AR076603A1 - Procedimiento para la fabricacion de productos intermedios de dronedarona - Google Patents
Procedimiento para la fabricacion de productos intermedios de dronedaronaInfo
- Publication number
- AR076603A1 AR076603A1 ARP100101811A ARP100101811A AR076603A1 AR 076603 A1 AR076603 A1 AR 076603A1 AR P100101811 A ARP100101811 A AR P100101811A AR P100101811 A ARP100101811 A AR P100101811A AR 076603 A1 AR076603 A1 AR 076603A1
- Authority
- AR
- Argentina
- Prior art keywords
- formula
- benzofuran
- base
- provides
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/80—Radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Furan Compounds (AREA)
- Catalysts (AREA)
Abstract
Reivindicacion 3: Un procedimiento segun la reivindicacion 1 o 2 para preparar un compuesto de la formula (1) en el que R1 es metoxi o hidroxilo; y sus sales; que comprende: a) acilar la 2-(2-hidroxi-5-nitrofenil)-1-(4-metoxifenil)-etanona de formula (4) con el cloruro de ácido de formula (6) en presencia de una base A que proporciona el nuevo éster de formula (7); b) calentar el éster de formula (7) con una base B y un catalizador de zeolita que proporciona el benzofurano de formula (1a); c) alentar, opcionalmente, el benzofurano de formula (1a) con HCI o HBr en presencia de una base B o calentar alternativamente el benzofurano de formula (1a) con HCI o HBr en un líquido ionico C que proporciona el compuesto de (1b). Reivindicacion 4: Un procedimiento segun la reivindicacion 1 o 2 para preparar un compuesto de la formula (1) en el que R1 es metoxi o hidroxilo; y sus sales; que comprende, como se indica en el esquema 1, a) hacer reaccionar un compuesto de formula (5), en el que M es Na o K, con un cloruro de ácido de formula (6) en presencia de una base A que proporciona el éster de formula (7); b) calentar el éster de formula (7) con una base B y un catalizador de zeolita que proporciona el benzofurano de formula (1a); c) calentar, opcionalmente, el benzofurano de formula (1a) con HCI o HBr en presencia de una base B o calentar alternativamente el benzofurano de formula (1a) con HCI o HBr en un líquido ionico C que proporciona el compuesto de la formula (1b).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09290394 | 2009-05-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR076603A1 true AR076603A1 (es) | 2011-06-22 |
Family
ID=41055218
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP100101811A AR076603A1 (es) | 2009-05-27 | 2010-05-26 | Procedimiento para la fabricacion de productos intermedios de dronedarona |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8658808B2 (es) |
| EP (1) | EP2435413B1 (es) |
| JP (1) | JP2012528115A (es) |
| KR (1) | KR20120018371A (es) |
| CN (1) | CN102448947A (es) |
| AR (1) | AR076603A1 (es) |
| AU (1) | AU2010251976A1 (es) |
| BR (1) | BRPI1012018A2 (es) |
| CA (1) | CA2766077A1 (es) |
| CO (1) | CO6480942A2 (es) |
| IL (1) | IL216322A0 (es) |
| MA (1) | MA33283B1 (es) |
| MX (1) | MX2011011893A (es) |
| MY (1) | MY183448A (es) |
| NZ (1) | NZ596732A (es) |
| RU (1) | RU2011153309A (es) |
| SG (1) | SG176212A1 (es) |
| TW (1) | TW201111354A (es) |
| UY (1) | UY32657A (es) |
| WO (1) | WO2010136502A1 (es) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201107303A (en) | 2009-05-27 | 2011-03-01 | Sanofi Aventis | Process for the production of benzofurans |
| HUP0900759A2 (en) | 2009-12-08 | 2011-11-28 | Sanofi Aventis | Novel process for producing dronedarone |
| HUP1000010A2 (en) | 2010-01-08 | 2011-11-28 | Sanofi Sa | Process for producing dronedarone |
| FR2957079B1 (fr) | 2010-03-02 | 2012-07-27 | Sanofi Aventis | Procede de synthese de derives de cetobenzofurane |
| FR2958290B1 (fr) | 2010-03-30 | 2012-10-19 | Sanofi Aventis | Procede de preparation de derives de sulfonamido-benzofurane |
| FR2958291B1 (fr) | 2010-04-01 | 2013-07-05 | Sanofi Aventis | Procede de preparation de derives d'amino-benzofurane |
| HUP1000330A2 (en) | 2010-06-18 | 2011-12-28 | Sanofi Sa | Process for the preparation of dronedarone and the novel intermediates |
| FR2962731B1 (fr) | 2010-07-19 | 2012-08-17 | Sanofi Aventis | Procede de preparation de derives d'amino-benzoyl-benzofurane |
| FR2963006B1 (fr) | 2010-07-21 | 2013-03-15 | Sanofi Aventis | Procede de preparation de derives de nitro-benzofurane |
| HUP1000386A2 (en) | 2010-07-22 | 2012-05-29 | Sanofi Sa | Novel process for producing dronedarone |
| HUP1100167A2 (en) | 2011-03-29 | 2012-11-28 | Sanofi Sa | Process for preparation of dronedarone by mesylation |
| HUP1100165A2 (en) | 2011-03-29 | 2012-12-28 | Sanofi Sa | Process for preparation of dronedarone by n-butylation |
| FR2983198B1 (fr) | 2011-11-29 | 2013-11-15 | Sanofi Sa | Procede de preparation de derives de 5-amino-benzoyl-benzofurane |
| EP2617718A1 (en) | 2012-01-20 | 2013-07-24 | Sanofi | Process for preparation of dronedarone by the use of dibutylaminopropanol reagent |
| US9221778B2 (en) | 2012-02-13 | 2015-12-29 | Sanofi | Process for preparation of dronedarone by removal of hydroxyl group |
| WO2013121234A1 (en) | 2012-02-14 | 2013-08-22 | Sanofi | Process for the preparation of dronedarone by oxidation of a sulphenyl group |
| WO2013124745A1 (en) | 2012-02-22 | 2013-08-29 | Sanofi | Process for preparation of dronedarone by oxidation of a hydroxyl group |
| US9238636B2 (en) | 2012-05-31 | 2016-01-19 | Sanofi | Process for preparation of dronedarone by Grignard reaction |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3577441A (en) | 1967-03-07 | 1971-05-04 | Warner Lambert Pharmaceutical | Nitro substituted benzofurans |
| US3657350A (en) | 1967-05-09 | 1972-04-18 | Sterling Drug Inc | Process and compositions |
| FR2665444B1 (fr) * | 1990-08-06 | 1992-11-27 | Sanofi Sa | Derives d'amino-benzofuranne, benzothiophene ou indole, leur procede de preparation ainsi que les compositions les contenant. |
| FR2800067B1 (fr) | 1999-10-21 | 2004-12-17 | Rhodia Chimie Sa | Intermediaires de fabrication d'un derive de type benzofurane ou benzothiophene nitre en position 5 et leurs utilisations |
| FR2809397B1 (fr) * | 2000-05-24 | 2002-07-19 | Rhodia Chimie Sa | Procede de preparation d'un compose de type benzofuranne ou benzothiophene |
| JP2003512365A (ja) * | 1999-10-21 | 2003-04-02 | ロデイア・シミ | ベンゾフラン化合物あるいはベンゾチオフェン化合物を調製する方法 |
| FR2817865B1 (fr) | 2000-12-11 | 2005-02-18 | Sanofi Synthelabo | Derive aminoalkoxybenzoyle sous forme de sel, son procede de preparation et son utilisation comme intermediaire de synthese |
| IL146389A0 (en) | 2001-11-08 | 2002-07-25 | Isp Finetech Ltd | Process for the preparation of dronedarone |
| FR2833259B1 (fr) * | 2001-12-10 | 2004-08-27 | Oreal | Procede de preparation de 2-arylbenzofuranes, composes intermediaires, 2-arylbenzofuranes et compositions les comprenant |
| JP2008510742A (ja) | 2004-08-24 | 2008-04-10 | ビーエーエスエフ ソシエタス・ヨーロピア | 高純度の第４級アンモニウム化合物の製造方法 |
| GB0611210D0 (en) * | 2006-06-07 | 2006-07-19 | Cambrex Karlskoga Ab | Process |
| GB0719180D0 (en) * | 2007-10-02 | 2007-11-14 | Cambrex Karlskoga Ab | New process |
| TW201107303A (en) | 2009-05-27 | 2011-03-01 | Sanofi Aventis | Process for the production of benzofurans |
-
2010
- 2010-05-25 TW TW099116588A patent/TW201111354A/zh unknown
- 2010-05-25 UY UY0001032657A patent/UY32657A/es not_active Application Discontinuation
- 2010-05-26 NZ NZ596732A patent/NZ596732A/xx not_active IP Right Cessation
- 2010-05-26 RU RU2011153309/04A patent/RU2011153309A/ru not_active Application Discontinuation
- 2010-05-26 AR ARP100101811A patent/AR076603A1/es not_active Application Discontinuation
- 2010-05-26 WO PCT/EP2010/057272 patent/WO2010136502A1/en active Application Filing
- 2010-05-26 EP EP10724025.1A patent/EP2435413B1/en active Active
- 2010-05-26 KR KR1020117031011A patent/KR20120018371A/ko not_active Application Discontinuation
- 2010-05-26 MA MA34362A patent/MA33283B1/fr unknown
- 2010-05-26 CN CN2010800231580A patent/CN102448947A/zh active Pending
- 2010-05-26 MX MX2011011893A patent/MX2011011893A/es active IP Right Grant
- 2010-05-26 CA CA2766077A patent/CA2766077A1/en not_active Abandoned
- 2010-05-26 AU AU2010251976A patent/AU2010251976A1/en not_active Abandoned
- 2010-05-26 BR BRPI1012018A patent/BRPI1012018A2/pt not_active IP Right Cessation
- 2010-05-26 MY MYPI2011005294A patent/MY183448A/en unknown
- 2010-05-26 SG SG2011086667A patent/SG176212A1/en unknown
- 2010-05-26 JP JP2012512364A patent/JP2012528115A/ja not_active Abandoned
- 2010-05-26 US US13/322,094 patent/US8658808B2/en active Active
-
2011
- 2011-11-13 IL IL216322A patent/IL216322A0/en unknown
- 2011-12-23 CO CO11177469A patent/CO6480942A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI1012018A2 (pt) | 2015-09-22 |
| MX2011011893A (es) | 2011-12-08 |
| CN102448947A (zh) | 2012-05-09 |
| SG176212A1 (en) | 2012-01-30 |
| AU2010251976A1 (en) | 2011-12-22 |
| IL216322A0 (en) | 2012-01-31 |
| US20120077995A1 (en) | 2012-03-29 |
| UY32657A (es) | 2010-12-31 |
| NZ596732A (en) | 2013-07-26 |
| EP2435413B1 (en) | 2014-05-07 |
| US8658808B2 (en) | 2014-02-25 |
| WO2010136502A1 (en) | 2010-12-02 |
| MY183448A (en) | 2021-02-18 |
| EP2435413A1 (en) | 2012-04-04 |
| CA2766077A1 (en) | 2010-12-02 |
| TW201111354A (en) | 2011-04-01 |
| CO6480942A2 (es) | 2012-07-16 |
| KR20120018371A (ko) | 2012-03-02 |
| RU2011153309A (ru) | 2013-07-10 |
| JP2012528115A (ja) | 2012-11-12 |
| MA33283B1 (fr) | 2012-05-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |