AR089807A1 - Compuestos de imidazopirrolidinona - Google Patents
Compuestos de imidazopirrolidinonaInfo
- Publication number
- AR089807A1 AR089807A1 ARP130100227A ARP130100227A AR089807A1 AR 089807 A1 AR089807 A1 AR 089807A1 AR P130100227 A ARP130100227 A AR P130100227A AR P130100227 A ARP130100227 A AR P130100227A AR 089807 A1 AR089807 A1 AR 089807A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- nr9r10
- optionally substituted
- independently selected
- halo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Cosmetics (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Compuestos en el tratamiento de un trastorno o una enfermedad mediada por la actividad de MDM2 y/o MDM4, y composiciones que comprenden tales compuestos. Los compuestos de la presente se utilizan como agentes antineoplasicos. Reivindicación 1: Un compuesto de la fórmula (1) o una sal del mismo, en donde A se selecciona a partir del grupo de formulas (2); B se selecciona a partir del grupo de formulas (3); cada R¹ se selecciona independientemente a partir de halo y metilo; R² se selecciona a partir de cloro, fluoro, trifluorometilo, metilo y ciano; R³ se selecciona a partir de isopropilo, ciclopropilo, isobutilo, ciclobutilo y ciclopentilo, o R³ es un resto de formula (4), en donde R²² se selecciona a partir de OH, OCH₃, NH₂, NHMe, NMe₂, NHCOMe y NHCOH; R⁴ se selecciona a partir del grupo de formulas (5), en donde R¹⁵ se selecciona independientemente a partir de OCH₃, CH₂CH₃, OH, OCF₃ y H; R¹⁶ se selecciona a partir de H, -O-alquilo C₁₋₄, halo, OCF₃, CN, -C(O)NR⁹R¹⁰, -C(O)-morfolinil-4-ilo, hidroxi-azetidin-1-il-carbonilo, -CH₂NR⁹R¹⁰, -CH₂NR⁹-C(O)R¹⁰, CH₂CN, metil-imidazolil-, -CH₂C(O)NR⁹R¹⁰, -CH₂C(O)OH, -C(O)OH, -CH₂C(O)O-alquilo C₁₋₄, -N(R⁹)-C(O)-alquilo C₁₋₄, -NR⁹R¹⁰ y alquilo C₁₋₄ opcionalmente sustituido por 1 ó 2 OH; R¹⁷ se selecciona a partir de H, -O-alquilo C₁₋₄, -CH₂C(O)NR⁹R¹⁰, -CH₂C(O)O-alquilo C₁₋₄, -CH₂C(O)OH, -NR⁹R¹⁰, -C(O)NR⁹R¹⁰, -CH₂NR⁹R¹⁰, -C(O)OCH₃ y -CH₂CN; R¹⁸ se selecciona a partir de H, -O-alquilo C₁₋₄, OH, CH₂NR⁹R¹⁰, -NR⁹R¹⁰ y azetidin-1-ilo, dicho azetidin-1-ilo es sustituido por OH o ambos CH₃ y OH; R¹⁹ se selecciona a partir de H, -O-alquilo C₁₋₄, alquilo C₁₋₄, -NR⁹R¹⁰, -N(R⁹)-C(O)alquilo C₁₋₄ y -C(O)NR⁹R¹⁰; R²⁰ se selecciona a partir de H, CH₃ y -CH₂CH₃; R²¹ se selecciona a partir de -NR⁹R¹⁰, -CH₂NR⁹R¹⁰, C(O)NR⁹R¹⁰ y CN; R⁵ se selecciona a partir de: H, heterociclilo¹-C(O)-(CH₂)ₙ-, alquilo C₁₋₄-, dicho alquilo C₁₋₄ opcionalmente sustituido por 1 ó 2 sustituyentes independientemente seleccionados a partir de OH, =O, heterociclilo¹-alquilo C₁₋₄-, en donde dicho alquilo de heterociclilo¹-alquilo C₁₋₄- es opcionalmente sustituido por 1 ó 2 OH, y dicho heterociclilo¹ puede ser opcionalmente sustituido por metilo o etilo, alquilo C₁₋₄-OC(O)(CH₂)ₘ-, y ciano; R⁶ se selecciona a partir de: H, alquilo C₁₋₄-, opcionalmente sustituido por alcoxilo C₁₋₄, alcoxilo C₁₋₄, opcionalmente sustituido por alcoxilo C₁₋₄, alcoxi C₁₋₄alcoxi C₁₋₄alquilo C₁₋₄-, halo, R⁹(R¹⁰)N-C(O)-(CH₂)ₘ-, ciano, R⁹(R¹⁰)N-(CH₂)ₘ-, R⁹(R¹⁰)N-(CH₂)ₙ-O-(CH₂)ₘ-, alquilo C₁₋₄-C(O)-(R¹⁰)N-(CH₂)ₘ-, -O-(CH₂)ₚ-heteroarilo²; R⁷ se selecciona a partir de: H, halo, y alquilo C₁₋₄-, opcionalmente sustituido por alcoxilo C₁₋₄; cada R⁸ se selecciona independientemente a partir de H, metilo, etilo, hidroxietilo y metoxietilo-, en donde dicho metilo o etilo es opcionalmente sustituido por 1, 2 ó 3 sustituyentes fluoro; cada R⁹ se selecciona independientemente a partir de H, metilo o etilo; cada R¹⁰ se selecciona independientemente a partir de H y alquilo C₁₋₄ en donde dicho alquilo C₁₋₄ es opcionalmente sustituido por 1 ó 2 sustituyentes independientemente seleccionados a partir de metoxilo, etoxilo, hidroxilo y halo; o R⁹ y R¹⁰, junto con el átomo N al cual están unidos, pueden formar un anillo heterocíclico saturado de 5 ó 6 miembros que comprende además átomos de carbono cíclicos y opcionalmente un heteroátomo cíclico independientemente seleccionado a partir de N, O y S, y en donde, cuando el anillo contiene un átomo S, dicho S es opcionalmente sustituido por uno o dos sustituyentes oxo; R¹¹ es H, alquilo C₁₋₄, alcoxilo C₁₋₄ o halo; R¹² es H o halo; R¹³ se selecciona a partir de NH₂, -C(O)OH, -NH(C(O)-CH₃) y -C(O)-NH(CH₃); R¹⁴ se selecciona a partir de -C(O)-NR⁹(R¹⁰), alquilo C₁₋₄, -C(O)-alquilo C₁₋₄, -C(O)O-alquilo C₁₋₄; cada R²³ se selecciona independientemente a partir de H, halo, ciclopropilo y alquilo C₁₋₄; n es 1, 2 ó 3; d es 0, 1, 2, ó 3; heterociclilo¹ es un grupo monocíclico completamente saturado o parcialmente saturado de 3, 4, 5 ó 6 miembros que comprende átomos de carbono cíclicos y 1 ó 2 heteroátomos cíclicos independientemente seleccionado a partir de N, O y S; heteroarilo² es un grupo monocíclico completamente insaturado de 5 ó 6 miembros que comprende átomos de carbono cíclicos y 1, 2, 3 ó 4 heteroátomos cíclicos independientemente seleccionados a partir de N, O y S, en donde el número total de átomos de S cíclicos no excede 1, y el número total de átomos de O cíclicos no excede 1; y m es 0, 1 ó 2; * indica el punto de fijación al resto de la molécula.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261591001P | 2012-01-26 | 2012-01-26 | |
| US201261669902P | 2012-07-10 | 2012-07-10 | |
| CNPCT/CN2012/086703 | 2012-12-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR089807A1 true AR089807A1 (es) | 2014-09-17 |
Family
ID=47997596
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP130100227A AR089807A1 (es) | 2012-01-26 | 2013-01-25 | Compuestos de imidazopirrolidinona |
Country Status (45)
Families Citing this family (82)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0811643D0 (en) | 2008-06-25 | 2008-07-30 | Cancer Rec Tech Ltd | New therapeutic agents |
| US8440693B2 (en) | 2009-12-22 | 2013-05-14 | Novartis Ag | Substituted isoquinolinones and quinazolinones |
| JP5992054B2 (ja) | 2011-11-29 | 2016-09-14 | ノバルティス アーゲー | ピラゾロピロリジン化合物 |
| US8815926B2 (en) * | 2012-01-26 | 2014-08-26 | Novartis Ag | Substituted pyrrolo[3,4-D]imidazoles for the treatment of MDM2/4 mediated diseases |
| EP2855483B1 (en) | 2012-05-24 | 2017-10-25 | Novartis AG | Pyrrolopyrrolidinone compounds |
| BR112015013611A2 (pt) | 2012-12-20 | 2017-11-14 | Merck Sharp & Dohme | composto, e, composição farmacêutica |
| WO2014115077A1 (en) | 2013-01-22 | 2014-07-31 | Novartis Ag | Substituted purinone compounds |
| EP2948453B1 (en) | 2013-01-22 | 2017-08-02 | Novartis AG | Pyrazolo[3,4-d]pyrimidinone compounds as inhibitors of the p53/mdm2 interaction |
| US8975417B2 (en) | 2013-05-27 | 2015-03-10 | Novartis Ag | Pyrazolopyrrolidine derivatives and their use in the treatment of disease |
| EA029312B1 (ru) * | 2013-05-27 | 2018-03-30 | Новартис Аг | Производные имидазопирролидинона и их применение при лечении заболеваний |
| WO2014191906A1 (en) | 2013-05-28 | 2014-12-04 | Novartis Ag | Pyrazolo-pyrrolidin-4-one derivatives as bet inhibitors and their use in the treatment of disease |
| ES2650562T3 (es) | 2013-05-28 | 2018-01-19 | Novartis Ag | Derivados de pirazolo-pirrolidin-4-ona y su uso en el tratamiento de enfermedades |
| US9550796B2 (en) | 2013-11-21 | 2017-01-24 | Novartis Ag | Pyrrolopyrrolone derivatives and their use as BET inhibitors |
| WO2015084804A1 (en) | 2013-12-03 | 2015-06-11 | Novartis Ag | Combination of mdm2 inhibitor and braf inhibitor and their use |
| RU2016129953A (ru) * | 2013-12-23 | 2018-01-30 | Новартис Аг | Фармацевтические комбинации |
| ES2864352T3 (es) * | 2013-12-23 | 2021-10-13 | Novartis Ag | Combinaciones farmacéuticas |
| JOP20200094A1 (ar) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | جزيئات جسم مضاد لـ pd-1 واستخداماتها |
| JOP20200096A1 (ar) | 2014-01-31 | 2017-06-16 | Children’S Medical Center Corp | جزيئات جسم مضاد لـ tim-3 واستخداماتها |
| ME03558B (me) | 2014-03-14 | 2020-07-20 | Novartis Ag | Molekuli anti-lag-3 antiтela i njihove upotrebe |
| TW201613576A (en) * | 2014-06-26 | 2016-04-16 | Novartis Ag | Intermittent dosing of MDM2 inhibitor |
| MA41044A (fr) | 2014-10-08 | 2017-08-15 | Novartis Ag | Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer |
| UY36351A (es) | 2014-10-14 | 2016-06-01 | Novartis Ag | Moléculas de anticuerpo que se unen a pd-l1 y usos de las mismas |
| WO2016100882A1 (en) | 2014-12-19 | 2016-06-23 | Novartis Ag | Combination therapies |
| JO3746B1 (ar) | 2015-03-10 | 2021-01-31 | Aduro Biotech Inc | تركيبات وطرق لتنشيط الإشارات المعتمدة على "منبه أو تحفيز جين انترفيرون" |
| US20180222982A1 (en) | 2015-07-29 | 2018-08-09 | Novartis Ag | Combination therapies comprising antibody molecules to pd-1 |
| EP3317301B1 (en) | 2015-07-29 | 2021-04-07 | Novartis AG | Combination therapies comprising antibody molecules to lag-3 |
| EP3316902A1 (en) | 2015-07-29 | 2018-05-09 | Novartis AG | Combination therapies comprising antibody molecules to tim-3 |
| TWI804010B (zh) | 2015-08-03 | 2023-06-01 | 瑞士商諾華公司 | 作為血液學毒性生物標記之gdf-15 |
| KR20180037975A (ko) * | 2015-08-14 | 2018-04-13 | 노파르티스 아게 | 포도막 흑색종을 치료하기 위한 mdm2 억제제 |
| JP2018528949A (ja) * | 2015-08-28 | 2018-10-04 | ノバルティス アーゲー | Ｐｉ３ｋ阻害剤およびｍｄｍ２阻害剤を使用する組み合わせ療法 |
| JP2018528206A (ja) * | 2015-08-28 | 2018-09-27 | ノバルティス アーゲー | Ｍｄｍ２阻害剤およびその組み合わせ物 |
| GB201517216D0 (en) | 2015-09-29 | 2015-11-11 | Cancer Res Technology Ltd And Astex Therapeutics Ltd | Pharmaceutical compounds |
| GB201517217D0 (en) | 2015-09-29 | 2015-11-11 | Astex Therapeutics Ltd And Cancer Res Technology Ltd | Pharmaceutical compounds |
| CA3004138A1 (en) | 2015-11-03 | 2017-05-11 | Janssen Biotech, Inc. | Antibodies specifically binding pd-1 and tim-3 and their uses |
| US20180371093A1 (en) | 2015-12-17 | 2018-12-27 | Novartis Ag | Antibody molecules to pd-1 and uses thereof |
| CN109152843A (zh) | 2016-05-20 | 2019-01-04 | 豪夫迈·罗氏有限公司 | Protac抗体缀合物及其使用方法 |
| US11098077B2 (en) | 2016-07-05 | 2021-08-24 | Chinook Therapeutics, Inc. | Locked nucleic acid cyclic dinucleotide compounds and uses thereof |
| DK3541387T3 (da) | 2016-11-15 | 2021-07-19 | Novartis Ag | Dosis og regime for hdm2-p53-interaktionsinhibitorer |
| WO2018092064A1 (en) | 2016-11-18 | 2018-05-24 | Novartis Ag | Combinations of mdm2 inhibitors and bcl-xl inhibitors |
| HUE057029T2 (hu) | 2016-11-22 | 2022-04-28 | Novartis Ag | Kémiai eljárás imidazopirrolidinon-származékok és ezek köztitermékei elõállítására |
| WO2018158225A1 (en) | 2017-02-28 | 2018-09-07 | Les Laboratoires Servier | Combination of a bcl-2 inhibitor and a mdm2 inhibitor, uses and pharmaceutical compositions thereof |
| WO2018161871A1 (zh) * | 2017-03-06 | 2018-09-13 | 罗欣生物科技（上海）有限公司 | 作为p53-MDM2抑制剂的咪唑并吡咯酮化合物 |
| GB201704965D0 (en) | 2017-03-28 | 2017-05-10 | Astex Therapeutics Ltd | Pharmaceutical compounds |
| GB201704966D0 (en) | 2017-03-28 | 2017-05-10 | Astex Therapeutics Ltd | Pharmaceutical compounds |
| AU2018242612B2 (en) * | 2017-03-31 | 2020-05-21 | Novartis Ag | Dose and regimen for an HDM2-p53 interaction inhibitor in hematological tumors |
| WO2018185135A1 (en) * | 2017-04-05 | 2018-10-11 | Boehringer Ingelheim International Gmbh | Anticancer combination therapy |
| UY37695A (es) | 2017-04-28 | 2018-11-30 | Novartis Ag | Compuesto dinucleótido cíclico bis 2’-5’-rr-(3’f-a)(3’f-a) y usos del mismo |
| US20200172628A1 (en) | 2017-06-22 | 2020-06-04 | Novartis Ag | Antibody molecules to cd73 and uses thereof |
| US11413284B2 (en) | 2017-09-12 | 2022-08-16 | Novartis Ag | Protein kinase C inhibitors for treatment of uveal melanoma |
| US11642315B2 (en) | 2017-10-02 | 2023-05-09 | Novartis Ag | Method for preparing a pharmaceutical product |
| JP7332589B2 (ja) | 2017-10-12 | 2023-08-23 | ノバルティス アーゲー | 癌を治療するためのｍｄｍ２阻害剤とｅｒｋの阻害剤との組合せ |
| TW201922291A (zh) | 2017-11-16 | 2019-06-16 | 瑞士商諾華公司 | 組合療法 |
| KR20200105837A (ko) * | 2017-12-29 | 2020-09-09 | 간 앤 리 파마슈티칼스 | 종양 억제제로 사용될 수 있는 화합물 및 이의 제조방법과 용도 |
| EP3511334A1 (en) * | 2018-01-16 | 2019-07-17 | Adamed sp. z o.o. | 1,2,3',5'-tetrahydro-2'h-spiro[indole-3,1'-pyrrolo[3,4-c]pyrrole]-2,3'-dione compounds as therapeutic agents activating tp53 |
| EP3766883B1 (en) * | 2018-03-12 | 2022-09-28 | Luoxin Pharmaceutical (Shanghai) Co., Ltd. | Imidaxopyrolone compound and application thereof |
| CN111868088A (zh) | 2018-03-20 | 2020-10-30 | 诺华股份有限公司 | 药物组合 |
| AR126019A1 (es) | 2018-05-30 | 2023-09-06 | Novartis Ag | Anticuerpos frente a entpd2, terapias de combinación y métodos de uso de los anticuerpos y las terapias de combinación |
| AR116109A1 (es) | 2018-07-10 | 2021-03-31 | Novartis Ag | Derivados de 3-(5-amino-1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos |
| CN113194952A (zh) | 2018-12-20 | 2021-07-30 | 诺华股份有限公司 | Hdm2-p53相互作用抑制剂和bcl2抑制剂的组合及其治疗癌症的用途 |
| MX2021007392A (es) | 2018-12-20 | 2021-08-24 | Novartis Ag | Regimen de dosificacion y combinacion farmaceutica que comprende derivados de 3-(1-oxoisoindolin-2-il)piperidina-2,6-diona. |
| EP3898675A1 (en) | 2018-12-21 | 2021-10-27 | Novartis AG | Use of il-1 beta antibodies in the treatment or prevention of myelodysplastic syndrome |
| EP3898674A1 (en) | 2018-12-21 | 2021-10-27 | Novartis AG | Use of il-1beta binding antibodies |
| US10610280B1 (en) | 2019-02-02 | 2020-04-07 | Ayad K. M. Agha | Surgical method and apparatus for destruction and removal of intraperitoneal, visceral, and subcutaneous fat |
| MX2021009763A (es) | 2019-02-15 | 2021-09-08 | Novartis Ag | Derivados de 3-(1-oxo-5-(piperidin-4-il)isoindolin-2-il)piperidina -2,6-diona y usos de los mismos. |
| EA202192029A1 (ru) | 2019-02-15 | 2021-10-27 | Новартис Аг | Замещенные производные 3-(1-оксоизоиндолин-2-ил)пиперидин-2,6-диона и варианты их применения |
| KR20210149039A (ko) * | 2019-04-04 | 2021-12-08 | 노파르티스 아게 | 시레마들린 숙시네이트 |
| WO2021047466A1 (zh) * | 2019-09-12 | 2021-03-18 | 罗欣药业(上海)有限公司 | 一种p53-MDM2抑制剂的晶型及其制备方法 |
| KR20220063215A (ko) | 2019-09-16 | 2022-05-17 | 노파르티스 아게 | 골수섬유증의 치료를 위한 mdm2 억제제의 용도 |
| US20220348651A1 (en) | 2019-09-18 | 2022-11-03 | Novartis Ag | Entpd2 antibodies, combination therapies, and methods of using the antibodies and combination therapies |
| CA3165399A1 (en) | 2019-12-20 | 2021-06-24 | Novartis Ag | Uses of anti-tgf-beta antibodies and checkpoint inhibitors for the treatment of proliferative diseases |
| GB201919219D0 (en) | 2019-12-23 | 2020-02-05 | Otsuka Pharma Co Ltd | Cancer biomarkers |
| IL298262A (en) | 2020-06-23 | 2023-01-01 | Novartis Ag | Dosing regimen comprising 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives |
| TW202214248A (zh) | 2020-08-27 | 2022-04-16 | 日商大塚製藥股份有限公司 | 使用ｍｄｍ２拮抗劑的癌症療法之生物標記 |
| TW202218665A (zh) | 2020-09-21 | 2022-05-16 | 德國阿爾伯特路德維希弗萊堡大學 | 用於治療或預防造血細胞移植後血液科贅瘤(neoplasm)復發之mdm2抑制劑 |
| GB202103080D0 (en) | 2021-03-04 | 2021-04-21 | Otsuka Pharma Co Ltd | Cancer biomarkers |
| TW202304979A (zh) | 2021-04-07 | 2023-02-01 | 瑞士商諾華公司 | 抗ＴＧＦβ抗體及其他治療劑用於治療增殖性疾病之用途 |
| AR125874A1 (es) | 2021-05-18 | 2023-08-23 | Novartis Ag | Terapias de combinación |
| WO2023056069A1 (en) | 2021-09-30 | 2023-04-06 | Angiex, Inc. | Degrader-antibody conjugates and methods of using same |
| TW202329968A (zh) | 2021-10-19 | 2023-08-01 | 瑞士商諾華公司 | 包含mdm2抑制劑、bcl2抑制劑和低甲基化劑的藥物組合及其用於治療血液惡性腫瘤之用途 |
| WO2024097948A1 (en) * | 2022-11-04 | 2024-05-10 | Roivant Discovery, Inc. | Degraders of mdm2 and uses thereof |
| CN116178279A (zh) * | 2023-03-15 | 2023-05-30 | 上海药坦药物研究开发有限公司 | 一种5-溴-4-环丙基-6-甲氧基嘧啶及其中间体的制备方法 |
| WO2024240858A1 (en) | 2023-05-23 | 2024-11-28 | Valerio Therapeutics | Protac molecules directed against dna damage repair system and uses thereof |
Family Cites Families (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR901228A (fr) | 1943-01-16 | 1945-07-20 | Deutsche Edelstahlwerke Ag | Système d'aimant à entrefer annulaire |
| GB1524747A (en) | 1976-05-11 | 1978-09-13 | Ici Ltd | Polypeptide |
| EP0100172B1 (en) | 1982-07-23 | 1987-08-12 | Imperial Chemical Industries Plc | Amide derivatives |
| GB8327256D0 (en) | 1983-10-12 | 1983-11-16 | Ici Plc | Steroid derivatives |
| US5093330A (en) | 1987-06-15 | 1992-03-03 | Ciba-Geigy Corporation | Staurosporine derivatives substituted at methylamino nitrogen |
| US5010099A (en) | 1989-08-11 | 1991-04-23 | Harbor Branch Oceanographic Institution, Inc. | Discodermolide compounds, compositions containing same and method of preparation and use |
| US5395855A (en) | 1990-05-07 | 1995-03-07 | Ciba-Geigy Corporation | Hydrazones |
| NZ243082A (en) | 1991-06-28 | 1995-02-24 | Ici Plc | 4-anilino-quinazoline derivatives; pharmaceutical compositions, preparatory processes, and use thereof |
| GB9300059D0 (en) | 1992-01-20 | 1993-03-03 | Zeneca Ltd | Quinazoline derivatives |
| TW225528B (es) | 1992-04-03 | 1994-06-21 | Ciba Geigy Ag | |
| ATE348110T1 (de) | 1992-10-28 | 2007-01-15 | Genentech Inc | Hvegf rezeptor als vegf antagonist |
| GB9314893D0 (en) | 1993-07-19 | 1993-09-01 | Zeneca Ltd | Quinazoline derivatives |
| US5508300A (en) | 1994-01-14 | 1996-04-16 | Pfizer Inc. | Dihydro pyrazolopyrroles, compositions and use |
| EP1110953B1 (en) | 1995-03-30 | 2009-10-28 | Pfizer Products Inc. | Quinazoline derivatives |
| GB9508538D0 (en) | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
| US5747498A (en) | 1996-05-28 | 1998-05-05 | Pfizer Inc. | Alkynyl and azido-substituted 4-anilinoquinazolines |
| US5843901A (en) | 1995-06-07 | 1998-12-01 | Advanced Research & Technology Institute | LHRH antagonist peptides |
| US5880141A (en) | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
| KR100437582B1 (ko) | 1995-07-06 | 2004-12-17 | 노파르티스 아게 | 피롤로피리미딘및그들의제조방법 |
| US5760041A (en) | 1996-02-05 | 1998-06-02 | American Cyanamid Company | 4-aminoquinazoline EGFR Inhibitors |
| GB9603095D0 (en) | 1996-02-14 | 1996-04-10 | Zeneca Ltd | Quinazoline derivatives |
| CA2249446C (en) | 1996-04-12 | 2008-06-17 | Warner-Lambert Company | Irreversible inhibitors of tyrosine kinases |
| ATE308527T1 (de) | 1996-06-24 | 2005-11-15 | Pfizer | Phenylamino-substituierte triicyclische derivate zur behandlung hyperproliferativer krankheiten |
| JP2001500851A (ja) | 1996-08-30 | 2001-01-23 | ノバルティス アクチエンゲゼルシャフト | エポシロンの製造法および製造過程中に得られる中間生産物 |
| CA2264908C (en) | 1996-09-06 | 2006-04-25 | Obducat Ab | Method for anisotropic etching of structures in conducting materials |
| DE19638745C2 (de) | 1996-09-11 | 2001-05-10 | Schering Ag | Monoklonale Antikörper gegen die extrazelluläre Domäne des menschlichen VEGF - Rezeptorproteins (KDR) |
| CA2265630A1 (en) | 1996-09-13 | 1998-03-19 | Gerald Mcmahon | Use of quinazoline derivatives for the manufacture of a medicament in the treatment of hyperproliferative skin disorders |
| EP0837063A1 (en) | 1996-10-17 | 1998-04-22 | Pfizer Inc. | 4-Aminoquinazoline derivatives |
| EP0941227B2 (de) | 1996-11-18 | 2009-10-14 | Gesellschaft für biotechnologische Forschung mbH (GBF) | Epothilon d, dessen herstellung und dessen verwendung als cytostatisches mittel bzw. als pflanzenschutzmittel |
| US6441186B1 (en) | 1996-12-13 | 2002-08-27 | The Scripps Research Institute | Epothilone analogs |
| CO4950519A1 (es) | 1997-02-13 | 2000-09-01 | Novartis Ag | Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion |
| CO4940418A1 (es) | 1997-07-18 | 2000-07-24 | Novartis Ag | Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso |
| GB9721069D0 (en) | 1997-10-03 | 1997-12-03 | Pharmacia & Upjohn Spa | Polymeric derivatives of camptothecin |
| US6194181B1 (en) | 1998-02-19 | 2001-02-27 | Novartis Ag | Fermentative preparation process for and crystal forms of cytostatics |
| MXPA00008365A (es) | 1998-02-25 | 2002-11-07 | Sloan Kettering Inst Cancer | Sintesis de epotilonas, intermediarios y analogos de las mismas. |
| WO2000009495A1 (en) | 1998-08-11 | 2000-02-24 | Novartis Ag | Isoquinoline derivatives with angiogenesis inhibiting activity |
| UA71587C2 (uk) | 1998-11-10 | 2004-12-15 | Шерінг Акцієнгезелльшафт | Аміди антранілової кислоти та їхнє застосування як лікарських засобів |
| GB9824579D0 (en) | 1998-11-10 | 1999-01-06 | Novartis Ag | Organic compounds |
| AU768220B2 (en) | 1998-11-20 | 2003-12-04 | Kosan Biosciences, Inc. | Recombinant methods and materials for producing epothilone and epothilone derivatives |
| EP1140173B2 (en) | 1998-12-22 | 2013-04-03 | Genentech, Inc. | Vascular endothelial cell growth factor antagonists and uses thereof |
| AU766081B2 (en) | 1999-03-30 | 2003-10-09 | Novartis Ag | Phthalazine derivatives for treating inflammatory diseases |
| PE20010306A1 (es) | 1999-07-02 | 2001-03-29 | Agouron Pharma | Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa |
| GB0018891D0 (en) | 2000-08-01 | 2000-09-20 | Novartis Ag | Organic compounds |
| AU8765401A (en) | 2000-08-10 | 2002-02-18 | Pharmacia Italia Spa | Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation andpharmaceutical compositions comprising them |
| PE20020354A1 (es) | 2000-09-01 | 2002-06-12 | Novartis Ag | Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda) |
| US6995162B2 (en) | 2001-01-12 | 2006-02-07 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
| TWI238824B (en) | 2001-05-14 | 2005-09-01 | Novartis Ag | 4-amino-5-phenyl-7-cyclobutyl-pyrrolo[2,3-d]pyrimidine derivatives |
| GB0119249D0 (en) | 2001-08-07 | 2001-10-03 | Novartis Ag | Organic compounds |
| JP4477351B2 (ja) * | 2001-12-18 | 2010-06-09 | エフ．ホフマン−ラ ロシュ アーゲー | シス−２，４，５−トリフェニル−イミダゾリン類及び腫瘍の処理へのそれらの使用 |
| WO2004078163A2 (en) | 2003-02-28 | 2004-09-16 | Transform Pharmaceuticals, Inc. | Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen |
| WO2003095625A2 (en) | 2002-05-13 | 2003-11-20 | 3-Dimensional Pharmaceuticals, Inc. | Method for cytoprotection through mdm2 and hdm2 inhibition |
| US7145012B2 (en) * | 2003-04-23 | 2006-12-05 | Pfizer Inc. | Cannabinoid receptor ligands and uses thereof |
| KR20110033964A (ko) | 2004-05-18 | 2011-04-01 | 에프. 호프만-라 로슈 아게 | 신규 ｃｉｓ-이미다졸린 |
| ES2349358T3 (es) * | 2004-09-22 | 2010-12-30 | Janssen Pharmaceutica Nv | Inhibidores de la interacción entre mdm2 y p53. |
| US20060069085A1 (en) | 2004-09-28 | 2006-03-30 | Rulin Zhao | Preparation of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones |
| CA2589830A1 (en) | 2005-01-05 | 2006-07-13 | Rigel Pharmaceuticals, Inc. | Ubiquitin ligase inhibitors |
| CA2631907A1 (en) | 2005-12-12 | 2007-06-21 | Nerviano Medical Sciences S.R.L. | Substituted pyrrolo-pyrazole derivatives active as kinase inhibitors |
| WO2007096334A1 (en) | 2006-02-24 | 2007-08-30 | Pfizer Italia Srl | Pyrrolopyrrolones active as kinase inhibitors |
| US8367699B2 (en) | 2006-09-15 | 2013-02-05 | Nexuspharma, Inc. | Tetrahydro-isoquinolines |
| JP5624762B2 (ja) | 2007-03-30 | 2014-11-12 | 塩野義製薬株式会社 | 新規ピロリノン誘導体およびそれを含有する医薬組成物 |
| CA2709784A1 (en) | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| TW201016702A (en) | 2008-09-25 | 2010-05-01 | Shionogi & Co | Novel pyrrolinone derivative and pharmaceutical composition comprising the same |
| WO2010141738A2 (en) | 2009-06-03 | 2010-12-09 | President And Fellows Of Harvard College | Compositions and method for inhibiting tumor growth |
| US8440693B2 (en) | 2009-12-22 | 2013-05-14 | Novartis Ag | Substituted isoquinolinones and quinazolinones |
| US20120065210A1 (en) | 2010-09-15 | 2012-03-15 | Xin-Jie Chu | Substituted hexahydropyrrolo[1,2-c]imidazolones |
| GB201016880D0 (en) | 2010-10-07 | 2010-11-17 | Riotech Pharmaceuticals Ltd | Phosphodiesterase inhibitors |
| JP5992054B2 (ja) * | 2011-11-29 | 2016-09-14 | ノバルティス アーゲー | ピラゾロピロリジン化合物 |
| US8815926B2 (en) * | 2012-01-26 | 2014-08-26 | Novartis Ag | Substituted pyrrolo[3,4-D]imidazoles for the treatment of MDM2/4 mediated diseases |
| EP2855483B1 (en) | 2012-05-24 | 2017-10-25 | Novartis AG | Pyrrolopyrrolidinone compounds |
-
2013
- 2013-01-24 US US13/748,790 patent/US8815926B2/en active Active
- 2013-01-24 UY UY0001034591A patent/UY34591A/es active IP Right Grant
- 2013-01-24 JO JOP/2013/0025A patent/JO3357B1/ar active
- 2013-01-25 AU AU2013213260A patent/AU2013213260B2/en active Active
- 2013-01-25 CU CUP2014000091A patent/CU24336B1/es unknown
- 2013-01-25 ES ES13711952.5T patent/ES2632430T3/es active Active
- 2013-01-25 EA EA201790134A patent/EA201790134A3/ru unknown
- 2013-01-25 SI SI201330691T patent/SI2807164T1/sl unknown
- 2013-01-25 KR KR1020147023313A patent/KR101694383B1/ko active IP Right Grant
- 2013-01-25 PL PL13711952T patent/PL2807164T3/pl unknown
- 2013-01-25 DK DK13711952.5T patent/DK2807164T3/en active
- 2013-01-25 PE PE2014001168A patent/PE20141655A1/es active IP Right Grant
- 2013-01-25 KR KR1020167035785A patent/KR20160150292A/ko not_active Application Discontinuation
- 2013-01-25 MY MYPI2014002033A patent/MY177242A/en unknown
- 2013-01-25 BR BR112014018475-5A patent/BR112014018475B1/pt active IP Right Grant
- 2013-01-25 WO PCT/IB2013/050655 patent/WO2013111105A1/en active Application Filing
- 2013-01-25 MX MX2014009089A patent/MX353315B/es active IP Right Grant
- 2013-01-25 GE GEAP201313535A patent/GEP20166438B/en unknown
- 2013-01-25 SM SM20170336T patent/SMT201700336T1/it unknown
- 2013-01-25 RS RS20170670A patent/RS56197B1/sr unknown
- 2013-01-25 CA CA2860951A patent/CA2860951C/en active Active
- 2013-01-25 NZ NZ627277A patent/NZ627277A/en not_active IP Right Cessation
- 2013-01-25 AP AP2014007810A patent/AP2014007810A0/xx unknown
- 2013-01-25 JP JP2014553845A patent/JP5865519B2/ja active Active
- 2013-01-25 EP EP16161001.9A patent/EP3064502A1/en not_active Withdrawn
- 2013-01-25 EA EA201491423A patent/EA027130B1/ru not_active IP Right Cessation
- 2013-01-25 UA UAA201407720A patent/UA115231C2/uk unknown
- 2013-01-25 SG SG11201403935VA patent/SG11201403935VA/en unknown
- 2013-01-25 TW TW105143227A patent/TW201713644A/zh unknown
- 2013-01-25 ES ES17182338T patent/ES2743962T3/es active Active
- 2013-01-25 TW TW102103027A patent/TWI579284B/zh active
- 2013-01-25 PT PT137119525T patent/PT2807164T/pt unknown
- 2013-01-25 LT LTEP13711952.5T patent/LT2807164T/lt unknown
- 2013-01-25 CN CN201380016617.6A patent/CN104203952B/zh active Active
- 2013-01-25 EP EP17182338.8A patent/EP3272754B1/en active Active
- 2013-01-25 AR ARP130100227A patent/AR089807A1/es active IP Right Grant
- 2013-01-25 EP EP13711952.5A patent/EP2807164B1/en active Active
-
2014
- 2014-07-10 US US14/327,639 patent/US20140343084A1/en not_active Abandoned
- 2014-07-14 CL CL2014001855A patent/CL2014001855A1/es unknown
- 2014-07-18 MA MA37217A patent/MA35869B1/fr unknown
- 2014-07-21 IL IL233739A patent/IL233739A/en active IP Right Grant
- 2014-07-22 DO DO2014000170A patent/DOP2014000170A/es unknown
- 2014-07-22 CR CR20140354A patent/CR20140354A/es unknown
- 2014-07-23 TN TNP2014000319A patent/TN2014000319A1/fr unknown
- 2014-07-24 CO CO14161419A patent/CO7010838A2/es active IP Right Grant
- 2014-07-25 PH PH12014501702A patent/PH12014501702B1/en unknown
- 2014-07-25 NI NI201400083A patent/NI201400083A/es unknown
- 2014-07-25 GT GT201400164A patent/GT201400164A/es unknown
- 2014-08-25 EC ECIEPI201415553A patent/ECSP14015553A/es unknown
- 2014-12-04 HK HK14112230.9A patent/HK1198761A1/xx unknown
-
2015
- 2015-12-22 JP JP2015250003A patent/JP2016106095A/ja not_active Withdrawn
-
2017
- 2017-02-23 JP JP2017031964A patent/JP2017125037A/ja active Pending
- 2017-07-03 HR HRP20171005TT patent/HRP20171005T1/hr unknown
- 2017-07-05 CY CY20171100717T patent/CY1119058T1/el unknown
-
2018
- 2018-04-23 HK HK18105237.2A patent/HK1245780B/zh unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR089807A1 (es) | Compuestos de imidazopirrolidinona | |
| AR092838A1 (es) | COMPUESTOS TIPO PIRROLO-PIRROLIDINONA COMO INHIBIDORES DE LA INTERACCION ENTRE p53 Y MDM2 Y/O MDM4 | |
| AR096643A1 (es) | Procedimiento de síntesis para la preparación de análogos macrocíclicos c1-ceto de halicondrina b e intermediarios útiles en la misma incluyendo intermediarios que contienen grupos -so₂-(p-tolilo) | |
| AR107616A1 (es) | Compuestos de 6,7-dihidro-5h-benzo[7]anuleno sustituidos, procesos para su preparación y usos terapéuticos de los mismos | |
| AR098721A1 (es) | Inhibidores de biarilo de tirosina quinasa de bruton | |
| AR093404A1 (es) | Compuestos macrociclicos que modulan la actividad de los inhibidores de la apoptosis | |
| AR086829A1 (es) | Compuestos heterociclicos fusionados como moduladores del canal ionico | |
| AR088828A1 (es) | DERIVADOS DE CICLOHEXILAMINA QUE TIENEN ACTIVIDAD COMO AGONISTAS ADRENERGICOS b2 Y COMO ANTAGONISTAS MUSCARINICOS M3 | |
| AR091424A1 (es) | Compuestos triciclicos sustituidos como inhibidores de receptores del factor de crecimiento del fibroplasto (fgfr) | |
| AR089143A1 (es) | Triazolopiridinas sustituidas con actividad inhibidora de ttk | |
| AR086198A1 (es) | Inhibidores sustituidos de acetil-coa carboxilasa y composiciones farmaceuticas que los contienen | |
| AR102177A1 (es) | Compuestos de heteroarilo como inhibidores de btk y usos de los mismos | |
| AR096837A1 (es) | Heterociclos tricíclicos como inhibidores de proteínas bet | |
| AR098136A1 (es) | Compuestos de heteroarilo como inhibidores de btk y usos de los mismos | |
| AR089051A1 (es) | Compuestos de 2-(fenilo sustituido)-ciclopentan-1,3-diona y derivados de los mismos | |
| PE20161405A1 (es) | Analogos de cortistatina y sintesis y usos de los mismos | |
| PE20160608A1 (es) | Compuestos de quinolina selectivamente sustituida | |
| AR082886A1 (es) | Compuestos y composiciones farmaceuticas que los contienen | |
| AR095311A1 (es) | 3-pirimidin-4-il-oxazolidin-2-onas como inhibidores de idh mutante | |
| AR098492A1 (es) | Derivados de purina | |
| AR103265A1 (es) | Compuestos de azolina sustituidos con un sistema de anillos condensado | |
| AR118706A2 (es) | Compuesto para el control de plagas y vegetación no deseada, procedimiento para prepararlo, composición que lo comprende, y compuesto intermediario relacionado | |
| AR094876A1 (es) | Derivados de ácido betulínico modificados con alquilo c-3 y alquenilo | |
| AR092288A1 (es) | Ligandos del receptor ep1 | |
| AR094812A1 (es) | Derivado de piridina monocíclico como inhibidor del fgfr |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |