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AT258481B - Verfahren zur Herstellung neuer Derivate von 6-Methyl- und 1,6-Dimethylergolin - Google Patents

Verfahren zur Herstellung neuer Derivate von 6-Methyl- und 1,6-Dimethylergolin

Info

Publication number
AT258481B
AT258481B AT461263A AT461263A AT258481B AT 258481 B AT258481 B AT 258481B AT 461263 A AT461263 A AT 461263A AT 461263 A AT461263 A AT 461263A AT 258481 B AT258481 B AT 258481B
Authority
AT
Austria
Prior art keywords
dimethylergoline
methyl
preparation
new derivatives
derivatives
Prior art date
Application number
AT461263A
Other languages
English (en)
Inventor
Luigi Bernardi
Germano Bosisio
Onofrio Goffredo
Original Assignee
Farmaceutici Italia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmaceutici Italia filed Critical Farmaceutici Italia
Application granted granted Critical
Publication of AT258481B publication Critical patent/AT258481B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT461263A 1962-06-11 1963-06-07 Verfahren zur Herstellung neuer Derivate von 6-Methyl- und 1,6-Dimethylergolin AT258481B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT1167062 1962-06-11

Publications (1)

Publication Number Publication Date
AT258481B true AT258481B (de) 1967-11-27

Family

ID=11136772

Family Applications (1)

Application Number Title Priority Date Filing Date
AT461263A AT258481B (de) 1962-06-11 1963-06-07 Verfahren zur Herstellung neuer Derivate von 6-Methyl- und 1,6-Dimethylergolin

Country Status (8)

Country Link
US (1) US3228943A (de)
AT (1) AT258481B (de)
BR (1) BR6349779D0 (de)
CH (1) CH446367A (de)
DK (1) DK103780C (de)
ES (1) ES288887A1 (de)
GB (1) GB981827A (de)
SE (1) SE315904B (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3879554A (en) * 1970-03-20 1975-04-22 Farmaceutici Italia Use of 1,6-dimethyl-8-{62 -(5-bromonicotinoyloxymethyl)-10 {60 -methoxyergoline in treating cerebral and peripheral metabolic vascular disorders
NL159384B (nl) * 1971-03-13 1979-02-15 Farmaceutici Italia Werkwijze voor het bereiden van een geneesmiddel met een adrenolytische activiteit, alsmede werkwijze voor het bereiden van een ester van 1-methyl-10-methoxylumilysergol.
DE2330912C3 (de) * 1972-06-22 1979-01-11 Societa Farmaceutici Italia S.P.A., Mailand (Italien) Verfahren zur Herstellung von Bromergolinverbindungen
NL7400790A (de) * 1973-02-02 1974-08-06
US3996228A (en) * 1973-12-21 1976-12-07 Societa' Farmaceutici Italia S.P.A. Pyrimidinoaminoethyl ergoline derivatives
US3929796A (en) * 1974-08-02 1975-12-30 Lilly Co Eli Synthesis of penniclavine and elymoclavine
US4199579A (en) * 1975-03-14 1980-04-22 Siphar S. A. Carbamates of 2-haloergolines and 2-haloergolenes and process for the preparation thereof
US4054567A (en) * 1975-08-11 1977-10-18 Eli Lilly And Company 6-Methyl-8β-hydroxymethyl-8-γ-substituted-9-ergolene compounds
US4082753A (en) * 1976-02-17 1978-04-04 Eli Lilly And Company Penniclavine acetonide
YU40004B (en) * 1977-07-21 1985-06-30 Lek Tovarna Farmacevtskih Praocess for preparing n-substituted esters of 9,10-dihydrlysergic acid
IT1094965B (it) * 1978-04-05 1985-08-10 Corvi Mora E Procedimento di preparazione di derivati del lisergolo
US4382940A (en) * 1979-12-06 1983-05-10 Farmitalia Carlo Erba S.P.A. Ercoline derivatives and therapeutic compositions having CNS affecting activity
IT1173489B (it) * 1984-03-27 1987-06-24 Inverni Della Beffa Spa Procedimento di preparazione di 1-metil-10alfa-metossilumilisergolo e di suci esteri,e intermedi per la loro preparazione
IT1213206B (it) * 1984-08-07 1989-12-14 Inverni Della Beffa Spa Procedimento per la preparazione di derivati del lisergolo.
HU193782B (en) * 1985-06-21 1987-11-30 Richter Gedeon Vegyeszet Process for producing 2-halogeno-nicergoline derivatives and acid additional salts thereof
FR2584720B1 (fr) * 1985-07-11 1987-10-02 Rhone Poulenc Sante Procede de preparation de derives n-methyles de l'ergoline
FR2584719B1 (fr) * 1985-07-11 1987-10-02 Rhone Poulenc Sante Procede de preparation des derives n-methyles du lysergol et du methoxy-10a lumilysergol
FR2584721B1 (fr) * 1985-07-11 1987-10-02 Rhone Poulenc Sante Procede de preparation des derives n-methyles du dihydrolysergate de methyle ou du methoxylumilysergate de methyle
US4713385A (en) * 1985-10-01 1987-12-15 Eli Lilly And Company Alkoxy and dialkoxyalkyl esters of dihydrolysergic acid and related compounds useful as 5HT receptor antagonists
US4683237A (en) * 1985-12-20 1987-07-28 Eli Lilly And Company Fluoroalkyl esters of dihydrolysergic acid useful as 5HT2 receptor antagonists
US5211504A (en) * 1991-01-31 1993-05-18 Roger Trudel Adjustable manhole top
FR2786100B1 (fr) 1998-11-24 2002-03-01 Aventis Laboratoire Nouvelle application therapeutique de la nicergoline
FR2786101B1 (fr) 1998-11-24 2002-07-05 Aventis Laboratoire Utilisation de la nicergoline dans le traitement de la spasticite
OA12905A (en) 2002-08-19 2006-10-13 Pfizer Prod Inc Combination therapy for hyperproliferative diseases.
US20050037063A1 (en) * 2003-07-21 2005-02-17 Bolton Anthony E. Combined therapies
US20060063803A1 (en) * 2004-09-23 2006-03-23 Pfizer Inc 4-Amino substituted-2-substituted-1,2,3,4-tetrahydroquinoline compounds
GT200600381A (es) 2005-08-25 2007-03-28 Compuestos organicos
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
US8383660B2 (en) 2006-03-10 2013-02-26 Pfizer Inc. Dibenzyl amine compounds and derivatives
US7919506B2 (en) 2006-03-10 2011-04-05 Pfizer Inc. Dibenzyl amine compounds and derivatives
WO2008070496A2 (en) 2006-12-01 2008-06-12 Bristol-Myers Squibb Company N- ( (3-benzyl) -2, 2- (bis-phenyl) -propan-1-amine derivatives as cetp inhibitors for the treatment of atherosclerosis and cardiovascular diseases
RU2618628C1 (ru) 2013-04-17 2017-05-05 Пфайзер Инк. Производные N-пиперидин-3-илбензамида для лечения сердечно-сосудистых заболеваний
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
CA3125765A1 (en) 2019-01-18 2020-07-23 Astrazeneca Ab Pcsk9 inhibitors and methods of use thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3155667A (en) * 1964-11-03 Process for the preparation of
GB786138A (en) * 1955-02-04 1957-11-13 Sandoz Ltd New ergot alkaloid derivatives and process of making same

Also Published As

Publication number Publication date
ES288887A1 (es) 1963-12-16
BR6349779D0 (pt) 1973-07-03
SE315904B (de) 1969-10-13
DE1470241A1 (de) 1969-12-11
US3228943A (en) 1966-01-11
CH446367A (de) 1967-11-15
DK103780C (da) 1966-02-21
GB981827A (en) 1965-01-27

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