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FR2263752A1 - 1,8-Naphthyridine derivs - tranquillizers and anti-convulsants - Google Patents

1,8-Naphthyridine derivs - tranquillizers and anti-convulsants

Info

Publication number
FR2263752A1
FR2263752A1 FR7408730A FR7408730A FR2263752A1 FR 2263752 A1 FR2263752 A1 FR 2263752A1 FR 7408730 A FR7408730 A FR 7408730A FR 7408730 A FR7408730 A FR 7408730A FR 2263752 A1 FR2263752 A1 FR 2263752A1
Authority
FR
France
Prior art keywords
naphthyridine
tranquillizers
convulsants
alkyl
derivs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7408730A
Other languages
French (fr)
Other versions
FR2263752B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc Industries SA
Original Assignee
Rhone Poulenc Industries SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Industries SA filed Critical Rhone Poulenc Industries SA
Priority to FR7408730A priority Critical patent/FR2263752A1/en
Priority to OA55189A priority patent/OA04700A/en
Priority to PH15794A priority patent/PH11400A/en
Priority to NL7406194A priority patent/NL7406194A/xx
Priority to IE1012/74A priority patent/IE39263B1/en
Priority to JP49052378A priority patent/JPS5758345B2/ja
Priority to GB2108174A priority patent/GB1417935A/en
Priority to HURO780A priority patent/HU169609B/hu
Priority to AU68880/74A priority patent/AU478373B2/en
Priority to IL44815A priority patent/IL44815A/en
Priority to NO741744A priority patent/NO140012C/en
Priority to LU70071A priority patent/LU70071A1/xx
Priority to ES426335A priority patent/ES426335A1/en
Priority to ES426337A priority patent/ES426337A1/en
Priority to CH53477A priority patent/CH592663A5/xx
Priority to MX561874U priority patent/MX4617E/en
Priority to CA199,810A priority patent/CA1012971A/en
Priority to ES426336A priority patent/ES426336A1/en
Priority to SU7402026597A priority patent/SU583757A3/en
Priority to SE7406452A priority patent/SE410857B/en
Priority to DK263374AA priority patent/DK136819B/en
Priority to CH659574A priority patent/CH592662A5/xx
Priority to DD178499A priority patent/DD111078A5/xx
Priority to DE2423650A priority patent/DE2423650A1/en
Priority to CS743472A priority patent/CS191881B2/en
Priority to PL1974171103A priority patent/PL90061B1/en
Priority to AT400874A priority patent/AT336030B/en
Priority to PL18664174A priority patent/PL94204B1/pl
Priority to AR253755A priority patent/AR209421A1/en
Priority to PL1974186640A priority patent/PL94079B1/en
Priority to YU01336/74A priority patent/YU133674A/en
Priority to FI1498/74A priority patent/FI55659C/en
Priority to AR257458A priority patent/AR210851A1/en
Priority to SU752112823A priority patent/SU589916A3/en
Priority to SU752114917A priority patent/SU629877A3/en
Publication of FR2263752A1 publication Critical patent/FR2263752A1/en
Priority to US05/623,359 priority patent/US4016274A/en
Priority to US05/623,358 priority patent/US4038391A/en
Priority to AT86676A priority patent/AT336031B/en
Priority to CS766364A priority patent/CS191887B2/en
Application granted granted Critical
Publication of FR2263752B1 publication Critical patent/FR2263752B1/fr
Priority to YU02877/81A priority patent/YU287781A/en
Priority to YU287681A priority patent/YU287681A/en
Priority to JP57024659A priority patent/JPS5827279B2/en
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Title cpds. are of formula (I): (where one X=N and the others CY; Y=H, hal, 1-4C alkoxy, 1-4C alkyl, CN or NO2; A and A'=CH or N and if A=CH, A'=CH or N, but if A=N, A'=N; Z=H, hal, 1-4C alkyl, 1-4C alkoxy, or NO2; and either n=O and R=H, 1-4C alkyl, 2-4C alkenyl, 2-4C alkynyl, 1-4C hydroxyalkyl, or Ph, or n=1 and R=1-4C alkenyl, 1-4C hydroxyalkyl, or Ph. (I) are prepd. (a) by condensing a chlorocarbonylpiperazine with an appropriate hydroxy-naphthyridine (n=O) or (b) by condensing an N-substd. piperazine with a mixed carbonate deriv. of the naphthyridine.
FR7408730A 1973-05-15 1974-03-14 1,8-Naphthyridine derivs - tranquillizers and anti-convulsants Granted FR2263752A1 (en)

Priority Applications (42)

Application Number Priority Date Filing Date Title
FR7408730A FR2263752A1 (en) 1974-03-14 1974-03-14 1,8-Naphthyridine derivs - tranquillizers and anti-convulsants
OA55189A OA04700A (en) 1973-05-15 1974-04-29 New derivatives of naphthyridine and their preparation process.
PH15794A PH11400A (en) 1973-05-15 1974-04-30 Naphthyridine derivatives and pharmaceutical composition thereof
NL7406194A NL7406194A (en) 1973-05-15 1974-05-08
JP49052378A JPS5758345B2 (en) 1973-05-15 1974-05-13
GB2108174A GB1417935A (en) 1973-05-15 1974-05-13 Naphthyridine derivatives
HURO780A HU169609B (en) 1973-05-15 1974-05-13
AU68880/74A AU478373B2 (en) 1973-05-15 1974-05-13 Naphthyridine derivatives
IL44815A IL44815A (en) 1973-05-15 1974-05-13 3-(piperazin-1-yl) carbonyloxy (naphthyridin-2-yl) isoindolinones pyrrolo (3,4-b) pyrazines and pyrrolo (3,4-b) pyridines processes for the preparation thereof and pharmaceutical compositions containing the same
IE1012/74A IE39263B1 (en) 1973-05-15 1974-05-13 Naphthyridine derivatives
CH659574A CH592662A5 (en) 1973-05-15 1974-05-14
ES426335A ES426335A1 (en) 1973-05-15 1974-05-14 Naphthyridine derivatives
ES426337A ES426337A1 (en) 1974-03-14 1974-05-14 Procedure for preparing naftiridine derivatives. (Machine-translation by Google Translate, not legally binding)
CH53477A CH592663A5 (en) 1973-05-15 1974-05-14
MX561874U MX4617E (en) 1973-05-15 1974-05-14 PROCEDURE FOR THE PREPARATION OF NAFTIRIDINE DERIVATIVES
CA199,810A CA1012971A (en) 1973-05-15 1974-05-14 Naphtyridine derivatives, method of manufacture and compositions that contain them
ES426336A ES426336A1 (en) 1973-05-15 1974-05-14 Naphthyridine derivatives
SU7402026597A SU583757A3 (en) 1973-05-15 1974-05-14 Method of preparing naphthyridine derivatives or salts thereof
SE7406452A SE410857B (en) 1973-05-15 1974-05-14 PROCEDURE FOR THE PREPARATION OF NEW NAFTYRIDINE DERIVATIVES
DK263374AA DK136819B (en) 1973-05-15 1974-05-14 Analogous process for the preparation of derivatives of naphthyridine or acid addition salts thereof.
NO741744A NO140012C (en) 1973-05-15 1974-05-14 ANALOGICAL PROCEDURE FOR THE PREPARATION OF NEW THERAPEUTICALLY ACTIVE DERIVATIVES OF NAFTYRIDINE
DD178499A DD111078A5 (en) 1973-05-15 1974-05-14
LU70071A LU70071A1 (en) 1973-05-15 1974-05-14
AT400874A AT336030B (en) 1973-05-15 1974-05-15 PROCESS FOR THE PREPARATION OF NEW NAPHTHYRIDE DERIVATIVES AND THEIR ACID ADDITIONAL SALTS
CS743472A CS191881B2 (en) 1973-05-15 1974-05-15 Method of producing novel derivatives of naphtyridine
PL1974171103A PL90061B1 (en) 1973-05-15 1974-05-15 Naphthydridine[au6888074a]
DE2423650A DE2423650A1 (en) 1973-05-15 1974-05-15 NEW NAPHTYRIDE DERIVATIVES, THEIR PRODUCTION AND COMPOSITIONS THEREOF
PL18664174A PL94204B1 (en) 1973-05-15 1974-05-15
AR253755A AR209421A1 (en) 1973-05-15 1974-05-15 PROCEDURE FOR THE PREPARATION OF ISOINDOLINONE-1 AND ITS MONO AND DIAZOTATED (NAPHTHYRIDINE-1.8 IL-2) -6 (PIPERAZINIL) -6 (PIPERAZINIL-1-CARBONYLOXY) RIVATES -1-CARBONYLOXY) -7-OXO 5 PYRROLPYRIDINES AND (NAPHTHYRIDINE1,8 IL-2), 6 (PIPERAZINYL-1 CARBONYLOXY) -7 OXO-5 PYRROLPYRIDINES
PL1974186640A PL94079B1 (en) 1974-03-14 1974-05-15 Manufacture of novel naphthyridine derivative [jp57150693a] [jp1194027c]
YU01336/74A YU133674A (en) 1973-05-15 1974-05-15 Process for obtaining new naphthiridine derivatives
FI1498/74A FI55659C (en) 1973-05-15 1974-05-15 FORM OF THERAPEUTIC ACTIVATION OF THERAPEUTIC ACTIVITIES 3- (4-SUBSTITUTES-PIPERAZIN-1-YLCARBONYLOXY) -2- (1,8-NAPHTHYRIDIN-2-YL) ISOINDOLIN-1-ONER
AR257458A AR210851A1 (en) 1973-05-15 1975-01-29 PROCEDURE TO PREPARE NEW DERIVATIVES OF (NAPHTHYRIDINE-1,8 IL-2) 1 (PIPERAZINIL) -1CARBONYLOXY-3) -2 OXO-5 PYRROLINE
SU752112823A SU589916A3 (en) 1973-05-15 1975-03-18 Method of preparing naphthyridine derivatives or salts thereof
SU752114917A SU629877A3 (en) 1974-03-14 1975-03-19 Method of obtaining naphthyridine derivatives or salts thereof
US05/623,359 US4016274A (en) 1973-05-15 1975-10-17 Naphthyridine derivatives
US05/623,358 US4038391A (en) 1973-05-15 1975-10-17 6-(1,8-Naphthyridin-2-yl)-5-piperazino carbonyloxy-7-oxo-6,7-dihydro-5H-pyrrolo-[3,4-b]pyrazines and related pyridines
AT86676A AT336031B (en) 1973-05-15 1976-02-09 PROCESS FOR THE PREPARATION OF NEW NAPHTHYRIDE DERIVATIVES AND THEIR ACID ADDITIONAL SALTS
CS766364A CS191887B2 (en) 1973-05-15 1976-10-01 Method of producing novel derivatives of naphtyridine
YU02877/81A YU287781A (en) 1973-05-15 1981-12-08 Process for obtaining new naphthiridine derivatives
YU287681A YU287681A (en) 1974-03-14 1981-12-08 Process for obtaining new naphthiridine derivatives
JP57024659A JPS5827279B2 (en) 1974-03-14 1982-02-19 Method for producing new naphthyridine derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7408730A FR2263752A1 (en) 1974-03-14 1974-03-14 1,8-Naphthyridine derivs - tranquillizers and anti-convulsants

Publications (2)

Publication Number Publication Date
FR2263752A1 true FR2263752A1 (en) 1975-10-10
FR2263752B1 FR2263752B1 (en) 1978-07-28

Family

ID=9136327

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7408730A Granted FR2263752A1 (en) 1973-05-15 1974-03-14 1,8-Naphthyridine derivs - tranquillizers and anti-convulsants

Country Status (3)

Country Link
JP (1) JPS5827279B2 (en)
FR (1) FR2263752A1 (en)
PL (1) PL94079B1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000050424A1 (en) * 1999-02-22 2000-08-31 Biochem Pharma Inc. [1,8] naphthyridine derivatives having antiviral activity

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6081987U (en) * 1983-11-09 1985-06-06 新キャタピラ−三菱株式会社 Clamp device for construction machinery
JPS60173587U (en) * 1984-04-25 1985-11-16 飯田　星祥 ▲Pulling machine
JPS618685U (en) * 1984-06-23 1986-01-18 正己 川名 Special opening/closing device installed on heavy machinery

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000050424A1 (en) * 1999-02-22 2000-08-31 Biochem Pharma Inc. [1,8] naphthyridine derivatives having antiviral activity
US6340690B1 (en) 1999-02-22 2002-01-22 Bio-Chem Pharma Inc. Antiviral methods using [1,8]naphthyridine derivatives

Also Published As

Publication number Publication date
JPS5827279B2 (en) 1983-06-08
PL94079B1 (en) 1977-07-30
FR2263752B1 (en) 1978-07-28
JPS57150693A (en) 1982-09-17

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Legal Events

Date Code Title Description
ST Notification of lapse