[go: up one dir, main page]

AR101392A1 - COMPUESTOS DE 6,7-DIHIDROPIRAZOLO[1,5-A]PIRAZIN-4(5H)-ONA Y SU USO COMO MODULADORES ALOSTÉRICOS NEGATIVOS DE RECEPTORES mGluR2 - Google Patents

COMPUESTOS DE 6,7-DIHIDROPIRAZOLO[1,5-A]PIRAZIN-4(5H)-ONA Y SU USO COMO MODULADORES ALOSTÉRICOS NEGATIVOS DE RECEPTORES mGluR2

Info

Publication number
AR101392A1
AR101392A1 ARP150102461A ARP150102461A AR101392A1 AR 101392 A1 AR101392 A1 AR 101392A1 AR P150102461 A ARP150102461 A AR P150102461A AR P150102461 A ARP150102461 A AR P150102461A AR 101392 A1 AR101392 A1 AR 101392A1
Authority
AR
Argentina
Prior art keywords
alkyl
group
monohalo
polyhalo
nrr
Prior art date
Application number
ARP150102461A
Other languages
English (en)
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of AR101392A1 publication Critical patent/AR101392A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Reivindicación 1: Un compuesto de fórmula (1) o una forma estereoisomérica del mismo, en donde R¹ es fenilo o 2-piridinilo, cada uno opcionalmente sustituido por uno o más sustituyentes seleccionados cada uno independientemente del grupo que consiste en halo, alquilo C₁₋₄, monohalo-alquilo C₁₋₄, polihalo-alquilo C₁₋₄, -alquil C₁₋₄-OH, -CN, -alquil C₁₋₄-O-alquilo C₁₋₄, cicloalquilo C₁₋₄, -O-alquilo C₁₋₄, monohalo-alquil C₁₋₄oxi, polihalo-alquil C₁₋₄oxi, SF₅, alquil C₁₋₄tio, monohalo-alquil C₁₋₄tio y polihalo-alquil C₁₋₄tio; R² se selecciona del grupo que consiste en hidrógeno; alquilo C₁₋₄; cicloalquilo C₃₋₇; Het¹; arilo; -C(O)R⁵; -C(O)Het²; Het²; y alquilo C₁₋₄ sustituido por uno o más sustituyentes seleccionados cada uno independientemente del grupo que consiste en halo, cicloalquilo C₃₋₇, arilo, Het¹ y Het²; en donde R⁵ se selecciona del grupo que consiste en hidrógeno, alquilo C₁₋₄ y cicloalquilo C₃₋₇; arilo es fenilo opcionalmente sustituido por uno o más sustituyentes seleccionados cada uno independientemente del grupo que consiste en halo, alquilo C₁₋₄, -alquil C₁₋₄-OH, monohalo-alquilo C₁₋₄, polihalo-alquilo C₁₋₄, -CN, -O-alquilo C₁₋₄, -OH, alquil C₁₋₄-O-alquilo C₁₋₄, -NRR, -NHC(O)alquilo C₁₋₄, -C(O)NRR, -C(O)NH[C(O)alquil C₁₋₄], -S(O)₂NRR, -S(O)₂NH[C(O)alquil C₁₋₄] y -SO₂-alquilo C₁₋₄; Het¹ se selecciona del grupo que consiste en oxetanilo, tetrahidrofuranilo y tetrahidropiranilo; Het² es (a) un sustituyente heterociclilo aromático de 6 miembros que se selecciona del grupo que consiste en piridinilo, pirimidinilo, pirazinilo y piridazinilo, cada uno de los cuales puede sustituirse opcionalmente con uno o más sustituyentes seleccionados cada uno independientemente del grupo que consiste en halo, alquilo C₁₋₄, -alquil C₁₋₄-OH, monohalo-alquilo C₁₋₄, polihalo-alquilo C₁₋₄, -CN, -O-alquilo C₁₋₄, -OH, -alquil C₁₋₄-O-alquilo C₁₋₄, -NRR, -NHC(O)alquilo C₁₋₄, -C(O)NRR, -C(O)NH[C(O)alquil C₁₋₄], -S(O)₂NRR, -S(O)₂NH[C(O)alquil C₁₋₄] y -SO₂-alquilo C₁₋₄; o (b) un heterociclilo aromático de 5 miembros que se selecciona del grupo que consiste en tiazolilo, oxazolilo, 1H-pirazolilo y 1H-imidazolilo, cada uno de los cuales puede sustituirse opcionalmente con uno o más sustituyentes seleccionados cada una independientemente del grupo que consiste en halo, alquilo C₁₋₄, -alquil C₁₋₄-OH, monohalo-alquilo C₁₋₄, polihalo-alquilo C₁₋₄, -CN, -O-alquilo C₁₋₄, -OH, -alquil C₁₋₄-O-alquilo C₁₋₄, -NRR, -NHC(O)alquilo C₁₋₄, -C(O)NRR, -C(O)NH[C(O)alquil C₁₋₄], -S(O)₂NRR, -S(O)₂NH[C(O)alquil C₁₋₄] y -SO₂-alquilo C₁₋₄; cada R y R se selecciona independientemente de hidrógeno y alquilo C₁₋₄; y R³ se selecciona de hidrógeno y alquilo C₁₋₄; R⁴ se selecciona del grupo que consiste en hidrógeno, alquilo C₁₋₄, monohalo-alquilo C₁₋₄, polihalo-alquilo C₁₋₄, -alquil C₁₋₄-O-alquilo C₁₋₄ y -alquil C₁₋₄-OH; o un N-óxido, o una sal farmacéuticamente aceptable o un solvato del mismo.
ARP150102461A 2014-08-01 2015-07-31 COMPUESTOS DE 6,7-DIHIDROPIRAZOLO[1,5-A]PIRAZIN-4(5H)-ONA Y SU USO COMO MODULADORES ALOSTÉRICOS NEGATIVOS DE RECEPTORES mGluR2 AR101392A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP14179598 2014-08-01

Publications (1)

Publication Number Publication Date
AR101392A1 true AR101392A1 (es) 2016-12-14

Family

ID=51257437

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP150102461A AR101392A1 (es) 2014-08-01 2015-07-31 COMPUESTOS DE 6,7-DIHIDROPIRAZOLO[1,5-A]PIRAZIN-4(5H)-ONA Y SU USO COMO MODULADORES ALOSTÉRICOS NEGATIVOS DE RECEPTORES mGluR2

Country Status (34)

Country Link
US (3) US10005786B2 (es)
EP (1) EP3177623B1 (es)
JP (1) JP6662846B2 (es)
KR (1) KR102531689B1 (es)
CN (1) CN106573936B (es)
AR (1) AR101392A1 (es)
AU (1) AU2015295298B2 (es)
BR (1) BR112017001726A2 (es)
CA (1) CA2954093C (es)
CL (1) CL2017000192A1 (es)
CY (1) CY1121649T1 (es)
DK (1) DK3177623T3 (es)
EA (1) EA031087B1 (es)
ES (1) ES2708215T3 (es)
HR (1) HRP20181997T1 (es)
HU (1) HUE042871T2 (es)
IL (1) IL250298A0 (es)
JO (1) JOP20150179B1 (es)
LT (1) LT3177623T (es)
MA (1) MA39582B1 (es)
ME (1) ME03320B (es)
MX (1) MX376289B (es)
NZ (1) NZ728122A (es)
PH (1) PH12017500161B1 (es)
PL (1) PL3177623T3 (es)
PT (1) PT3177623T (es)
RS (1) RS58279B1 (es)
SG (1) SG11201700638YA (es)
SI (1) SI3177623T1 (es)
SM (1) SMT201900038T1 (es)
TR (1) TR201901074T4 (es)
TW (1) TWI696624B (es)
WO (1) WO2016016380A1 (es)
ZA (1) ZA201700759B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SMT202100103T1 (it) 2014-01-21 2021-03-15 Janssen Pharmaceutica Nv Combinazione comprendente modulatori allosterici postivi del recettore glutammatergico metabotropico sottotipo 2 e loro utilizzo
HUE045610T2 (hu) 2014-01-21 2020-01-28 Janssen Pharmaceutica Nv 2-es altípusú metabotróp glutamáterg receptor pozitív allosztérikus modulátorait vagy ortosztérikus agonistáit tartalmazó kombinációk és alkalmazásuk
JOP20150179B1 (ar) * 2014-08-01 2021-08-17 Janssen Pharmaceutica Nv مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2
JOP20150177B1 (ar) 2014-08-01 2021-08-17 Janssen Pharmaceutica Nv مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2
WO2016087487A1 (en) 2014-12-03 2016-06-09 Janssen Pharmaceutica Nv 6,7-DIHYDROPYRAZOLO[1,5-α]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
CA2967542C (en) 2014-12-03 2022-11-29 Janssen Pharmaceutica Nv Radiolabelled mglur2 pet ligands
ES2828976T3 (es) 2015-12-18 2021-05-28 Janssen Pharmaceutica Nv Ligandos de mGluR2/3 radiomarcados para TEP
WO2017103179A1 (en) 2015-12-18 2017-06-22 Janssen Pharmaceutica Nv Radiolabelled mglur2/3 pet ligands
JP2020011902A (ja) * 2016-10-26 2020-01-23 大日本住友製薬株式会社 縮環ピロール誘導体およびその医薬用途
CN107298682B (zh) * 2017-06-29 2019-03-01 天津药明康德新药开发有限公司 一种4,5,6,7-四氢吡唑并[1,5-a]吡嗪-2-甲酸乙酯的合成方法
JP7242548B2 (ja) 2017-11-24 2023-03-20 住友ファーマ株式会社 ６，７－ジヒドロピラゾロ［１，５－ａ］ピラジノン誘導体及びその医薬用途
AU2019212093B2 (en) * 2018-01-26 2024-05-30 Recordati Industria Chimica E Farmaceutica S.P.A Triazole, imidazole and pyrrole condensed piperazine derivatives and their use as modulators of mGlu5 receptors

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0756200B1 (en) 1995-07-26 1999-11-10 Konica Corporation Silver halide color photographic light-sensitive material
US6482821B2 (en) 1996-12-20 2002-11-19 Hoechst Aktiengellschaft Vitronectin receptor antagonists, their preparation and their use
DE19653647A1 (de) 1996-12-20 1998-06-25 Hoechst Ag Vitronectin - Rezeptorantagonisten, deren Herstellung sowie deren Verwendung
US6754375B1 (en) 1999-07-16 2004-06-22 Packard Bioscience Company Method and system for interactively developing at least one grid pattern and computer-readable storage medium having a program for executing the method
US6831074B2 (en) 2001-03-16 2004-12-14 Pfizer Inc Pharmaceutically active compounds
US20030114448A1 (en) 2001-05-31 2003-06-19 Millennium Pharmaceuticals, Inc. Inhibitors of factor Xa
TWI372050B (en) 2003-07-03 2012-09-11 Astex Therapeutics Ltd (morpholin-4-ylmethyl-1h-benzimidazol-2-yl)-1h-pyrazoles
WO2005061507A1 (en) 2003-12-16 2005-07-07 Pfizer Products Inc. Bicyclic pyrazol-4-one cannabinoid receptor ligands and uses thereof
RU2378277C2 (ru) 2004-06-21 2010-01-10 Ф. Хоффманн-Ля Рош Аг Производные пиразолпиримидина
WO2006030847A1 (ja) 2004-09-17 2006-03-23 Dainippon Sumitomo Pharma Co., Ltd. 新規二環性ピラゾール誘導体
DE102004054665A1 (de) 2004-11-12 2006-05-18 Bayer Cropscience Gmbh Substituierte bi- und tricyclische Pyrazol-Derivate Verfahren zur Herstellung und Verwendung als Herbizide und Pflanzenwachstumsregulatoren
CA2597608C (en) 2005-02-11 2013-12-24 F. Hoffmann-La Roche Ag Pyrazolo-pyrimidine derivatives as mglur2 antagonists
SI1863818T1 (sl) 2005-03-23 2010-05-31 Hoffmann La Roche Derivati acetilenil pirazolo pirimidina kot antagonisti mglur
US7998959B2 (en) 2006-01-12 2011-08-16 Incyte Corporation Modulators of 11-β hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same
US8435970B2 (en) 2006-06-29 2013-05-07 Astex Therapeutics Limited Pharmaceutical combinations of 1-cyclopropyl-3-[3-(5-morpholin-4-ylmethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-urea
US20110206607A1 (en) 2007-05-10 2011-08-25 Roger Olsson Imidazol (1,2-a)pyridines and related compounds with activity at cannabinoid cb2 receptors
EP2085390A1 (en) 2008-01-31 2009-08-05 Institut National De La Sante Et De La Recherche Medicale (Inserm) Labelled analogues of halobenzamides as multimodal radiopharmaceuticals and their precursors
US9446995B2 (en) 2012-05-21 2016-09-20 Illinois Institute Of Technology Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions
ES2524259T3 (es) 2008-03-24 2014-12-04 Novartis Ag Inhibidores de metaloproteinasa de matriz a base de arilsulfonamida
JPWO2010024258A1 (ja) 2008-08-29 2012-01-26 塩野義製薬株式会社 Ｐｉ３ｋ阻害活性を有する縮環アゾール誘導体
AU2010246609B2 (en) 2009-05-12 2013-09-05 Addex Pharma S.A. 1,2,4-triazolo [4,3-a] pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
EP2627648A1 (en) 2010-09-16 2013-08-21 Novartis AG 17aHYDROXYLASE/C17,20-LYASE INHIBITORS
AU2011328196A1 (en) 2010-11-08 2013-05-02 Janssen Pharmaceuticals, Inc. Radiolabelled mGluR2 PET ligands
EP2651222A4 (en) * 2010-12-17 2014-04-30 Univ Vanderbilt BICYCLIC TRIAZOL AND PYRAZOLLACTAME AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS
GB201106817D0 (en) 2011-04-21 2011-06-01 Astex Therapeutics Ltd New compound
WO2012172093A1 (en) 2011-06-17 2012-12-20 Merz Pharma Gmbh & Co. Kgaa Dihydroindolizine derivate as metabotropic glutamate receptor modulators
CN103930422A (zh) 2011-07-19 2014-07-16 无限药品股份有限公司 杂环化合物及其用途
JP6027611B2 (ja) 2011-07-19 2016-11-16 インフィニティー ファーマシューティカルズ， インコーポレイテッド 複素環式化合物及びその使用
MY167423A (en) * 2011-11-03 2018-08-27 Merck Sharp & Dohme Quinoline carboxamide and quinoline carbonitrile derivatives as mglur2-negative allosteric modulators,compositions,and their use
JP5783264B2 (ja) 2011-11-25 2015-09-24 日本電気株式会社 セル識別子割当方法、基地局、保守サーバ、移動通信システム
US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
US20130281397A1 (en) 2012-04-19 2013-10-24 Rvx Therapeutics Inc. Treatment of diseases by epigenetic regulation
EP2666775A1 (en) * 2012-05-21 2013-11-27 Domain Therapeutics Substituted pyrazoloquinazolinones and pyrroloquinazolinones as allosteric modulators of group II metabotropic glutamate receptors
US20130345205A1 (en) * 2012-06-20 2013-12-26 Vanderbilt University Substituted bicyclic aralkyl pyrazole lactam analogs as allosteric modulators of mglur5 receptors
WO2013192347A1 (en) 2012-06-20 2013-12-27 Vanderbilt University Substituted bicyclic cycloalkyl pyrazole lactam analogs as allosteric modulators of mglur5 receptors
EP2863922A4 (en) * 2012-06-20 2015-11-04 Univ Vanderbilt SUBSTITUTED BICYCLIC ALKOXYPYRAZOL ANALOGUES AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS
CA2885808A1 (en) * 2012-10-23 2014-05-01 F. Hoffmann-La Roche Ag Mglu2/3 antagonists for the treatment of autistic disorders
CN103772686B (zh) 2012-10-26 2015-01-07 苏州雷纳药物研发有限公司 一种两亲性嵌段共聚物及其制备方法、以及该共聚物与抗肿瘤药物形成的胶束载药系统
JO3368B1 (ar) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
JOP20150179B1 (ar) * 2014-08-01 2021-08-17 Janssen Pharmaceutica Nv مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2
JO3601B1 (ar) 2014-08-01 2020-07-05 Janssen Pharmaceutica Nv مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2
CN107001373B (zh) 2014-08-01 2020-01-07 詹森药业有限公司 6,7-二氢吡唑并[1,5-a]吡嗪-4(5H)-酮化合物及其作为MGLUR2受体的负向别构调节剂的用途
JOP20150177B1 (ar) 2014-08-01 2021-08-17 Janssen Pharmaceutica Nv مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2
EP3174882B1 (en) 2014-08-01 2018-11-07 Janssen Pharmaceutica NV 6,7-dihydropyrazolo[1,5-a]pyrazin-4(5h)-one compounds and their use as negative allosteric modulators of mglu2 receptors
CA2967542C (en) 2014-12-03 2022-11-29 Janssen Pharmaceutica Nv Radiolabelled mglur2 pet ligands
WO2016087487A1 (en) 2014-12-03 2016-06-09 Janssen Pharmaceutica Nv 6,7-DIHYDROPYRAZOLO[1,5-α]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
WO2017103179A1 (en) 2015-12-18 2017-06-22 Janssen Pharmaceutica Nv Radiolabelled mglur2/3 pet ligands
ES2828976T3 (es) 2015-12-18 2021-05-28 Janssen Pharmaceutica Nv Ligandos de mGluR2/3 radiomarcados para TEP

Also Published As

Publication number Publication date
ES2708215T3 (es) 2019-04-09
JP6662846B2 (ja) 2020-03-11
SMT201900038T1 (it) 2019-02-28
EP3177623B1 (en) 2018-11-07
HUE042871T2 (hu) 2019-07-29
CA2954093A1 (en) 2016-02-04
EA201692540A1 (ru) 2017-05-31
MX376289B (es) 2025-03-07
EA031087B1 (ru) 2018-11-30
ZA201700759B (en) 2018-12-19
US20180256569A1 (en) 2018-09-13
JOP20150179B1 (ar) 2021-08-17
CA2954093C (en) 2022-11-29
JP2017522340A (ja) 2017-08-10
AU2015295298A1 (en) 2017-01-12
NZ728122A (en) 2022-07-29
TW201617346A (zh) 2016-05-16
SI3177623T1 (sl) 2019-01-31
KR102531689B1 (ko) 2023-05-10
LT3177623T (lt) 2019-02-11
SG11201700638YA (en) 2017-02-27
CN106573936A (zh) 2017-04-19
US10512646B2 (en) 2019-12-24
HRP20181997T1 (hr) 2019-01-25
DK3177623T3 (en) 2019-02-25
RS58279B1 (sr) 2019-03-29
US10005786B2 (en) 2018-06-26
TWI696624B (zh) 2020-06-21
MX2017001452A (es) 2017-05-09
PH12017500161A1 (en) 2017-06-28
US20200121677A1 (en) 2020-04-23
MA39582B1 (fr) 2019-10-31
ME03320B (me) 2019-10-20
MA39582A1 (fr) 2018-06-29
PL3177623T3 (pl) 2019-04-30
CN106573936B (zh) 2020-01-07
KR20170031247A (ko) 2017-03-20
CL2017000192A1 (es) 2017-07-28
PH12017500161B1 (en) 2022-05-18
TR201901074T4 (tr) 2019-02-21
BR112017001726A2 (pt) 2017-11-21
IL250298A0 (en) 2017-03-30
EP3177623A1 (en) 2017-06-14
US20170217972A1 (en) 2017-08-03
CY1121649T1 (el) 2020-07-31
PT3177623T (pt) 2019-02-01
WO2016016380A8 (en) 2017-01-19
AU2015295298B2 (en) 2019-07-11
WO2016016380A1 (en) 2016-02-04

Similar Documents

Publication Publication Date Title
AR101392A1 (es) COMPUESTOS DE 6,7-DIHIDROPIRAZOLO[1,5-A]PIRAZIN-4(5H)-ONA Y SU USO COMO MODULADORES ALOSTÉRICOS NEGATIVOS DE RECEPTORES mGluR2
BR112017006251A2 (pt) novos compostos
AR104995A1 (es) Fenoxifenilamidinas sustituidas con halógeno y el uso de estas como fungicidas
AR101558A1 (es) Difluoropirrolidinas como moduladores del receptor de orexina
AR102204A1 (es) Compuestos derivados de amino-alquilbenzotiazepinas
TR201900050T4 (tr) Kaynaştırılmış heterosiklik bileşik ve bunun haşere kontrol uygulaması.
AR101815A1 (es) Compuestos y composiciones como inhibidores de quinasa
AR092790A1 (es) Derivados bencimidazolicos del acido hidroxamico
EA201791066A1 (ru) Твердые формы ингибитора ask1
MX379536B (es) Compuestos de pirimidinio sustituido y derivados para combatir plagas de animales.
EA201791304A1 (ru) Производные изохинолина для лечения вич
AR097866A1 (es) Derivados de 4-azaindol
CL2019001694A1 (es) Compuestos de pirazolopirimidina y métodos de uso de los mismos.
AR101393A1 (es) COMPUESTOS DE 6,7-DIHIDROPIRAZOLO[1,5-A]PIRAZIN-4(5H)-ONA Y SU USO COMO MODULADORES ALOSTÉRICOS NEGATIVOS DE RECEPTORES mGluR2
AR107428A1 (es) COMPUESTOS DE ISOXAZOL DE ÁCIDO HIDROXÁMICO COMO INHIBIDORES DE LpxC
AR104528A1 (es) Compuestos y derivados de sulfonimidoilpurinona para el tratamiento y profilaxis de infecciones víricas
AR105549A1 (es) Compuestos de 1-alquil-6-oxo-1,6-dihidropiridin-3-ilo y usos de los mismos
AR109296A1 (es) Derivados de oxadiazolopiridina para el uso como inhibidores de ghrelin o-aciltransferasa (goat)
MX2016005324A (es) Composiciones pesticidas y metodos relacionados.
ES2721073T3 (es) Derivados de 4-amino-6-fenil-6,7-dihidro[1,2,3]triazolo[1,5 a]pirazina como inhibidores de beta-secretasa (BACE)
DK3298008T3 (da) Krystallinsk form af forbindelsen (s)-3-{4-[5-(2-cyclopentyl-6-methoxy-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-ethyl-6-methyl-phenoxy}-propan-1,2-diol
AR098713A1 (es) 4-amino-6-(halo-alquil-sustituido)-picolinatos y su uso como herbicidas
AR101394A1 (es) COMPUESTO DE 6,7-DIHIDROPIRAZOLO[1,5-A]PIRAZIN-4(5H)-ONA Y SU USO COMO MODULADORES ALOSTÉRICOS NEGATIVOS DE RECEPTORES mGluR2
AR103078A1 (es) Derivados de fumagilol
AR101588A1 (es) Compuesto tetrahidroimidazo[1,5-d][1,4]oxazepínico

Legal Events

Date Code Title Description
FB Suspension of granting procedure