ATE233552T1 - Thiol-sulfonen als metalloproteinaseinhibitoren - Google Patents
Thiol-sulfonen als metalloproteinaseinhibitorenInfo
- Publication number
- ATE233552T1 ATE233552T1 AT97936169T AT97936169T ATE233552T1 AT E233552 T1 ATE233552 T1 AT E233552T1 AT 97936169 T AT97936169 T AT 97936169T AT 97936169 T AT97936169 T AT 97936169T AT E233552 T1 ATE233552 T1 AT E233552T1
- Authority
- AT
- Austria
- Prior art keywords
- inhibitors
- thiol
- sulfones
- proteinase
- metalloproteinase inhibitors
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K31/10—Sulfides; Sulfoxides; Sulfones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C317/22—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
- C07C323/65—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfone or sulfoxide groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/20—Esters of monothiocarboxylic acids
- C07C327/24—Esters of monothiocarboxylic acids having carbon atoms of esterified thiocarboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/20—Esters of monothiocarboxylic acids
- C07C327/26—Esters of monothiocarboxylic acids having carbon atoms of esterified thiocarboxyl groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Lubricants (AREA)
- Peptides Or Proteins (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pyridine Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Compounds Of Unknown Constitution (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2204396P | 1996-07-22 | 1996-07-22 | |
| PCT/US1997/012874 WO1998003164A1 (en) | 1996-07-22 | 1997-07-22 | Thiol sulfone metalloprotease inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE233552T1 true ATE233552T1 (de) | 2003-03-15 |
Family
ID=21807522
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97936169T ATE233552T1 (de) | 1996-07-22 | 1997-07-22 | Thiol-sulfonen als metalloproteinaseinhibitoren |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6013649A (de) |
| EP (1) | EP0939628B1 (de) |
| JP (1) | JP2001505869A (de) |
| KR (1) | KR20000067963A (de) |
| CN (1) | CN1230884A (de) |
| AT (1) | ATE233552T1 (de) |
| AU (1) | AU714687B2 (de) |
| BR (1) | BR9710758A (de) |
| CA (1) | CA2260859A1 (de) |
| CZ (1) | CZ16799A3 (de) |
| DE (1) | DE69719538T2 (de) |
| DK (1) | DK0939628T3 (de) |
| ES (1) | ES2194209T3 (de) |
| IL (1) | IL128079A0 (de) |
| NO (1) | NO990262L (de) |
| NZ (1) | NZ333824A (de) |
| PL (1) | PL331369A1 (de) |
| PT (1) | PT939628E (de) |
| RU (1) | RU2221781C2 (de) |
| WO (1) | WO1998003164A1 (de) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6747027B1 (en) * | 1996-07-22 | 2004-06-08 | Pharmacia Corporation | Thiol sulfonamide metalloprotease inhibitors |
| US6696449B2 (en) | 1997-03-04 | 2004-02-24 | Pharmacia Corporation | Sulfonyl aryl hydroxamates and their use as matrix metalloprotease inhibitors |
| US6794511B2 (en) | 1997-03-04 | 2004-09-21 | G. D. Searle | Sulfonyl aryl or heteroaryl hydroxamic acid compounds |
| US7115632B1 (en) | 1999-05-12 | 2006-10-03 | G. D. Searle & Co. | Sulfonyl aryl or heteroaryl hydroxamic acid compounds |
| US6750228B1 (en) | 1997-11-14 | 2004-06-15 | Pharmacia Corporation | Aromatic sulfone hydroxamic acid metalloprotease inhibitor |
| US20010039287A1 (en) | 1997-11-14 | 2001-11-08 | Thomas E Barta | Aromatic sulfone hydroxamic acid metalloprotease inhibitor |
| CA2306460A1 (en) * | 1997-11-14 | 1999-05-27 | G.D. Searle & Co. | Aromatic sulfone hydroxamic acid metalloprotease inhibitor |
| CA2344412A1 (en) | 1998-09-21 | 2000-03-30 | Takeda Chemical Industries, Ltd. | Thiol compound, their production and use |
| US6288261B1 (en) * | 1998-12-18 | 2001-09-11 | Abbott Laboratories | Inhibitors of matrix metalloproteinases |
| US20040122011A1 (en) * | 1998-12-23 | 2004-06-24 | Pharmacia Corporation | Method of using a COX-2 inhibitor and a TACE inhibitors as a combination therapy |
| DK1149074T3 (da) * | 1999-01-27 | 2005-01-10 | Wyeth Corp | Acetyleniske sulfonamid-thiol-TACE-inhibitirer |
| US6313123B1 (en) | 1999-01-27 | 2001-11-06 | American Cyanamid Company | Acetylenic sulfonamide thiol tace inhibitors |
| US6800646B1 (en) | 1999-02-08 | 2004-10-05 | Pharmacia Corporation | Sulfamato hydroxamic acid metalloprotease inhibitor |
| US6583299B1 (en) * | 1999-05-20 | 2003-06-24 | G.D. Searle & Co. | α-amino-β-sulfonyl hydroxamic acid compounds |
| US6683093B2 (en) * | 2000-05-12 | 2004-01-27 | Pharmacia Corporation | Aromatic sulfone hydroxamic acids and their use as protease inhibitors |
| US8795706B2 (en) | 2000-08-16 | 2014-08-05 | Encore Health, Llc | Methods of treating ocular diseases using derivatives of lipoic acid |
| GB0108592D0 (en) * | 2001-04-05 | 2001-05-23 | Merck Sharp & Dohme | Therapeutic agents |
| AR040928A1 (es) | 2001-05-11 | 2005-04-27 | Pharmacia Corp | Compuestos de acidos sulfona-hidroxamicos aromaticos, composiciones farmaceuticas y su uso en la preparacion de medicamentos utiles como inhibidores de proteasas |
| US6683078B2 (en) | 2001-07-19 | 2004-01-27 | Pharmacia Corporation | Use of sulfonyl aryl or heteroaryl hydroxamic acids and derivatives thereof as aggrecanase inhibitors |
| FR2827859B1 (fr) * | 2001-07-30 | 2005-09-23 | Lipha | Derives 4-(arylthio) - ou 4-(heteroarylthio) -butyrique dans la preparation de medicaments destines au traitement du diabete |
| JP2003081838A (ja) * | 2001-09-11 | 2003-03-19 | Rohto Pharmaceut Co Ltd | グルコサミン製剤 |
| PE20030701A1 (es) | 2001-12-20 | 2003-08-21 | Schering Corp | Compuestos para el tratamiento de trastornos inflamatorios |
| DE10201392A1 (de) * | 2002-01-16 | 2003-07-31 | Bayer Ag | Phenylsulfoxide und-sulfone |
| US20050209278A1 (en) * | 2002-04-25 | 2005-09-22 | Mcdonald Joseph J | Piperidinyl- and piperazinyl-sulfonylmethyl hydroxamic acids and their use as protease inhibitors |
| JP2005537228A (ja) * | 2002-04-25 | 2005-12-08 | ファルマシア・コーポレーション | ピペリジニル−及びピペラジニル−スルホニルメチルヒドロキサム酸並びにプロテアーゼ阻害剤としてのその使用 |
| WO2004000811A1 (en) * | 2002-06-25 | 2003-12-31 | Pharmacia Corporation | Arylsulfonylhydroxamic acid and amide derivatives and their use as protease inhibitors |
| EP1585555A2 (de) * | 2002-12-27 | 2005-10-19 | Angiotech International Ag | Zusammensetzungen und verwendungen mit kollagen und mmpi |
| ATE457716T1 (de) | 2002-12-30 | 2010-03-15 | Angiotech Int Ag | Wirkstofffreisetzung von schnell gelierender polymerzusammensetzung |
| US20050043533A1 (en) * | 2003-03-25 | 2005-02-24 | Babiak Kevin A. | Process for making alpha-substituted hydroxamic acids |
| SE0301010D0 (sv) | 2003-04-07 | 2003-04-07 | Astrazeneca Ab | Novel compounds |
| SA04250253B1 (ar) | 2003-08-21 | 2009-11-10 | استرازينيكا ايه بي | احماض فينوكسي اسيتيك مستبدلة باعتبارها مركبات صيدلانية لعلاج الامراض التنفسية مثل الربو ومرض الانسداد الرئوي المزمن |
| US20050277897A1 (en) * | 2004-06-14 | 2005-12-15 | Ghannoum Ziad R | Handpiece tip |
| GB0415320D0 (en) | 2004-07-08 | 2004-08-11 | Astrazeneca Ab | Novel compounds |
| GB0418830D0 (en) | 2004-08-24 | 2004-09-22 | Astrazeneca Ab | Novel compounds |
| SI1817282T1 (sl) | 2004-11-23 | 2011-10-28 | Astrazeneca Ab | Derivati fenoksiocetne kisline, uporabni za zdravljenje respiratornih bolezni |
| TW200745003A (en) | 2005-10-06 | 2007-12-16 | Astrazeneca Ab | Novel compounds |
| WO2007039736A1 (en) * | 2005-10-06 | 2007-04-12 | Astrazeneca Ab | Novel compounds |
| US20100226922A1 (en) * | 2006-06-08 | 2010-09-09 | Dorothea Maetzel | Specific protease inhibitors and their use in cancer therapy |
| EP2190293A4 (de) * | 2007-09-28 | 2011-11-09 | Absolute Science Inc | Verbindungen und verfahren zur behandlung von durch zink-matrix-metalloprotease vermittelten krankheiten |
| CA2737437A1 (en) * | 2008-09-19 | 2010-03-25 | Absolute Science, Inc. | Methods of treating a botulinum toxin related condition in a subject |
| FR2950890B1 (fr) * | 2009-10-06 | 2011-12-30 | Tetrahedron | Procede de synthese de la 2-thiohistidine et analogues |
| GB201313238D0 (en) * | 2013-07-24 | 2013-09-04 | Avexxin As | Process for the preparation of a polyunsaturated ketone compound |
| CN116785450A (zh) | 2017-02-28 | 2023-09-22 | 伊缪诺金公司 | 具有自分解肽接头的类美登素衍生物和其缀合物 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4595700A (en) * | 1984-12-21 | 1986-06-17 | G. D. Searle & Co. | Thiol based collagenase inhibitors |
| US5274094A (en) * | 1990-08-15 | 1993-12-28 | British Bio-Technology Limited | Production of heterobicyclic containing benzene sulfonamides |
| EP0593559A1 (de) * | 1991-07-05 | 1994-04-27 | MERCK SHARP & DOHME LTD. | Aromatische verbindungen, diese enthaltende arzneimittel und ihre therapeutische verwendung |
| GB9200210D0 (en) * | 1992-01-07 | 1992-02-26 | British Bio Technology | Compounds |
| US5376664A (en) * | 1992-07-27 | 1994-12-27 | The Du Pont Merck Pharmaceutical Company | Unsymmetrical mono-3-nitro bis-naphthalimides as anticancer agents |
| GB9307956D0 (en) * | 1993-04-17 | 1993-06-02 | Walls Alan J | Hydroxamic acid derivatives |
| AU682051B2 (en) * | 1993-08-10 | 1997-09-18 | James Black Foundation Limited | Gastrin and CCK receptor ligands |
| DK0726763T3 (da) * | 1993-11-04 | 2000-07-10 | Liposome Co Inc | Behandlingsmetoder under anvendelse af unilamellare liposomale arachidonsyremetabolitformuleringer |
| GB9323162D0 (en) * | 1993-11-10 | 1994-01-05 | British Bio Technology | 4-(1h-2-methylimidazo(4,5-c)pyridinylmethyl)phenylsulphonamid e derivatives as antagonists of paf |
| GB9323165D0 (en) * | 1993-11-10 | 1994-01-05 | Chiros Ltd | Compounds |
| US5475138A (en) * | 1994-07-07 | 1995-12-12 | Pharm-Eco Laboratories Incorporated | Method preparing amino acid-derived diaminopropanols |
| ATE179431T1 (de) * | 1994-10-05 | 1999-05-15 | Darwin Discovery Ltd | Peptidische verbindungen und deren therapeutische verwendung als metalloproteinase-inhibitoren |
| AU6951296A (en) * | 1995-08-08 | 1997-03-05 | Fibrogen, Inc. | C-proteinase inhibitors for the treatment of disorders related to the overproduction of collagen |
| GEP20012388B (en) * | 1995-12-08 | 2001-03-25 | Agouron Pharma | Metalloproteinase Inhibitors, Pharmaceutical Compositions on Their Base, Use and Methods for Obtaining and Intermediates |
-
1997
- 1997-07-22 AU AU38904/97A patent/AU714687B2/en not_active Ceased
- 1997-07-22 US US08/900,028 patent/US6013649A/en not_active Expired - Fee Related
- 1997-07-22 BR BR9710758A patent/BR9710758A/pt not_active IP Right Cessation
- 1997-07-22 RU RU99103642/04A patent/RU2221781C2/ru not_active IP Right Cessation
- 1997-07-22 AT AT97936169T patent/ATE233552T1/de not_active IP Right Cessation
- 1997-07-22 CA CA002260859A patent/CA2260859A1/en not_active Abandoned
- 1997-07-22 KR KR1019997000465A patent/KR20000067963A/ko not_active Application Discontinuation
- 1997-07-22 DK DK97936169T patent/DK0939628T3/da active
- 1997-07-22 ES ES97936169T patent/ES2194209T3/es not_active Expired - Lifetime
- 1997-07-22 WO PCT/US1997/012874 patent/WO1998003164A1/en not_active Application Discontinuation
- 1997-07-22 NZ NZ333824A patent/NZ333824A/xx unknown
- 1997-07-22 CN CN97198098A patent/CN1230884A/zh active Pending
- 1997-07-22 EP EP97936169A patent/EP0939628B1/de not_active Expired - Lifetime
- 1997-07-22 PL PL97331369A patent/PL331369A1/xx unknown
- 1997-07-22 CZ CZ99167A patent/CZ16799A3/cs unknown
- 1997-07-22 DE DE69719538T patent/DE69719538T2/de not_active Expired - Fee Related
- 1997-07-22 IL IL12807997A patent/IL128079A0/xx unknown
- 1997-07-22 JP JP50719698A patent/JP2001505869A/ja not_active Abandoned
- 1997-07-22 PT PT97936169T patent/PT939628E/pt unknown
-
1999
- 1999-01-21 NO NO990262A patent/NO990262L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0939628B1 (de) | 2003-03-05 |
| CN1230884A (zh) | 1999-10-06 |
| EP0939628A1 (de) | 1999-09-08 |
| CZ16799A3 (cs) | 1999-06-16 |
| AU3890497A (en) | 1998-02-10 |
| NO990262L (no) | 1999-03-17 |
| DK0939628T3 (da) | 2003-07-07 |
| EP0939628A4 (de) | 1999-12-22 |
| NO990262D0 (no) | 1999-01-21 |
| ES2194209T3 (es) | 2003-11-16 |
| AU714687B2 (en) | 2000-01-06 |
| KR20000067963A (ko) | 2000-11-25 |
| DE69719538T2 (de) | 2004-02-19 |
| DE69719538D1 (en) | 2003-04-10 |
| PL331369A1 (en) | 1999-07-05 |
| RU2221781C2 (ru) | 2004-01-20 |
| US6013649A (en) | 2000-01-11 |
| WO1998003164A1 (en) | 1998-01-29 |
| CA2260859A1 (en) | 1998-01-29 |
| NZ333824A (en) | 2000-08-25 |
| IL128079A0 (en) | 1999-11-30 |
| PT939628E (pt) | 2003-07-31 |
| BR9710758A (pt) | 1999-08-17 |
| JP2001505869A (ja) | 2001-05-08 |
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