AT244357B - Process for obtaining pharmaceutically acceptable globulin - Google Patents
Process for obtaining pharmaceutically acceptable globulinInfo
- Publication number
- AT244357B AT244357B AT42861A AT42861A AT244357B AT 244357 B AT244357 B AT 244357B AT 42861 A AT42861 A AT 42861A AT 42861 A AT42861 A AT 42861A AT 244357 B AT244357 B AT 244357B
- Authority
- AT
- Austria
- Prior art keywords
- globulin
- pharmaceutically acceptable
- obtaining pharmaceutically
- mixed
- separated
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J1/00—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
- A23J1/08—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from eggs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Description
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Verfahren zur Gewinnung von pharmazeutisch verwendbarem Globulin
Es ist bereits bekannt, Globulin aus proteinhaltigen Lösungen durch Fällung mit Magnesiumsulfat oder Ammoniumsulfat abzuscheiden, doch ist es schwierig, mit Hilfe dieses Verfahrens ein reines pharmazeutisch verwendbares Globulin zu erhalten,. da die Reste des Füllungsmittels schwer zu entfernen sind und umständliche Reinigungsoperationen, wie z. B. eine Dialyse, erfordern. Es ist weiterhin bekannt, dass man bei der Gewinnung von Serumalbumin das Serumglobulin aus dem mit Wasser verdünnten Blutserum durch Einleiten von Kohlensäure abscheiden kann.
Es wurde nun gefunden, dass man aus dem Eiklar, insbesondere aus Hühnereiern, ein reines, pharmazeutisch verwendbares Globulin in einfacher Weise und mit geringen Herstellungskosten erhalten kann,
EMI1.1
mitvermischt und der gebildete Niederschlag abgetrennt wird, worauf aus dem Filtrat das Globulin in für die Eiweissfällung an sich bekannter Weise mittels C02 ausgeschieden und in üblicher Weise isoliert wird.
Das folgende Ausführungsbeispiel erläutert die Erfindung : Eiklar wird im Verhältnis von 1 Vol.-Teil zu 1, 5 Vol.-Teilen 0, Seiger Kochsalzlösung vermischt, dann wird zentrifugiert und das Filtrat im Ver-
EMI1.2
Kohlendioxyd eingeleitet, der Niederschlag einige Zeit absetzen gelassen und sodann das Globulin durch Ausschleudern abgetrennt, mit Wasser und schonend getrocknet, bis man das reine, pharmazeutisch verwendbare Globulin als trockenes Pulver erhält.
**WARNUNG** Ende DESC Feld kannt Anfang CLMS uberlappen**.
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Process for obtaining pharmaceutically acceptable globulin
It is already known to separate globulin from protein-containing solutions by precipitation with magnesium sulfate or ammonium sulfate, but it is difficult to obtain a pure pharmaceutically usable globulin with the aid of this method. since the remnants of the filling agent are difficult to remove and cumbersome cleaning operations, such as. B. dialysis require. It is also known that when serum albumin is obtained, the serum globulin can be separated from the blood serum diluted with water by introducing carbonic acid.
It has now been found that a pure, pharmaceutically usable globulin can be obtained in a simple manner and at low production costs from egg white, in particular from chicken eggs,
EMI1.1
mixed and the precipitate formed is separated off, whereupon the globulin is excreted from the filtrate in a manner known per se for protein precipitation by means of CO 2 and isolated in the usual way.
The following exemplary embodiment explains the invention: Egg white is mixed in a ratio of 1 part by volume to 1.5 parts by volume of 0 Seiger saline solution, then it is centrifuged and the filtrate is mixed
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Carbon dioxide was introduced, the precipitate was allowed to settle for some time and the globulin was then separated off by centrifugation, dried gently with water until the pure, pharmaceutically acceptable globulin was obtained as a dry powder.
** WARNING ** End of DESC field may overlap beginning of CLMS **.
Claims (1)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BE244357X | 1960-06-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AT244357B true AT244357B (en) | 1966-01-10 |
Family
ID=3866468
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT42861A AT244357B (en) | 1960-06-29 | 1961-01-19 | Process for obtaining pharmaceutically acceptable globulin |
Country Status (1)
| Country | Link |
|---|---|
| AT (1) | AT244357B (en) |
-
1961
- 1961-01-19 AT AT42861A patent/AT244357B/en active
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