[go: up one dir, main page]

ATE215950T1 - Carbolinderivate - Google Patents

Carbolinderivate

Info

Publication number
ATE215950T1
ATE215950T1 AT97922960T AT97922960T ATE215950T1 AT E215950 T1 ATE215950 T1 AT E215950T1 AT 97922960 T AT97922960 T AT 97922960T AT 97922960 T AT97922960 T AT 97922960T AT E215950 T1 ATE215950 T1 AT E215950T1
Authority
AT
Austria
Prior art keywords
carboline derivatives
carboline
derivatives
Prior art date
Application number
AT97922960T
Other languages
English (en)
Inventor
Agnes Bombrun
Original Assignee
Icos Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9609777.9A external-priority patent/GB9609777D0/en
Priority claimed from GBGB9609820.7A external-priority patent/GB9609820D0/en
Application filed by Icos Corp filed Critical Icos Corp
Application granted granted Critical
Publication of ATE215950T1 publication Critical patent/ATE215950T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT97922960T 1996-05-10 1997-05-05 Carbolinderivate ATE215950T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9609777.9A GB9609777D0 (en) 1996-05-10 1996-05-10 Chemical compounds
GBGB9609820.7A GB9609820D0 (en) 1996-05-10 1996-05-10 Chemical compounds
PCT/EP1997/002277 WO1997043287A1 (en) 1996-05-10 1997-05-05 Carboline derivatives

Publications (1)

Publication Number Publication Date
ATE215950T1 true ATE215950T1 (de) 2002-04-15

Family

ID=26309303

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97922960T ATE215950T1 (de) 1996-05-10 1997-05-05 Carbolinderivate

Country Status (26)

Country Link
US (2) US6117881A (de)
EP (1) EP0912567B1 (de)
JP (1) JP3418405B2 (de)
KR (1) KR20000010918A (de)
CN (1) CN1067071C (de)
AP (1) AP9801365A0 (de)
AT (1) ATE215950T1 (de)
AU (1) AU711885B2 (de)
BG (1) BG102879A (de)
BR (1) BR9709230A (de)
CA (1) CA2253948C (de)
CZ (1) CZ358598A3 (de)
DE (1) DE69711882T2 (de)
EA (1) EA199800907A1 (de)
EE (1) EE9800390A (de)
ES (1) ES2175404T3 (de)
HU (1) HUP9901478A3 (de)
IL (1) IL126951A0 (de)
IS (1) IS4864A (de)
NO (1) NO985222L (de)
OA (1) OA10920A (de)
PL (1) PL329875A1 (de)
SK (1) SK154498A3 (de)
TR (1) TR199802282T2 (de)
WO (1) WO1997043287A1 (de)
YU (1) YU49898A (de)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA199800907A1 (ru) * 1996-05-10 1999-04-29 Айкос Корпорейшн Производные карболина
US6331543B1 (en) 1996-11-01 2001-12-18 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use
DE19837069C1 (de) * 1998-08-17 2000-01-05 Bayer Ag Substituierte Zimtsäuren und Zimtsäureester, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung von substituierten Indanoncarbonsäureestern
CA2339630C (en) * 1998-09-16 2006-05-23 Icos Corporation Carboline derivatives as cgmp phosphodiesterase inhibitors
DE19903087A1 (de) * 1999-01-27 2000-08-10 Forssmann Wolf Georg Behandlung von erektilen Dysfunktionen mit C-Typ Natriuretischem Polypeptid (CNP) als Monotherapie oder in Kombination mit Phosphodiesterasehemmern
JP2002539247A (ja) 1999-03-24 2002-11-19 ハーバー ブランチ オーシャノグラフィック インスティテューション インク． マンズアミンの抗炎症作用の使用
HUP0001632A3 (en) 1999-04-30 2001-12-28 Lilly Icos Llc Wilmington Pharmaceutical compositions comprising selective phosphodiestherase inhibitors
US6451807B1 (en) 1999-04-30 2002-09-17 Lilly Icos, Llc. Methods of treating sexual dysfunction in an individual suffering from a retinal disease, class 1 congestive heart failure, or myocardial infarction using a PDE5 inhibitor
ATE343388T1 (de) 2000-04-19 2006-11-15 Lilly Icos Llc Pde-v hemmer zur behandlung von morbus parkinson
UA74826C2 (en) * 2000-05-17 2006-02-15 Ortho Mcneil Pharm Inc ?-carboline derivatives as phosphodiesterase inhibitors
ES2269408T3 (es) 2000-06-23 2007-04-01 Lilly Icos Llc Inhibidores de fosfodiesterasa especifica de gmp ciclico.
US6821978B2 (en) 2000-09-19 2004-11-23 Schering Corporation Xanthine phosphodiesterase V inhibitors
JP4220779B2 (ja) * 2001-02-12 2009-02-04 リリー アイコス リミテッド ライアビリティ カンパニー 化学化合物
JP4223285B2 (ja) * 2001-02-12 2009-02-12 リリー アイコス リミテッド ライアビリティ カンパニー 化合物
ATE348101T1 (de) * 2001-04-25 2007-01-15 Lilly Icos Llc Carbolin derivate als hemmstoffe von phospphodiesterase 5 (pde5) zur behandlung kardiovaskulärer erkrankungen und der erektilen dysfunktion
MXPA03011081A (es) 2001-06-05 2004-07-08 Lilly Icos Llc Derivados de carbolina como inhibidores de pde5.
US6984641B2 (en) 2001-06-21 2006-01-10 Lilly Icos Llc. Carboline derivatives as PDE5 inhibitors
MXPA04004370A (es) 2001-11-09 2004-08-11 Schering Corp Derivados policiclicos de guanina inhibidores de fosfodiesterasa v.
ATE455758T1 (de) 2001-12-20 2010-02-15 Merck Serono Sa Pyrrolidin-derivatie als prostaglandin- modulatoren
US7595311B2 (en) 2002-05-24 2009-09-29 Exelixis, Inc. Azepinoindole derivatives as pharmaceutical agents
TWI329111B (en) 2002-05-24 2010-08-21 X Ceptor Therapeutics Inc Azepinoindole and pyridoindole derivatives as pharmaceutical agents
CA2529307C (en) 2003-06-13 2013-12-24 Microbia, Inc. Methods and compositions for the treatment of gastrointestinal disorders
WO2004113300A1 (ja) * 2003-06-23 2004-12-29 Ono Pharmaceutical Co., Ltd. 新規三環性複素環化合物
US7767689B2 (en) 2004-03-15 2010-08-03 Ptc Therapeutics, Inc. Carboline derivatives useful in the treatment of cancer
US8076353B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Inhibition of VEGF translation
US8076352B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Administration of carboline derivatives useful in the treatment of cancer and other diseases
ES2401335T3 (es) 2004-03-15 2013-04-18 Ptc Therapeutics, Inc. Derivados de carbolina útiles en la inhibición de la angiogénesis
CN1972916B (zh) * 2004-05-26 2013-03-27 卫材R&D管理有限公司 肉桂酰胺类化合物
RU2361872C2 (ru) 2004-05-26 2009-07-20 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Циннамидное соединение
JPWO2006046575A1 (ja) 2004-10-26 2008-05-22 エーザイ・アール・アンド・ディー・マネジメント株式会社 シンナミド化合物の非晶質体
PL1829874T3 (pl) 2004-12-22 2014-07-31 Ono Pharmaceutical Co Tricykliczny związek i jego zastosowanie
US8506934B2 (en) 2005-04-29 2013-08-13 Robert I. Henkin Methods for detection of biological substances
EP2258357A3 (de) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenese mit Acetylcholinesterasehemmer
EP1928437A2 (de) 2005-08-26 2008-06-11 Braincells, Inc. Neurogenese mittels muscarinrezeptormodulation
CA2625153A1 (en) 2005-10-21 2007-04-26 Braincells, Inc. Modulation of neurogenesis by pde inhibition
JP2009513672A (ja) 2005-10-31 2009-04-02 ブレインセルス，インコーポレイティド 神経発生のｇａｂａ受容体媒介調節
MX2008006076A (es) 2005-11-09 2008-12-16 Combinatorx Inc Metodos, composiciones y kits para el tratamiento de condiciones medicas.
AU2006316005A1 (en) * 2005-11-18 2007-05-24 Eisai R & D Management Co., Ltd. Process for production of cinnamamide derivative
EP1953151A4 (de) * 2005-11-18 2010-06-02 Eisai R&D Man Co Ltd Salze aus einer cynnamidverbindung oder solvate daraus
TWI370130B (en) 2005-11-24 2012-08-11 Eisai R&D Man Co Ltd Two cyclic cinnamide compound
RU2381225C1 (ru) 2005-11-24 2010-02-10 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Производное циннамида типа морфолина
US20070117839A1 (en) * 2005-11-24 2007-05-24 Eisai R&D Management Co., Ltd. Two cyclic cinnamide compound
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
TWI378091B (en) 2006-03-09 2012-12-01 Eisai R&D Man Co Ltd Multi-cyclic cinnamide derivatives
EP2377531A2 (de) 2006-05-09 2011-10-19 Braincells, Inc. Neurogenese mittels Angiotensin-Modulation
CA2651862A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. 5 ht receptor mediated neurogenesis
SA07280403B1 (ar) 2006-07-28 2010-12-01 إيساي أر أند دي منجمنت كو. ليمتد ملح رباعي لمركب سيناميد
EP2068872A1 (de) 2006-09-08 2009-06-17 Braincells, Inc. Kombinationen mit einem 4-acylaminopyridin-derivat
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
US8293489B2 (en) 2007-01-31 2012-10-23 Henkin Robert I Methods for detection of biological substances
TW200848054A (en) * 2007-02-28 2008-12-16 Eisai R&D Man Co Ltd Two cyclic oxomorpholine derivatives
WO2008140111A1 (ja) * 2007-05-16 2008-11-20 Eisai R & D Management Co., Ltd. シンナミド誘導体のワンポット製造方法
JP5433418B2 (ja) 2007-08-31 2014-03-05 エーザイ・アール・アンド・ディー・マネジメント株式会社 多環式化合物
US7935815B2 (en) * 2007-08-31 2011-05-03 Eisai R&D Management Co., Ltd. Imidazoyl pyridine compounds and salts thereof
MX2010007969A (es) * 2008-01-28 2010-08-04 Eisai R&D Man Co Ltd Compuestos cristalinos de cinamida o sales de los mismos.
US8580801B2 (en) 2008-07-23 2013-11-12 Robert I. Henkin Phosphodiesterase inhibitor treatment
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
US20150119399A1 (en) 2012-01-10 2015-04-30 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use
EP2903619B1 (de) 2012-10-05 2019-06-05 Robert I. Henkin Phosphodiesterasehemmer zur behandlung von geschmacks- und geruchsstörungen
WO2015126944A1 (en) 2014-02-18 2015-08-27 Henkin Robert I Methods and compositions for diagnosing and treating loss and/or distortion of taste or smell
AU2016326718B2 (en) 2015-09-23 2022-12-15 Minerva Biotechnologies Corporation Method of screening for agents for differentiating stem cells

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3644384A (en) * 1969-06-09 1972-02-22 Sterling Drug Inc Certain 2-(alpha-haloacetyl) - 1 2 3 4-tetrahydro - 9h - pyrido(3 4-b)indole-3-carboxylates and derivatives
US3717638A (en) * 1971-03-11 1973-02-20 Sterling Drug Inc 1,2,3,4,6,7,12,12A-OCTAHYDRO-2-PHENYLPYRAZINO[2',1':6,1]PYRIDO[3,4-b]INDOLES AND INTERMEDIATES THEREFOR
US3917599A (en) * 1973-03-30 1975-11-04 Council Scient Ind Res 2-Substituted-1,2,3,4,6,7,12,12A-octahydropyrazino(2{40 ,1{40 :6,1)pyrido(3,4-B)indoles
GB1454171A (en) * 1973-10-19 1976-10-27 Council Scient Ind Res Tetracyclic compounds
US4188390A (en) * 1977-11-05 1980-02-12 Pfizer Inc. Antihypertensive 4-amino-2-[4-(1,4-benzodioxan-2-carbonyl) piperazin-1-yl or homopiperazin-1-yl]quinazolines
US4656174A (en) * 1982-07-24 1987-04-07 Pfizer Inc. Quinoline therapeutic agents
IT1217190B (it) * 1988-04-22 1990-03-14 Recordati Chem Pharm Composti utili per il trattamento e diagnosi di disfunzioni frettili
FI892362L (fi) * 1988-06-01 1989-12-02 Eisai Co Ltd Buten- eller propensyraderivat.
EP0357122A3 (de) * 1988-08-29 1991-10-23 Duphar International Research B.V Verwendung von Beta-Carbolinen und deren bio-isosterischen Benzofuran- und Benzothiophenanalogen zur Herstellung eines Arzneimittels mit cytostatischer Wirkung
DE3830096A1 (de) * 1988-09-03 1990-03-15 Hoechst Ag Piperazindione mit psychotroper wirkung
FR2649613B1 (fr) * 1989-07-11 1991-09-27 Virag Ronald Medicament vaso-actif
JPH0344324A (ja) * 1989-07-13 1991-02-26 Kazuoki Tsuchiya 性機能賦活剤
DK0459666T3 (da) * 1990-05-31 1994-12-05 Pfizer Lægemidler mod impotens
US5270323A (en) * 1990-05-31 1993-12-14 Pfizer Inc. Method of treating impotence
GB9013750D0 (en) * 1990-06-20 1990-08-08 Pfizer Ltd Therapeutic agents
GB9114760D0 (en) * 1991-07-09 1991-08-28 Pfizer Ltd Therapeutic agents
GB9218322D0 (en) * 1992-08-28 1992-10-14 Pfizer Ltd Therapeutic agents
GB9311920D0 (en) * 1993-06-09 1993-07-28 Pfizer Ltd Therapeutic agents
GB9401090D0 (en) * 1994-01-21 1994-03-16 Glaxo Lab Sa Chemical compounds
EA199800907A1 (ru) * 1996-05-10 1999-04-29 Айкос Корпорейшн Производные карболина
US5874437A (en) * 1996-11-01 1999-02-23 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
US6043252A (en) * 1997-05-05 2000-03-28 Icos Corporation Carboline derivatives

Also Published As

Publication number Publication date
EP0912567A1 (de) 1999-05-06
PL329875A1 (en) 1999-04-12
CN1067071C (zh) 2001-06-13
TR199802282T2 (xx) 1999-03-22
IS4864A (is) 1998-10-13
YU49898A (sh) 2000-03-21
DE69711882D1 (en) 2002-05-16
US6306870B1 (en) 2001-10-23
EP0912567B1 (de) 2002-04-10
JP3418405B2 (ja) 2003-06-23
CA2253948A1 (en) 1997-11-20
CA2253948C (en) 2005-07-26
WO1997043287A1 (en) 1997-11-20
BR9709230A (pt) 1999-08-10
NO985222L (no) 1999-01-11
DE69711882T2 (de) 2002-10-31
CZ358598A3 (cs) 1999-03-17
AU2891097A (en) 1997-12-05
CN1218471A (zh) 1999-06-02
KR20000010918A (ko) 2000-02-25
SK154498A3 (en) 2000-01-18
AP9801365A0 (en) 1998-12-31
NO985222D0 (no) 1998-11-09
EA199800907A1 (ru) 1999-04-29
AU711885B2 (en) 1999-10-21
JP2000513717A (ja) 2000-10-17
IL126951A0 (en) 1999-09-22
HUP9901478A3 (en) 1999-11-29
ES2175404T3 (es) 2002-11-16
HUP9901478A2 (hu) 1999-08-30
US6117881A (en) 2000-09-12
OA10920A (en) 2003-02-21
EE9800390A (et) 1999-06-15
BG102879A (en) 1999-09-30

Similar Documents

Publication Publication Date Title
ATE215950T1 (de) Carbolinderivate
ATE236155T1 (de) Naphthyridin-derivate
ATE323682T1 (de) Aryl-pyrimidin-derivate
ATE261942T1 (de) 6-phenylpyridinderivate
DK1005446T3 (da) N-aroylphenylalaninderivater
ATE235220T1 (de) Resorcinderivate
NO981946D0 (no) Imidazoquinazolin-derivater
IS4800A (is) Nýjar 19-nor-pregnene afleiður
DE69817186D1 (de) Diaminorhodamin-derivate
DE69732576D1 (de) Tetrahydrobenzindolon-derivate
BR9709065A (pt) Derivados de alquilaminobenzotiazole e-benzoxazol
ATE440854T1 (de) 5-deoxy-cytidin-derivate
IS5026A (is) 2-metoxýfenýlpíperasín afleiður
PT906279E (pt) Derivados de pirrol
PT931087E (pt) Novos derivados de piranosido
ATE292632T1 (de) Cis-disubstituierte aminocycloalkyl-pyrrolidin- derivate
DE69724941D1 (de) Aminopyridin-derivate
FI970330L (fi) Imidatsopyridiini-atsolidinonit
DE69515498D1 (de) Naphthyridinderivate
FI965181L (fi) Polyalkoholi-peptidijohdannaiset
BR9706980A (pt) Derivados de isooxacefem
BR9708310A (pt) Derivados de 2-tioxotetrahidropirimidin-4-ona
BR9609892A (pt) Derivados de imidazopiridina
DE69706321D1 (de) Cephemderivate
ATA69896A (de) 3-methylimino-3-cephemderivate 3-methylimino-3-cephemderivate

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties