ATE181052T1 - Retinoesäure x-rezeptor liganden - Google Patents

Retinoesäure x-rezeptor liganden

Info

Publication number: ATE181052T1
Authority: AT; Austria
Prior art keywords: pct; retinoic acid; receptor ligands; sec; date
Prior art date: 1994-08-10

Application number

AT95930430T

Other languages

English (en)

Inventor

Michael Klaus

Allen John Lovey

Peter Mohr

Michael Rosenberger

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-08-10

Filing date

1995-07-29

Publication date

1999-06-15

1995-07-29 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1999-06-15 Application granted granted Critical

1999-06-15 Publication of ATE181052T1 publication Critical patent/ATE181052T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4056—Esters of arylalkanephosphonic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/52—Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
- C07C69/533—Monocarboxylic acid esters having only one carbon-to-carbon double bond
- C07C69/56—Crotonic acid esters; Vinyl acetic acid esters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
- C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
- C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
- C07C45/298—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups with manganese derivatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
- C07C47/24—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
- C07C47/277—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/46—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid
- C07C57/50—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid containing condensed ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Dermatology (AREA)
Hematology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Diabetes (AREA)
Obesity (AREA)
Nutrition Science (AREA)
Oncology (AREA)
Epidemiology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Steroid Compounds (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Paints Or Removers (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

AT95930430T 1994-08-10 1995-07-29 Retinoesäure x-rezeptor liganden ATE181052T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP94112461		1994-08-10
EP95110460		1995-07-05

Publications (1)

Publication Number	Publication Date
ATE181052T1 true ATE181052T1 (de)	1999-06-15

Family

ID=26135772

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95930430T ATE181052T1 (de)	1994-08-10	1995-07-29	Retinoesäure x-rezeptor liganden

Country Status (24)

Country	Link
US (1)	US5801253A (de)
EP (1)	EP0775103B1 (de)
JP (1)	JP2848964B2 (de)
KR (1)	KR100363545B1 (de)
CN (1)	CN1091092C (de)
AT (1)	ATE181052T1 (de)
AU (1)	AU696501B2 (de)
BR (1)	BR9508985A (de)
CA (1)	CA2196197C (de)
CY (1)	CY2170B1 (de)
CZ (1)	CZ288526B6 (de)
DE (1)	DE69510203T2 (de)
DK (1)	DK0775103T3 (de)
ES (1)	ES2133798T3 (de)
FI (1)	FI112357B (de)
GR (1)	GR3031154T3 (de)
HU (1)	HU218268B (de)
MX (1)	MX9700778A (de)
NO (1)	NO307702B1 (de)
NZ (1)	NZ292121A (de)
PL (1)	PL180048B1 (de)
RU (1)	RU2146241C1 (de)
TR (1)	TR199500976A2 (de)
WO (1)	WO1996005165A1 (de)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5466861A (en) *	1992-11-25	1995-11-14	Sri International	Bridged bicyclic aromatic compounds and their use in modulating gene expression of retinoid receptors
US5968908A (en) *	1994-12-19	1999-10-19	American Cyanamid Company	Restricted 9-cis retinoids
IL116259A (en) *	1994-12-19	2000-07-16	American Cyanamid Co	Analogs of 9-cis retinoic acid and their use
US7115728B1 (en)	1995-01-30	2006-10-03	Ligand Pharmaceutical Incorporated	Human peroxisome proliferator activated receptor γ
US5675033A (en) *	1995-06-06	1997-10-07	Allergan	2,4-pentadienoic acid derivatives having retinoid-like biological activity
US6942980B1 (en)	1995-09-01	2005-09-13	Allergan, Inc.	Methods of identifying compounds having nuclear receptor negative hormone and/or antagonist activities
AU7074496A (en)	1995-09-18	1997-04-09	Ligand Pharmaceuticals Incorporated	Ppar gamma antagonists for treating obesity
JP2002515025A (ja)	1995-10-06	2002-05-21	リガンド・ファーマシューティカルズ・インコーポレイテッド	ダイマー選択的ｒｘｒモジュレーターおよびその使用方法
FR2746101B1 (fr) *	1996-03-14	1998-04-30		Composes bicycliques-aromatiques
JP2000511558A (ja) *	1996-06-21	2000-09-05	アラーガン・セイルズ・インコーポレイテッド	レチノイドおよび／またはレチノイド拮抗剤様生物学的活性を有する置換テトラヒドロナフタレンおよびジヒドロナフタレン誘導体
US5741896A (en)	1996-06-21	1998-04-21	Allergan	O- or S- substituted tetrahydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity
ATE462433T1 (de)	1996-12-11	2010-04-15	Dana Farber Cancer Inst Inc	Methoden und pharmazeutische zusammensetzungen zur inhibition des tumorwachstums
US5728846A (en)	1996-12-12	1998-03-17	Allergan	Benzo 1,2-g!-chrom-3-ene and benzo 1,2-g!-thiochrom-3-ene derivatives
US5919970A (en) *	1997-04-24	1999-07-06	Allergan Sales, Inc.	Substituted diaryl or diheteroaryl methanes, ethers and amines having retinoid agonist, antagonist or inverse agonist type biological activity
WO1999005161A1 (en)	1997-07-25	1999-02-04	Ligand Pharmaceuticals Incorporated	HUMAN PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA (PPARη) GENE REGULATORY SEQUENCES AND USES THEREFOR
WO1999024024A2 (en)	1997-11-12	1999-05-20	F. Hoffmann-La Roche Ag	Treatment of t-helper cell type 2 mediated immune diseases with retinoid antagonists
US6242196B1 (en)	1997-12-11	2001-06-05	Dana-Farber Cancer Institute	Methods and pharmaceutical compositions for inhibiting tumor cell growth
JP2003520758A (ja) *	1998-06-12	2003-07-08	リガンド・ファーマシューティカルズ・インコーポレイテッド	抗エストロゲン耐性乳癌のｒｘｒモジュレーターを用いた処置
US6403638B1 (en)	1998-10-01	2002-06-11	Allergan Sales, Inc.	2,4-pentadienoic acid derivatives having selective activity for retinoid X (RXR) receptors
US6048873A (en) *	1998-10-01	2000-04-11	Allergan Sales, Inc.	Tetrahdroquinolin-2-one 6 or 7-yl, tetrahdroquinilin-2-thione 6 or 7-yl pentadienoic acid and related derivatives having retinoid-like biological activity
US6147224A (en) *	1998-10-01	2000-11-14	Allergan Sales, Inc.	2,4-pentadienoic acid derivatives having selective activity for retinoid X (RXR) receptors
US6326397B1 (en)	1998-11-10	2001-12-04	Hoffman-La Roche Inc.	Retinoid antagonists and use thereof
JP2003508397A (ja)	1999-08-27	2003-03-04	リガンド・ファーマシューティカルズ・インコーポレイテッド	アンドロゲンレセプターモジュレーターとしての８−置換−６−トリフルオロメチル−９−ピリド［３，２−ｇ］キノリン化合物
US6566372B1 (en)	1999-08-27	2003-05-20	Ligand Pharmaceuticals Incorporated	Bicyclic androgen and progesterone receptor modulator compounds and methods
CN1391576A (zh)	1999-08-27	2003-01-15	利甘德药品公司	雄激素受体调节剂化合物及方法
CA2383565A1 (en)	1999-09-14	2001-03-22	Ligand Pharmaceuticals Incorporated	Rxr modulators with improved pharmacologic profile
ES2301142T3 (es)	2000-01-21	2008-06-16	Novartis Ag	Combinaciones que comprenden inhibidores de dipeptidilpeptidasa-iv y agentes antidiabeticos.
US6313107B1 (en)	2000-08-29	2001-11-06	Allergan Sales, Inc.	Methods of providing and using compounds having activity as inhibitors of cytochrome P450RAI
US6380256B1 (en)	2000-08-29	2002-04-30	Allergan Sales, Inc.	Compounds having activity as inhibitors of cytochrome P450RAI
US6369225B1 (en)	2000-08-29	2002-04-09	Allergan Sales, Inc.	Compounds having activity as inhibitors of cytochrome P450RAI
JP2004532194A (ja) *	2001-03-14	2004-10-21	エリリリーアンドカンパニー	レチノイドｘレセプターモジュレータ
US6720423B2 (en) *	2002-04-30	2004-04-13	Allergan, Inc.	Dihydrobenzofuran and dihydrobenzothiophene 2,4-pentadienoic acid derivatives having selective activity for retinoid X (RXR) receptors
WO2004048390A1 (en) *	2002-11-25	2004-06-10	Amedis Pharmaceuticals Ltd.	Silicon compounds
US6759547B1 (en) *	2003-01-14	2004-07-06	Allergan, Inc.	5,6,7,8-tetrahydronaphthalen-2-yl 2,6-difluoroheptatrienoic acid derivatives having serum glucose reducing activity
US7019034B2 (en) *	2003-01-28	2006-03-28	Allergan, Inc.	Compositions and methods for reducing serum glucose and triglyceride levels in diabetic mammals
US6759546B1 (en)	2003-02-04	2004-07-06	Allergan, Inc.	3,5-di-iso-propyl-heptatrienoic acid derivatives having serum glucose reducing activity
US6884820B2 (en) *	2003-04-03	2005-04-26	Allergan, Inc.	5,6,7,8-tetrahydronaphthalen-2-yl-7-fluoroalkyl-heptatrienoic acid derivatives having serum glucose reducing activity
US6734193B1 (en)	2003-06-03	2004-05-11	Allergan, Inc.	(1,2,3,4-tetrahydroquinolin-8-yl)-heptatrienoic acid derivatives having serum glucose reducing activity
JP2007501800A (ja) *	2003-08-07	2007-02-01	アラーガン　インコーポレイテッド	レチノイドリガンドを用いて悪液質を処置するための方法
US6887896B1 (en)	2003-10-29	2005-05-03	Allergan, Inc.	7-[(7-Alkoxy)-chrom-3-en-6-yl]-heptatrienoic acid and 7-[(3-alkoxy)-5,6-dihydronaphthalen-2-yl]-heptatrienoic acid derivatives having serum glucose reducing activity
US9050310B2 (en)	2004-06-25	2015-06-09	Minas Theodore Coroneo	Treatment of ocular lesions
WO2007048510A1 (en) *	2005-10-25	2007-05-03	Werner Bollag	Rxr agonists and antagonists, alone or in combination with ppar ligands, in the treatment of metabolic and cardiovascular diseases
US20070185055A1 (en) *	2006-02-06	2007-08-09	Guang Liang Jiang	Method for treating cachexia with retinoid ligands
WO2009102789A2 (en) *	2008-02-15	2009-08-20	Wyeth	Use of rxr agonists for the treatment of osteroarthritis
JP5877466B2 (ja) *	2012-02-29	2016-03-08	国立大学法人岡山大学	テルペノイド由来レチノイド化合物
US20160263189A1 (en)	2013-10-23	2016-09-15	Acadia Pharmaceuticals Inc.	Treatment of a neurodegenerative disease or disorder
US11045441B2 (en)	2015-10-13	2021-06-29	Wisconsin Alumni Research Foundation	Use of retinoic acid and analogs thereof to treat central neural apneas
WO2019064109A1 (en) *	2017-09-28	2019-04-04	Johnson & Johnson Consumer Inc.	COSMETIC COMPOSITIONS AND METHOD FOR TREATING SKIN
MA54296A (fr)	2018-11-26	2021-10-06	Denali Therapeutics Inc	Procédés de traitement du métabolisme lipidique dérégulé

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH651007A5 (de) *	1982-06-24	1985-08-30	Hoffmann La Roche	Polyenverbindungen.
EP0170105B1 (de) *	1984-07-07	1990-10-17	Koichi Prof. Dr. Shudo	Benzoesäurederivate
CA2133587C (en) *	1992-04-22	2008-11-18	Marcus F. Boehm	Compounds having selectivity for retinoid x receptors
US5466861A (en) *	1992-11-25	1995-11-14	Sri International	Bridged bicyclic aromatic compounds and their use in modulating gene expression of retinoid receptors
ES2129115T3 (es) *	1993-01-11	1999-06-01	Ligand Pharm Inc	Compuestos que tienen actividad selectiva para los receptores de retinoides x, y medios para la modulacion de procesos mediados por receptores de retinoides x.
US5344959A (en) *	1993-05-18	1994-09-06	Allergan, Inc.	Tetrahydronaphthyl and cyclopropyl substituted 1,3-butadienes having retinoid-like activity

1995
- 1995-07-29 DE DE69510203T patent/DE69510203T2/de not_active Expired - Fee Related
- 1995-07-29 US US08/776,087 patent/US5801253A/en not_active Expired - Fee Related
- 1995-07-29 CN CN95194064A patent/CN1091092C/zh not_active Expired - Fee Related
- 1995-07-29 NZ NZ292121A patent/NZ292121A/xx unknown
- 1995-07-29 AU AU33821/95A patent/AU696501B2/en not_active Ceased
- 1995-07-29 DK DK95930430T patent/DK0775103T3/da active
- 1995-07-29 MX MX9700778A patent/MX9700778A/es not_active IP Right Cessation
- 1995-07-29 CA CA002196197A patent/CA2196197C/en not_active Expired - Fee Related
- 1995-07-29 KR KR1019970700814A patent/KR100363545B1/ko not_active Expired - Fee Related
- 1995-07-29 CZ CZ1997382A patent/CZ288526B6/cs not_active IP Right Cessation
- 1995-07-29 AT AT95930430T patent/ATE181052T1/de not_active IP Right Cessation
- 1995-07-29 BR BR9508985A patent/BR9508985A/pt not_active IP Right Cessation
- 1995-07-29 PL PL95318557A patent/PL180048B1/pl not_active IP Right Cessation
- 1995-07-29 RU RU97106022A patent/RU2146241C1/ru not_active IP Right Cessation
- 1995-07-29 EP EP95930430A patent/EP0775103B1/de not_active Expired - Lifetime
- 1995-07-29 HU HU9700356A patent/HU218268B/hu not_active IP Right Cessation
- 1995-07-29 JP JP8506962A patent/JP2848964B2/ja not_active Expired - Fee Related
- 1995-07-29 ES ES95930430T patent/ES2133798T3/es not_active Expired - Lifetime
- 1995-07-29 WO PCT/EP1995/003021 patent/WO1996005165A1/en active IP Right Grant
- 1995-08-08 TR TR95/00976A patent/TR199500976A2/xx unknown
1997
- 1997-02-07 FI FI970547A patent/FI112357B/fi not_active IP Right Cessation
- 1997-02-07 NO NO970580A patent/NO307702B1/no unknown
1999
- 1999-09-03 GR GR990402243T patent/GR3031154T3/el unknown
2000
- 2000-05-08 CY CY0000016A patent/CY2170B1/xx unknown

Also Published As

Publication number	Publication date
WO1996005165A1 (en)	1996-02-22
EP0775103A1 (de)	1997-05-28
TR199500976A2 (tr)	1996-06-21
MX9700778A (es)	1997-05-31
AU3382195A (en)	1996-03-07
CN1091092C (zh)	2002-09-18
JP2848964B2 (ja)	1999-01-20
DE69510203D1 (de)	1999-07-15
PL180048B1 (en)	2000-12-29
NO970580L (no)	1997-02-07
KR970704663A (ko)	1997-09-06
RU2146241C1 (ru)	2000-03-10
CY2170B1 (en)	2002-08-23
EP0775103B1 (de)	1999-06-09
NO307702B1 (no)	2000-05-15
DE69510203T2 (de)	1999-12-23
HUT76839A (en)	1997-11-28
CA2196197C (en)	2007-04-17
FI970547A0 (fi)	1997-02-07
US5801253A (en)	1998-09-01
NZ292121A (en)	1998-10-28
FI970547L (fi)	1997-02-07
AU696501B2 (en)	1998-09-10
CZ38297A3 (en)	1997-06-11
NO970580D0 (no)	1997-02-07
DK0775103T3 (da)	1999-11-15
BR9508985A (pt)	1998-01-06
ES2133798T3 (es)	1999-09-16
HU218268B (hu)	2000-06-28
PL318557A1 (en)	1997-06-23
CN1152302A (zh)	1997-06-18
JPH09512830A (ja)	1997-12-22
KR100363545B1 (ko)	2003-02-19
CA2196197A1 (en)	1996-02-22
FI112357B (fi)	2003-11-28
GR3031154T3 (en)	1999-12-31
CZ288526B6 (cs)	2001-07-11

Publication	Publication Date	Title
ATE181052T1 (de)	1999-06-15	Retinoesäure x-rezeptor liganden
ES2148593T3 (es)	2000-10-16	Compuestos retinoides trienoicos novedosos y metodos.
DE69530701D1 (de)	2003-06-12	Verwendung von 2,7,8-Trimethyl-2-( beta-Carboxyethyl )-6-Hydroxy-Chroman (LLU-alpha)
PL365167A1 (en)	2004-12-27	Skin conditioning compositions containing compounds for mimicking the effect on skin of retinoic acid
DE69530403D1 (de)	2003-05-22	Analogen des keratinozytenwachstumfaktors
EP0982988A4 (de)	2000-04-05	Im wesentlichen reines zonulin als physiologischer modulator von "tight junctions" bei säugern
ATE176797T1 (de)	1999-03-15	Haftbindemittel für pvdf, seine verwendung als sperrmaterial und damit erhaltene gegenstände
DE59610175D1 (de)	2003-04-03	Hydantoinderivate als zwischenprodukte für pharmazeutische wirkstoffe
ATE185799T1 (de)	1999-11-15	Retinoide
ATE242236T1 (de)	2003-06-15	N-substituierte 3-azabicyclo(3.2.0)heptan- derivate als neuroleptika
ES2141978T3 (es)	2000-04-01	Retinoides triciclicos, metodos para su produccion y uso.
PL309772A1 (en)	1996-02-05	Novel compositions based on synegically acting mixture consisting of at least one ligand specific in respect to rxr and at least one ligand specific in respect to rar-a and their application
AR004476A1 (es)	1998-12-16	Compuestos biciclicos, su preparacion y su utilizacion en composiciones farmaceuticas
DE69323191D1 (de)	1999-03-04	Wasserlösliche retinoide
ES274106Y (es)	1985-08-01	Dispositivo de union para combinar entre si utiles de servicios higienicos
ATE221068T1 (de)	2002-08-15	Anellierte beta-carboline
KR960033288U (ko)	1996-11-19	2초에 착용하는 향기 넥타이
SE9203923D0 (sv)	1992-12-29	Hjaelpmedel mot inkontinens
MD950100A (en)	1996-06-28	Substituted oximethers method of their preparation and application for pests and fungus control

Legal Events

Date	Code	Title	Description
2000-01-15	UEP	Publication of translation of european patent specification
2010-04-15	REN	Ceased due to non-payment of the annual fee