AR116853A1 - Inhibidores de aminopeptidasa a y composiciones farmacéuticas que comprenden los mismos - Google Patents
Inhibidores de aminopeptidasa a y composiciones farmacéuticas que comprenden los mismosInfo
- Publication number
- AR116853A1 AR116853A1 ARP190103083A ARP190103083A AR116853A1 AR 116853 A1 AR116853 A1 AR 116853A1 AR P190103083 A ARP190103083 A AR P190103083A AR P190103083 A ARP190103083 A AR P190103083A AR 116853 A1 AR116853 A1 AR 116853A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- compound
- hydrogen atom
- alkyl
- formula
- Prior art date
Links
- 102000006485 Glutamyl Aminopeptidase Human genes 0.000 title 1
- 108010058940 Glutamyl Aminopeptidase Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 8
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 7
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000001188 haloalkyl group Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 208000010412 Glaucoma Diseases 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 229910018828 PO3H2 Inorganic materials 0.000 abstract 1
- 208000018262 Peripheral vascular disease Diseases 0.000 abstract 1
- 208000001647 Renal Insufficiency Diseases 0.000 abstract 1
- 229910006069 SO3H Inorganic materials 0.000 abstract 1
- 208000006011 Stroke Diseases 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000005360 alkyl sulfoxide group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 208000037849 arterial hypertension Diseases 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 125000004438 haloalkoxy group Chemical group 0.000 abstract 1
- 125000004995 haloalkylthio group Chemical group 0.000 abstract 1
- 125000004404 heteroalkyl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 201000006370 kidney failure Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 208000010125 myocardial infarction Diseases 0.000 abstract 1
- 208000031225 myocardial ischemia Diseases 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 201000001474 proteinuria Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/306—Arylalkanephosphinic acids, e.g. Ar-(CH2)n-P(=X)(R)(XH), (X = O,S, Se; n>=1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/32—Esters thereof
- C07F9/3258—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
- C07F9/3264—Esters with hydroxyalkyl compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
- C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
- C07F9/653—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
- C07F9/653—Five-membered rings
- C07F9/65306—Five-membered rings containing two nitrogen atoms
- C07F9/65312—Five-membered rings containing two nitrogen atoms having the two nitrogen atoms in positions 1 and 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
- C07F9/6539—Five-membered rings
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente se refiere a un compuesto, a una composición que comprende el mismo, a métodos para preparar el compuesto, y el uso de este compuesto en terapia. En particular, la presente se relaciona con un compuesto que es útil en el tratamiento y prevención de hipertensión arterial primaria y secundaria, ictus, isquemia miocárdica, insuficiencia cardíaca y renal, infarto al miocardio, enfermedad vascular periférica, proteinuria diabética, Síndrome X y glaucoma. Reivindicación 1: Un compuesto con la fórmula (1), y más específicamente que tiene la fórmula (2), en donde: AH representa -CO₂H, -SO₃H, -PO₃H₂; l es 1, 2 ó 3; m y n son independientemente 0, 1 ó 2; R³ y R⁴ representan independientemente un átomo de hidrógeno, un grupo hidroxi, un átomo de halógeno, un grupo alquilo o un grupo haloalquilo; el anillo (ilustrado mediante un círculo en las fórmulas) representa un arilo o un heterociclo; representando R¹ y R² independientemente un átomo de hidrógeno, un átomo de halógeno, un grupo ciano, un grupo alquilo, un grupo alcoxi, un grupo alquiltio, un grupo alquilsulfóxido, un grupo alquilsulfonilo, un grupo haloalquilo, un grupo haloalcoxi, un grupo haloalquiltio, un grupo acilo, un grupo O-cicloalquilo, un grupo heteroalquilo, un grupo O-arilo, un grupo O-arilalquilo, un grupo arilo, un grupo heterociclo o un grupo arilalquilo; una sal, solvato, forma zwitteriónica o prodroga farmacéuticos de los mismos. Reivindicación 6: Un compuesto que tiene la fórmula (3), y más específicamente, la fórmula (4), en donde: l, m, n, R¹, R², R³, R⁴ son como se define en una cualquiera de las reivindicaciones 1 - 5; A representa -SO₃Z -CO₂Z o -P(O)(OZ)₂, estando seleccionado Z del grupo que consiste en un átomo de hidrógeno, un grupo alquilo y arilalquilo; X representa un átomo de hidrógeno, -(CO)-alquilo, -(CO)-alcoxi, -(CO)-benciloxi, o un compuesto del grupo de fórmulas (5); donde R representa un grupo alquilo y, R y R representan independientemente un átomo de hidrógeno o un grupo alquilo, Y representa un átomo de hidrógeno, un grupo alquilo, arilo, arilalquilo o un compuesto de fórmula (6), donde R, R y R, siendo idénticos o diferentes, son como se define más arriba, y en donde al menos uno de Z, X y Y es diferente de un átomo de hidrógeno.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18306396 | 2018-10-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR116853A1 true AR116853A1 (es) | 2021-06-23 |
Family
ID=64267736
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP190103083A AR116853A1 (es) | 2018-10-26 | 2019-10-25 | Inhibidores de aminopeptidasa a y composiciones farmacéuticas que comprenden los mismos |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US11192907B2 (es) |
| EP (1) | EP3870591A1 (es) |
| JP (1) | JP7051009B2 (es) |
| KR (1) | KR102380042B1 (es) |
| CN (1) | CN113166182A (es) |
| AR (1) | AR116853A1 (es) |
| AU (1) | AU2019365119B2 (es) |
| BR (1) | BR112021007116A2 (es) |
| CA (1) | CA3112851C (es) |
| EA (1) | EA202191150A1 (es) |
| IL (1) | IL282591B (es) |
| MX (1) | MX2021004741A (es) |
| TW (1) | TW202029962A (es) |
| WO (1) | WO2020084131A1 (es) |
| ZA (1) | ZA202103580B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2021004728A (es) * | 2018-10-26 | 2021-10-13 | Quantum Genomics | Nuevos derivados aminofosfinicos como inhibidores de aminopeptidasa a. |
| TW202207917A (zh) * | 2020-05-06 | 2022-03-01 | 法商量子基因科技有限公司 | 包含腦胺肽酶抑制劑、利尿劑及全身性腎素－血管收縮素系統阻斷劑之醫藥組合物 |
| CN115385789B (zh) * | 2022-09-19 | 2024-06-04 | 安徽大学 | 一种4-氧代丁酸甲酯的合成方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2773712B1 (fr) * | 1998-01-16 | 2000-06-02 | Inst Nat Sante Rech Med | Composition pharmaceutique comprenant au moins un inhibiteur de l'aminopeptidase a |
| ES2369256T3 (es) * | 2000-06-26 | 2011-11-28 | Helen Of Troy Limited | Sistema de lámpara recargable. |
| AR058296A1 (es) * | 2005-12-09 | 2008-01-30 | Kalypsys Inc | Inhibidores de histona desacetilasa y composicion farmaceutica |
| US20080146524A1 (en) | 2006-12-14 | 2008-06-19 | Solvay Pharmaceuticals B.V. | Selective inhibitors of neurotensin degrading enzymes |
| FR2934267B1 (fr) | 2008-07-23 | 2010-08-13 | Pharmaleads | Derives aminophosphiniques utiles dans le traitement de la douleur |
| MX2021004728A (es) * | 2018-10-26 | 2021-10-13 | Quantum Genomics | Nuevos derivados aminofosfinicos como inhibidores de aminopeptidasa a. |
-
2019
- 2019-10-23 TW TW108138218A patent/TW202029962A/zh unknown
- 2019-10-25 JP JP2021523669A patent/JP7051009B2/ja active Active
- 2019-10-25 AU AU2019365119A patent/AU2019365119B2/en not_active Ceased
- 2019-10-25 CN CN201980070944.7A patent/CN113166182A/zh active Pending
- 2019-10-25 CA CA3112851A patent/CA3112851C/en active Active
- 2019-10-25 US US17/288,516 patent/US11192907B2/en active Active
- 2019-10-25 KR KR1020217015043A patent/KR102380042B1/ko active IP Right Grant
- 2019-10-25 IL IL282591A patent/IL282591B/en unknown
- 2019-10-25 EA EA202191150A patent/EA202191150A1/ru unknown
- 2019-10-25 AR ARP190103083A patent/AR116853A1/es not_active Application Discontinuation
- 2019-10-25 WO PCT/EP2019/079229 patent/WO2020084131A1/en unknown
- 2019-10-25 EP EP19790023.6A patent/EP3870591A1/en not_active Withdrawn
- 2019-10-25 MX MX2021004741A patent/MX2021004741A/es unknown
- 2019-10-25 BR BR112021007116-4A patent/BR112021007116A2/pt not_active Application Discontinuation
-
2021
- 2021-05-26 ZA ZA2021/03580A patent/ZA202103580B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR112021007116A2 (pt) | 2021-07-20 |
| KR20210079336A (ko) | 2021-06-29 |
| US11192907B2 (en) | 2021-12-07 |
| MX2021004741A (es) | 2022-03-16 |
| TW202029962A (zh) | 2020-08-16 |
| JP2021535189A (ja) | 2021-12-16 |
| CA3112851A1 (en) | 2020-04-30 |
| CN113166182A (zh) | 2021-07-23 |
| KR102380042B1 (ko) | 2022-03-28 |
| IL282591B (en) | 2022-08-01 |
| CA3112851C (en) | 2023-01-24 |
| IL282591A (en) | 2021-06-30 |
| JP7051009B2 (ja) | 2022-04-08 |
| ZA202103580B (en) | 2022-08-31 |
| AU2019365119A1 (en) | 2021-04-15 |
| AU2019365119B2 (en) | 2021-07-29 |
| US20210309678A1 (en) | 2021-10-07 |
| EP3870591A1 (en) | 2021-09-01 |
| EA202191150A1 (ru) | 2021-07-15 |
| WO2020084131A1 (en) | 2020-04-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |