[go: up one dir, main page]

ATE211482T1 - Selektive inhibitoren des faktors x, eine azepinonstruktur enthaltend - Google Patents

Selektive inhibitoren des faktors x, eine azepinonstruktur enthaltend

Info

Publication number
ATE211482T1
ATE211482T1 AT98939911T AT98939911T ATE211482T1 AT E211482 T1 ATE211482 T1 AT E211482T1 AT 98939911 T AT98939911 T AT 98939911T AT 98939911 T AT98939911 T AT 98939911T AT E211482 T1 ATE211482 T1 AT E211482T1
Authority
AT
Austria
Prior art keywords
factor
selective inhibitors
azepine
azepine structure
compounds
Prior art date
Application number
AT98939911T
Other languages
English (en)
Inventor
Robert M Scarborough
Original Assignee
Cor Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cor Therapeutics Inc filed Critical Cor Therapeutics Inc
Application granted granted Critical
Publication of ATE211482T1 publication Critical patent/ATE211482T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
AT98939911T 1997-08-11 1998-08-11 Selektive inhibitoren des faktors x, eine azepinonstruktur enthaltend ATE211482T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8231697P 1997-08-11 1997-08-11
US90777997A 1997-08-11 1997-08-11
PCT/US1998/016704 WO1999007730A1 (en) 1997-08-11 1998-08-11 SELECTIVE FACTOR Xa INHIBITORS CONTAINING A FUSED AZEPINONE STRUCTURE

Publications (1)

Publication Number Publication Date
ATE211482T1 true ATE211482T1 (de) 2002-01-15

Family

ID=26767316

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98939911T ATE211482T1 (de) 1997-08-11 1998-08-11 Selektive inhibitoren des faktors x, eine azepinonstruktur enthaltend

Country Status (7)

Country Link
EP (1) EP0994893B1 (de)
JP (1) JP2001512741A (de)
AT (1) ATE211482T1 (de)
CA (1) CA2299612A1 (de)
DE (1) DE69803383T2 (de)
NZ (1) NZ502803A (de)
WO (1) WO1999007730A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ525513A (en) 1998-08-07 2004-09-24 Pont Pharmaceuticals Du Succinoylamino lactams as inhibitors of Abeta protein production
HRP990246A2 (en) 1998-08-07 2000-06-30 Du Pont Pharm Co Succinoylamino benzodiazepines as inhibitors of a beta protein production
CA2347671A1 (en) 1998-12-24 2000-07-06 Dupont Pharmaceuticals Company Succinoylamino benzodiazepines as inhibitors of a.beta. protein production
US6960576B2 (en) 1999-09-13 2005-11-01 Bristol-Myers Squibb Pharma Company Hydroxyalkanoylaminolactams and related structures as inhibitors of Aβ protein production
US6503902B2 (en) 1999-09-13 2003-01-07 Bristol-Myers Squibb Pharma Company Hydroxyalkanoylaminolactams and related structures as inhibitors of a β protein production
EP1222176A1 (de) 1999-10-08 2002-07-17 Bristol-Myers Squibb Pharma Company Amino-laktam-sulfonamide als inhibitoren der bildung von a-beta-protein
EP1261610A2 (de) 2000-02-17 2002-12-04 Bristol-Myers Squibb Pharma Company Succinoylamino-carbocyclen und -heterocyclen als hemmer der a-beta-proteinbildung
AU2001253090A1 (en) 2000-04-03 2001-10-15 Bristol-Myers Squibb Pharma Company Cyclic lactams as inhibitors of abeta protein production
CN1434803A (zh) 2000-04-03 2003-08-06 布里斯托尔-迈尔斯斯奎布药品公司 作为Aβ蛋白质产生抑制剂的环内酰胺
US6632812B2 (en) 2000-04-11 2003-10-14 Dupont Pharmaceuticals Company Substituted lactams as inhibitors of Aβ protein production
WO2001079261A1 (en) * 2000-04-14 2001-10-25 Corvas International, Inc. Tetrahydro-azepinone derivatives as thrombin inhibitors
AU783857B2 (en) 2000-06-01 2005-12-15 Bristol-Myers Squibb Pharma Company Lactams substituted by cyclic succinates as inhibitors of a beta protein production
ES2543588T3 (es) 2002-12-03 2015-08-20 Pharmacyclics Llc Derivados de 2-(2-hidroxibifenil-3-il)-1H-benzoimidazol-5-carboxamidina como inhibidores del factor VIIa

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1277405B1 (it) * 1995-08-01 1997-11-10 Menarini Farma Ind Derivati di lattami biciclici come inibitori della trombina

Also Published As

Publication number Publication date
NZ502803A (en) 2001-11-30
DE69803383T2 (de) 2002-09-26
WO1999007730A1 (en) 1999-02-18
CA2299612A1 (en) 1999-02-18
JP2001512741A (ja) 2001-08-28
DE69803383D1 (de) 2002-02-28
EP0994893A1 (de) 2000-04-26
EP0994893B1 (de) 2002-01-02

Similar Documents

Publication Publication Date Title
WO2000071493A3 (en) INHIBITORS OF FACTOR Xa
BR0014078A (pt) Inibidores de fator xa
WO1998016523A3 (en) Selective factor xa inhibitors
ATE311366T1 (de) Benzamide und ähnliche inhibitoren vom faktor xa
WO2000071515A3 (en) INHIBITORS OF FACTOR Xa
ATE234812T1 (de) Integrin antagonisten
DE69725825D1 (de) 5-HT1F-Agonisten
IL155155A0 (en) BENZAMIDES AND RELATED INHIBITORS OF FACTOR Xa
FI961809A0 (fi) Uudet (R)-5-karbamoyyli-8-fluori-3-N,N-disubstituoitu-amino 3,4-dihydro-2H-1-bentsopyraanit
BR0007527A (pt) Fenilfenantridinas com atividade inibitória depde-iv
DE59903921D1 (de) Indolderivate und deren verwendung zur behandlung von malignen und anderen, auf pathologischen zellproliferationen beruhenden erkrankungen
YU19499A (sh) Benzonaftiridini kao bronhijalni terapeutici
ATE211482T1 (de) Selektive inhibitoren des faktors x, eine azepinonstruktur enthaltend
MX9709910A (es) Compuestos que contienen arginina e imitaciones de arginina, su uso y composiciones que los contienen.
DK1077941T3 (da) Forbindelser med væksthormonfrigörende egenskaber
ATE386525T1 (de) 3-substituierte 6,7- dihydroxytetrahydroisochinolin-derivate zur verwendung als antibkaterielle mittel
WO2002006280A3 (en) INHIBITORS OF FACTOR Xa
ID25478A (id) Agonis 5-ht1f
ATE207063T1 (de) Uracilderivate
IT1270261B (it) Derivati peptidici ad attivita' inibitrice delle metallopeptidasi
MX9709908A (es) Compuestos cetoheterociclicos, uso de los mismos y composiciones que los contienen.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0994893

Country of ref document: EP

REN Ceased due to non-payment of the annual fee