ATE156361T1 - Proteinhaftige arzneimittel mit verzögerter wirkstoffabgabe - Google Patents
Proteinhaftige arzneimittel mit verzögerter wirkstoffabgabeInfo
- Publication number
- ATE156361T1 ATE156361T1 AT93920157T AT93920157T ATE156361T1 AT E156361 T1 ATE156361 T1 AT E156361T1 AT 93920157 T AT93920157 T AT 93920157T AT 93920157 T AT93920157 T AT 93920157T AT E156361 T1 ATE156361 T1 AT E156361T1
- Authority
- AT
- Austria
- Prior art keywords
- protein
- delayed release
- medicinal products
- contained medicinal
- sustained
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/25—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Pregnancy & Childbirth (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US94787292A | 1992-09-21 | 1992-09-21 | |
US96336592A | 1992-10-20 | 1992-10-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE156361T1 true ATE156361T1 (de) | 1997-08-15 |
Family
ID=27130263
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT93920157T ATE156361T1 (de) | 1992-09-21 | 1993-08-23 | Proteinhaftige arzneimittel mit verzögerter wirkstoffabgabe |
Country Status (12)
Country | Link |
---|---|
US (1) | US6011011A (de) |
EP (1) | EP0661989B1 (de) |
JP (2) | JP3756512B2 (de) |
AT (1) | ATE156361T1 (de) |
AU (1) | AU5018693A (de) |
DE (1) | DE69312947T2 (de) |
DK (1) | DK0661989T3 (de) |
ES (1) | ES2107051T3 (de) |
GR (1) | GR3024632T3 (de) |
MX (1) | MX9305729A (de) |
TW (1) | TW224055B (de) |
WO (1) | WO1994006452A1 (de) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1130222C (zh) | 1996-01-11 | 2003-12-10 | 法玛西雅厄普约翰美国公司 | 水性延长释放配剂 |
KR100594519B1 (ko) * | 1996-07-03 | 2007-03-02 | 앨자 코포레이션 | 비수성양성자성펩티드제제 |
KR100593221B1 (ko) * | 1996-07-03 | 2007-03-02 | 알자 코포레이션 | 비수성극성비양성자성펩타이드제제 |
EP0909175B1 (de) * | 1996-07-03 | 2003-06-04 | Alza Corporation | Nicht-waessrige protische peptidzubereitungen |
US5932547A (en) * | 1996-07-03 | 1999-08-03 | Alza Corporation | Non-aqueous polar aprotic peptide formulations |
US5981489A (en) * | 1996-07-18 | 1999-11-09 | Alza Corporation | Non-aqueous protic peptide formulations |
IN184589B (de) | 1996-10-16 | 2000-09-09 | Alza Corp | |
US7732404B2 (en) * | 1999-12-30 | 2010-06-08 | Dexcel Ltd | Pro-nanodispersion for the delivery of cyclosporin |
US6773711B2 (en) * | 2000-02-15 | 2004-08-10 | Allergan, Inc. | Botulinum toxin therapy for Hashimoto's thyroiditis |
US6524580B1 (en) | 2000-02-15 | 2003-02-25 | Allergan Sales, Inc. | Method for treating thyroid disorders |
US6358513B1 (en) | 2000-02-15 | 2002-03-19 | Allergan Sales, Inc. | Method for treating Hashimoto's thyroiditis |
US6328977B1 (en) | 2000-02-22 | 2001-12-11 | Allergan Sales, Inc. | Method for treating hyperparathyroidism |
US20040033241A1 (en) * | 2000-06-02 | 2004-02-19 | Allergan, Inc. | Controlled release botulinum toxin system |
US6306423B1 (en) | 2000-06-02 | 2001-10-23 | Allergan Sales, Inc. | Neurotoxin implant |
US20040170665A1 (en) * | 2000-06-02 | 2004-09-02 | Allergan, Inc. | Intravitreal botulinum toxin implant |
AU2002211629A1 (en) * | 2000-10-10 | 2002-04-22 | Microchips, Inc. | Microchip reservoir devices using wireless transmission of power and data |
KR100838219B1 (ko) * | 2001-07-13 | 2008-06-13 | 동아제약주식회사 | 인간성장호르몬의 지속적인 방출이 가능한 생분해성약학적 조성물 및 미립구 제형 |
WO2004022033A1 (en) * | 2002-09-04 | 2004-03-18 | Microchips, Inc. | Method and device for the controlled delivery of parathyroid hormone |
US7074425B2 (en) * | 2002-09-26 | 2006-07-11 | Bonewax, Llc | Hemostatic compositions and methods |
LT2891666T (lt) | 2002-10-16 | 2017-10-10 | Purdue Pharma L.P. | Antikūnai, kurie prisiriša su ląstelėmis susijusį ca 125/o722p ir jų naudojimo būdas |
US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
EP1663296A4 (de) * | 2003-09-25 | 2009-11-25 | Cangene Corp | Flüssige menschliche wachstumshormonformulierung mit polyethylenglykol |
JP5105578B2 (ja) | 2003-11-05 | 2012-12-26 | サーコード バイオサイエンス インコーポレイテッド | 細胞接着のモジュレーター |
CA2595457A1 (en) * | 2005-01-25 | 2006-08-03 | Microchips, Inc. | Control of drug release by transient modification of local microenvironments |
TW200640492A (en) | 2005-02-21 | 2006-12-01 | Lg Life Sciences Ltd | Sustained release composition of protein drug |
EP1928551B1 (de) * | 2005-06-10 | 2012-05-30 | Althea Technologies, Inc. | Verfahren zur reduzierung der oxalat-konzentration durch verabreichung von oxalat-oxidase-kristallen |
US7756524B1 (en) | 2006-01-31 | 2010-07-13 | Nextel Communications Inc. | System and method for partially count-based allocation of vocoder resources |
US20070178138A1 (en) * | 2006-02-01 | 2007-08-02 | Allergan, Inc. | Biodegradable non-opthalmic implants and related methods |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
CA2688161C (en) | 2007-06-04 | 2020-10-20 | Kunwar Shailubhai | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
JP5808037B2 (ja) | 2007-10-19 | 2015-11-10 | サーコード バイオサイエンス インク. | 糖尿病性網膜症の治療のための組成物及び方法 |
BRPI0819235A2 (pt) * | 2007-11-02 | 2017-08-22 | Acrux Dds Pty Ltd | Sistema de distribuição transdérmica para hormônios e esteróides |
US9107815B2 (en) | 2008-02-22 | 2015-08-18 | Allergan, Inc. | Sustained release poloxamer containing pharmaceutical compositions |
CN102065893A (zh) * | 2008-04-15 | 2011-05-18 | 萨可德公司 | Lfa-1拮抗剂向胃肠系统的递送 |
ES2522968T3 (es) | 2008-06-04 | 2014-11-19 | Synergy Pharmaceuticals Inc. | Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos |
WO2010009319A2 (en) | 2008-07-16 | 2010-01-21 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
JP5486690B2 (ja) * | 2009-11-16 | 2014-05-07 | イプセン ファルマ ソシエテ パール アクシオン サンプリフィエ | メラノコルチン受容体リガンドの医薬組成物 |
DE102009056745A1 (de) * | 2009-12-04 | 2011-06-09 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System für die Verabreichung von Peptiden |
JP2013515081A (ja) * | 2009-12-21 | 2013-05-02 | アンブルックス,インコーポレイテッド | 修飾されているブタのソマトトロピンポリペプチドおよびそれらの使用 |
BR112012015461A2 (pt) * | 2009-12-21 | 2017-01-10 | Ambrx Inc | polipeptídeos de somatotropina boviina modificados e seus usos |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
ES2985784T3 (es) | 2011-11-18 | 2024-11-07 | Regeneron Pharma | Micropartículas de proteínas recubiertas con polímeros para formulaciones de liberación prolongada para su uso en el humor vítreo del ojo para tratar trastornos oculares vasculares |
AR091784A1 (es) * | 2012-07-17 | 2015-02-25 | Bayer New Zealand Ltd | Formaciones inyectables de antibiotico y sus metodos de aplicacion |
JP6499591B2 (ja) | 2013-02-25 | 2019-04-10 | シナジー ファーマシューティカルズ インコーポレイテッド | 結腸洗浄において用いるためのグアニル酸シクラーゼ受容体アゴニスト |
EP2968439A2 (de) | 2013-03-15 | 2016-01-20 | Synergy Pharmaceuticals Inc. | Zusammensetzungen zur behandlung von magen-darm-störungen |
CA2905438A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
JP6661531B2 (ja) | 2013-10-10 | 2020-03-11 | シナジー ファーマシューティカルズ インコーポレイテッド | オピオイド誘発性機能障害の治療に有用なグアニル酸シクラーゼのアゴニスト |
TW201618783A (zh) | 2014-08-07 | 2016-06-01 | 艾森塔製藥公司 | 以布魯頓(Bruton)氏酪胺酸激酶(BTK)佔據和BTK再合成速率為基礎之治療癌症、免疫和自體免疫疾病及發炎性疾病之方法 |
MY193964A (en) * | 2015-10-16 | 2022-11-03 | Regeneron Pharma | Stable protein compositions |
JP2019506383A (ja) | 2016-01-11 | 2019-03-07 | シナジー ファーマシューティカルズ インコーポレイテッド | 潰瘍性大腸炎を治療するための製剤および方法 |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1185340A (en) * | 1967-12-19 | 1970-03-25 | Gen Foods Corp | Water Dispersable Hydrophilic Colloid Composition. |
US4041155A (en) * | 1974-10-29 | 1977-08-09 | American Home Products Corporation | Long acting somatostatin composition |
US3966962A (en) * | 1975-03-27 | 1976-06-29 | The Upjohn Company | Triacetin solutions of PGE-type compounds |
US4301175A (en) * | 1980-12-29 | 1981-11-17 | The Upjohn Company | E-Type prostaglandin compositions |
ZA831186B (en) * | 1982-03-22 | 1983-11-30 | Upjohn Ltd | Gelled pge2/triacetin solutions |
DE3484584D1 (de) * | 1983-10-14 | 1991-06-20 | Sumitomo Pharma | Injektionen mit verzoegerter abgabe. |
JPS60224638A (ja) * | 1984-04-23 | 1985-11-09 | Kao Corp | 経皮吸収促進剤およびこれを含有する外用剤 |
KR890002631B1 (ko) * | 1984-10-04 | 1989-07-21 | 몬산토 캄파니 | 생물학적으로 활성인 소마토트로핀을 지속적으로 유리하는 조성물 |
US4977140A (en) * | 1985-08-23 | 1990-12-11 | Eli Lilly And Company | Injectable sustained release formulation |
JPS62123112A (ja) * | 1985-11-22 | 1987-06-04 | Sunstar Inc | 軟膏基剤 |
US4917685A (en) * | 1986-05-16 | 1990-04-17 | International Minerals & Chem. Corp. | Delivery device for the administration of stabilized growth promoting hormones |
FR2606597B1 (fr) * | 1986-11-17 | 1989-01-27 | Rhone Poulenc Sante | Nouvelle composition pour l'alimentation des ruminants contenant une substance biologiquement active et sa preparation |
US4795641A (en) * | 1987-08-20 | 1989-01-03 | Eastman Kodak Company | Polymer blends having reverse phase morphology for controlled delivery of bioactive agents |
US5004728A (en) * | 1988-03-11 | 1991-04-02 | The Trustees Of The University Of Pennsylvania | Methods of increasing milk yields in ruminants |
IT1230576B (it) * | 1988-10-20 | 1991-10-28 | Angeli Inst Spa | Formulazioni farmaceutiche per via orale a liberazione selettiva nel colon |
ZA903756B (en) * | 1989-05-16 | 1991-02-27 | Puetter Medice Chem Pharm | Pharmaceutical preparation |
NZ234802A (en) * | 1989-08-14 | 1992-11-25 | Merck & Co Inc | Long acting injectable formulations comprising an avermectin compound and triacetin. treatment for internal and external parasites of animals |
US5179189A (en) * | 1990-01-19 | 1993-01-12 | Nova Pharmaceutical Corporation | Fatty acid terminated polyanhydrides |
WO1991016929A1 (en) * | 1990-05-10 | 1991-11-14 | Novo Nordisk A/S | A pharmaceutical preparation containing n-glycofurols and n-ethylene glycols |
US5091185A (en) * | 1990-06-20 | 1992-02-25 | Monsanto Company | Coated veterinary implants |
US5206219A (en) * | 1991-11-25 | 1993-04-27 | Applied Analytical Industries, Inc. | Oral compositions of proteinaceous medicaments |
-
1993
- 1993-08-23 ES ES93920157T patent/ES2107051T3/es not_active Expired - Lifetime
- 1993-08-23 AU AU50186/93A patent/AU5018693A/en not_active Abandoned
- 1993-08-23 DE DE69312947T patent/DE69312947T2/de not_active Expired - Fee Related
- 1993-08-23 EP EP93920157A patent/EP0661989B1/de not_active Expired - Lifetime
- 1993-08-23 WO PCT/US1993/007756 patent/WO1994006452A1/en active IP Right Grant
- 1993-08-23 JP JP50808394A patent/JP3756512B2/ja not_active Expired - Fee Related
- 1993-08-23 DK DK93920157.0T patent/DK0661989T3/da active
- 1993-08-23 AT AT93920157T patent/ATE156361T1/de not_active IP Right Cessation
- 1993-08-31 TW TW082107064A patent/TW224055B/zh active
- 1993-09-20 MX MX9305729A patent/MX9305729A/es not_active IP Right Cessation
-
1995
- 1995-03-20 US US08/407,327 patent/US6011011A/en not_active Expired - Fee Related
-
1997
- 1997-09-04 GR GR970402270T patent/GR3024632T3/el unknown
-
2004
- 2004-07-13 JP JP2004206098A patent/JP2004285079A/ja not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
TW224055B (de) | 1994-05-21 |
WO1994006452A1 (en) | 1994-03-31 |
ES2107051T3 (es) | 1997-11-16 |
DK0661989T3 (da) | 1998-03-02 |
DE69312947T2 (de) | 1998-01-08 |
AU5018693A (en) | 1994-04-12 |
GR3024632T3 (en) | 1997-12-31 |
US6011011A (en) | 2000-01-04 |
JP2004285079A (ja) | 2004-10-14 |
JPH08501305A (ja) | 1996-02-13 |
EP0661989A1 (de) | 1995-07-12 |
DE69312947D1 (de) | 1997-09-11 |
MX9305729A (es) | 1994-03-31 |
EP0661989B1 (de) | 1997-08-06 |
JP3756512B2 (ja) | 2006-03-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE156361T1 (de) | Proteinhaftige arzneimittel mit verzögerter wirkstoffabgabe | |
AU6819294A (en) | Oral drug delivery compositions and methods | |
EP0570916A3 (de) | Menschliches rekombinantes Serum-Albumin, Verfahren zur dessen Herstellung und diese enthaltende pharmazeutischen Präparate. | |
HK1021824A1 (en) | Compositions and methods for treating infections using analogues of indolicidin | |
ATE425181T1 (de) | Therapeutische zusammensetzungen aus antikorper und antisens nukleinsäuren gegen serrate | |
ATE333464T1 (de) | Zusammensetzungen und verfahren zur behandlung von infektionen unter verwendung von kationischen peptiden allein oder in kombination mit antibiotika | |
EP1686172A3 (de) | Herztransplantate und dafür nützliche Zellzusammensetzungen | |
CA2045869A1 (en) | Fusion proteins with immunoglobulin portions, the preparation and use thereof | |
ATE234111T1 (de) | Therapeutische verwendungen von bpi-protein produkten bei menschen mit durch trauma verursachter blutung | |
EP0422125A4 (en) | Platelet blocking peptides | |
EA200000685A1 (ru) | Комплекс ifnar2/ifn | |
WO2002058589A3 (en) | Agents and methods for promoting bone growth | |
ATE225806T1 (de) | D-2-alkyltryptophan enthaltende polypeptide mit wachstumhormon freisetzender aktivitaet | |
CA2071757A1 (en) | Implant compositions containing a biologically active protein, peptide or polypeptide | |
AU3629389A (en) | Novel peptides suppressing the function of the immune system, pharmaceutical compositions containing them and process for preparing same | |
EP1174439A3 (de) | Zusammensetzungen und Methoden zur Behandlung von Infektionen unter Verwendung von Indolicidinanalogen | |
ATE189262T1 (de) | Interferon-alpha/beta bindendes protein, seine herstellung und seine enthaltende pharmazeutische zusammensetzungen | |
WO2004089973A3 (en) | Peptides, polypeptides, and proteins of reduced immunogenicity and methods for their production | |
CA2163805A1 (en) | Novel activating factor of leukocytes | |
FR2684878B1 (fr) | Composition pharmaceutique stabilisee d'il2 humaine recombinante non glycosylee sous forme reduite et son procede de preparation. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |