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AR125344A1 - Anticuerpo anti-c1s - Google Patents

Anticuerpo anti-c1s

Info

Publication number
AR125344A1
AR125344A1 ARP220100938A ARP220100938A AR125344A1 AR 125344 A1 AR125344 A1 AR 125344A1 AR P220100938 A ARP220100938 A AR P220100938A AR P220100938 A ARP220100938 A AR P220100938A AR 125344 A1 AR125344 A1 AR 125344A1
Authority
AR
Argentina
Prior art keywords
hvr
seq
nos
amino acid
acid sequences
Prior art date
Application number
ARP220100938A
Other languages
English (en)
Inventor
Hikaru Koga
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of AR125344A1 publication Critical patent/AR125344A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención proporciona anticuerpos que comprenden una región de unión al antígeno y una región constante del anticuerpo y se une a C1s de una manera dependiente de pH. La presente invención también da a conocer composiciones farmacéuticas que comprenden uno cualquiera de los anticuerpos y métodos para tratar a un individuo que tiene una enfermedad o un trastorno mediado por complemento, o para prevenir que un individuo potencialmente tenga una enfermedad o un trastorno mediado por complemento, el método que comprende administrar uno cualquiera de los anticuerpos al individuo. Reivindicación 1: Un anticuerpo aislado caracterizado porque comprende una región de unión al antígeno y una región constante del anticuerpo, donde el anticuerpo promueve la disociación del C1q del complejo C1qrs y/o inhibe la unión del C1q al C1r2s2, y donde la región de unión al antígeno comprende una combinación de HVR-H1, HVR-H2, HVR-H3, HVR-L1, HVR-L2 y HVR-L3 seleccionadas del grupo que consiste en 1) a 6) a continuación: 1) HVR-H1, HVR-H2, HVR-H3, HVR-L1, HVR-L2 y HVR-L3 que comprenden las secuencias de aminoácidos que consisten en las SEQ ID Nº 25, 26, 27, 60, 61 y 62, respectivamente; 2) HVR-H1, HVR-H2, HVR-H3, HVR-L1, HVR-L2 y HVR-L3 que comprenden las secuencias de aminoácidos que consisten en las SEQ ID Nº 37, 38, 39, 56, 57 y 58, respectivamente; 3) HVR-H1, HVR-H2, HVR-H3, HVR-L1, HVR-L2 y HVR-L3 que comprenden las secuencias de aminoácidos que consisten en las SEQ ID Nº 25, 26, 27, 56, 57 y 58, respectivamente; 4) HVR-H1, HVR-H2, HVR-H3, HVR-L1, HVR-L2 y HVR-L3 que comprenden las secuencias de aminoácidos que consisten en las SEQ ID Nº 25, 26, 27, 48, 49 y 50, respectivamente; 5) HVR-H1, HVR-H2, HVR-H3, HVR-L1, HVR-L2 y HVR-L3 que comprenden las secuencias de aminoácidos que consisten en las SEQ ID Nº 29, 30, 31, 52, 53 y 54, respectivamente; y 6) HVR-H1, HVR-H2, HVR-H3, HVR-L1, HVR-L2 y HVR-L3 que comprenden las secuencias de aminoácidos que consisten en las SEQ ID Nº 33, 34, 35, 56, 57 y 58, respectivamente.
ARP220100938A 2021-04-15 2022-04-13 Anticuerpo anti-c1s AR125344A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2021068964 2021-04-15

Publications (1)

Publication Number Publication Date
AR125344A1 true AR125344A1 (es) 2023-07-05

Family

ID=83640739

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP220100938A AR125344A1 (es) 2021-04-15 2022-04-13 Anticuerpo anti-c1s

Country Status (17)

Country Link
US (1) US20240287163A1 (es)
EP (1) EP4324925A1 (es)
JP (1) JPWO2022220275A1 (es)
KR (1) KR20230170017A (es)
CN (1) CN117120615A (es)
AR (1) AR125344A1 (es)
AU (1) AU2022257471A1 (es)
BR (1) BR112023015422A2 (es)
CA (1) CA3213912A1 (es)
CL (1) CL2023003047A1 (es)
CO (1) CO2023012831A2 (es)
CR (1) CR20230528A (es)
IL (1) IL305041A (es)
MX (1) MX2023010764A (es)
PE (1) PE20242224A1 (es)
TW (1) TW202304977A (es)
WO (1) WO2022220275A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021502967A (ja) 2017-11-14 2021-02-04 中外製薬株式会社 抗Ｃ１ｓ抗体および使用方法

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Also Published As

Publication number Publication date
US20240287163A1 (en) 2024-08-29
PE20242224A1 (es) 2024-11-19
IL305041A (en) 2023-10-01
MX2023010764A (es) 2023-09-22
AU2022257471A1 (en) 2023-08-24
BR112023015422A2 (pt) 2023-11-07
CN117120615A (zh) 2023-11-24
AU2022257471A9 (en) 2024-07-18
TW202304977A (zh) 2023-02-01
WO2022220275A1 (ja) 2022-10-20
CO2023012831A2 (es) 2023-10-19
CL2023003047A1 (es) 2024-03-15
JPWO2022220275A1 (es) 2022-10-20
EP4324925A1 (en) 2024-02-21
KR20230170017A (ko) 2023-12-18
CR20230528A (es) 2023-12-05
CA3213912A1 (en) 2022-10-20

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