ATE123306T1 - Alpha-glycosyl-l-ascorbinsäure und ihre herstellung und verwendungen. - Google Patents
Alpha-glycosyl-l-ascorbinsäure und ihre herstellung und verwendungen.Info
- Publication number
- ATE123306T1 ATE123306T1 AT90303484T AT90303484T ATE123306T1 AT E123306 T1 ATE123306 T1 AT E123306T1 AT 90303484 T AT90303484 T AT 90303484T AT 90303484 T AT90303484 T AT 90303484T AT E123306 T1 ATE123306 T1 AT E123306T1
- Authority
- AT
- Austria
- Prior art keywords
- ascorbic acid
- alpha
- glycosyl
- preparation
- saccharide
- Prior art date
Links
- 239000002211 L-ascorbic acid Substances 0.000 title abstract 6
- 229960005070 ascorbic acid Drugs 0.000 title abstract 6
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 abstract 4
- 235000000069 L-ascorbic acid Nutrition 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 239000002250 absorbent Substances 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- -1 alpha -glucosyl saccharide Chemical class 0.000 abstract 1
- 239000003963 antioxidant agent Substances 0.000 abstract 1
- 230000003078 antioxidant effect Effects 0.000 abstract 1
- 235000006708 antioxidants Nutrition 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000002537 cosmetic Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000001603 reducing effect Effects 0.000 abstract 1
- 239000003381 stabilizer Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/82—Acid flavourants
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/16—Preparation of compounds containing saccharide radicals produced by the action of an alpha-1, 6-glucosidase, e.g. amylose, debranched amylopectin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/58—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound through only acyclic carbon atoms to a non-saccharide heterocyclic ring, e.g. bleomycin, phleomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/522—Antioxidants; Radical scavengers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Polymers & Plastics (AREA)
- Nutrition Science (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Mycology (AREA)
- Cosmetics (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12707289 | 1989-05-19 | ||
JP1274518A JP2926412B2 (ja) | 1989-05-19 | 1989-10-20 | α―グリコシル―L―アスコルビン酸とその製造方法並びに用途 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE123306T1 true ATE123306T1 (de) | 1995-06-15 |
Family
ID=26463107
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT90303484T ATE123306T1 (de) | 1989-05-19 | 1990-03-30 | Alpha-glycosyl-l-ascorbinsäure und ihre herstellung und verwendungen. |
Country Status (7)
Country | Link |
---|---|
US (3) | US5137723A (de) |
EP (1) | EP0398484B1 (de) |
AT (1) | ATE123306T1 (de) |
DE (1) | DE69019779T2 (de) |
DK (1) | DK0398484T3 (de) |
ES (1) | ES2075148T3 (de) |
HK (1) | HK111196A (de) |
Families Citing this family (82)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE123306T1 (de) * | 1989-05-19 | 1995-06-15 | Hayashibara Biochem Lab | Alpha-glycosyl-l-ascorbinsäure und ihre herstellung und verwendungen. |
JP2832848B2 (ja) * | 1989-10-21 | 1998-12-09 | 株式会社林原生物化学研究所 | 結晶2―O―α―D―グルコピラノシル―L―アスコルビン酸とその製造方法並びに用途 |
JP2926432B2 (ja) * | 1990-06-11 | 1999-07-28 | 株式会社林原生物化学研究所 | 養毛剤 |
TW197375B (de) * | 1990-11-19 | 1993-01-01 | Hayashibara Biochem Lab | |
US5215767A (en) * | 1991-03-16 | 1993-06-01 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Additive for aquaculture feed for fish and shellfish and aquaculture feed for fish and shellfish which contains same |
US5272136A (en) * | 1991-10-12 | 1993-12-21 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | 5-0-α-D-Glucopyranosyl-L-ascorbic acid, and its preparation and uses |
JP3072535B2 (ja) * | 1991-10-21 | 2000-07-31 | 株式会社林原生物化学研究所 | 5−O−α−D−グルコピラノシル−L−アスコルビン酸とその製造方法並びに用途 |
JP3134235B2 (ja) * | 1991-10-23 | 2001-02-13 | 株式会社林原生物化学研究所 | 2−O−α−D−グルコピラノシル−L−アスコルビン酸高含有物の製造方法 |
US5314678A (en) * | 1992-01-28 | 1994-05-24 | Mallinckrodt Medical, Inc. | Sodium iodide 131 I capsules |
JP3134236B2 (ja) * | 1992-01-30 | 2001-02-13 | 株式会社林原生物化学研究所 | α−グリコシル−L−アスコルビン酸高含有物の製造方法とその製造のための分離システム |
EP0561585B1 (de) * | 1992-03-17 | 1997-05-28 | Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo | Verfahren zur Herstellung von pulverförmigem kristallinem Maltitol |
EP0649648B1 (de) * | 1993-10-26 | 2001-09-19 | Shiseido Company Limited | Hautbleichende Mittel enthaltend Glykoside |
US5455035A (en) * | 1994-01-13 | 1995-10-03 | Elizabeth Arden Company, Division Of Conopco, Inc. | Clear two-phase cosmetic composition |
US5935584A (en) * | 1994-01-13 | 1999-08-10 | Elizabeth Arden Company | Vitamin C delivery system |
GB9403855D0 (en) * | 1994-03-01 | 1994-04-20 | Scotia Holdings Plc | Fatty acid derivatives |
US5573398A (en) * | 1994-06-10 | 1996-11-12 | Towle; Lawrence E. | Dental hygiene device and cleaning solution |
US5837222A (en) * | 1994-06-10 | 1998-11-17 | Cloonan; Richard A. | Liquid dental cleaning solution |
US6224376B1 (en) | 1994-06-10 | 2001-05-01 | Richard A. Cloonan | Dental cleaning liquid and gel |
FR2733148B1 (fr) * | 1995-04-20 | 1997-05-30 | Oreal | Composition pour lutter contre les taches et/ou le vieillissement de la peau, ses utilisations |
US5853741A (en) * | 1996-06-28 | 1998-12-29 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Vitamin C delivery system |
JP4981198B2 (ja) | 1998-03-31 | 2012-07-18 | 格 山本 | グリコシル−l−アスコルビン酸のアシル化誘導体 |
US6656920B2 (en) | 2000-04-04 | 2003-12-02 | Amarillo Biosciences, Inc. | Composition and method for promoting oral health |
FR2807322B1 (fr) | 2000-04-10 | 2004-02-20 | Oreal | Composition, notamment cosmetique, comprenant de l'acide ascorbique en association avec un derive d'acide ascorbique |
FR2807320B1 (fr) * | 2000-04-10 | 2002-05-24 | Oreal | Utilisation de derives d'acide ascorbique pour augmenter la synthese des creramides epidermiques |
JP2002326924A (ja) * | 2001-05-07 | 2002-11-15 | Hayashibara Biochem Lab Inc | 洗顔料 |
KR100440191B1 (ko) * | 2001-08-23 | 2004-07-12 | 박관화 | 항산화 효과 및 높은 안정성을 갖는 아스코르브산 유도체및 그것의 제조방법 |
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JP4043312B2 (ja) * | 2002-08-06 | 2008-02-06 | 株式会社林原生物化学研究所 | 2−O−α−D−グルコピラノシル−L−アスコルビン酸の製造方法 |
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EP2129231A4 (de) * | 2007-02-01 | 2015-01-21 | Nat Res Council Canada | Formulierungen lipophiler bioaktiver moleküle |
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EP3184552B1 (de) | 2008-09-02 | 2020-08-12 | Tautona Group LP | Stränge aus hyaluronsäure, verfahren zur herstellung davon und verwendungen davon |
JP4885245B2 (ja) * | 2009-01-15 | 2012-02-29 | 日本航空電子工業株式会社 | Rdコンバータ及び角度検出装置 |
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WO2011030816A1 (ja) * | 2009-09-14 | 2011-03-17 | 国立大学法人北海道大学 | 抗植物ウイルス剤 |
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AU2012298791B2 (en) | 2011-08-25 | 2015-09-24 | Allergan Industrie, Sas | Dermal filler compositions including antioxidants |
US20130244943A1 (en) | 2011-09-06 | 2013-09-19 | Allergan, Inc. | Hyaluronic acid-collagen matrices for dermal filling and volumizing applications |
US9662422B2 (en) | 2011-09-06 | 2017-05-30 | Allergan, Inc. | Crosslinked hyaluronic acid-collagen gels for improving tissue graft viability and soft tissue augmentation |
WO2014103475A1 (ja) | 2012-12-27 | 2014-07-03 | 株式会社林原 | アンチエイジング用皮膚外用組成物及びその製造方法 |
CN103755756B (zh) * | 2014-02-11 | 2015-07-08 | 江苏诚信药业有限公司 | 一种制备维生素c葡萄糖苷的工艺系统及其工艺方法 |
US10722444B2 (en) | 2014-09-30 | 2020-07-28 | Allergan Industrie, Sas | Stable hydrogel compositions including additives |
WO2016128783A1 (en) | 2015-02-09 | 2016-08-18 | Allergan Industrie Sas | Compositions and methods for improving skin appearance |
US20210402064A1 (en) | 2018-05-09 | 2021-12-30 | The Johns Hopkins University | Nanofiber-hydrogel composites for enhanced soft tissue replacement and regeneration |
EP3790602A1 (de) | 2018-05-09 | 2021-03-17 | The Johns Hopkins University | Nanofaserhydrogel-verbundstoffe für zell- und gewebefreisetzung |
EP4129283A4 (de) | 2020-03-31 | 2024-04-24 | Natural Medicine Institute of Zhejiang Yangshengtang Co., Ltd. | Pharmazeutische kombination und verwendung davon |
WO2021197334A1 (zh) | 2020-03-31 | 2021-10-07 | 浙江养生堂天然药物研究所有限公司 | 药物组合及其用途 |
WO2021213455A1 (zh) | 2020-04-23 | 2021-10-28 | 浙江养生堂天然药物研究所有限公司 | 药物组合及其用途 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DD33788A (de) * | ||||
JPS4838158B1 (de) * | 1970-10-05 | 1973-11-15 | ||
US4065557A (en) * | 1974-03-21 | 1977-12-27 | Bayer Aktiengesellschaft | Amino sugars and their use in improving the meat:fat ratio in animals |
DD141832A1 (de) * | 1978-10-31 | 1980-05-21 | Joachim Schmidt | Verfahren und vorrichtung zur herstellung von l-ascorbinsaeure |
EP0112332B1 (de) * | 1982-06-30 | 1993-06-16 | The General Hospital Corporation | Vitamin d glycoside |
JPS60130582A (ja) * | 1983-12-19 | 1985-07-12 | Takeda Chem Ind Ltd | 食品用酸化防止剤,アスコルビン酸誘導体およびその製造法 |
US4822816A (en) * | 1987-04-10 | 1989-04-18 | Oxycal Laboratories, Inc. | Compositions and methods for administering vitamin C |
ATE123306T1 (de) * | 1989-05-19 | 1995-06-15 | Hayashibara Biochem Lab | Alpha-glycosyl-l-ascorbinsäure und ihre herstellung und verwendungen. |
JP2832848B2 (ja) * | 1989-10-21 | 1998-12-09 | 株式会社林原生物化学研究所 | 結晶2―O―α―D―グルコピラノシル―L―アスコルビン酸とその製造方法並びに用途 |
-
1990
- 1990-03-30 AT AT90303484T patent/ATE123306T1/de not_active IP Right Cessation
- 1990-03-30 DE DE69019779T patent/DE69019779T2/de not_active Expired - Lifetime
- 1990-03-30 US US07/501,899 patent/US5137723A/en not_active Expired - Lifetime
- 1990-03-30 EP EP90303484A patent/EP0398484B1/de not_active Expired - Lifetime
- 1990-03-30 ES ES90303484T patent/ES2075148T3/es not_active Expired - Lifetime
- 1990-03-30 DK DK90303484.1T patent/DK0398484T3/da active
-
1991
- 1991-12-11 US US07/805,169 patent/US5616611A/en not_active Expired - Lifetime
-
1996
- 1996-06-27 HK HK111196A patent/HK111196A/xx not_active IP Right Cessation
-
1997
- 1997-01-14 US US08/783,099 patent/US5767149A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DK0398484T3 (da) | 1995-07-24 |
DE69019779T2 (de) | 1995-12-14 |
US5137723A (en) | 1992-08-11 |
EP0398484A3 (de) | 1991-02-27 |
EP0398484A2 (de) | 1990-11-22 |
US5616611A (en) | 1997-04-01 |
US5767149A (en) | 1998-06-16 |
EP0398484B1 (de) | 1995-05-31 |
HK111196A (en) | 1996-07-05 |
ES2075148T3 (es) | 1995-10-01 |
DE69019779D1 (de) | 1995-07-06 |
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UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |