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AR247891A1 - Procedimiento para preparar nuevos derivados de 2'-halometilidencitidina y uridina - Google Patents

Procedimiento para preparar nuevos derivados de 2'-halometilidencitidina y uridina

Info

Publication number
AR247891A1
AR247891A1 AR89315416A AR31541689A AR247891A1 AR 247891 A1 AR247891 A1 AR 247891A1 AR 89315416 A AR89315416 A AR 89315416A AR 31541689 A AR31541689 A AR 31541689A AR 247891 A1 AR247891 A1 AR 247891A1
Authority
AR
Argentina
Prior art keywords
formula
uridine
halogen
halomethylidene
ethenylidene
Prior art date
Application number
AR89315416A
Other languages
English (en)
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Application granted granted Critical
Publication of AR247891A1 publication Critical patent/AR247891A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

FABRICACION DE COMPUESTOS DE 2'-HALOMETILIDENCITIDINA O URIDINA DE FORMULA I EN LA QUE X1 Y X2 SON H O HALOGENO, SIENDO UNA DE ELLAS HALOGENO Y B TIENE FORMULA II DONDE Y5 ES AMINO O ALCOXILO O SALES FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS, QUE COMPRENDE LAS ETAPAS DE: A) HACER REACCIONAR UN DERIVADO DE 3, 5-0-TETRAISOPROPILIDENSILOXANO-1, 3-DIIL-2-CETONUCLEOSIDO DE FORMULA III CON UNAMETILIDENFOSFOROILIDA DE FORMULA IV EN LA QUE XHAL ES HALOGENO, XO ES XHAL O AR-SO2-, DONDE AR ES FENILO; LP ES FENIL-P(O)<, PARA OBTENER 3, 5-0-TETRAISOPROPILSILOXAN- 1, 3-DIIL-HALOMETILIDEN-NUCLEOSIDOS DE FORMULA V; B) HACERLOS REACCIONAR CON F- O ACIDOS PARA SEPARAR EL GRUPO BLOQUEANTE TETRAISOPROPILDISILOXANO PARA FORMAR LOS NUCLEOSIDOS DE FORMULA VI; C) SEPARAR EL GRUPO AR-SO2- POR AMALGAMA DE MERCURIO, AMALGAMA DE SODIO/MERCURIO O HIDRURO DE TRIBUTILESTANO/AZO-BISISOBUTILNITRILO, PARA DAR NUCLEOSIDOS DONDE XO ES H; Y D) CONVERTIR EL GRUPO ALCOXI DONDE Y5 ES AMINO O HO (CETO), HACIENDO REACCI ONAR LOS COMPUESTOS OBTENIDOS CON AMONIACO O UNA BASE.
AR89315416A 1988-11-15 1989-11-10 Procedimiento para preparar nuevos derivados de 2'-halometilidencitidina y uridina AR247891A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US27147988A 1988-11-15 1988-11-15

Publications (1)

Publication Number Publication Date
AR247891A1 true AR247891A1 (es) 1995-04-28

Family

ID=23035764

Family Applications (1)

Application Number Title Priority Date Filing Date
AR89315416A AR247891A1 (es) 1988-11-15 1989-11-10 Procedimiento para preparar nuevos derivados de 2'-halometilidencitidina y uridina

Country Status (19)

Country Link
EP (1) EP0372268B1 (es)
JP (1) JP2802947B2 (es)
KR (1) KR0144865B1 (es)
CN (1) CN1022248C (es)
AR (1) AR247891A1 (es)
AT (1) ATE105297T1 (es)
AU (1) AU621160B2 (es)
CA (1) CA2002648C (es)
DE (1) DE68915128T2 (es)
DK (1) DK171844B1 (es)
ES (1) ES2056180T3 (es)
FI (1) FI92588C (es)
HU (3) HU205134B (es)
IE (1) IE63563B1 (es)
IL (1) IL92293A (es)
NO (1) NO172240C (es)
NZ (1) NZ231365A (es)
PT (1) PT92309B (es)
ZA (1) ZA898567B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458772B1 (en) 1909-10-07 2002-10-01 Medivir Ab Prodrugs
EP0310673B1 (en) * 1987-03-19 1995-07-05 Yamasa Shoyu Kabushiki Kaisha 2'-alkylidenepyrimidine nucleoside derivatives, process for their preparation, and their use
NZ234534A (en) * 1989-07-17 1994-12-22 Univ Birmingham Pyrimidine 4'-thionucleoside derivatives and their preparation; intermediates therefor
US5521163A (en) * 1990-07-13 1996-05-28 University Of Birmingham Antiviral pyrimidine nucleosides and methods for using same
FR2668153B1 (fr) * 1990-10-22 1995-03-31 Pasteur Merieux Serums Vacc Nouveaux composes ribonucleosides, leur procede de preparation et les medicaments les contenant.
WO1993022327A1 (en) * 1992-04-23 1993-11-11 Yoshitomi Pharmaceutical Industries, Ltd. 2'-methylidenenucleoside compound and pharmaceutical use thereof
ATE146183T1 (de) * 1992-05-12 1996-12-15 Merrell Pharma Inc Verfahren zur herstellung von ribonukleotid- reduktasehemmern
US5589587A (en) * 1992-05-12 1996-12-31 Merrell Pharmaceuticals Inc. Process for the preparation of ribonucleotide reductase inhibitors
HUT72604A (en) * 1992-12-03 1996-05-28 Merrell Dow Pharma Compositions containing acyclovir-like compounds and 2`-vinyl substituted nucleoside analogs for the treatment of viral infections
WO1995018815A1 (en) * 1994-01-07 1995-07-13 Merrell Pharmaceuticals Inc. Monohydrate of (e)-2'-deoxy-2'-(fluoromethylene)cytidine
US5627053A (en) * 1994-03-29 1997-05-06 Ribozyme Pharmaceuticals, Inc. 2'deoxy-2'-alkylnucleotide containing nucleic acid
WO1996001638A1 (en) * 1994-07-11 1996-01-25 Hoechst Marion Roussel, Inc. Method of treating a neoplastic disease state by conjunctive therapy with 2'-fluoromethylidene derivatives and radiation or chemotherapy
US5811408A (en) * 1994-07-12 1998-09-22 Yamasa Corporation 2'-deoxy-2'-(substituted or unsubstituted)methylidene-4'-thionucleosides
JP2005536440A (ja) * 2001-09-28 2005-12-02 イデニクス（ケイマン）リミテツド ４’位が修飾されたヌクレオシドを使用するフラビウイルスおよびペスチウイルスの治療のための方法および組成物
WO2003068162A2 (en) * 2002-02-14 2003-08-21 Pharmasset Ltd. Modified fluorinated nucleoside analogues
KR20040036417A (ko) * 2002-10-25 2004-04-30 정낙신 항암 활성을 갖는 티오뉴클레오시드 유도체 및 이를함유하는 약학적 조성물
CN100389119C (zh) * 2004-10-27 2008-05-21 北京东华康明生物科技有限公司 （反式）-2-脱氧-2-（氟亚甲基）-4-r酰胞苷化合物及其制备方法
LT2794627T (lt) 2011-12-22 2019-01-10 Alios Biopharma, Inc. Pakeistieji nukleozidai, nukleotidai ir jų analogai
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
WO2014078463A1 (en) * 2012-11-19 2014-05-22 Merck Sharp & Dohme Corp. 2 -alkynyl substituted nucleoside derivatives for treating viral diseases
WO2018092107A1 (en) * 2016-11-21 2018-05-24 Munisekhar Medasani Novel anti-viral and anti-cancer molecule

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0310673B1 (en) * 1987-03-19 1995-07-05 Yamasa Shoyu Kabushiki Kaisha 2'-alkylidenepyrimidine nucleoside derivatives, process for their preparation, and their use

Also Published As

Publication number Publication date
DK171844B1 (da) 1997-06-30
HU00045A9 (en) 1995-01-30
CN1042715A (zh) 1990-06-06
HU210343A9 (en) 1995-03-28
DE68915128D1 (de) 1994-06-09
AU621160B2 (en) 1992-03-05
NO894539L (no) 1990-05-16
CA2002648C (en) 2000-02-29
NO172240C (no) 1993-06-23
JP2802947B2 (ja) 1998-09-24
IE893651L (en) 1990-05-15
JPH02178272A (ja) 1990-07-11
NO172240B (no) 1993-03-15
HU895900D0 (en) 1990-02-28
NZ231365A (en) 1992-08-26
CA2002648A1 (en) 1990-05-15
FI895417A0 (fi) 1989-11-14
HU205134B (en) 1992-03-30
ES2056180T3 (es) 1994-10-01
FI92588B (fi) 1994-08-31
DK570089A (da) 1990-05-16
KR900007833A (ko) 1990-06-02
ZA898567B (en) 1990-08-29
FI92588C (fi) 1994-12-12
HUT51642A (en) 1990-05-28
PT92309A (pt) 1990-05-31
ATE105297T1 (de) 1994-05-15
AU4461189A (en) 1990-05-24
DK570089D0 (da) 1989-11-14
CN1022248C (zh) 1993-09-29
DE68915128T2 (de) 1994-08-25
KR0144865B1 (ko) 1998-07-01
EP0372268B1 (en) 1994-05-04
NO894539D0 (no) 1989-11-14
PT92309B (pt) 1996-06-28
IL92293A (en) 1995-01-24
IE63563B1 (en) 1995-05-17
EP0372268A1 (en) 1990-06-13
IL92293A0 (en) 1990-07-26

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