[go: up one dir, main page]

AR081575A1 - Formas de dosificacion oral de bendamustina y su uso terapeutico - Google Patents

Formas de dosificacion oral de bendamustina y su uso terapeutico

Info

Publication number
AR081575A1
AR081575A1 ARP110101916A ARP110101916A AR081575A1 AR 081575 A1 AR081575 A1 AR 081575A1 AR P110101916 A ARP110101916 A AR P110101916A AR P110101916 A ARP110101916 A AR P110101916A AR 081575 A1 AR081575 A1 AR 081575A1
Authority
AR
Argentina
Prior art keywords
bendamustine
pharmaceutically acceptable
minutes
pharmaceutical composition
group
Prior art date
Application number
ARP110101916A
Other languages
English (en)
Inventor
Taoufik Ouatas
Thomas Alfred Profitlich
Ulrich Patzak
Margaretha Olthoff
Jeffrey Colledge
Original Assignee
Astellas Deutschland Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44261747&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR081575(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astellas Deutschland Gmbh filed Critical Astellas Deutschland Gmbh
Publication of AR081575A1 publication Critical patent/AR081575A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A61K9/4825—Proteins, e.g. gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/485—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Oncology (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Mycology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Composición farmacéutica de administración oral que comprende bendamustina como ingrediente activo, o un éster, una sal o un solvato de ésta, y un excipiente farmacéuticamente aceptable, que presenta una disolución de la bendamustina de al menos 60% en 20 minutos, 70% en 40 minutos y 80% en 60 minutos, medida con un aparato con paletas a 50 rpm, de acuerdo con la Farmacopea Europea, en 500 mI de un medio de disolución a un pH de 1,5, y donde el excipiente farmacéuticamente aceptable es un agente tensioactivo no iónico farmacéuticamente aceptable seleccionado del grupo que consiste en el aceite de ricino polietoxilado o un derivado de éste y un copolímero de bloques de óxido de etileno y óxido de propileno, o un sacárido farmacéuticamente aceptable seleccionado del grupo que consiste en uno o más monosacáridos, disacáridos, oligosacáridos, oligosacáridos cíclicos, polisacáridos y alcoholes de sacáridos, donde la proporción en peso entre el ingrediente activo y los uno o más excipientes sacáridos se halla en el rango de 1:1-5. Uso de una composición farmacéutica como la anterior en el tratamiento oral de una condición médica seleccionada entre la leucemia linfocítica crónica, la leucemia linfocítica aguda, la leucemia mielocítica crónica, la leucemia mielocítica aguda, la enfermedad de Hodgkin, el linfoma no Hodgkin, el mieloma múltiple, el cáncer de mama, el cáncer de ovario, el cáncer de las células pulmonares pequeñas y el cáncer de las células pulmonares no pequeñas. Uso de una composición farmacéutica como la anterior en un régimen de dosificación que comprende al menos la administración de una dosis de entre 100 y 600 mg/m2 de bendamustina por persona el día 1 y el día 2, opcionalmente de una dosis i.v. u oral de entre 50 y 150 mg/m2 de un corticosteroide los días 1 a 5, y opcionalmente de una dosis apropiada de un agente activo adicional seleccionado del grupo que consiste en un anticuerpo específico para CD20, un derivado de antraciclina, un vinca alcaloide o un derivado de platina; y la repetición de dicho régimen de dosificación entre 4 y 15 veces, después de intervalos de entre dos y cuatro semanas.
ARP110101916A 2010-06-02 2011-06-02 Formas de dosificacion oral de bendamustina y su uso terapeutico AR081575A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10005762 2010-06-02
EP11075046 2011-03-14

Publications (1)

Publication Number Publication Date
AR081575A1 true AR081575A1 (es) 2012-10-03

Family

ID=44261747

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP110101916A AR081575A1 (es) 2010-06-02 2011-06-02 Formas de dosificacion oral de bendamustina y su uso terapeutico

Country Status (26)

Country Link
US (2) US20130209558A1 (es)
EP (1) EP2575785B1 (es)
JP (2) JP2013527206A (es)
KR (1) KR101830147B1 (es)
CN (1) CN103037852B (es)
AR (1) AR081575A1 (es)
AU (1) AU2011260614B2 (es)
BR (1) BR112012030658B1 (es)
CA (1) CA2800277A1 (es)
CL (1) CL2012003340A1 (es)
CO (1) CO6640268A2 (es)
DK (1) DK2575785T3 (es)
EA (1) EA027786B1 (es)
ES (1) ES2935792T3 (es)
FI (1) FI2575785T3 (es)
IL (2) IL223309B (es)
JO (1) JO3659B1 (es)
MX (1) MX2012013873A (es)
MY (1) MY173881A (es)
NZ (1) NZ603874A (es)
PH (1) PH12012502282B1 (es)
PL (1) PL2575785T3 (es)
SG (1) SG185794A1 (es)
TW (1) TWI556819B (es)
WO (1) WO2011151086A1 (es)
ZA (1) ZA201208822B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102048079B1 (ko) * 2011-09-18 2019-11-22 유로-셀띠끄 소시에떼 아노님 약학적 조성물
TWI573792B (zh) 2012-02-01 2017-03-11 歐陸斯迪公司 新穎治療劑
EP2641592A1 (en) 2012-03-23 2013-09-25 Salmon Pharma GmbH Pharmaceutical formulation comprising bendamustine
EP2656843B1 (en) 2012-04-26 2015-03-18 Helmut Schickaneder Esters of bendamustine and related compounds, and medical use thereof
CN104968335A (zh) * 2013-01-07 2015-10-07 三亚制药(株) 具有改善的溶解度的新型快速溶解颗粒制剂
ES2957541T3 (es) * 2013-08-27 2024-01-22 Vasilios Voudouris Composiciones farmacéuticas de bendamustina
GB201409471D0 (en) 2014-05-28 2014-07-09 Euro Celtique Sa Pharmaceutical composition
GB201409485D0 (en) 2014-05-28 2014-07-09 Euro Celtique Sa Pharmaceutical composition
GB201409488D0 (en) 2014-05-28 2014-07-09 Euro Celtique Sa Pharmaceutical composition
CN105726472B (zh) * 2016-03-25 2019-12-13 南京康玻斯医药科技有限公司 苯达莫司汀药剂组合物及应用
US11266631B2 (en) 2016-10-11 2022-03-08 Purdue Pharmaceutical Products L.P. Hodgkin lymphoma therapy
GB201709403D0 (en) 2017-06-13 2017-07-26 Euro Celtique Sa Compounds for treating sarcoma
GB201709405D0 (en) 2017-06-13 2017-07-26 Euro Celtique Sa Compounds for treating ovarian cancer
GB201709406D0 (en) 2017-06-13 2017-07-26 Euro-Cletique S A Compounds for treating TNBC
GB201709402D0 (en) 2017-06-13 2017-07-26 Euro Celtique Sa Compounds for treating t-pll
CN112848583B (zh) * 2020-12-31 2022-08-05 雅达环保科技(玉田)有限公司 一种阻燃保温板及其制备方法
WO2023113650A1 (ru) * 2021-12-15 2023-06-22 Владимир Евгеньевич НЕБОЛЬСИН Фармацевтическая композиция 1-[2-(1-метилимидазол-4-ил)-этил]пергидроазин-2,6-дион для терапии заболеваний верхних дыхательных путей

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE159289C (es) * 1903-10-08 1905-03-16
US20040072889A1 (en) * 1997-04-21 2004-04-15 Pharmacia Corporation Method of using a COX-2 inhibitor and an alkylating-type antineoplastic agent as a combination therapy in the treatment of neoplasia
DE19826517B4 (de) * 1998-06-15 2006-03-23 Baxter Healthcare S.A. Verfahren zur Herstellung von Filmtabletten mit Cyclophosphamid als Wirkstoff und daraus hergestellte Cyclophosphamid-Filmtablette
US7374779B2 (en) 1999-02-26 2008-05-20 Lipocine, Inc. Pharmaceutical formulations and systems for improved absorption and multistage release of active agents
US6395300B1 (en) * 1999-05-27 2002-05-28 Acusphere, Inc. Porous drug matrices and methods of manufacture thereof
US20030105141A1 (en) 2001-04-17 2003-06-05 Ping Gao Finely self-emulsifiable pharmaceutical composition
DE10304403A1 (de) * 2003-01-28 2004-08-05 Röhm GmbH & Co. KG Verfahren zur Herstellung einer oralen Arzneiform mit unmittelbarem Zerfall und Wirkstofffreisetzung
WO2004069180A2 (en) 2003-01-31 2004-08-19 Smithkline Beecham Corporation Solid dispersion compositions
EP1605916A4 (en) * 2003-02-12 2012-02-22 R & P Korea Co Ltd SOLUBENT SOLVENT SYSTEM WITH SOLUBLE PEEL WITH IMPROVED ELUTION RATE
DK2335725T3 (en) * 2003-04-04 2017-01-23 Genentech Inc Highly concentrated antibody and protein formulations
AU2005317047A1 (en) * 2004-11-05 2006-06-22 Cephalon, Inc. Cancer treatments
US8436190B2 (en) 2005-01-14 2013-05-07 Cephalon, Inc. Bendamustine pharmaceutical compositions
AU2008237246B2 (en) * 2007-04-05 2014-06-05 University Of Kansas Rapidly dissolving pharmaceutical compositions comprising pullulan
EA201000016A1 (ru) 2007-07-12 2010-10-29 Трагара Фармасьютикалс, Инк. Способы и композиции для лечения рака, опухолей и нарушений, связанных с опухолями
WO2009061864A1 (en) * 2007-11-06 2009-05-14 3M Innovative Properties Company Processing device tablet
AR072777A1 (es) 2008-03-26 2010-09-22 Cephalon Inc Formas solidas de clorhidrato de bendamustina
KR101725469B1 (ko) * 2008-06-06 2017-04-11 베링거 인겔하임 인터내셔날 게엠베하 인돌리논 유도체의 현탁 제형을 포함하는 캡슐 약제학적 투여 형태
US8349353B2 (en) 2008-06-27 2013-01-08 Otonomy, Inc. Controlled release cytotoxic agent compositions and methods for the treatment of otic disorders
UA107186C2 (xx) * 2008-12-03 2014-12-10 Тверді форми дозування бендамустину
UA102120C2 (ru) * 2008-12-03 2013-06-10 Астеллас Дойчленд Гмбх Пероральная форма дозирования бендамустина
US20100273730A1 (en) * 2009-04-27 2010-10-28 Innopharmax, Inc. Self-emulsifying pharmaceutical compositions of hydrophilic drugs and preparation thereof
CA2760085A1 (en) * 2009-04-28 2010-11-04 Cephalon, Inc. Oral formulations of bendamustine
US20100297194A1 (en) 2009-04-30 2010-11-25 Nathaniel Catron Formulation for oral administration of apoptosis promoter

Also Published As

Publication number Publication date
CN103037852B (zh) 2016-06-15
CN103037852A (zh) 2013-04-10
IL223309A0 (en) 2013-02-03
JP6259490B2 (ja) 2018-01-10
CA2800277A1 (en) 2011-12-08
CL2012003340A1 (es) 2014-03-28
JP2016172763A (ja) 2016-09-29
US20150258070A1 (en) 2015-09-17
EP2575785A1 (en) 2013-04-10
DK2575785T3 (da) 2023-01-30
PH12012502282B1 (en) 2019-06-14
IL223309B (en) 2020-05-31
AU2011260614A1 (en) 2013-01-10
PH12012502282A1 (en) 2013-02-11
US10485787B2 (en) 2019-11-26
KR20130116164A (ko) 2013-10-23
MY173881A (en) 2020-02-26
TW201210591A (en) 2012-03-16
BR112012030658B1 (pt) 2022-08-02
SG185794A1 (en) 2013-01-30
CO6640268A2 (es) 2013-03-22
MX2012013873A (es) 2013-07-03
AU2011260614B2 (en) 2016-12-15
NZ603874A (en) 2014-08-29
US20130209558A1 (en) 2013-08-15
JP2013527206A (ja) 2013-06-27
BR112012030658A2 (pt) 2016-08-16
KR101830147B1 (ko) 2018-02-20
EA027786B1 (ru) 2017-09-29
TWI556819B (zh) 2016-11-11
ES2935792T3 (es) 2023-03-10
WO2011151086A1 (en) 2011-12-08
PL2575785T3 (pl) 2023-02-20
EP2575785B1 (en) 2022-10-26
JO3659B1 (ar) 2020-08-27
FI2575785T3 (fi) 2023-01-31
EA201291249A1 (ru) 2014-07-30
IL272501A (en) 2020-03-31
ZA201208822B (en) 2014-08-27

Similar Documents

Publication Publication Date Title
AR081575A1 (es) Formas de dosificacion oral de bendamustina y su uso terapeutico
Israel et al. Phytochemicals: Current strategies for treating breast cancer
RU2743643C2 (ru) Комбинированная терапия противоопухолевым алкалоидом
RU2567044C2 (ru) Ингибиторы 1 киназы контрольной точки клеточного цикла для усиления днк-повреждающих агентов
Gupta et al. Analysis of intestinal permeability in mice
CO6400185A2 (es) Formas de dosificación sólida de bendamustina
US20130209578A1 (en) Combinatory Cancer Treatment
ECSP109935A (es) Derivados de morfolino pirimidina utilizados en enfermedades relacionadas con mtor quinasa y/o pi3k
McCarthy et al. In vivo anticancer synergy mechanism of doxorubicin and verapamil combination treatment is impaired in BALB/c mice with metastatic breast cancer
US11524009B2 (en) Combination comprising at least one spliceosome modulator and at least one inhibitor chosen from BCL2 inhibitors, BCL2/BCLxL inhibitors, and BCLxL inhibitors and methods of use
JP2016526039A5 (es)
CA2854461A1 (en) Administration of nedd8-activating enzyme inhibitor and hypomethylating agent
JP2019530706A5 (es)
KR20160135230A (ko) 암의 치료를 위한 병용 요법으로서의 에리불린 및 mTOR 억제제의 용도
AR081835A1 (es) Formas de dosificacion oral de bendamustina
BR112019015023A2 (pt) Intensificadores de canibalismo celular para uso para sensibilizar tumores para terapia por radiação
AR075866A1 (es) Una dosis de ave5026 para el tratamiento de tromboembolismo venoso en pacientes con deterioro renal severo. uso. composicion farmaceutica.
CN103877005A (zh) 一种复方奥氮平皮下埋植缓释剂
AR086491A1 (es) Composicion farmaceutica que comprende fexofenadina
RU2346692C2 (ru) Применение 9-оксоакридин-10-уксусной кислоты, ее солей и сложных эфиров в комбинированной терапии рака яичников, способ лечения и наборы
Momin et al. Acute generalized exanthematous pustulosis: an enigmatic drug-induced reaction
RU2013150335A (ru) Применение секнидазола для лечения одонтогенных инфекций
Secades et al. Role of citicoline on the treatment of ischemic stroke: a formal and cumulative meta-analysis
TWI434829B (zh) 以密環菌乙素來治療癌症之新穎用途
Chico et al. Quinine for the treatment of malaria in pregnancy

Legal Events

Date Code Title Description
FC Refusal