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ATE109658T1 - INJECTABLE MEDICATION. - Google Patents

INJECTABLE MEDICATION.

Info

Publication number
ATE109658T1
ATE109658T1 AT91910762T AT91910762T ATE109658T1 AT E109658 T1 ATE109658 T1 AT E109658T1 AT 91910762 T AT91910762 T AT 91910762T AT 91910762 T AT91910762 T AT 91910762T AT E109658 T1 ATE109658 T1 AT E109658T1
Authority
AT
Austria
Prior art keywords
microspheres
formulations
contain
dia
microns
Prior art date
Application number
AT91910762T
Other languages
German (de)
Inventor
Garza Flores Josue
Soto Laura P Laiseca
Pichardo Jose Guillen
Uribe Juan Angeles
Original Assignee
Aplicaciones Farmaceuticas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aplicaciones Farmaceuticas filed Critical Aplicaciones Farmaceuticas
Application granted granted Critical
Publication of ATE109658T1 publication Critical patent/ATE109658T1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

New non-porous solid microspheres have a dia. of 1-300 microns and consist of at least one injectable drug. More Specifically the dia. is 5-100 microns. The microspheres have a m.pt. above 60 deg. C and may contain additives. The microspheres are formulated as suspensions in aq. media (esp. saline) or oils in which they are insoluble. Contraceptive formulations contain progesterone microspheres and 17beta-oestradiol microspheres. Post partum (sic) contraceptive formulations, and formulations for prevention of osteoporosis in menopausal women, contain progesterone microspheres. Analgesic formulations contain naproxen or indomethacin. The microspheres are produced by melting the drug in an inert gas atmos., spraying the melt under inert gas pressure, cooling the spray to solidify the droplets, and screening the resulting microspheres.
AT91910762T 1990-06-14 1991-06-12 INJECTABLE MEDICATION. ATE109658T1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9007416A FR2663223B1 (en) 1990-06-14 1990-06-14 PARENTERAL GALENIC FORM.

Publications (1)

Publication Number Publication Date
ATE109658T1 true ATE109658T1 (en) 1994-08-15

Family

ID=9397598

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91910762T ATE109658T1 (en) 1990-06-14 1991-06-12 INJECTABLE MEDICATION.

Country Status (30)

Country Link
US (3) US5360616A (en)
EP (1) EP0533739B1 (en)
JP (1) JP2675675B2 (en)
KR (1) KR0157439B1 (en)
CN (1) CN1057442C (en)
AT (1) ATE109658T1 (en)
AU (1) AU661275B2 (en)
BG (1) BG61179B1 (en)
BR (1) BR9106545A (en)
CA (1) CA2085344C (en)
CZ (1) CZ286793B6 (en)
DE (1) DE69103419T2 (en)
DK (1) DK0533739T3 (en)
ES (1) ES2059142T3 (en)
FI (1) FI107698B (en)
FR (1) FR2663223B1 (en)
HU (1) HUT68709A (en)
IE (1) IE62679B1 (en)
IL (1) IL98459A (en)
NO (1) NO302998B1 (en)
NZ (1) NZ238542A (en)
PL (1) PL167234B1 (en)
PT (1) PT97975B (en)
RU (1) RU2104692C1 (en)
SK (1) SK280564B6 (en)
TN (1) TNSN91048A1 (en)
UA (1) UA27043C2 (en)
UY (1) UY23240A1 (en)
WO (1) WO1991019484A1 (en)
ZA (1) ZA914550B (en)

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FR2663224B1 (en) * 1990-06-14 1995-01-20 Applicationes Farmaceuticas Sa PARENTERAL GALENIC FORM.
NZ260408A (en) 1993-05-10 1996-05-28 Euro Celtique Sa Controlled release preparation comprising tramadol
GB9313642D0 (en) * 1993-07-01 1993-08-18 Glaxo Group Ltd Method and apparatus for the formation of particles
US5965161A (en) 1994-11-04 1999-10-12 Euro-Celtique, S.A. Extruded multi-particulates
FR2732621B1 (en) * 1995-04-10 1997-06-06 Rhone Poulenc Chimie PEARLS OF A PRODUCT HAVING THE SURFUSION PHENOMENON AND THEIR PRODUCTION METHOD
US5904935A (en) * 1995-06-07 1999-05-18 Alza Corporation Peptide/protein suspending formulations
US6028057A (en) * 1998-02-19 2000-02-22 Thorn Bioscience, Llc Regulation of estrus and ovulation in gilts
US6287693B1 (en) * 1998-02-25 2001-09-11 John Claude Savoir Stable shaped particles of crystalline organic compounds
JP2002504505A (en) * 1998-02-25 2002-02-12 アボット・ラボラトリーズ Butorphanol sustained release formulation
AU6852900A (en) * 1999-08-20 2001-03-19 Norton Healthcare Ltd Method to produce powders for pulmonary or nasal administration
US20070254008A1 (en) * 2001-07-13 2007-11-01 Flow Focusing, Inc. Antibiotic formulation and method of treatment
US20030055075A1 (en) * 2001-07-13 2003-03-20 Rubsamen Reid M. Programmable controlled release injectable opioid formulation
US20070254009A1 (en) * 2001-07-13 2007-11-01 Flow Focusing, Inc. Antibiotic/bone morphogenic protein formulation and method of treatment
GB0117696D0 (en) * 2001-07-20 2001-09-12 Bradford Particle Design Plc Particle information
AU2004246870B2 (en) * 2003-06-13 2009-07-23 Skendi Finance Ltd Slow release estradiol-progesterone formulation for contraception and hormone replacement therapy
US20050032811A1 (en) 2003-08-06 2005-02-10 Josiah Brown Methods for administering aripiprazole
HUE025239T2 (en) 2003-09-03 2016-03-29 Miscon Trading S A Methods for the treatment of endometriosis
US7205281B2 (en) 2003-10-03 2007-04-17 Thorn Bioscience, Llc Process for the synchronization of ovulation for timed breeding without heat detection
SI1675573T2 (en) 2003-10-23 2012-08-31 Otsuka Pharma Co Ltd Controlled release sterile injectable aripiprazole formulation and method
US7413690B1 (en) 2003-10-29 2008-08-19 The University Of Mississippi Process and apparatus for producing spherical pellets using molten solid matrices
US7491263B2 (en) 2004-04-05 2009-02-17 Technology Innovation, Llc Storage assembly
US7392635B2 (en) * 2005-06-09 2008-07-01 Tipper Tie, Inc. Breech loader packaging systems and associated breech loading chutes and methods
US20070197435A1 (en) * 2006-02-17 2007-08-23 Webel Stephen K Process for the synchronization of ovulation for timed breeding without heat detection
CA2667890C (en) 2006-10-31 2015-01-27 Surmodics Pharmaceuticals, Inc. Spheronized polymer particles
ES2661037T3 (en) 2007-07-31 2018-03-27 Otsuka Pharmaceutical Co., Ltd. Procedures for producing a suspension of aripiprazole and a lyophilized formulation
CA2721509A1 (en) * 2008-04-14 2009-10-22 Posi Visionary Solutions Llp Method and pharmaceutical composition for obtaining the plasmatic progesterone levels required for different therapeutic indications
BRPI1014362A2 (en) 2009-04-23 2016-04-05 Pennatek Llc method and composition to synchronize insemination time
UY33103A (en) 2009-12-15 2011-07-29 Techsphere S A De C V PARENTERAL PHARMACEUTICAL FORMULATION IN SUSPENSION, SUSTAINED RELEASE, IN LOW AND ULTRA LOW DOSE, IN HORMONAL THERAPY IN THE CLIMATE SYNDROME
CN104994865A (en) 2012-11-28 2015-10-21 杰碧斯联合动物健康第二有限责任公司 Method for synchronizing time of insemination in gilts
WO2017105512A1 (en) 2015-12-18 2017-06-22 Proinvet Innovations S.A. Formulations and methods for controlling the reproductive cycle and ovulation
AU2017223595B2 (en) * 2016-02-24 2022-11-24 Eastern Virginia Medical School An improved formulation of long-acting levonorgestrel butanoate injectable depot suspension
CN106063783B (en) * 2016-06-16 2019-03-12 浙江爱生药业有限公司 A kind of progesterone slow-releasing microcapsule preparation and preparation method thereof
US11376220B2 (en) 2017-06-30 2022-07-05 Therio, LLC Single-injection methods and formulations to induce and control multiple ovarian follicles in bovine, caprine, ovine, camelid and other female animals
CN115212170B (en) * 2021-04-19 2024-01-26 中国人民解放军军事科学院军事医学研究院 A dense and round drug spherical microcrystal, its preparation method and its application
CN116036022A (en) * 2021-12-24 2023-05-02 中国人民解放军军事科学院军事医学研究院 Preparation and application of novel drug microsphere containing carrier material

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BE670438A (en) * 1964-10-06 1966-01-31
US3773919A (en) * 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US3928566A (en) * 1970-08-14 1975-12-23 Du Pont Lyophilized biological products
JPS5017525A (en) * 1973-06-14 1975-02-24
CA1077842A (en) * 1975-10-09 1980-05-20 Minnesota Mining And Manufacturing Company Albumin medicament carrier system
US4244949A (en) * 1978-04-06 1981-01-13 The Population Council, Inc. Manufacture of long term contraceptive implant
US4349580A (en) * 1978-08-18 1982-09-14 Queen's University At Kingston Process and solution for preserving green plant tissues
US4384975A (en) * 1980-06-13 1983-05-24 Sandoz, Inc. Process for preparation of microspheres
US4349530A (en) * 1980-12-11 1982-09-14 The Ohio State University Implants, microbeads, microcapsules, preparation thereof and method of administering a biologically-active substance to an animal
US4963367A (en) * 1984-04-27 1990-10-16 Medaphore, Inc. Drug delivery compositions and methods
IL79407A (en) * 1985-08-01 1991-03-10 Theragenics Corp System and method for delivering insoluble material into a living body
DE3777721D1 (en) * 1986-08-11 1992-04-30 American Cyanamid Co COMPOSITIONS FOR PARENTERAL ADMINISTRATION AND THEIR USE.
US4837381A (en) * 1986-08-11 1989-06-06 American Cyanamid Company Compositions for parenteral administration and their use
US4748024A (en) * 1987-04-06 1988-05-31 Endocon, Inc. Flash flow fused medicinal implants
EP0357644B1 (en) * 1987-04-06 1994-08-17 Aberlyn Capital Management Limited Partnership Flash flow fused medicinal implants
US4892734A (en) * 1987-04-06 1990-01-09 Endocon, Inc. Dispensing paste for forming medicinal pellets
DE69005800T2 (en) * 1989-05-01 1994-05-19 Alkermes Inc METHOD FOR PRODUCING SMALL PARTICLES OF BIOLOGICALLY ACTIVE MOLECULES.
US5019400A (en) * 1989-05-01 1991-05-28 Enzytech, Inc. Very low temperature casting of controlled release microspheres

Also Published As

Publication number Publication date
DE69103419D1 (en) 1994-09-15
US5633014A (en) 1997-05-27
NZ238542A (en) 1993-09-27
US5512303A (en) 1996-04-30
EP0533739B1 (en) 1994-08-10
JP2675675B2 (en) 1997-11-12
FR2663223A1 (en) 1991-12-20
IL98459A0 (en) 1992-07-15
FI107698B (en) 2001-09-28
NO302998B1 (en) 1998-05-18
UY23240A1 (en) 1991-07-12
DK0533739T3 (en) 1995-01-09
FI925661L (en) 1992-12-11
AU661275B2 (en) 1995-07-20
BR9106545A (en) 1993-06-01
NO924792D0 (en) 1992-12-11
PL167234B1 (en) 1995-08-31
BG97166A (en) 1993-12-24
UA27043C2 (en) 2000-02-28
TNSN91048A1 (en) 1992-10-25
ZA914550B (en) 1992-03-25
CS181691A3 (en) 1992-06-17
IL98459A (en) 1996-09-12
HU9203958D0 (en) 1993-03-29
US5360616A (en) 1994-11-01
NO924792L (en) 1993-02-03
RU2104692C1 (en) 1998-02-20
WO1991019484A1 (en) 1991-12-26
IE912017A1 (en) 1991-12-18
CN1057961A (en) 1992-01-22
KR0157439B1 (en) 1998-11-16
PT97975B (en) 1998-11-30
PT97975A (en) 1992-04-30
PL290677A1 (en) 1992-11-30
HUT68709A (en) 1995-07-28
SK280564B6 (en) 2000-03-13
CN1057442C (en) 2000-10-18
EP0533739A1 (en) 1993-03-31
BG61179B1 (en) 1997-02-28
IE62679B1 (en) 1995-02-22
FI925661A0 (en) 1992-12-11
CZ286793B6 (en) 2000-07-12
FR2663223B1 (en) 1994-12-02
DE69103419T2 (en) 1995-03-30
AU8084791A (en) 1992-01-07
CA2085344C (en) 1998-06-30
ES2059142T3 (en) 1994-11-01
JPH05507694A (en) 1993-11-04
CA2085344A1 (en) 1991-12-15

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee