[go: up one dir, main page]

ATE159945T1 - Beta-aminoalkyl und beta-n- peptidylaminoalkylborsäure - Google Patents

Beta-aminoalkyl und beta-n- peptidylaminoalkylborsäure

Info

Publication number
ATE159945T1
ATE159945T1 AT93918597T AT93918597T ATE159945T1 AT E159945 T1 ATE159945 T1 AT E159945T1 AT 93918597 T AT93918597 T AT 93918597T AT 93918597 T AT93918597 T AT 93918597T AT E159945 T1 ATE159945 T1 AT E159945T1
Authority
AT
Austria
Prior art keywords
beta
acid
peptidylaminoalkylboric
aminoalkyl
alkyl
Prior art date
Application number
AT93918597T
Other languages
English (en)
Inventor
David William Bjorkquist
Rajan Keshav Panandiker
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Application granted granted Critical
Publication of ATE159945T1 publication Critical patent/ATE159945T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16Organic compounds
    • C11D3/38Products with no well-defined composition, e.g. natural products
    • C11D3/386Preparations containing enzymes, e.g. protease or amylase
    • C11D3/38663Stabilised liquid enzyme compositions
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02Boron compounds
    • C07F5/025Boronic and borinic acid compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06191Dipeptides containing heteroatoms different from O, S, or N
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Detergent Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT93918597T 1992-08-14 1993-08-03 Beta-aminoalkyl und beta-n- peptidylaminoalkylborsäure ATE159945T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/931,809 US5442100A (en) 1992-08-14 1992-08-14 β-aminoalkyl and β-N-peptidylaminoalkyl boronic acids

Publications (1)

Publication Number Publication Date
ATE159945T1 true ATE159945T1 (de) 1997-11-15

Family

ID=25461390

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93918597T ATE159945T1 (de) 1992-08-14 1993-08-03 Beta-aminoalkyl und beta-n- peptidylaminoalkylborsäure

Country Status (10)

Country Link
US (2) US5442100A (de)
EP (1) EP0655067B1 (de)
JP (1) JPH08500113A (de)
CN (1) CN1047596C (de)
AT (1) ATE159945T1 (de)
AU (1) AU4799793A (de)
DE (1) DE69315079T2 (de)
MX (1) MX9304970A (de)
TW (1) TW251274B (de)
WO (1) WO1994004542A1 (de)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2098484T3 (es) * 1992-08-14 1997-05-01 Procter & Gamble Detergentes liquidos que contienen un acido alfa-amino-boronico.
CN1127014A (zh) * 1993-07-09 1996-07-17 诺沃挪第克公司 作为酶稳定剂的一烃基硼酸或二烃基硼酸衍生物
US5834415A (en) * 1994-04-26 1998-11-10 Novo Nordisk A/S Naphthalene boronic acids
DE4422433A1 (de) * 1994-06-28 1996-01-04 Cognis Bio Umwelt Mehrenzymgranulat
US5731439A (en) * 1995-03-24 1998-03-24 The Dupont Merck Pharmaceutical Company Piperidine containing aminobornic acids
US6036727A (en) 1995-06-05 2000-03-14 Creative Products Resource, Inc. Anhydrous dry-cleaning compositions containing polysulfonic acid, and dry-cleaning kits for delicate fabrics
US6086634A (en) 1995-06-05 2000-07-11 Custom Cleaner, Inc. Dry-cleaning compositions containing polysulfonic acid
AU5950696A (en) 1995-06-05 1996-12-24 Creative Products Resource, Inc. Dry-cleaning kit for in-dryer use
US5658651A (en) 1995-09-29 1997-08-19 Creative Products Resource, Inc. Fabric treatment and softener system for in-dryer use
DE69621131T2 (de) * 1995-06-13 2002-11-28 Novozymes A/S, Bagsvaerd 4-substituierte-phenylboronsäuren als enzymstabilisatoren
ATE509912T1 (de) * 1999-06-14 2011-06-15 Wisconsin Alumni Res Found Oligomere und polymere von zyklischen imino- carbonsäuren
EP1786891A1 (de) * 2004-09-08 2007-05-23 The Procter and Gamble Company Wäschebehandlungszusammensetzungen mit verbessertem duft
ES2568768T3 (es) * 2008-01-04 2016-05-04 The Procter & Gamble Company Una composición detergente para lavado de ropa que comprende glicosil hidrolasa
US20090209447A1 (en) 2008-02-15 2009-08-20 Michelle Meek Cleaning compositions
EP2300588B1 (de) 2008-06-06 2019-02-06 The Procter and Gamble Company Waschmittel mit variante einer xyloglucocanase der familie 44
PL2318419T3 (pl) * 2008-06-17 2015-08-31 Millennium Pharm Inc Związki estrów boronianowych i ich kompozycje farmaceutyczne
WO2011005730A1 (en) 2009-07-09 2011-01-13 The Procter & Gamble Company A catalytic laundry detergent composition comprising relatively low levels of water-soluble electrolyte
JP2012532246A (ja) 2009-07-09 2012-12-13 ザ プロクター アンド ギャンブル カンパニー 比較的低濃度の水溶性電解質を含む触媒性洗濯洗剤組成物
US8933131B2 (en) 2010-01-12 2015-01-13 The Procter & Gamble Company Intermediates and surfactants useful in household cleaning and personal care compositions, and methods of making the same
WO2011112910A1 (en) 2010-03-12 2011-09-15 The Procter & Gamble Company Liquid detergent compositions comprising ph tuneable amido-gellants, and processes for making
JP5571202B2 (ja) 2010-03-12 2014-08-13 ザ プロクター アンド ギャンブル カンパニー ジアミドゲル化剤を含む流体洗剤組成物及び製造方法
HUE048859T2 (hu) 2010-08-10 2020-08-28 Rempex Pharmaceuticals Inc Gyûrûs bórsavészter származékok, eljárás elõállításukra, és terápiás alkalmazásuk
JP2014506581A (ja) 2011-02-17 2014-03-17 ザ プロクター アンド ギャンブル カンパニー バイオベースの直鎖アルキルフェニルスルホネート
EP2678410B1 (de) 2011-02-17 2017-09-13 The Procter and Gamble Company Zusammensetzungen mit mischungen aus c10-c13-alkylphenyl-sulfonaten
WO2013016371A1 (en) 2011-07-25 2013-01-31 The Procter & Gamble Company Detergents having acceptable color
US20130303427A1 (en) 2011-09-13 2013-11-14 Susana Fernandez Prieto MICROCAPSULE COMPOSITIONS COMPRISING pH TUNEABLE DI-AMIDO GELLANTS
RU2014131370A (ru) * 2012-01-09 2016-02-27 Юниверсити Оф Тромсё Терапевтические соединения, содержащие бор
EP2716644B1 (de) 2012-10-03 2017-04-05 The Procter and Gamble Company Stabile Enzymstabilisatorvormischung
KR20150103269A (ko) 2013-01-04 2015-09-09 렘펙스 파머수티클스 인코퍼레이티드 보론산 유도체 및 그의 치료적 용도
US9241947B2 (en) 2013-01-04 2016-01-26 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
EP2970830B1 (de) 2013-03-14 2017-12-13 Novozymes A/S Protease und hemmer enthaltend in wasserlöslichen filmen
MX365786B (es) 2013-05-03 2019-06-14 Novozymes As Microencapsulacion de enzimas detergentes.
SMT201900611T1 (it) 2014-05-05 2020-01-14 Rempex Pharmaceuticals Inc Sintesi di sali boronati e usi degli stessi
ES2985626T3 (es) 2014-05-05 2024-11-06 Melinta Therapeutics Inc Sales y polimorfos de derivados cíclicos de éster de ácido borónico y usos terapéuticos de los mismos
KR20170007448A (ko) 2014-05-19 2017-01-18 렘펙스 파머수티클스 인코퍼레이티드 보론산 유도체 및 그의 치료적 용도
CN106659761A (zh) 2014-05-20 2017-05-10 千年药物公司 初级癌症疗法后使用的含硼蛋白酶体抑制剂
KR20170024087A (ko) 2014-07-01 2017-03-06 렘펙스 파머수티클스 인코퍼레이티드 보론산 유도체 및 그의 치료적 용도
WO2016001319A1 (en) 2014-07-03 2016-01-07 Novozymes A/S Improved stabilization of non-protease enzyme
US10662205B2 (en) 2014-11-18 2020-05-26 Qpex Biopharma, Inc. Cyclic boronic acid ester derivatives and therapeutic uses thereof
CN117904083A (zh) 2014-12-19 2024-04-19 诺维信公司 蛋白酶变体以及对其进行编码的多核苷酸
US10364257B2 (en) 2014-12-19 2019-07-30 Rempex Pharmaceuticals, Inc. Apparatus and continuous flow process for production of boronic acid derivatives
US20180051041A1 (en) 2015-03-17 2018-02-22 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
CN107969136B (zh) 2015-07-06 2021-12-21 诺维信公司 脂肪酶变体以及编码它们的多核苷酸
US10675589B2 (en) 2015-10-14 2020-06-09 Novozymes A/S Cleaning of water filtration membranes
MX389349B (es) 2016-06-30 2025-03-20 Qpex Biopharma Inc Derivados de ácido borónico y usos terapéuticos de los mismos.
WO2018202846A1 (en) 2017-05-05 2018-11-08 Novozymes A/S Compositions comprising lipase and sulfite
WO2019002356A1 (en) 2017-06-30 2019-01-03 Novozymes A/S ENZYMATIC SUSPENSION COMPOSITION
KR102626967B1 (ko) 2017-10-11 2024-01-18 큐펙스 바이오파마 인코포레이티드 보론산 유도체 및 이의 합성
BR112020008737A2 (pt) 2017-11-01 2020-10-13 Novozymes A/S polipeptídeos e composições que compreendam tais polipeptídeos
EP3704240A1 (de) 2017-11-01 2020-09-09 Novozymes A/S Polypeptide und zusammensetzungen mit solchen polypeptiden
WO2019175240A1 (en) 2018-03-13 2019-09-19 Novozymes A/S Microencapsulation using amino sugar oligomers
CA3097127A1 (en) 2018-04-20 2019-10-24 Qpex Biopharma, Inc. Boronic acid derivatives and therapeutic uses thereof
EP3647397A1 (de) 2018-10-31 2020-05-06 Henkel AG & Co. KGaA Reinigungsmittel mit dispersins iv
ES2981999T3 (es) 2018-10-31 2024-10-14 Henkel Ag & Co Kgaa Composiciones limpiadoras que contienen dispersinas V
US11879110B2 (en) 2019-11-27 2024-01-23 The Procter & Gamble Company Alkylbenzenesulfonate surfactants
US20220411773A1 (en) 2019-12-20 2022-12-29 Novozymes A/S Polypeptides having proteolytic activity and use thereof
WO2022189521A1 (en) 2021-03-12 2022-09-15 Novozymes A/S Polypeptide variants
WO2024131880A2 (en) 2022-12-23 2024-06-27 Novozymes A/S Detergent composition comprising catalase and amylase

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2872479A (en) * 1955-06-30 1959-02-03 Callery Chemical Co Preparation of organoboron compounds
US3912595A (en) * 1974-02-25 1975-10-14 Us Health Method of purifying enzymes using boronic acids covalently bonded to an insoluble support
IT1129814B (it) * 1980-07-02 1986-06-11 Unilever Nv Composizione detergente enzimatica liquida
US4462922A (en) * 1981-11-19 1984-07-31 Lever Brothers Company Enzymatic liquid detergent composition
GB8311314D0 (en) * 1983-04-26 1983-06-02 Unilever Plc Aqueous enzyme-containing compositions
US4652394A (en) * 1983-05-31 1987-03-24 Colgate Palmolive Co. Built single phase liquid anionic detergent compositions containing stabilized enzymes
DE3413571A1 (de) * 1984-04-11 1985-10-24 Hoechst Ag, 6230 Frankfurt Verwendung von kristallinen schichtfoermigen natriumsilikaten zur wasserenthaertung und verfahren zur wasserenthaertung
US4537707A (en) * 1984-05-14 1985-08-27 The Procter & Gamble Company Liquid detergents containing boric acid and formate to stabilize enzymes
US4566985A (en) * 1984-09-19 1986-01-28 Applied Biochemists, Inc. Method of cleaning using liquid compositions comprising stabilized mixtures of enzymes
US4747977A (en) * 1984-11-09 1988-05-31 The Procter & Gamble Company Ethanol-free liquid laundry detergent compositions
US4842769A (en) * 1985-07-26 1989-06-27 Colgate-Palmolive Co. Stabilized fabric softening built detergent composition containing enzymes
US4900475A (en) * 1985-07-26 1990-02-13 Colgate-Palmolive Co. Stabilized built liquid detergent composition containing enzyme
JPH0697997B2 (ja) * 1985-08-09 1994-12-07 ギスト ブロカデス ナ−ムロ−ゼ フエンノ−トチヤツプ 新規の酵素的洗浄剤添加物
EG18543A (en) * 1986-02-20 1993-07-30 Albright & Wilson Protected enzyme systems
US4842758A (en) * 1986-10-31 1989-06-27 Colgate-Palmolive Company Stabilized enzyme system for use in aqueous liquid built detergent compositions
US4704233A (en) * 1986-11-10 1987-11-03 The Procter & Gamble Company Detergent compositions containing ethylenediamine-N,N'-disuccinic acid
US5187157A (en) * 1987-06-05 1993-02-16 Du Pont Merck Pharmaceutical Company Peptide boronic acid inhibitors of trypsin-like proteases
DK571587D0 (da) * 1987-11-02 1987-11-02 Novo Industri As Enzymatisk detergentsammensaetning
EP0315574A3 (de) * 1987-11-05 1990-08-22 Hoechst Aktiengesellschaft Renin-Inhibitoren
GB8810822D0 (en) * 1988-05-06 1988-06-08 Unilever Plc Liquid detergent compositions
US4963655A (en) * 1988-05-27 1990-10-16 Mayo Foundation For Medical Education And Research Boron analogs of amino acid/peptide protease inhibitors
US5039446A (en) * 1988-07-01 1991-08-13 Genencor International, Inc. Liquid detergent with stabilized enzyme
DE3840452A1 (de) * 1988-12-01 1990-06-07 Hoechst Ag (beta)-amino-boronsaeure-derivate
CA2006527A1 (en) * 1988-12-30 1990-06-30 Martin S. Cardinali Enzymatic liquid detergent compositions
US4959179A (en) * 1989-01-30 1990-09-25 Lever Brothers Company Stabilized enzymes liquid detergent composition containing lipase and protease
US4908150A (en) * 1989-02-02 1990-03-13 Lever Brothers Company Stabilized lipolytic enzyme-containing liquid detergent composition
EP0385401A1 (de) * 1989-02-27 1990-09-05 Occidental Chemical Corporation Besondere Mikrobielle Lipasen mit einer Aktivität bei Temperaturen und pH-Werten, die ihnen für die Verwendung in Detergentien Eignung verleiht
DE69033423T2 (de) * 1989-05-15 2000-05-25 The Clorox Co., Oakland Wäschewaschverfahren
EP0450702A3 (en) * 1990-04-06 1993-06-02 Unilever N.V. Process for preparing liquid enzymatic detergent compositions
EP0478050A1 (de) * 1990-09-24 1992-04-01 Unilever N.V. Detergentzusammensetzung
EP0486073B1 (de) * 1990-11-14 1996-07-24 The Procter & Gamble Company Lipase- und proteasehaltige flüssige Waschmittelzusammensetzung

Also Published As

Publication number Publication date
WO1994004542A1 (en) 1994-03-03
US5488157A (en) 1996-01-30
EP0655067B1 (de) 1997-11-05
US5442100A (en) 1995-08-15
EP0655067A1 (de) 1995-05-31
CN1047596C (zh) 1999-12-22
DE69315079T2 (de) 1998-06-04
AU4799793A (en) 1994-03-15
DE69315079D1 (de) 1997-12-11
TW251274B (de) 1995-07-11
CN1090850A (zh) 1994-08-17
JPH08500113A (ja) 1996-01-09
MX9304970A (es) 1994-05-31

Similar Documents

Publication Publication Date Title
ATE159945T1 (de) Beta-aminoalkyl und beta-n- peptidylaminoalkylborsäure
YU34896A (sh) Supstituisani n-(indol-2-karbonil)-glicinamidi, njihovi intermedijeri i farmaceutske kompozicije
AU4249189A (en) Novel peptidase inhibitors
DE69415343D1 (de) 2'-amido-und 2'-peptido-modifizierte oligonukleotide
NO934423D0 (no) Preparater for vedvarende frigiving
MY137301A (en) Peptide analogs as irreversible interleukin-1b protease inhibitors
NZ296479A (en) Amino acid or peptide derivatives which are inhibitors of multicatalytic protease (mcp)
DK0609415T3 (da) Salpetersyreestere af 2-(2,6-di-halogen-phenylamino)phenyleddikesyrederivater og fremgangsmåde til deres fremstilling
ATE90107T1 (de) Peptide mit collagenase hemmender wirkung.
NZ335157A (en) N-(aryl/heteroaryl) amino acid derivatives and methods for inhibiting beta-amyloid peptide release or its synthesis
NO942740L (no) Pyridinkarboksimidamid-forbindelse og anvendelse av samme
DK0868429T3 (da) Oligopeptidforbindelser indeholdende D-2-alkyltryptophan hvilke er i stand til at fremme frigivelsen af væksthormon
UA26459C2 (uk) Іhгібітор впливу амілоїдhих білків
FI930166A0 (fi) Nya salter av dialkylaminoalkyl-26-sulfonylpristinamycin iib-derivat
ATE46347T1 (de) Immunostimulierende peptide.
DK1041082T3 (da) Fremgangsmåde til peptidsyntese ud fra N-carboxyandridaminosyrer
ES2004804A6 (es) Un procedimiento para preparar derivados de carboxialquildipeptidos
TH14443A (th) (สูตร) - อะมิโนแอลคิลและ (สูตร)-n- เพปทิดิลอะมิโนแอลคิลปอโรนิคแอซิด
MY106459A (en) (n-( (gamma) -glutamyl) glycyl) alanine derivatives.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties