide as a therapeutic agent
WO2009039994A1 (en) 2007-09-11 2009-04-02 Mondobiotech Laboratories Ag Proadrenomedullin alone or in combination with big gastrin i as a therapeutic agent
KR20100056517A (ko) 2007-09-11 2010-05-27 몬도바이오테크 래보래토리즈 아게 치료제로서의 펩티드의 용도
EP2090322A1 (de) 2008-02-18 2009-08-19 INSERM (Institut National de la Santé et de la Recherche Médicale) Verwendung von FSH-Rezeptorliganden zur Diagnose und Behandlung von Krebs
CA2748995C (en) 2008-10-07 2018-01-16 Bracco Suisse Sa Targeting construct comprising anti-polymer antibody and liposomes or microvesicles binding to the same
CN101649293B (zh) * 2009-09-02 2012-07-18 中国农业大学 一种微生物冷冻干燥保护剂及其应用
CN103079599B (zh) 2010-08-09 2017-05-10 博莱科瑞士股份有限公司 靶向气体填充微囊
EP2426202A1 (de) 2010-09-03 2012-03-07 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Kinasen als Targets für antidiabetische Therapien
BR112013016244B1 (pt) 2010-12-24 2021-12-21 Bracco Suisse Sa Formulação farmacêutica compreendendo microvesículas cheias de gás e precursor da mesma
PT2768484T (pt) * 2011-10-21 2019-10-28 Jazz Pharmaceuticals Res Llc Lipossomas liofilizados
EP2589383A1 (de) 2011-11-06 2013-05-08 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Berlin FKBP-subtypspezifisches Rapamycin-Analogon zur Verwendung bei der Behandlung von Erkrankungen
GB201405735D0 (en) * 2014-03-31 2014-05-14 Ge Healthcare As Ultrasound precursor preparation method
GB201411423D0 (en) * 2014-06-26 2014-08-13 Ge Healthcare As Lipid sterilisation method
EP3020813A1 (de) 2014-11-16 2016-05-18 Neurovision Pharma GmbH Antisense-Oligonukleotide als Inhibitoren der TGF-R-Signalgebung
CN107206065A (zh) 2014-12-22 2017-09-26 博莱科瑞士股份有限公司 用作疫苗的气体填充的微囊
US20190117800A1 (en) * 2016-04-19 2019-04-25 Microvascuar Therapeutics Llc Systems and methods for filling vials with gases
KR20210003737A (ko) 2018-03-07 2021-01-12 브라코 스위스 에스.에이. 크기-제어 미세소포의 제조
WO2020260423A1 (en) * 2019-06-25 2020-12-30 Bracco Suisse Sa Freeze-dried composition for preparing calibrated gas-filled microvesicles
DK3990032T3 (da) 2019-06-25 2023-12-18 Bracco Suisse Sa Frysetørret sammensætning til fremstilling af kalibrerede gasfyldte mikrovesikler
US10953023B1 (en) 2020-01-28 2021-03-23 Applaud Medical, Inc. Phospholipid compounds and formulations
CN112891565A (zh) * 2021-04-09 2021-06-04 上海师范大学 锌-二甲基吡啶胺在制备诊断血栓性疾病药物中的应用
EP4105328A1 (de) 2021-06-15 2022-12-21 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Antisense-oligonukleotide zur prävention von nierenfunktionsstörungen, die durch endotheliale dysfunktion gefördert werden, durch unterdrückung von ephrin-b2

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4857319A (en) * 1985-01-11 1989-08-15 The Regents Of The University Of California Method for preserving liposomes
US4642903A (en) * 1985-03-26 1987-02-17 R. P. Scherer Corporation Freeze-dried foam dosage form
JPH06211645A (ja) * 1993-01-14 1994-08-02 Mitsubishi Kasei Corp リポソーム凍結乾燥製剤

Also Published As

Publication number Publication date
JP4250747B2 (ja) 2009-04-08
DE69720979T2 (de) 2004-02-26
NO983584L (no) 1998-10-16
CN1213971A (zh) 1999-04-14
HUP9900812A3 (en) 1999-11-29
EA199800739A1 (ru) 1999-02-25
PL328309A1 (en) 1999-01-18
NO313815B1 (no) 2002-12-09
DE69720979D1 (de) 2003-05-22
AU722735B2 (en) 2000-08-10
ES2197331T3 (es) 2004-01-01
NZ331372A (en) 2000-01-28
EE9800248A (et) 1999-02-15
AU1805197A (en) 1997-09-02
CA2246778A1 (en) 1997-08-21
CN1092988C (zh) 2002-10-23
HUP9900812A2 (hu) 1999-07-28
WO1997029782A1 (en) 1997-08-21
CZ262698A3 (cs) 1999-03-17
IL125800A0 (en) 1999-04-11
EP0885016A1 (de) 1998-12-23
EA000900B1 (ru) 2000-06-26
KR100501863B1 (ko) 2005-09-27
KR19990082670A (ko) 1999-11-25
NO983584D0 (no) 1998-08-05
EP0885016B1 (de) 2003-04-16
JP2000506122A (ja) 2000-05-23

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Legal Events

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