ATE174513T1 - Pharmazeutische zubereitung enthaltend eine beta-lactam antibiotikum abbauende verbindung, und deren verwendung - Google Patents
Pharmazeutische zubereitung enthaltend eine beta-lactam antibiotikum abbauende verbindung, und deren verwendungInfo
- Publication number
- ATE174513T1 ATE174513T1 AT93902271T AT93902271T ATE174513T1 AT E174513 T1 ATE174513 T1 AT E174513T1 AT 93902271 T AT93902271 T AT 93902271T AT 93902271 T AT93902271 T AT 93902271T AT E174513 T1 ATE174513 T1 AT E174513T1
- Authority
- AT
- Austria
- Prior art keywords
- beta
- pct
- pharmaceutical preparation
- antibiotic
- preparation containing
- Prior art date
Links
- 239000003782 beta lactam antibiotic agent Substances 0.000 title abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 title abstract 2
- 239000002132 β-lactam antibiotic Substances 0.000 title abstract 2
- 229940124586 β-lactam antibiotics Drugs 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 1
- 230000000593 degrading effect Effects 0.000 title 1
- 230000003115 biocidal effect Effects 0.000 abstract 3
- 108090000204 Dipeptidase 1 Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000006635 beta-lactamase Human genes 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract 1
- 230000002779 inactivation Effects 0.000 abstract 1
- 238000000968 medical method and process Methods 0.000 abstract 1
- 210000002784 stomach Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/50—Hydrolases (3) acting on carbon-nitrogen bonds, other than peptide bonds (3.5), e.g. asparaginase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/56—Protease inhibitors from plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/57—Protease inhibitors from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
- C12Y305/01—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amides (3.5.1)
- C12Y305/01004—Amidase (3.5.1.4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
- C12Y305/02—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amides (3.5.2)
- C12Y305/02006—Beta-lactamase (3.5.2.6)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Inorganic Chemistry (AREA)
- Botany (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Polyesters Or Polycarbonates (AREA)
- Macromonomer-Based Addition Polymer (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI920206A FI920206A0 (fi) | 1992-01-17 | 1992-01-17 | Medicinsk anvaendning, medicinskt foerfarande och preparat. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE174513T1 true ATE174513T1 (de) | 1999-01-15 |
Family
ID=8534042
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT93902271T ATE174513T1 (de) | 1992-01-17 | 1993-01-18 | Pharmazeutische zubereitung enthaltend eine beta-lactam antibiotikum abbauende verbindung, und deren verwendung |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5607671A (de) |
| EP (1) | EP0671942B1 (de) |
| AT (1) | ATE174513T1 (de) |
| DE (1) | DE69322659T2 (de) |
| DK (1) | DK0671942T3 (de) |
| ES (1) | ES2129078T3 (de) |
| FI (1) | FI920206A0 (de) |
| GR (1) | GR3029699T3 (de) |
| WO (1) | WO1993013795A1 (de) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0913151T3 (da) * | 1996-05-09 | 2002-10-14 | Sankyo Co | Anti-helicobacter Pylori-præparater indeholdende 1-methylcarbapenemderivater som den aktive bestanddel |
| GB2318732A (en) | 1996-11-01 | 1998-05-06 | Johnson & Johnson Medical | Wound healing compositions containing alpha-1-antitrypsin |
| FI20020332A0 (fi) * | 2002-02-20 | 2002-02-20 | Heino Pekka Untamo | Valmiste ja menetelmä painon pudottamiseksi |
| FR2843301B1 (fr) * | 2002-08-09 | 2004-10-22 | Centre Nat Rech Scient | Forme galenique pour la delivrance colique de principes actifs |
| FR2843302B1 (fr) | 2002-08-09 | 2004-10-22 | Centre Nat Rech Scient | Forme galenique pour la delivrance colique de principes actifs |
| US7387793B2 (en) * | 2003-11-14 | 2008-06-17 | Eurand, Inc. | Modified release dosage forms of skeletal muscle relaxants |
| CN101128187A (zh) * | 2005-02-09 | 2008-02-20 | 达沃尔泰拉公司 | 活性剂的结肠递送 |
| FI119190B (fi) | 2006-06-21 | 2008-08-29 | Ipsat Therapies Oy | Modifioitu beta-laktamaasi ja menetelmä sen valmistamiseksi |
| US8273376B2 (en) * | 2006-11-17 | 2012-09-25 | Da Volterra | Colonic delivery of metallo-dependent enzymes |
| US20080124279A1 (en) * | 2006-11-17 | 2008-05-29 | Antoine Andremont | Colonic delivery using Zn/pectin beads with a Eudragit coating |
| EP2162119A2 (de) * | 2007-05-21 | 2010-03-17 | Phenomix Corporation | Stabile pharmazeutische formulierung für einen dpp-iv-hemmer |
| ITBO20080297A1 (it) * | 2008-05-16 | 2009-11-17 | Archimede R & D S R L | Composizione enzimatica per ridurre il rilascio di principi attivi farmaceutici nell'ambiente. |
| FI20105572A0 (fi) | 2010-05-24 | 2010-05-24 | Prevab R Lcc | Muokattu beeta-laktamaasi ja siihen liittyvät menetelmät ja käytöt |
| ITMI20121715A1 (it) * | 2012-10-11 | 2014-04-12 | Bioikos Ambiente S R L | Composizioni farmaceutiche con ridotto impatto ambientale |
| JP6685925B2 (ja) | 2014-04-17 | 2020-04-22 | シンセティック バイオロジクス，インコーポレイテッド | 治療用として改善された特性を有するβ−ラクタマーゼ |
| JP6803328B2 (ja) | 2014-08-28 | 2021-01-06 | シンセティック バイオロジクス，インコーポレイテッド | 大腸菌ベースでのベータラクタマーゼ生産 |
| ES2806426T3 (es) * | 2014-10-08 | 2021-02-17 | Synthetic Biologics Inc | Formulaciones de betalactamasas y usos de las mismas |
| FR3027307B1 (fr) * | 2014-10-16 | 2016-11-04 | Azurrx Sas | Molecule proteique hybride apte a inhiber au moins un antibiotique et composition pharmaceutique la comportant |
| US9744221B2 (en) | 2014-12-23 | 2017-08-29 | Synthetic Biologics, Inc. | Method and compositions for inhibiting or preventing adverse effects of oral antibiotics |
| WO2016137993A1 (en) | 2015-02-23 | 2016-09-01 | Synthetic Biologics, Inc. | Carbapenemases for use with antibiotics for the protection of the intestinal microbiome |
| WO2016144856A1 (en) | 2015-03-06 | 2016-09-15 | Synthetic Biologics, Inc. | Safe and effective beta-lactamase dosing for microbiome protection |
| WO2017144495A1 (en) | 2016-02-23 | 2017-08-31 | Da Volterra | Beta-lactamase variants |
| ES2922009T3 (es) | 2016-02-23 | 2022-09-06 | Da Volterra | Variantes de beta-lactamasa |
| CN111247246A (zh) | 2017-10-25 | 2020-06-05 | 达·沃尔泰拉公司 | β-内酰胺酶变体 |
| KR20220006072A (ko) * | 2019-05-06 | 2022-01-14 | 신세틱 바이오로직스, 인코퍼레이티드 | 이식편대숙주병의 치료를 위한 베타-락타마제 조성물 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2613624B1 (fr) * | 1987-04-10 | 1990-11-23 | Roussy Inst Gustave | Composition pharmaceutique, administrable par voie orale, destinee a reduire les effets des b-lactamines |
| CS275231B2 (en) * | 1989-09-29 | 1992-02-19 | Ustav Makormolekularni Chemie | Medicine bottle |
-
1992
- 1992-01-17 FI FI920206A patent/FI920206A0/fi unknown
-
1993
- 1993-01-18 DK DK93902271T patent/DK0671942T3/da active
- 1993-01-18 DE DE69322659T patent/DE69322659T2/de not_active Expired - Fee Related
- 1993-01-18 WO PCT/FI1993/000016 patent/WO1993013795A1/en active IP Right Grant
- 1993-01-18 AT AT93902271T patent/ATE174513T1/de not_active IP Right Cessation
- 1993-01-18 EP EP93902271A patent/EP0671942B1/de not_active Expired - Lifetime
- 1993-01-18 US US08/256,508 patent/US5607671A/en not_active Expired - Lifetime
- 1993-01-18 ES ES93902271T patent/ES2129078T3/es not_active Expired - Lifetime
-
1999
- 1999-03-16 GR GR990400783T patent/GR3029699T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US5607671A (en) | 1997-03-04 |
| FI920206A0 (fi) | 1992-01-17 |
| WO1993013795A1 (en) | 1993-07-22 |
| DE69322659D1 (de) | 1999-01-28 |
| ES2129078T3 (es) | 1999-06-01 |
| DK0671942T3 (da) | 1999-08-23 |
| EP0671942B1 (de) | 1998-12-16 |
| EP0671942A1 (de) | 1995-09-20 |
| DE69322659T2 (de) | 2000-01-05 |
| GR3029699T3 (en) | 1999-06-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEIH | Change in the person of patent owner | ||
| UEP | Publication of translation of european patent specification | ||
| EEFA | Change of the company name | ||
| REN | Ceased due to non-payment of the annual fee |