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ATE231149T1 - (1,8)-naphthyridinderivate derivate mit antiviraler wirkung - Google Patents

(1,8)-naphthyridinderivate derivate mit antiviraler wirkung

Info

Publication number
ATE231149T1
ATE231149T1 AT00906096T AT00906096T ATE231149T1 AT E231149 T1 ATE231149 T1 AT E231149T1 AT 00906096 T AT00906096 T AT 00906096T AT 00906096 T AT00906096 T AT 00906096T AT E231149 T1 ATE231149 T1 AT E231149T1
Authority
AT
Austria
Prior art keywords
derivatives
naphthyridine
antiviral effect
hepatitis
virus
Prior art date
Application number
AT00906096T
Other languages
English (en)
Inventor
Benoit Bachand
Nghe Nguyen-Ba
Arshad Siddiqui
Sophie Levesque
Original Assignee
Shire Biochem Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shire Biochem Inc filed Critical Shire Biochem Inc
Application granted granted Critical
Publication of ATE231149T1 publication Critical patent/ATE231149T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT00906096T 1999-02-22 2000-02-22 (1,8)-naphthyridinderivate derivate mit antiviraler wirkung ATE231149T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12108099P 1999-02-22 1999-02-22
PCT/CA2000/000181 WO2000050424A1 (en) 1999-02-22 2000-02-22 [1,8] naphthyridine derivatives having antiviral activity

Publications (1)

Publication Number Publication Date
ATE231149T1 true ATE231149T1 (de) 2003-02-15

Family

ID=22394395

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00906096T ATE231149T1 (de) 1999-02-22 2000-02-22 (1,8)-naphthyridinderivate derivate mit antiviraler wirkung

Country Status (8)

Country Link
US (2) US6340690B1 (de)
EP (1) EP1155017B1 (de)
JP (1) JP2002537396A (de)
AT (1) ATE231149T1 (de)
AU (1) AU777040B2 (de)
CA (1) CA2364652A1 (de)
DE (1) DE60001218D1 (de)
WO (1) WO2000050424A1 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3705975B2 (ja) * 1999-11-26 2005-10-12 独立行政法人科学技術振興機構 ミスマッチ認識分子
DE60136620D1 (de) * 2000-04-13 2009-01-02 Pharmasset Inc 3 oder 2 hydroxymethyl substituierte nucleoside derivate und ihre verwendung zur behandlung von virusinfektionen
MY164523A (en) * 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
CZ301182B6 (cs) 2000-05-26 2009-12-02 Idenix (Cayman) Limited Použití nukleosidových derivátu pro výrobu farmaceutických prostredku pro lécení infekcí vyvolaných flaviviry a pestiviry
EP1321463B1 (de) * 2001-12-21 2007-08-08 Virochem Pharma Inc. Thiazolderivate und ihre Verwendung zur Behandlung oder Vorbeugung von Infektionen durch Flaviviren
ES2268394T3 (es) * 2002-04-01 2007-03-16 Pfizer Inc. Inhibidores de piranona y pirandiona de la arn polimerasa dependiente del arn del virus de la hepatitis c.
BR0312278A (pt) * 2002-06-28 2007-06-19 Idenix Cayman Ltd éster 2'-c-metil-3'-o-l-valina de ribofuranosil citidina para tratamento de infecções por flaviviridae
US7608600B2 (en) * 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
NZ537662A (en) * 2002-06-28 2007-10-26 Idenix Cayman Ltd 2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
KR20050037585A (ko) * 2002-08-23 2005-04-22 카이론 코포레이션 벤지미다졸 퀴놀리논 및 그들의 사용
PL377342A1 (pl) * 2002-11-15 2006-01-23 Idenix (Cayman) Limited Nukleozydy rozgałęzione w pozycji 2' oraz mutacja Flaviviridae
ES2470771T3 (es) * 2002-12-12 2014-06-24 Idenix Pharmaceuticals, Inc Procedimiento para la producción de nucle�sidos ramificados en 2'
DE10311563A1 (de) * 2003-03-17 2004-09-30 Bayer Healthcare Ag Replikationsassay zur Auffindung antiviraler Substanzen mit HTS Verfahren
RU2006105640A (ru) * 2003-07-25 2007-09-10 Айденикс (Кайман) Лимитед (Ky) Аналоги пуриновых нуклеозидов для лечения flaviviridae, включая гепатит с
US7932272B2 (en) * 2003-09-30 2011-04-26 Eisai R&D Management Co., Ltd. Antifungal agent containing heterocyclic compound
US20070276009A1 (en) * 2003-10-15 2007-11-29 Zhi-Jie Ni Compositions and Methods for Viral Inhibition
DK2666481T3 (en) 2003-12-26 2019-02-25 Masatoshi Hagiwara A method for regulating the phosphorylation of SR protein and antiviral agents comprising an SR protein activity regulator as the active ingredient
WO2006000922A2 (en) * 2004-06-23 2006-01-05 Idenix (Cayman) Limited 5-aza-7-deazapurine derivatives for treating infections with flaviviridae
JP4516863B2 (ja) * 2005-03-11 2010-08-04 株式会社ケンウッド 音声合成装置、音声合成方法及びプログラム
TWI385169B (zh) * 2005-10-31 2013-02-11 Eisai R&D Man Co Ltd 經雜環取代之吡啶衍生物及含有彼之抗真菌劑
WO2007075876A2 (en) * 2005-12-23 2007-07-05 Idenix Pharmaceuticals, Inc. Process for preparing a synthetic intermediate for preparation of branched nucleosides
EP2065377B1 (de) 2006-09-21 2011-11-23 Eisai R&D Management Co., Ltd. Durch einen heteroarylring substituiertes pyridinderivat und antipilzmittel, das dieses enthält
EP1972627A1 (de) * 2007-03-19 2008-09-24 Technische Universität Carolo-Wilhelmina zu Braunschweig Aminonaphthyridin-Derivate
US8513420B2 (en) 2007-03-19 2013-08-20 Monika Mazik Amino-naphthyridine derivatives
TW200841879A (en) * 2007-04-27 2008-11-01 Eisai R&D Man Co Ltd Pyridine derivatives substituted by heterocyclic ring and phosphonoamino group, and anti-fungal agent containing same
WO2008136279A1 (ja) * 2007-04-27 2008-11-13 Eisai R & D Management Co., Ltd. ヘテロ環置換ピリジン誘導体の塩またはその結晶
US8513287B2 (en) * 2007-12-27 2013-08-20 Eisai R&D Management Co., Ltd. Heterocyclic ring and phosphonoxymethyl group substituted pyridine derivatives and antifungal agent containing same
US8188119B2 (en) * 2008-10-24 2012-05-29 Eisai R&D Management Co., Ltd Pyridine derivatives substituted with heterocyclic ring and γ-glutamylamino group, and antifungal agents containing same
JP2012176900A (ja) * 2009-06-24 2012-09-13 Eisai R & D Management Co Ltd （（ホスホノオキシ）メチル）ピリジニウム環を有するピリジン誘導体およびそれらを含有する抗真菌剤
KR101317656B1 (ko) 2011-06-30 2013-10-15 연세대학교 산학협력단 복제효소 인산화를 조절하는 신규 ｃ형 간염 예방 또는 치료용 조성물
WO2013056003A2 (en) 2011-10-12 2013-04-18 Yale University Catechol diethers as potent anti-hiv agents
BR112020011162A2 (pt) 2017-12-07 2020-11-17 Amplyx Pharmaceuticals, Inc. agentes antifúngicos derivados de piridina substituída por heterociclo

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2263752A1 (en) 1974-03-14 1975-10-10 Rhone Poulenc Ind 1,8-Naphthyridine derivs - tranquillizers and anti-convulsants
FR2567887B1 (fr) * 1984-07-19 1986-12-19 Rhone Poulenc Sante Nouveaux amides substitues, leur preparation et les medicaments qui les contiennent
CA1265803A (fr) 1985-07-11 1990-02-13 Claude Cotrel Amides substitues, leur preparation et les medicaments qui les contiennent
FR2592882B2 (fr) 1986-01-16 1988-03-11 Rhone Poulenc Sante Nouveaux amides substitues, leur preparation et les medicaments qui les contiennent
US4753941A (en) 1986-01-16 1988-06-28 Rhone-Poulenc Sante Amides based on certain 1,8-naphtyridine-2-amines useful as anxiolytics
DE3907938A1 (de) 1989-03-11 1990-09-13 Basf Ag 2,3-substituierte 1,8-naphthyridine, verfahren zu ihrer herstellung und ihre verwendung als antidots
FR2676056B1 (fr) * 1991-05-03 1993-07-16 Adir Nouveaux derives du benzopyranne leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
CA2123728A1 (en) 1993-05-21 1994-11-22 Noriyoshi Sueda Urea derivatives and their use as acat inhibitors
GB9605437D0 (en) 1996-03-15 1996-05-15 Iaf Biochem Int Cytomegalovirus inhibiting compounds
WO1997034870A1 (en) * 1996-03-22 1997-09-25 Neurogen Corporation Certain fused pyrrolecarboxamides as gaba brain receptor ligands

Also Published As

Publication number Publication date
WO2000050424A1 (en) 2000-08-31
US20020099072A1 (en) 2002-07-25
US6605614B2 (en) 2003-08-12
JP2002537396A (ja) 2002-11-05
AU777040B2 (en) 2004-09-30
EP1155017B1 (de) 2003-01-15
US6340690B1 (en) 2002-01-22
CA2364652A1 (en) 2000-08-31
DE60001218D1 (de) 2003-02-20
AU2788300A (en) 2000-09-14
EP1155017A1 (de) 2001-11-21

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