[go: up one dir, main page]

AR101036A1 - Amidas de benzoxazinona como reguladores del receptor mineralocorticoide - Google Patents

Amidas de benzoxazinona como reguladores del receptor mineralocorticoide

Info

Publication number
AR101036A1
AR101036A1 ARP150102098A ARP150102098A AR101036A1 AR 101036 A1 AR101036 A1 AR 101036A1 AR P150102098 A ARP150102098 A AR P150102098A AR P150102098 A ARP150102098 A AR P150102098A AR 101036 A1 AR101036 A1 AR 101036A1
Authority
AR
Argentina
Prior art keywords
benzoxazinona
amidas
mineralocorticoid
regulators
receiver
Prior art date
Application number
ARP150102098A
Other languages
English (en)
Inventor
Carl Hogner Anders
Kajanus Johan
Edman Karl
Kossenjans Michael
Omahony Gavin
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of AR101036A1 publication Critical patent/AR101036A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Reivindicación 1: Un compuesto de la fórmula (1) donde R¹ se selecciona a partir de CONH₂ o CONHCH₃; y R² se selecciona a partir de H, F, Cl o Br; o una sal del mismo adecuada para usos farmacéuticos.
ARP150102098A 2014-06-30 2015-06-30 Amidas de benzoxazinona como reguladores del receptor mineralocorticoide AR101036A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462018790P 2014-06-30 2014-06-30

Publications (1)

Publication Number Publication Date
AR101036A1 true AR101036A1 (es) 2016-11-16

Family

ID=53539739

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP150102098A AR101036A1 (es) 2014-06-30 2015-06-30 Amidas de benzoxazinona como reguladores del receptor mineralocorticoide

Country Status (26)

Country Link
US (2) US10017502B2 (es)
EP (1) EP3160948B1 (es)
JP (1) JP6368383B2 (es)
KR (1) KR102012222B1 (es)
CN (1) CN106536491B (es)
AR (1) AR101036A1 (es)
AU (1) AU2015282450C1 (es)
CA (1) CA2953655C (es)
CY (1) CY1121596T1 (es)
DK (1) DK3160948T3 (es)
EA (1) EA029518B1 (es)
ES (1) ES2707726T3 (es)
HR (1) HRP20190147T1 (es)
HU (1) HUE042370T2 (es)
LT (1) LT3160948T (es)
ME (1) ME03316B (es)
MX (1) MX367404B (es)
PL (1) PL3160948T3 (es)
PT (1) PT3160948T (es)
RS (1) RS58274B1 (es)
SI (1) SI3160948T1 (es)
SM (1) SMT201900039T1 (es)
TR (1) TR201900659T4 (es)
TW (1) TWI677498B (es)
UY (1) UY36195A (es)
WO (1) WO2016001631A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL3160948T3 (pl) * 2014-06-30 2019-04-30 Astrazeneca Ab Amidy benzoksazynonu jako modulatory receptorów mineralokortykoidowych
CA3105626A1 (en) 2018-07-19 2020-01-23 Astrazeneca Ab Methods of treating hfpef employing dapagliflozin and compositions comprising the same
CN112107568B (zh) * 2019-06-19 2022-03-25 北京龙嘉博创医药科技有限公司 二芳基酰胺类化合物及其应用
JOP20200098A1 (ar) 2019-08-30 2021-02-28 Astrazeneca Ab طرق علاج الفشل القلبي مع كسر قذفي منخفض بواسطة داباجليفلوزين
TW202220672A (zh) 2020-07-27 2022-06-01 瑞典商阿斯特捷利康公司 用達格列淨治療慢性腎臟病之方法
AU2022292685A1 (en) * 2021-06-15 2024-01-18 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Benzoxazinone derivatives
TW202409023A (zh) 2022-07-14 2024-03-01 美商富曼西公司 除草苯并𠯤
WO2024047574A1 (en) 2022-09-01 2024-03-07 Astrazeneca Ab Combination of sglt2 inhibitors and mineralcorticoid receptor modulators for use in treatment of cardiorenal diseases
WO2024125591A1 (zh) * 2022-12-15 2024-06-20 正大天晴药业集团股份有限公司 苯并恶嗪酮类化合物的结晶及其制备

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004528335A (ja) * 2001-04-23 2004-09-16 アストラゼネカ アクチボラグ 血管新生の治療に使用のベンゾオキサジノン誘導体
CA2510851A1 (en) * 2002-12-20 2004-07-08 Warner-Lambert Company Llc Benzoxazines and derivatives thereof as inhibitors of pi3ks
MX2007000449A (es) * 2004-07-14 2007-03-28 Ligand Pharm Inc Compuestos moduladores de receptor intracelular y metodos.
KR20070046150A (ko) * 2004-07-28 2007-05-02 아이알엠 엘엘씨 스테로이드 호르몬 핵 수용체의 조절제로서의 화합물 및조성물
JP2009523701A (ja) 2005-12-28 2009-06-25 武田薬品工業株式会社 縮合複素環化合物およびその用途
TWI385161B (zh) 2006-02-02 2013-02-11 Mitsubishi Tanabe Pharma Corp 含氮雜雙環化合物
SI2089367T1 (sl) 2006-10-31 2012-02-29 Pfizer Prod Inc Spojine pirazolina kot antagonisti mineralokortikoidnih receptorjev
DE102007009494A1 (de) 2007-02-27 2008-08-28 Bayer Healthcare Ag Substituierte 4-Aryl-1, 4-dihydro-1,6-naphthyridinamide und ihre Verwendung
JP2010522168A (ja) 2007-03-23 2010-07-01 メルク・シャープ・エンド・ドーム・コーポレイション 鉱質コルチコイドレセプターモジュレータ
JP5363312B2 (ja) 2007-04-09 2013-12-11 第一三共株式会社 ピロール誘導体のアトロプ異性体
JP5173653B2 (ja) * 2007-08-01 2013-04-03 田辺三菱製薬株式会社 医薬組成物
US8258131B2 (en) 2007-08-01 2012-09-04 Mitsubishi Tanabe Pharma Corporation Fused bicyclic compound
PE20091057A1 (es) 2007-12-19 2009-07-20 Lilly Co Eli Antagonistas del receptor mineralcorticoide y metodos de uso
UY31905A (es) * 2008-06-18 2010-01-29 Astrazeneca Ab Derivados de benzoxazinona, procesos de preparación, composiciones farmacéuticas conteniéndolos y aplicaciones.
US20100094000A1 (en) 2008-09-03 2010-04-15 Takeda Pharmaceutical Company Limited Pyrazole compounds
WO2010098286A1 (ja) 2009-02-25 2010-09-02 第一三共株式会社 ミネラルコルチコイド受容体拮抗薬を含有する医薬
EA019179B1 (ru) 2009-03-12 2014-01-30 Эли Лилли Энд Компани Антагонист минералокортикоидного рецептора и способы его применения
JP2012523405A (ja) 2009-04-10 2012-10-04 ファイザー・インク ４，５−ジヒドロ−１ｈ−ピラゾール化合物およびその薬学的使用
EP2569310A1 (en) 2010-05-11 2013-03-20 Pfizer Inc Morpholine compounds as mineralocorticoid receptor antagonists
US8979337B2 (en) 2010-05-11 2015-03-17 Koninklijke Philips N.V. Lighting module
JPWO2012008435A1 (ja) 2010-07-13 2013-09-09 大日本住友製薬株式会社 ビアリールアミド誘導体またはその薬理学的に許容される塩
JP2013542255A (ja) 2010-11-10 2013-11-21 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ミネラルコルチコイド受容体アンタゴニストとしてのピリジル尿素
PL3160948T3 (pl) * 2014-06-30 2019-04-30 Astrazeneca Ab Amidy benzoksazynonu jako modulatory receptorów mineralokortykoidowych

Also Published As

Publication number Publication date
KR102012222B1 (ko) 2019-10-21
CN106536491A (zh) 2017-03-22
MX367404B (es) 2019-08-20
ES2707726T3 (es) 2019-04-04
CA2953655A1 (en) 2016-01-07
MX2017000183A (es) 2017-04-25
CY1121596T1 (el) 2020-05-29
AU2015282450C1 (en) 2018-09-20
RS58274B1 (sr) 2019-03-29
PT3160948T (pt) 2019-02-01
US20170217945A1 (en) 2017-08-03
AU2015282450A1 (en) 2017-02-02
EP3160948B1 (en) 2018-10-24
EA201790046A1 (ru) 2017-08-31
CA2953655C (en) 2020-05-12
SMT201900039T1 (it) 2019-02-28
LT3160948T (lt) 2019-02-11
TWI677498B (zh) 2019-11-21
EA029518B1 (ru) 2018-04-30
TW201613909A (en) 2016-04-16
JP6368383B2 (ja) 2018-08-01
TR201900659T4 (tr) 2019-02-21
DK3160948T3 (en) 2019-02-18
KR20170021883A (ko) 2017-02-28
PL3160948T3 (pl) 2019-04-30
US9394291B2 (en) 2016-07-19
CN106536491B (zh) 2018-12-18
US10017502B2 (en) 2018-07-10
US20150376170A1 (en) 2015-12-31
SI3160948T1 (sl) 2020-06-30
UY36195A (es) 2016-01-08
HUE042370T2 (hu) 2019-06-28
JP2017522300A (ja) 2017-08-10
EP3160948A1 (en) 2017-05-03
ME03316B (me) 2019-10-20
HRP20190147T1 (hr) 2019-03-22
AU2015282450B2 (en) 2018-05-10
WO2016001631A1 (en) 2016-01-07

Similar Documents

Publication Publication Date Title
AR101036A1 (es) Amidas de benzoxazinona como reguladores del receptor mineralocorticoide
MX2017006266A (es) Compuestos de heteroarilo como inhibidores de cinasas asociadas al receptor de interleucina 1(irak) y sus usos.
BR112017006253A2 (pt) novos compostos
EA201501142A1 (ru) Гетероциклические соединения в качестве средств для борьбы с вредителями
EA201692219A1 (ru) Способы получения противовирусных соединений
CL2016002011A1 (es) Derivados de heterociclos bicíclicos condensados sustituidos con 2-(het)arilo como agentes para combatir parásitos
EA201791420A1 (ru) Соединения триазолопиримидина и их применения
EA201692203A1 (ru) Соединения, ингибирующие tank-связывающую киназу
LT3159409T (lt) Antiprasminė nukleorūgštis, skirta panaudoti diušeno raumenų distrofijos gydymui
CL2016002731A1 (es) Herbicidas de piridazinona
EA201791304A1 (ru) Производные изохинолина для лечения вич
EA201790395A1 (ru) Производные аминотриазина, подходящие для применения в качестве соединений-ингибиторов tank-связывающей киназы
DK3497081T3 (da) Fremgangsmåde til fremstilling af 4-ammonium-2,2,6,6-tetraalkylpiperidinylsalte
EA201790983A1 (ru) Синтез копанлисиба и его дигидрохлорида
AR105549A1 (es) Compuestos de 1-alquil-6-oxo-1,6-dihidropiridin-3-ilo y usos de los mismos
CL2017001130A1 (es) Síntesis de copanlisib y su sal diclorhidrato
BR112016027691A2 (pt) Composto de tetra-hidropiridopirimidina e seus usos
LT3210973T (lt) Heteroarilo junginiai, skirti akių ligų gydymui
BR112016029510A2 (pt) métodos para a preparação de um composto, e, composto intermediário.
TW201613912A (en) Bicyclic compounds as pesticides
EA201591915A1 (ru) Соединения феноксиэтил дигидро-1h-изохинолина
EA201790687A1 (ru) Хинолинкарбоксамиды для применения в лечении множественной миеломы
EA201691999A1 (ru) Новые сульфониламинобензамидные соединения
BR112016027455A2 (pt) moduladores ppar
DOP2019000021A (es) Derivado de triazolopirazinona útil como un inhibidor de pde1 humana

Legal Events

Date Code Title Description
FG Grant, registration