ATE157988T1 - Neuartige prolyl-endopeptidase-inhibitoren sna- 115 und sna-115t, ihre herstellung, und hierbei verwendete stämme - Google Patents
Neuartige prolyl-endopeptidase-inhibitoren sna- 115 und sna-115t, ihre herstellung, und hierbei verwendete stämmeInfo
- Publication number
- ATE157988T1 ATE157988T1 AT92912434T AT92912434T ATE157988T1 AT E157988 T1 ATE157988 T1 AT E157988T1 AT 92912434 T AT92912434 T AT 92912434T AT 92912434 T AT92912434 T AT 92912434T AT E157988 T1 ATE157988 T1 AT E157988T1
- Authority
- AT
- Austria
- Prior art keywords
- sna
- prolyl endopeptidase
- preparation
- strains used
- endopeptidase inhibitors
- Prior art date
Links
- 239000003649 prolyl endopeptidase inhibitor Substances 0.000 title abstract 3
- 208000030507 AIDS Diseases 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 2
- 229940122210 Prolyl endopeptidase inhibitor Drugs 0.000 abstract 2
- ORZXYSPOAVJYRU-UHFFFAOYSA-N benzyl 2-(2-formylpyrrolidine-1-carbonyl)pyrrolidine-1-carboxylate Chemical compound O=CC1CCCN1C(=O)C1N(C(=O)OCC=2C=CC=CC=2)CCC1 ORZXYSPOAVJYRU-UHFFFAOYSA-N 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 208000000044 Amnesia Diseases 0.000 abstract 1
- 208000031091 Amnestic disease Diseases 0.000 abstract 1
- 208000031886 HIV Infections Diseases 0.000 abstract 1
- 241000906785 Microbispora sp. Species 0.000 abstract 1
- 102000056251 Prolyl Oligopeptidases Human genes 0.000 abstract 1
- 101710178372 Prolyl endopeptidase Proteins 0.000 abstract 1
- 102000004142 Trypsin Human genes 0.000 abstract 1
- 108090000631 Trypsin Proteins 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000006986 amnesia Effects 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000012588 trypsin Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP17622891 | 1991-06-20 | ||
| JP04078262A JP3092877B2 (ja) | 1991-06-20 | 1992-02-28 | 新規ペプチドｓｎａ−１１５及びｓｎａ−１１５ｔ、その製造法及び新規ペプチド産生菌株 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE157988T1 true ATE157988T1 (de) | 1997-09-15 |
Family
ID=26419344
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92912434T ATE157988T1 (de) | 1991-06-20 | 1992-06-19 | Neuartige prolyl-endopeptidase-inhibitoren sna- 115 und sna-115t, ihre herstellung, und hierbei verwendete stämme |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US5449750A (de) |
| EP (1) | EP0553357B1 (de) |
| AT (1) | ATE157988T1 (de) |
| CA (1) | CA2089890A1 (de) |
| DE (1) | DE69222142T2 (de) |
| WO (1) | WO1993000361A1 (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6071895A (en) | 1992-03-11 | 2000-06-06 | Narhex Limited | Polar-substituted hydrocarbons |
| US5679688A (en) | 1992-03-11 | 1997-10-21 | Narhex Limited | Quinaldoyl-amine derivatives of oxo-and hydroxy-substituted hydrocarbons |
| US5888992A (en) | 1992-03-11 | 1999-03-30 | Narhex Limited | Polar substituted hydrocarbons |
| US5451660A (en) * | 1993-12-13 | 1995-09-19 | Genentech, Inc. | Method for purifying polypeptides |
| ATE462432T1 (de) | 2003-05-05 | 2010-04-15 | Probiodrug Ag | Glutaminylcyclase-hemmer |
| WO2005049027A2 (en) | 2003-11-03 | 2005-06-02 | Probiodrug Ag | Combinations useful for the treatment of neuronal disorders |
| AU2005210004B2 (en) | 2004-02-05 | 2010-10-28 | Probiodrug Ag | Novel inhibitors of glutaminyl cyclase |
| JP5379692B2 (ja) | 2006-11-09 | 2013-12-25 | プロビオドルグ エージー | 潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての３−ヒドロキシ−１，５−ジヒドロ−ピロール−２−オン誘導体 |
| EP2091948B1 (de) | 2006-11-30 | 2012-04-18 | Probiodrug AG | Neue inhibitoren von glutaminylcyclase |
| EP2481408A3 (de) | 2007-03-01 | 2013-01-09 | Probiodrug AG | Neue Verwendung von Inhibitoren der Glutaminyl Cyclase |
| EP2142514B1 (de) | 2007-04-18 | 2014-12-24 | Probiodrug AG | Thioharnstoffderivate als glutaminylcyclaseinhibitoren |
| WO2008144748A1 (en) | 2007-05-21 | 2008-11-27 | The Uab Research Foundation | Prolyl endopeptidase inhibitors for reducing or preventing neutrophilic inflammation |
| AU2010294214B2 (en) | 2009-09-11 | 2015-05-07 | Vivoryon Therapeutics N.V. | Heterocylcic derivatives as inhibitors of glutaminyl cyclase |
| ES2586231T3 (es) | 2010-03-03 | 2016-10-13 | Probiodrug Ag | Inhibidores de glutaminil ciclasa |
| MX2012010470A (es) | 2010-03-10 | 2012-10-09 | Probiodrug Ag | Inhibidores heterociclicos d ciclasa de glutaminilo (qc, ec .3 2. 5). |
| EP2560953B1 (de) | 2010-04-21 | 2016-01-06 | Probiodrug AG | Hemmer der glutaminylzyklase |
| EP2686313B1 (de) | 2011-03-16 | 2016-02-03 | Probiodrug AG | Benzimidazolderivate als glutaminylcyclase-hemmer |
| PL3461819T3 (pl) | 2017-09-29 | 2020-11-30 | Probiodrug Ag | Inhibitory cyklazy glutaminylowej |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1335079C (en) * | 1988-07-25 | 1995-04-04 | Kiyoshi Takatsuki | Preventive and curative agents for acquired immune deficiency syndrome (aids) |
| US4999349A (en) * | 1990-03-22 | 1991-03-12 | Bristol-Myers Squibb Co. | BU-4164E - A and B, prolyl endopeptidase inhibitors |
-
1992
- 1992-06-19 US US07/977,444 patent/US5449750A/en not_active Expired - Fee Related
- 1992-06-19 CA CA002089890A patent/CA2089890A1/en not_active Abandoned
- 1992-06-19 WO PCT/JP1992/000784 patent/WO1993000361A1/ja active IP Right Grant
- 1992-06-19 DE DE69222142T patent/DE69222142T2/de not_active Expired - Fee Related
- 1992-06-19 EP EP92912434A patent/EP0553357B1/de not_active Expired - Lifetime
- 1992-06-19 AT AT92912434T patent/ATE157988T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| WO1993000361A1 (fr) | 1993-01-07 |
| DE69222142D1 (de) | 1997-10-16 |
| EP0553357B1 (de) | 1997-09-10 |
| US5449750A (en) | 1995-09-12 |
| CA2089890A1 (en) | 1992-12-21 |
| EP0553357A4 (en) | 1994-09-21 |
| DE69222142T2 (de) | 1998-04-09 |
| EP0553357A1 (de) | 1993-08-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |