ATE226826T1 - Misoprostolhaltige feste stabilisierte dispersionen - Google Patents
Misoprostolhaltige feste stabilisierte dispersionenInfo
- Publication number
- ATE226826T1 ATE226826T1 AT96914641T AT96914641T ATE226826T1 AT E226826 T1 ATE226826 T1 AT E226826T1 AT 96914641 T AT96914641 T AT 96914641T AT 96914641 T AT96914641 T AT 96914641T AT E226826 T1 ATE226826 T1 AT E226826T1
- Authority
- AT
- Austria
- Prior art keywords
- cellulose
- excipients
- beta
- hydroxypropyl
- acetate
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Colloid Chemistry (AREA)
- Steroid Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45791495A | 1995-06-01 | 1995-06-01 | |
| PCT/US1996/006962 WO1996038153A1 (en) | 1995-06-01 | 1996-05-22 | Stabilized solid dispersions of misoprostol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE226826T1 true ATE226826T1 (de) | 2002-11-15 |
Family
ID=23818570
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96914641T ATE226826T1 (de) | 1995-06-01 | 1996-05-22 | Misoprostolhaltige feste stabilisierte dispersionen |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5935939A (de) |
| EP (1) | EP0828495B1 (de) |
| JP (1) | JPH11506100A (de) |
| AT (1) | ATE226826T1 (de) |
| AU (1) | AU5794196A (de) |
| CA (1) | CA2222811C (de) |
| DE (1) | DE69624564T2 (de) |
| DK (1) | DK0828495T3 (de) |
| ES (1) | ES2185773T3 (de) |
| PT (1) | PT828495E (de) |
| TW (1) | TW434029B (de) |
| WO (1) | WO1996038153A1 (de) |
| ZA (1) | ZA964482B (de) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5985248A (en) * | 1996-12-31 | 1999-11-16 | Inhale Therapeutic Systems | Processes for spray drying solutions of hydrophobic drugs and compositions thereof |
| EP0896823B1 (de) * | 1997-07-15 | 2002-09-25 | Development Center For Biotechnology | Verbesserte Stabilisierung von Misoprostol |
| PT901786E (pt) * | 1997-08-11 | 2007-08-07 | Pfizer Prod Inc | Disperções farmacêuticas sólidas com biodisponibilidade melhorada |
| GB9806477D0 (en) | 1998-03-26 | 1998-05-27 | Glaxo Group Ltd | Improved crystals |
| CA2241342C (en) * | 1998-06-15 | 2000-02-08 | Bernard Charles Sherman | Pharmaceutical tablets comprising an nsaid and a prostaglandin |
| EP1027886B1 (de) | 1999-02-10 | 2008-07-09 | Pfizer Products Inc. | Pharmazeutische feste Dispersionen |
| EP1404300B1 (de) * | 2001-06-22 | 2009-09-30 | Pfizer Products Inc. | Pharmazeutische zusammensetzungen enthaltend dispersionen aus arzneistoffen und neutralen polymeren |
| GB0222522D0 (en) | 2002-09-27 | 2002-11-06 | Controlled Therapeutics Sct | Water-swellable polymers |
| ATE461700T1 (de) * | 2002-12-20 | 2010-04-15 | Pfizer Prod Inc | Dosierungsform enthaltend einen cetp-hemmer und einen hmg-coa reduktase hemmer |
| AU2003286372A1 (en) * | 2002-12-20 | 2004-07-14 | Pfizer Products Inc. | Dosage forms comprising a cetp inhibitor and an hmg-coa reductase inhibitor |
| US20050142201A1 (en) | 2003-07-18 | 2005-06-30 | Julia Rashba-Step | Methods for fabrication, uses and compositions of small spherical particles of hGH prepared by controlled phase separation |
| KR20060033033A (ko) * | 2003-08-04 | 2006-04-18 | 화이자 프로덕츠 인크. | 콜레스테릴 에스테르 전달 단백질 억제제의 제어 방출 및ｈｍｇ-ｃｏａ 리덕타제 억제제의 순간 방출을 제공하는제형 |
| US20050232990A1 (en) * | 2003-12-31 | 2005-10-20 | Garth Boehm | Donepezil formulations |
| KR20120089705A (ko) | 2004-04-23 | 2012-08-13 | 사이덱스 파마슈티칼스, 인크. | 술포알킬 에테르 시클로덱스트린 함유 ｄｐｉ 제형 |
| GB0417401D0 (en) * | 2004-08-05 | 2004-09-08 | Controlled Therapeutics Sct | Stabilised prostaglandin composition |
| WO2006133048A2 (en) * | 2005-06-03 | 2006-12-14 | Duramed Pharmaceuticals, Inc. | Pharmaceutical compositions comprising prostanoid-receptor agonists and methods of making and using the same |
| US8148560B2 (en) * | 2005-09-23 | 2012-04-03 | Teva Women's Health, Inc. | Vaginal tablets comprising misoprostol and methods of making and using the same |
| US7629331B2 (en) | 2005-10-26 | 2009-12-08 | Cydex Pharmaceuticals, Inc. | Sulfoalkyl ether cyclodextrin compositions and methods of preparation thereof |
| US20080108664A1 (en) * | 2005-12-23 | 2008-05-08 | Liu Belle B | Solid-state form of AMG 706 and pharmaceutical compositions thereof |
| WO2007146795A2 (en) * | 2006-06-12 | 2007-12-21 | Ironwood Pharmaceuticals, Inc. | Pharmaceutical formulation for parenteral administration |
| GB0613333D0 (en) | 2006-07-05 | 2006-08-16 | Controlled Therapeutics Sct | Hydrophilic polyurethane compositions |
| GB0613638D0 (en) | 2006-07-08 | 2006-08-16 | Controlled Therapeutics Sct | Polyurethane elastomers |
| GB0620685D0 (en) | 2006-10-18 | 2006-11-29 | Controlled Therapeutics Sct | Bioresorbable polymers |
| US8309129B2 (en) | 2007-05-03 | 2012-11-13 | Bend Research, Inc. | Nanoparticles comprising a drug, ethylcellulose, and a bile salt |
| US8703204B2 (en) | 2007-05-03 | 2014-04-22 | Bend Research, Inc. | Nanoparticles comprising a cholesteryl ester transfer protein inhibitor and anon-ionizable polymer |
| US8974827B2 (en) | 2007-06-04 | 2015-03-10 | Bend Research, Inc. | Nanoparticles comprising a non-ionizable cellulosic polymer and an amphiphilic non-ionizable block copolymer |
| US9545384B2 (en) | 2007-06-04 | 2017-01-17 | Bend Research, Inc. | Nanoparticles comprising drug, a non-ionizable cellulosic polymer and tocopheryl polyethylene glocol succinate |
| WO2009073215A1 (en) | 2007-12-06 | 2009-06-11 | Bend Research, Inc. | Pharmaceutical compositions comprising nanoparticles and a resuspending material |
| US9233078B2 (en) | 2007-12-06 | 2016-01-12 | Bend Research, Inc. | Nanoparticles comprising a non-ionizable polymer and an Amine-functionalized methacrylate copolymer |
| TWI508753B (zh) * | 2012-02-03 | 2015-11-21 | Ono Pharmaceutical Co | For the manufacture of beta-cyclodextrin (LIMAPROST) preparations |
| JP6524744B2 (ja) * | 2014-03-25 | 2019-06-05 | 三菱ケミカルフーズ株式会社 | 難水溶性物質含有固体分散体の製造方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4113882A (en) * | 1974-10-21 | 1978-09-12 | Yamanouchi Pharmaceutical Co., Ltd. | Stabilized oral prostaglandin formulation and the process for the preparation thereof |
| DE2515001C2 (de) * | 1975-04-04 | 1986-10-02 | Schering AG, 1000 Berlin und 4709 Bergkamen | Prostaglandin enthaltende gefriergetrocknete Pulver |
| SE431821B (sv) * | 1979-01-29 | 1984-03-05 | Perstorp Ab | Lagringsstabilt, prostaglandininnehallande medicinskt preparat |
| US4211793A (en) * | 1979-03-19 | 1980-07-08 | American Cyanamid Company | Triethyl citrate solutions of PGE-type compounds |
| US4301146A (en) * | 1980-07-29 | 1981-11-17 | G. D. Searle & Co. | Stabilization of 16-oxygenated prostanoic acid derivatives |
| US4335097A (en) * | 1981-01-15 | 1982-06-15 | Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. | Stabilized, prostaglandin-containing tablets with controlled rate of solubility, for local use and process for the preparation thereof |
| US4431833A (en) * | 1982-12-27 | 1984-02-14 | American Cyanamid Company | Prostaglandin and hydroxylated fatty acid ester formulations |
| DE3346525C2 (de) * | 1983-12-22 | 1987-03-19 | A. Nattermann & Cie GmbH, 5000 Köln | Pharmazeutische Zubereitung mit speziellen 1,2-Diacyl-glycero-3-phosphocholinen zur Behandlung von Erkrankungen im Magen-Darmbereich |
| JPH03220201A (ja) * | 1988-11-18 | 1991-09-27 | Eisai Co Ltd | プロスタグランジン類と多糖類の結合体 |
-
1996
- 1996-05-22 DK DK96914641T patent/DK0828495T3/da active
- 1996-05-22 AT AT96914641T patent/ATE226826T1/de not_active IP Right Cessation
- 1996-05-22 PT PT96914641T patent/PT828495E/pt unknown
- 1996-05-22 ES ES96914641T patent/ES2185773T3/es not_active Expired - Lifetime
- 1996-05-22 CA CA002222811A patent/CA2222811C/en not_active Expired - Fee Related
- 1996-05-22 JP JP8536512A patent/JPH11506100A/ja active Pending
- 1996-05-22 WO PCT/US1996/006962 patent/WO1996038153A1/en active IP Right Grant
- 1996-05-22 AU AU57941/96A patent/AU5794196A/en not_active Abandoned
- 1996-05-22 EP EP96914641A patent/EP0828495B1/de not_active Expired - Lifetime
- 1996-05-22 DE DE69624564T patent/DE69624564T2/de not_active Expired - Fee Related
- 1996-05-31 ZA ZA964482A patent/ZA964482B/xx unknown
- 1996-07-02 TW TW085107993A patent/TW434029B/zh not_active IP Right Cessation
- 1996-09-09 US US08/709,708 patent/US5935939A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0828495B1 (de) | 2002-10-30 |
| CA2222811C (en) | 2008-09-30 |
| DE69624564T2 (de) | 2003-03-20 |
| JPH11506100A (ja) | 1999-06-02 |
| WO1996038153A1 (en) | 1996-12-05 |
| CA2222811A1 (en) | 1996-12-05 |
| PT828495E (pt) | 2003-01-31 |
| EP0828495A1 (de) | 1998-03-18 |
| ES2185773T3 (es) | 2003-05-01 |
| TW434029B (en) | 2001-05-16 |
| US5935939A (en) | 1999-08-10 |
| AU5794196A (en) | 1996-12-18 |
| DE69624564D1 (de) | 2002-12-05 |
| DK0828495T3 (da) | 2003-02-24 |
| ZA964482B (en) | 1997-02-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0828495 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |