[go: up one dir, main page]

AT381941B - Verfahren zur herstellung eines neuen carbapenem-antibiotikums - Google Patents

Verfahren zur herstellung eines neuen carbapenem-antibiotikums

Info

Publication number
AT381941B
AT381941B AT0226583A AT226583A AT381941B AT 381941 B AT381941 B AT 381941B AT 0226583 A AT0226583 A AT 0226583A AT 226583 A AT226583 A AT 226583A AT 381941 B AT381941 B AT 381941B
Authority
AT
Austria
Prior art keywords
producing
carbapenem antibiotic
new carbapenem
new
antibiotic
Prior art date
Application number
AT0226583A
Other languages
English (en)
Other versions
ATA226583A (de
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Priority to AT309385A priority Critical patent/AT381942B/de
Publication of ATA226583A publication Critical patent/ATA226583A/de
Application granted granted Critical
Publication of AT381941B publication Critical patent/AT381941B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AT0226583A 1982-06-18 1983-06-20 Verfahren zur herstellung eines neuen carbapenem-antibiotikums AT381941B (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT309385A AT381942B (de) 1983-06-07 1985-10-25 Verfahren zur herstellung neuer carbapenem-derivate

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38965282A 1982-06-18 1982-06-18
US06/499,690 US4536335A (en) 1982-06-18 1983-06-07 Carbapenem antibiotics

Publications (2)

Publication Number Publication Date
ATA226583A ATA226583A (de) 1986-05-15
AT381941B true AT381941B (de) 1986-12-10

Family

ID=27012789

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0226583A AT381941B (de) 1982-06-18 1983-06-20 Verfahren zur herstellung eines neuen carbapenem-antibiotikums

Country Status (23)

Country Link
US (1) US4536335A (de)
KR (1) KR890000192B1 (de)
AT (1) AT381941B (de)
AU (1) AU567294B2 (de)
CA (1) CA1273009A (de)
CH (1) CH658657A5 (de)
DE (1) DE3321864A1 (de)
DK (1) DK276683A (de)
ES (1) ES8407489A1 (de)
FI (1) FI77036C (de)
FR (1) FR2528847B1 (de)
GB (1) GB2122196B (de)
GR (1) GR78375B (de)
HU (1) HU191052B (de)
IE (1) IE55432B1 (de)
IL (1) IL69002A (de)
IT (1) IT1206324B (de)
LU (1) LU84864A1 (de)
MY (1) MY8800124A (de)
NL (1) NL8302183A (de)
OA (1) OA07468A (de)
PT (1) PT76887B (de)
SE (1) SE460791B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1198440A (en) * 1982-04-08 1985-12-24 Choung U. Kim Carbapenem antibiotics
US4683301A (en) * 1982-04-08 1987-07-28 Bristol-Myers Company Carbapenem antibiotics
US4552696A (en) * 1982-04-09 1985-11-12 Bristol-Myers Company Carbapenem antibiotics
US4640799A (en) * 1982-06-18 1987-02-03 Bristol-Myers Company Carbapenem antibiotics
US4746736A (en) * 1982-09-28 1988-05-24 Bristol-Myers Company Carbapenem antibiotics
DK140584A (da) * 1983-03-08 1984-09-09 Bristol Myers Co Fremgangsmaade til fremstilling af carbapenemderivater
GB8416651D0 (en) * 1984-06-29 1984-08-01 Erba Farmitalia Penem derivatives
IE851586L (en) * 1984-07-02 1986-01-02 Interchem Internat S A I methylcarbapenems having a 2-quaternary¹heteroarylalkylthio substituent
US4757066A (en) * 1984-10-15 1988-07-12 Sankyo Company Limited Composition containing a penem or carbapenem antibiotic and the use of the same
US4729993A (en) * 1984-12-13 1988-03-08 Merck & Co., Inc. Carbapenems and 1-methylcarbapenems having an externally alkylated mono- or bicyclic 2-quaternary heteroarylalkyl substituent
US4680292A (en) * 1984-12-13 1987-07-14 Merck & Co., Inc. Carbapenems and 1-methylcarbapenems having a 2-heteroaryliumaliphatic substituent
US4725594A (en) * 1984-12-13 1988-02-16 Merck & Co., Inc. Carbapenems having an internally or externally alkylated mono- or bicyclic 2-quaternary heteroarylalxyl heteromethyl substituent
GB8509181D0 (en) * 1985-04-10 1985-05-15 Erba Farmitalia Penem derivatives
US4788282A (en) * 1985-06-07 1988-11-29 Bristol-Myers Company Deprotection of allylic esters and ethers
US4665169A (en) * 1985-09-11 1987-05-12 Bristol-Myers Company Carbapenem antibiotics
US4880922A (en) * 1985-11-22 1989-11-14 Bristol-Myers Company Carbapenems with quaternized heterothioalkylthio substitution at position 2
CA1272719A (en) * 1986-03-06 1990-08-14 Pierre Dextraze Carbapenem antibiotics
US4894450A (en) * 1987-05-11 1990-01-16 Merck & Co., Inc. Process for 2-(aminoalkylthio) carbapenems
US5362723A (en) * 1991-07-29 1994-11-08 Merck & Co., Inc. 2-(heterocyclylheteroaryliumalkyl) phenyl carbapenem antibacterial agents
WO2004089954A1 (ja) * 2003-04-08 2004-10-21 Sumitomo Pharmaceuticals Co., Ltd. 新規なカルバペネム化合物
EP2623821A1 (de) 2012-02-06 2013-08-07 Siemens Aktiengesellschaft Getriebegehäuse, Getriebeeinheit mit einem solchen Getriebegehäuse und Getriebemotor mit einer solchen Getriebeeinheit
WO2018175670A1 (en) 2017-03-22 2018-09-27 The Research Foundation For The State University Of New York Matrix metalloproteinase-9 hemopexin domain inhibitors and methods of treatment using same

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235920A (en) * 1975-11-21 1980-11-25 Merck & Co., Inc. N-Alkylated derivatives of thienamycin
FR2332014A1 (fr) * 1975-11-21 1977-06-17 Merck & Co Inc Derives n-alcoyles de thienamycine utiles en tant qu'antibiotiques
US4226870A (en) * 1975-11-21 1980-10-07 Merck & Co., Inc. O-, N- and carboxyl derivatives of thienamycin
GB1591439A (en) * 1976-10-01 1981-06-24 Glaxo Operations Ltd 7-syn (oxyimino -acylamido) cephalosporins
US4234596A (en) * 1976-11-19 1980-11-18 Merck & Co., Inc. 3-(2-Aminoethylthio)-6-(1-hydroxyethyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
US4235917A (en) * 1977-05-05 1980-11-25 Merck & Co., Inc. N-Alkyl-N-acyl derivatives of thienamycin
AU4061378A (en) * 1977-10-19 1980-04-17 Merck & Co., Inc. 1-azabicyclo (3.2.0) hept-2-enes
AU531084B2 (en) * 1977-10-19 1983-08-11 Merck & Co., Inc. Azetidine derivatives
US4189493A (en) * 1977-12-28 1980-02-19 Merck & Co., Inc. N-heterocyclic derivatives of thienamycin
US4218463A (en) * 1977-12-28 1980-08-19 Merck & Co., Inc. 3-Substituted thio-6-amido-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
US4174316A (en) * 1978-08-14 1979-11-13 Merck & Co., Inc. 4-Iodomethylazetidin-2-one
EP0010317B1 (de) * 1978-10-24 1983-12-21 Merck & Co. Inc. 6-,1- und 2-substituierte 1-Carbapen-2-em-3-Carbonsäure, Verfahren zur Herstellung solcher Verbindungen und solche Verbindungen enthaltende pharmazeutische Zusammensetzungen
US4318912A (en) * 1979-01-02 1982-03-09 Merck & Co., Inc. 6-(1-Hydroxyethyl)-3-substituted-1-azabicyclo(3.2.0)-hept-2-en-7-one-2-carboxylic acid
EP0082133A3 (en) * 1979-04-19 1983-07-20 Merck & Co. Inc. A process for preparing intermediates useful for preparing 2-substituted-6-substituted-1-carbadethiapen-2-em-3-carboxylic acids
US4290947A (en) * 1979-04-27 1981-09-22 Merck & Co., Inc. Process for the preparation of thienamycin and intermediates
US4376774A (en) * 1979-05-29 1983-03-15 Merck & Co., Inc. Antibiotic N-heterocyclyl thienamycin
US4273709A (en) * 1979-07-23 1981-06-16 Merck & Co., Inc. Process for the preparation of thienamycin and intermediates
DE3070269D1 (en) * 1979-08-10 1985-04-18 Beecham Group Plc Beta-lactam antibiotics, their preparation, pharmaceutical compositions containing them and their preparation
US4282148A (en) * 1980-01-14 1981-08-04 Merck & Co., Inc. Synthesis of thienamycin via esters of (3SR, 4RS)-3-[(SR)-1-hydroxyethyl]-β,2-dioxo-4-azetidinebutanoic acid
US4287123A (en) * 1980-01-14 1981-09-01 Merck & Co., Inc. Synthesis of thienamycin via (3SR, 4RS)-3-((RS)-1-acyloxyethyl)-2-oxo-4-azetidineacetate
US4269772A (en) * 1980-01-14 1981-05-26 Merck & Co., Inc. Synthesis of thienamycin via trans-3-carboxymethylene-4-carboxy-5-methyl-Δ2 -isoxazoline
EP0037082B1 (de) * 1980-03-27 1985-03-20 Merck & Co. Inc. Verfahren zur Herstellung von 1-Carbapenem-Derivaten und von Zwischenprodukten via silyl-substituierter Dithioacetale
IE52147B1 (en) * 1980-03-27 1987-07-08 Merck & Co Inc 4-(3-carboxy-2-oxopropyl)-azetidin-2-ones and process for their preparation
US4309346A (en) * 1980-03-27 1982-01-05 Merck & Co., Inc. Process for the preparation of 1-carbapenems and intermediates via trithioorthoacetates
EP0038869A1 (de) * 1980-04-30 1981-11-04 Merck & Co. Inc. Verfahren zur Herstellung von 1-Carbapenemen und Zwischenprodukte für ihre Herstellung
JPS56161393A (en) * 1980-05-16 1981-12-11 Sanraku Inc Beta-lactam compound
EP0044170A1 (de) * 1980-07-11 1982-01-20 Beecham Group Plc Beta-Lactam-Antibiotika, ihre Herstellung und Verwendung
PT73791B (en) * 1980-10-17 1983-10-14 Merck & Co Inc Process for preparing 2-carbamimidoyl-6-substituted-1- -carbadethiapen-2-em-3-carboxylic acids
US4552873A (en) * 1981-08-19 1985-11-12 Sankyo Company Limited Carbapenem compounds, and compositions containing them
EP0074599A1 (de) * 1981-09-09 1983-03-23 Takeda Chemical Industries, Ltd. 5,6-Cis-Carbapenem-Derivate, ihre Herstellung und Verwendung
CA1198440A (en) * 1982-04-08 1985-12-24 Choung U. Kim Carbapenem antibiotics
US4552696A (en) * 1982-04-09 1985-11-12 Bristol-Myers Company Carbapenem antibiotics

Also Published As

Publication number Publication date
NL8302183A (nl) 1984-01-16
DK276683A (da) 1983-12-19
DE3321864A1 (de) 1983-12-22
MY8800124A (de) 1988-12-31
ES523315A0 (es) 1984-10-01
GB8316617D0 (en) 1983-07-20
OA07468A (fr) 1984-12-31
DE3321864C2 (de) 1992-03-26
US4536335A (en) 1985-08-20
IE55432B1 (en) 1990-09-12
AU1589183A (en) 1983-12-22
FI77036C (fi) 1989-01-10
GR78375B (de) 1984-09-26
LU84864A1 (fr) 1984-03-07
FR2528847A1 (fr) 1983-12-23
FI832175A0 (fi) 1983-06-15
IT8321682A0 (it) 1983-06-17
IE831431L (en) 1983-12-18
ATA226583A (de) 1986-05-15
CA1273009A (en) 1990-08-21
GB2122196A (en) 1984-01-11
PT76887B (en) 1986-04-09
IT1206324B (it) 1989-04-14
KR890000192B1 (en) 1989-03-10
FI77036B (fi) 1988-09-30
FR2528847B1 (fr) 1988-03-25
SE460791B (sv) 1989-11-20
SE8303502L (sv) 1984-02-10
KR840005145A (ko) 1984-11-03
PT76887A (en) 1983-07-01
DK276683D0 (da) 1983-06-15
FI832175L (fi) 1983-12-19
GB2122196B (en) 1986-01-15
ES8407489A1 (es) 1984-10-01
CH658657A5 (de) 1986-11-28
HU191052B (en) 1986-12-28
SE8303502D0 (sv) 1983-06-17
AU567294B2 (en) 1987-11-19
IL69002A (en) 1988-02-29

Similar Documents

Publication Publication Date Title
AT381941B (de) Verfahren zur herstellung eines neuen carbapenem-antibiotikums
AT383813B (de) Verfahren zur herstellung eines neuen aethylenter bzw. -tetrapolymeren
AT375082B (de) Verfahren zur herstellung von neuen cephalosporinen
AT372072B (de) Verfahren zur herstellung eines neuen platinisocitrat-komplexes
AT381507B (de) Verfahren zur herstellung von neuen antibiotischen verbindungen
AT382620B (de) Verfahren zur herstellung von neuen carbapenem-derivaten
AT382621B (de) Verfahren zur herstellung von neuen carbapenem-derivaten
AT386412B (de) Verfahren zur herstellung eines cephalosporins
AT377004B (de) Verfahren zur herstellung eines neuen komplexes eines polyaether-antibiotikums
AT371146B (de) Verfahren zur herstellung einer neuen antibiotischen substanz
ATA53783A (de) Verfahren zur herstellung eines neuen phosphoramidderivats
AT383126B (de) Verfahren zur herstellung von neuen carbapenem-antibiotika
ATA245286A (de) Verfahren zur herstellung neuer carbapenem-antibiotika
ATA183182A (de) Verfahren zur herstellung eines neuen thiophenderivats
ATA189186A (de) Verfahren zur herstellung eines neuen neodymhydroxynitrats
AT374343B (de) Verfahren zur herstellung eines salzlecksteines
ATA418082A (de) Verfahren zur herstellung eines neuen macrolid-antibiotikums
ATA78980A (de) Verfahren zur herstellung eines neuen polyacetylen-antibiotikums
AT358725B (de) Verfahren zur herstellung eines neuen antibiotikums
ATA189086A (de) Verfahren zur herstellung eines neuen neodymhydroxynitrats
AT378185B (de) Verfahren zur herstellung eines neuen cimetidin-monohydrats
ATA373685A (de) Verfahren zur herstellung von neuen carbapenem-derivaten
ATA34685A (de) Verfahren zur herstellung eines neuen metaboliten
ATA176885A (de) Verfahren zur herstellung eines neuen 2-aminothiazol-derivates
ATA93882A (de) Verfahren zur herstellung eines neuen 3-vinyl -cephalosporins

Legal Events

Date Code Title Description
ELJ Ceased due to non-payment of the annual fee