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AT45443B - Process for the preparation of hexamethylene amine triguayakol. - Google Patents

Process for the preparation of hexamethylene amine triguayakol.

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Publication number
AT45443B
AT45443B AT45443DA AT45443B AT 45443 B AT45443 B AT 45443B AT 45443D A AT45443D A AT 45443DA AT 45443 B AT45443 B AT 45443B
Authority
AT
Austria
Prior art keywords
triguayakol
preparation
hexamethylene amine
hexamethylene
amine
Prior art date
Application number
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German (de)
Original Assignee
Hoffmann La Roche & Co Fa F
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Publication date
Application filed by Hoffmann La Roche & Co Fa F filed Critical Hoffmann La Roche & Co Fa F
Application granted granted Critical
Publication of AT45443B publication Critical patent/AT45443B/en

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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Description

  

   <Desc/Clms Page number 1> 
 



  Verfahren zur Darstellung von Hexamethylenamintriguajakol. 



   Durch die Untersuchungen von Moschatos   und Tollens   (Liebig's Annalen der Chemie, Band   272,   S. 280) wurde bekannt, dass das Hexamethylen-(tetra)-amin sich   mit Phenolen   zu   wohlcharakterisiertcn Körpern   zu verbinden vermag. Diese Additionsprodukte, welche man in neuester Zeit   a) s Motekülverbindungen   auffasst, stellen eine sehr handliche Form, besonders der niedrig schmelzenden Phenole dar, da diese sich sehr leicht, z. B. durch Destillation im Wasserdampfstrome, aus ihnen regenerieren lassen. In der oben genannten Arbeit berichten Moschatos und Tollens auch, dass es nicht gelinge, derartige Produkte aus Phenolen von komplizierterer Konstitution, z.   B.   aus Guajakol, herzustellen. 



   Im Gegensatz zu diesen Angaben gelingt es indes, reines, kristallisiertes Guajakol mit dem Hexamothylenamin zu einem Produkt zu vereinigen, das seiner Zusammensetzung nach als Hexamethylenamintriguajakol bezeichnet werden muss. 



     Beispiel I   : Zu einer warmen Lösung von 6 kg Hexamethylenamin in 8 l Wasser fügt man 4 kg   kristallisiertes Guajuko)   und erwärmt, bis eine klare Lösung entstanden ist. 
 EMI1.1 
 methylenamintriguajakol zeigt ähnlich wie Hexamethylenamintriphenol keinen scharfen Schmelzpunkt. Es beginnt über 80  C zu erweichen und schmilzt bei etwa   95  zu einor   trüben Flüssigkeit. Es ist in kaltem Alkohol und in   Chloroform   leicht löslich. 



   Beim Übergiessen mit Wasser scheiden sich Öltropfen von Guajakol ab ; während aber reines Guajakol sich erst in GO bis 70 Teilen Wasser löst, gibt das Hexamethylenamintriguajakol bereits mit 25 Teilen Wasser eine klare Lösung. Durch Destillation im Wasserdampfstrome gelingt es, aus 100 g der Verbindung 70   9   reines kristallisiertes Guajakol zu regenerieren. 



   Bei s pie 1 Il : An Stelle des kristallisierten Hexamethylenamins im Beispiel I verwendet man direkt die Lösung, welche erhalten wird durch Versetzen einer 40prozentigen Formaldehydlösung mit Ammoniak und verfährt im übrigen nach Beispiel 1. 



   Beispiel III : Man fügt zu einer 40prozentigen   Formaldehydlösung   eine kon- 
 EMI1.2 
 

**WARNUNG** Ende DESC Feld kannt Anfang CLMS uberlappen**.



   <Desc / Clms Page number 1>
 



  Process for the preparation of hexamethylene amine triguayakol.



   Through the investigations of Moschatos and Tollens (Liebig's Annalen der Chemie, Volume 272, p. 280) it became known that hexamethylene (tetra) amine can combine with phenols to form well-characterized bodies. These addition products, which have recently been understood as a) s Motekülverbindungen, represent a very handy form, especially of the low-melting phenols, as these are very easy, e.g. B. by distillation in a stream of steam to regenerate from them. In the above-mentioned work, Moschatos and Tollens also report that it is not possible to obtain such products from phenols of more complex constitution, e.g. B. from guaiacol.



   In contrast to this information, however, it is possible to combine pure, crystallized guaiacol with hexamethylene amine to form a product which, according to its composition, has to be called hexamethylene amine triguayakol.



     Example I: 4 kg of crystallized guajuko are added to a warm solution of 6 kg of hexamethylene amine in 8 l of water and the mixture is heated until a clear solution has formed.
 EMI1.1
 Like hexamethyleneamine triphenol, methylenaminetriguajakol does not have a sharp melting point. It begins to soften above 80 C and melts at around 95 to a cloudy liquid. It is easily soluble in cold alcohol and in chloroform.



   When water is poured over it, oil droplets separate from guaiacol; But while pure guaiacol only dissolves in 70 parts of water, hexamethylene amine triguayakol gives a clear solution with 25 parts of water. Distillation in a stream of steam makes it possible to regenerate pure crystallized guaiacol from 100 g of compound 70 9.



   In the case of pie 1 II: Instead of the crystallized hexamethylene amine in Example I, the solution obtained by adding ammonia to a 40 percent formaldehyde solution is used directly, and the rest of the procedure is as in Example 1.



   Example III: A 40 percent formaldehyde solution is added
 EMI1.2
 

** WARNING ** End of DESC field may overlap beginning of CLMS **.

 

Claims (1)

Das Hexamethylenamintriguajakol ist ein neuer, für die Guajakoltherapie wertvoller Körper. EMI1.3 **WARNUNG** Ende CLMS Feld Kannt Anfang DESC uberlappen**. Hexamethyleneamine triguajakol is a new body that is valuable for guaiacol therapy. EMI1.3 ** WARNING ** End of CLMS field may overlap beginning of DESC **.
AT45443D 1908-10-05 1909-08-28 Process for the preparation of hexamethylene amine triguayakol. AT45443B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE45443X 1908-10-05

Publications (1)

Publication Number Publication Date
AT45443B true AT45443B (en) 1910-12-10

Family

ID=5624997

Family Applications (1)

Application Number Title Priority Date Filing Date
AT45443D AT45443B (en) 1908-10-05 1909-08-28 Process for the preparation of hexamethylene amine triguayakol.

Country Status (1)

Country Link
AT (1) AT45443B (en)

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