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EA201171065A1 - Очистка 1-[2-(2,4-диметилфенилсульфанил)фенил]пиперазина - Google Patents

Очистка 1-[2-(2,4-диметилфенилсульфанил)фенил]пиперазина

Info

Publication number
EA201171065A1
EA201171065A1 EA201171065A EA201171065A EA201171065A1 EA 201171065 A1 EA201171065 A1 EA 201171065A1 EA 201171065 A EA201171065 A EA 201171065A EA 201171065 A EA201171065 A EA 201171065A EA 201171065 A1 EA201171065 A1 EA 201171065A1
Authority
EA
Eurasian Patent Office
Prior art keywords
piperazine
phenyl
dimethilphenylsulfanyl
cleaning
dimethylphenylsulfanyl
Prior art date
Application number
EA201171065A
Other languages
English (en)
Other versions
EA020473B1 (ru
Inventor
Хенрик Виган Николайсен
Хайди Лопез Де Диего
Майкл Харолд Рок
Original Assignee
Х. Лундбекк А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Х. Лундбекк А/С filed Critical Х. Лундбекк А/С
Publication of EA201171065A1 publication Critical patent/EA201171065A1/ru
Publication of EA020473B1 publication Critical patent/EA020473B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Настоящее изобретение относится к способу получения 1-[2-(2,4-диметилфенилсульфанил)фенил]пиперазина.
EA201171065A 2009-02-17 2010-02-16 СПОСОБ ОЧИСТКИ 1-[2-(2,4-ДИМЕТИЛФЕНИЛСУЛЬФАНИЛ)ФЕНИЛ]ПИПЕРАЗИНА-HBr EA020473B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200900223 2009-02-17
PCT/DK2010/050039 WO2010094285A1 (en) 2009-02-17 2010-02-16 Purification of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine

Publications (2)

Publication Number Publication Date
EA201171065A1 true EA201171065A1 (ru) 2012-02-28
EA020473B1 EA020473B1 (ru) 2014-11-28

Family

ID=42101395

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201171065A EA020473B1 (ru) 2009-02-17 2010-02-16 СПОСОБ ОЧИСТКИ 1-[2-(2,4-ДИМЕТИЛФЕНИЛСУЛЬФАНИЛ)ФЕНИЛ]ПИПЕРАЗИНА-HBr

Country Status (27)

Country Link
US (1) US8598348B2 (ru)
EP (1) EP2398785B1 (ru)
JP (1) JP5738774B2 (ru)
KR (1) KR101639833B1 (ru)
CN (1) CN102317272B (ru)
AR (1) AR075436A1 (ru)
AU (1) AU2010214956B2 (ru)
BR (1) BRPI1006975B1 (ru)
CA (1) CA2751498C (ru)
CL (1) CL2011001992A1 (ru)
CO (1) CO6400224A2 (ru)
DK (1) DK2398785T3 (ru)
EA (1) EA020473B1 (ru)
ES (1) ES2441079T3 (ru)
HR (1) HRP20131236T1 (ru)
IL (1) IL214178A (ru)
MX (1) MX2011008661A (ru)
NZ (1) NZ594658A (ru)
PL (1) PL2398785T3 (ru)
PT (1) PT2398785E (ru)
RS (1) RS53074B (ru)
SG (1) SG173735A1 (ru)
SI (1) SI2398785T1 (ru)
SM (1) SMT201400010B (ru)
TW (1) TW201033181A (ru)
WO (1) WO2010094285A1 (ru)
ZA (1) ZA201105992B (ru)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX344144B (es) * 2012-01-03 2016-12-07 H Lundbeck As Proceso para la fabricacion de 1-[2-(2,4-dimetilfenilsulfanil)feni l] piperazina.
CN104797566B (zh) * 2012-09-19 2017-07-07 桑多斯股份公司 沃替西汀氢溴酸盐的新结晶形式
HUE036280T2 (hu) 2012-12-13 2018-06-28 H Lundbeck As Vortioxetint és donepezilt tartalmazó készítmények
AP2015008640A0 (en) * 2013-02-22 2015-08-31 Lundbeck & Co As H Vortioxetine manufacturing process
US20160200698A1 (en) 2013-09-12 2016-07-14 Hangzhou Pushai Pharmaceutical Technology Co., Ltd Vortioxetine salt and crystal thereof, their preparation method, pharmaceutical compositions and usage
US10414741B2 (en) 2013-09-30 2019-09-17 Cadila Healthcare Limited Amorphous vortioxetine and salts thereof
EP2878596A1 (en) * 2013-11-29 2015-06-03 LEK Pharmaceuticals d.d. Synthesis of vortioxetine via (2-(piperazine-1-yl)phenyl)lithium intermediates
CN103788020B (zh) * 2014-01-22 2015-11-04 苏州明锐医药科技有限公司 沃替西汀的制备方法
CN103788019B (zh) * 2014-01-22 2015-10-07 苏州明锐医药科技有限公司 沃替西汀的制备方法
EP3099669A1 (en) 2014-01-31 2016-12-07 Egis Gyógyszergyár Zrt. Process for the preparation of vortioxetine salts
CN104059030B (zh) * 2014-05-30 2016-05-04 镇江圣安医药有限公司 [(苯硫烷基)-苯基]哌嗪的衍生物及其药物组合物和用途
CN105218482B (zh) * 2014-06-24 2018-04-06 杭州和泽医药科技有限公司 沃替西汀氢溴酸盐β晶型的制备方法
US9687484B2 (en) 2014-07-18 2017-06-27 Dipharma Francis S.R.L. Crystalline forms of an antidepressant compound
WO2016079751A2 (en) 2014-11-17 2016-05-26 Megafine Pharma (P) Ltd. A process for preparation of vortioxetine and polymorphs thereof
CN105669594A (zh) * 2014-11-19 2016-06-15 康普药业股份有限公司 抗抑郁症药1-[2-(2,4-二甲基苯基硫基)苯基]哌嗪的制备方法
CN105801517A (zh) * 2014-12-30 2016-07-27 上海奥博生物医药技术有限公司 一种沃替西汀氢溴酸盐新晶型及其制备方法
WO2016125190A2 (en) 2015-02-04 2016-08-11 Mylan Laboratories Limited Novel crystalline forms of vortioxetine, premixes, and processes for the preparation thereof
WO2016151328A1 (en) 2015-03-26 2016-09-29 Cipla Limited Method for making serotonin reuptake inhibitors
CN105439980B (zh) * 2015-05-08 2017-10-24 北京北陆药业股份有限公司 一种氢溴酸沃替西汀一仲丁醇合物及其制备方法
CN105367515B (zh) * 2015-05-08 2017-10-27 北京北陆药业股份有限公司 一种氢溴酸沃替西汀α晶型的制备方法
CN106316985B (zh) * 2015-06-18 2021-11-09 郑州深蓝海生物医药科技有限公司 一种β型高效氢溴酸沃替西汀转晶方法
WO2017125504A1 (en) * 2016-01-20 2017-07-27 Amneal Pharmaceuticals Company Gmbh Polymorphic forms of vortioxetine hydrobromide tert-butanolate
MX2018015759A (es) 2016-07-01 2019-03-21 H Lundbeck As Regimenes de dosificacion de vortioxetina para el rapido inicio del efecto antidepresivo.
US10519121B2 (en) 2016-12-30 2019-12-31 Apicore Us Llc Process and novel polymorphic form of vortioxetine and its pharmaceutically acceptable salts
IL270052B2 (en) * 2017-04-25 2023-12-01 H Lundbeck As A process for the production of vortioxetine hydrobromide alpha form
CN108017595A (zh) * 2017-12-20 2018-05-11 安徽源久源科技有限公司 一种1-[2-(2,5-二甲基苯硫基)苯基]哌嗪的制备方法
CN112125868B (zh) * 2020-09-25 2021-08-03 中山万远新药研发有限公司 一种氢溴酸伏硫西汀晶型及其制备方法、组合物与用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB852974A (en) 1958-04-17 1960-11-02 Parke Davis & Co Ethers and means for producing the same
FR2186237B1 (ru) 1972-05-03 1975-10-31 Synthelabo
US5576460A (en) 1994-07-27 1996-11-19 Massachusetts Institute Of Technology Preparation of arylamines
UA81749C2 (ru) * 2001-10-04 2008-02-11 Х. Луннбек А/С производные фенилпиперазина как ингибиторы обратного захвата серотонинА
EP2044043B2 (en) * 2006-06-16 2021-03-03 H. Lundbeck A/S 1- ý[- (2, 4-dimethylphenylsulfanyl) -phenyl]piperazine hydrobromide as a compound with combined serotonin reuptake, 5-ht3 and 5-ht1a activity for the treatment of cognitive impairment
US8299095B2 (en) * 2006-06-16 2012-10-30 H. Lundbeck A/S Crystalline forms of 4-[2-(4-methylphenylsulfanyl)-phenyl] piperidine with combined serotonin and norepinephrine reuptake inhibition and uses thereof
TW200848411A (en) * 2007-03-20 2008-12-16 Lundbeck & Co As H Novel therapeutic uses of 1-[2-(2, 4-dimethylphenylsulfanyl)phenyl]-piperazine

Also Published As

Publication number Publication date
RS53074B (en) 2014-04-30
EP2398785B1 (en) 2013-11-27
AR075436A1 (es) 2011-03-30
CN102317272A (zh) 2012-01-11
SI2398785T1 (sl) 2014-01-31
EA020473B1 (ru) 2014-11-28
HK1165955A1 (en) 2012-10-12
KR20110126625A (ko) 2011-11-23
EP2398785A1 (en) 2011-12-28
DK2398785T3 (da) 2013-12-16
MX2011008661A (es) 2011-09-06
US20120004409A1 (en) 2012-01-05
CA2751498C (en) 2017-09-12
BRPI1006975B1 (pt) 2022-11-22
HRP20131236T1 (hr) 2014-02-14
IL214178A0 (en) 2011-08-31
PL2398785T3 (pl) 2014-07-31
AU2010214956B2 (en) 2012-08-23
IL214178A (en) 2014-09-30
ZA201105992B (en) 2012-10-31
WO2010094285A1 (en) 2010-08-26
KR101639833B1 (ko) 2016-07-14
SMT201400010B (it) 2014-03-07
CL2011001992A1 (es) 2012-04-09
NZ594658A (en) 2013-02-22
TW201033181A (en) 2010-09-16
US8598348B2 (en) 2013-12-03
CO6400224A2 (es) 2012-03-15
JP5738774B2 (ja) 2015-06-24
AU2010214956A1 (en) 2011-09-22
CN102317272B (zh) 2014-11-12
ES2441079T3 (es) 2014-01-31
PT2398785E (pt) 2013-12-26
CA2751498A1 (en) 2010-08-26
JP2012517961A (ja) 2012-08-09
SG173735A1 (en) 2011-09-29
BRPI1006975A2 (pt) 2020-08-18

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KZ KG MD TJ TM