[go: up one dir, main page]

AR071909A1 - Compuesto triazina, composicion que lo comprende y metodo para elaborar el compuesto - Google Patents

Compuesto triazina, composicion que lo comprende y metodo para elaborar el compuesto

Info

Publication number
AR071909A1
AR071909A1 ARP090101879A ARP090101879A AR071909A1 AR 071909 A1 AR071909 A1 AR 071909A1 AR P090101879 A ARP090101879 A AR P090101879A AR P090101879 A ARP090101879 A AR P090101879A AR 071909 A1 AR071909 A1 AR 071909A1
Authority
AR
Argentina
Prior art keywords
alkyl
optionally substituted
heterocyclyl
amino
membered
Prior art date
Application number
ARP090101879A
Other languages
English (en)
Inventor
Arie Zask
Aranapakam Venkatesan
Santos Osvaldo Dos
Zecheng Chen
Christoph Dehnardt
Jeroen C Verheijen
Tarek S Mansour
Semiramis Ayral-Kaloustian
Joshua Aaron Kaplan
Kevin J Curran
Santos Efren Guillermo Delos
David J Richard
Ariamala Gopalsamy
Mengxiao Shi
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40911929&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR071909(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of AR071909A1 publication Critical patent/AR071909A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/14—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom
    • C07D251/16—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom
    • C07D251/18—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom with nitrogen atoms directly attached to the two other ring carbon atoms, e.g. guanamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Estos compuestos inhiben la quinasa PI3 y mTOR, y se pueden utilizar para tratar enfermedades mediadas por quinasa PI3 e y mTOR, tal como una variedad de c nceres. Se describen metodos para elaborar y utilizar los compuestos de esta solicitud. Tambien se describen aqu¡ varias composiciones que contienen los compuestos de esta solicitud. Reivindicacion 1: Un compuesto de la formula 1 caracterizado porque R1 es como en formulas (2) o (3) en donde R6, R7, R8, R9 se seleccionan cada uno independientemente del grupo que consiste de un  tomo de hidrogeno, y un alquilo C1-6 opcionalmente sustituido con alquenilo C2-6, alcadienilo C4-6, alquinilo C2-6 o alcadinilo C4-6; y uno de R6 y R9, R6 y R8, o R7 y R8 se adhieren por un grupo de ligado (CH2)y, (CH2-X-), o (CH2-X-CH2) en donde uno o dos  tomos de hidrogeno en el grupo de ligado se pueden reemplazar independientemente por alquilo C1-6, (alquilo C1-6)NH-, (alquilo C1-6)2N-, (arilo C6-14)alquil-O-, halo, heterociclilo C1-9 de 3-10 miembros opcionalmente sustituido con alquilo C1-6-, HO-, o H2N-; en donde dos  tomos de hidrogeno cualesquiera en el mismo  tomo de carbono del grupo ligado se puede reemplazar por un  tomo de ox¡geno para formar un sustituyente oxo (=O), y es 1, 2 o 3; X es O, S(O)n, o NR10; n es 0, 1 o 2; la l¡nea intermitente ------ representa un segundo enlace opcional; R10 se selecciona del grupo que consiste de H, alquilo C1-6, -SO2(alquilo C1-6), -COO(alquilo C1-6), -CONH(alquilo C1-6), -CON(alquilo C1-6)2, -CO(alquilo C1-6), y -SO2NHR11; R11 se selecciona del grupo que consiste de H, alquilo C1-6 opcionalmente sustituido con OH, NR11R11 o un heterociclilo C1-6 de 3-7 miembros, -CO(alquilo C1- 6), arilo C6-10 opcionalmente sustituido, y heteroarilo C1-9 opcionalmente sustituido; R2 es arilo C6-14 opcionalmente sustituido-NH-COR3, heteroarilo C1-9 opcionalmente sustituido-NH-COR3, -CH=CH-arilo C6-10-NH-COR3 o -CH=CH-heteroarilo C1-9-NH-COR3; R3 es OR5, NR5R5 o NHR5; R5 se selecciona independientemente del grupo que consiste de alquilo C1-6, alquenilo C3-6, alquinilo C3-6, arilo C6-10 opcionalmente sustituido, haloalquilo C1-6, heteroarilo C1-9 opcionalmente sustituido, hidroxialquilo C1-6, cicloalquilo C3-10 mono o bic¡clico saturado no saturado C3-10 opcionalmente sustituido con OH, NR11R11 o heterociclilo C1-6 de 3-7 miembros, y heterociclilo C1-9 mono o bic¡clico saturado o insaturado de 3-10 miembros; con la condicion que se saturan los anillos heterociclilo y cicloalquilo de tres miembros; o dos grupos R5 tomados juntos con el  tomo de nitrogeno al cual ellos se adhieren para formar un sistema de anillo de 3 a 8 miembros opcionalmente sustituido con alquilo C1-6, cuyo sistema de anillo se satura o no se satura y tiene, en adicion a dicho  tomo de nitrogeno, miembros de anillo de 0 a 2 hetero tomos seleccionados de O, S, S(O), S(O)2 y NR10; R4 se selecciona del grupo que consiste de: a) alquilo C1-6 opcionalmente sustituido con: i) heterociclilo C1-9 de 3-10 miembros opcionalmente sustituido con alquilo C1-6-, ii) H2N-, iii) (alquilo C1-6)NH-, iv) (alquilo C1-6)2N-, v) NH(CH2)aN(alquilo C1-6)2 en donde a es 2, 3 o 4, y vi) CHO, b) alquenilo C3-6, c) alquinilo C3-6, d) -O-alquilo C1-8 opcionalmente sustituido con -O-alquilo C1-8, e) -O-alquenilo C3-8, f) -O-alquinilo C3-8, g) cicloalquilo C3-8 mono o bic¡clico saturado o no saturado, y h) -O-cicloalquilo C3-12 mono o bic¡clico saturado o no saturado, todos los anteriores opcionalmente sustituido con OH, NR11R11 o un heterociclilo C1-6 de 3-7 miembros opcionalmente sustituido con alquilo C1-6-, dado que un OH o NR11R11 no se une directamente en un  tomo de carbono que se une doble o triple a otro  tomo de carbono; i) -CH=CH-arilo C6-10, j) -CH=CH-heteroarilo C1-9, k) arilo C6-10 opcionalmente sustituido; l) heteroarilo C1-9 de 5- 10 miembros opcionalmente sustituido adherido al grupo funcional triazina por v¡a del  tomo de carbono; m) heterociclilo C1-9 mono o bic¡clico saturado o insaturado de 3-10 miembros adherido al grupo funcional triazina a traves de un  tomo de nitrogeno o carbono y opcionalmente sustituido con de 1 a 3 sustituyentes seleccionados independientemente de: OH, NR11R11, alquilo C1-6, (alquilo C1-6)amido-, (alquilo C1-6)C(O)-, (alcoxi C1-6)carbonil-, adamantilo, hidroxialquilo C1-6, o un heterociclilo C1-6 de 3-7 miembros, con la condicion que el heterociclilo de 3 miembros se satura y se adhiere al grupo funcional triazina a traves de un  tomo de nitrogeno, y el heterociclilo bic¡clico de 5 miembros se satura; n) -O-arilo C6-10 opcionalmente sustituido; o) -O-heteroarilo C1-9 opcionalmente sustituido; p) -O- (mono o bic¡clico saturado o insaturado de 3-12 miembros)heterociclilo C1-9 opcionalmente sustituido con (alcoxi C1-6)carbonil-, H2NS(O)2-, o alquilo C1-6 adicionalmente opcionalmente sustituido con OH, NR11R11 o un heterociclilo C1-6 de 3-7 miembros1 con la condicion que se satura el heterociclilo de tres miembros; q) - NHarilo C6-10, r) -NHheteroarilo C1-9, s) -NHNH2, t) -NHNHalquilo C1-6, u) -NHN(alquilo C1-6)2, v) -NHOH, w) -COOH, x) -COO-alquilo C1-6, y) -CONR12R13, z) -NR12R13, los grupos de formulas (4) en donde Z es Ch2, O, S(O)n o NR10; ee) halogeno, ff) arilo C6-14-S(O)2-NH-, gg) R11NHC(O)NH-O-, y hh) heteroarilo C1-4 monociclico de 5 miembros opcionalmente sustituido adherido al grupo funcional triazina por v¡a de un  tomo de nitrogeno; R12 y R13 se seleccionan cada uno independientemente de H, alquilo C1-8 opcionalmente mono o disustituido, alquenilo C3-8 opcionalmente sustituido, y alquinilo C3-8 opcionalmente sustituido, los sustituyentes opcionales se seleccionan de alcoxi C1-6, OH, NR11R11, y heterociclilo C1-6 de 3-7 miembros, dado que un OH o NR11R11 no se une directamente en un  tomo de carbono que se une doble o triple a otro  tomo de carbono; o R12 y R13 tomados junto con el  tomo de nitrogeno al cual ellos se adhieren forman un sistema de anillo de 3 a 8 miembros opcionalmente sustituido con alquilo C1-6, cuyo sistema de anillo se satura o no se satura y tiene, en adicion a dicho  tomo de nitrogeno, miembros de anillo de 0 a 2 hetero tomos seleccionados de O, S(O)n y NR10; o R12 y R13 tomados junto con el  tomo de nitrogeno al cual ellos se adhieren forman los compuestos de formulas (5) en donde a y b son cada uno independientemente -CH2-, O, S, o NR10, y x es 1-3; heteroarilo C1-9 se refiere a un sistema de anillo arom tico de 5-10 miembros que tiene uno o m s anillos y 1; 2; 3 o 4 miembros de anillo seleccionados independientemente de O, NR10 y S(O)n, heterociclilo C1-9 se refiere a un sistema de anillo de 3-10 miembros que tiene uno o m s anillos y 1; 2; 3 o 4 miembros de anillo seleccionados independientemente de O, NR10 y S(O)n, y los grupos arilo y heteroarilo opcionalmente sustituidos se sustituyen o no se sustituyen con 1 o 2 grupos funcionales seleccionados del grupo que consiste de: a) alquilo C1-6 opcionalmente sustituido con OH, NH2, NH(alquilo C1-6), N(alquilo C1-6)2, -NH(CH2)wN(alquilo C1-6)2 en donde w es 2, 3 o 4, o heterociclilo C1-9 de 3-10 miembros opcionalmente sustituido con 1 a 3 sustituyentes alquilo C1-6 seleccionados independientemente; b) halogeno; c) hidroxi; d) NH2, e) NO2, f) SO2NH2, g) COOH; h) COO(alquilo C1-6); i) NHCOO(alquilo C1-6); j) NH(alquilo C1-6); k) N(alquilo C1-6)2, l) C(O)NRaRb, en donde Ra es H o alquilo C1-6, y Rb es H, alquilo C1-6, (arilo C6-14)alquil-, o (heteroarilo C1-9)alquil-; m) -Y-Q, en donde Y es: i) O, ii) NH, iii) N(alquilo C1-6), iv) NHSO2, v) SO2NH, vi) NHCONH, vii) NHCON(alquilo C1-6), viii) S(O)q, q es 0, 1 o 2, ix) -C(O)NH-, x) -C(O)N(CH3)-, xi) -NHC(O)-, xii) C(O), o xiii) ausente, y Q se selecciona de: i) arilo C6-10, opcionalmente sustituido con de 1 a 3 sustituyentes seleccionados independientemente de: A) alcoxi C1-6 opcionalmente sustituido con 1) H2N-, 2) (alquilo C1-6)amino-, 3) di(alquilo C1-6)amino-, 4) heterociclilo C1-9- opcionalmente sustituido por alquilo C1-6-, o 5) hidroxilo, B) (alcoxi C1-6)carbonil-, C) (alcoxi C1-6)C(O)NH-, D) alquilo C1-6- opcionalmente sustituido con 1) H2N-, 2) (alquilo C1-6)amino-, o 3) di(alquilo C1-6)amino-, E) (alquilo C1-6)amino-, F) di(alquilo C1-6)amino-, G) (alquilo C1-6)amido- opcionalmente sustituido con 1) H2N-, 2) (alquilo C1-6)amino-, o 3) di(alquilo C1-6)amino-, H) (alquilo C1-6)carboxiamido-, I) heterociclilo C1-9- opcionalmente sustituido por alquilo C1-6- o hidroxialquilo C1-6-, J) heterociclilo(alquilo C1-6)- opcionalmente sustituido por alquilo C1-6,K) halogeno, L) hidroxilo, M) hidroxialquilo C1-6-, N) perfluoro(C1-6)alquil-, O) H2N-, P) ON-, Q) H2NSO2 R) HO2C-, y S) NC-, ii) heteroarilo C1-9 de 5-10 miembros, opcionalmente sustituido con de 1 a 3 sustituyentes seleccionados independientemente de: A) alcoxi C1-6- opcionalmente sustituido con 1) H2N-, 2) (alquilo C1-6)amino-, 3) di(alquilo C1-6)amino-, 4) heterociclilo C1-9- opcionalmente sustituido por alquilo C1-6-, o 5) hidroxilo, B) (alcoxi C1-6)carbonil-, C) (alcoxi C1-6)C(O)NH-, D) alquilo C1-6- opcionalmente sustituido con 1) H2N-, 2) (alquilo C1-6)amino-, o 3) di(alquilo C1-6)amino-, E) (alquilo C1-6)amino-, F) di(alquilo C1-6)amino-, G) (alquilo C1-6)amido- opcionalmente sustituido con 1) H2N-, 2) (alquilo C1-6)amino-, o 3) di(alquilo C1-6)amino-, H) (alquilo C1-6)carboxiamido-, I) heterociclilo C1-9- opcionalmente sustituido por alquilo C1-6- o hidroxialquilo C1-6, J) heterociclilo(alquilo C1-6)- opcionalmente sustituido por alquilo C1-6-, K) halogeno, L) hidroxilo, M) hidroxialquilo C1-6-, N) perfluoro(C1-6)alquil-, O) H2N-, P) O2N-, Q) H2NSO2, R) HO2C-, y S) NC-, iii) heterociclilo C1-9 de 3-10 miembros, opcionalmente sustituido con de 1 a 3 sustituyentes seleccionados independientemente de: A) alquilo C1-6-, B) heterociclilo(alquilo C1-6)-, C) (arilo C6-14)alquil-, D) acilo C1-8-, E) (alcoxi C1-6)carbonil-, F) (alquilo C1-6)carboxil- , G) halogeno, H) haloalquilo C1-6-, I) hidroxilo, J) hidroxialquilo C1-6, K) H2N-, L) (alquilo C1-6)amino-, M) di(alquilo C1-6)amino-, N) H
ARP090101879A 2008-05-23 2009-05-26 Compuesto triazina, composicion que lo comprende y metodo para elaborar el compuesto AR071909A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5566108P 2008-05-23 2008-05-23

Publications (1)

Publication Number Publication Date
AR071909A1 true AR071909A1 (es) 2010-07-21

Family

ID=40911929

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP090101879A AR071909A1 (es) 2008-05-23 2009-05-26 Compuesto triazina, composicion que lo comprende y metodo para elaborar el compuesto
ARP090101878A AR071908A1 (es) 2008-05-23 2009-05-26 Compuesto triazina, composiciones que lo comprenden, metodo para elaborar el compuesto y metodo para tratar un trastorno de tipo cancerigeno

Family Applications After (1)

Application Number Title Priority Date Filing Date
ARP090101878A AR071908A1 (es) 2008-05-23 2009-05-26 Compuesto triazina, composiciones que lo comprenden, metodo para elaborar el compuesto y metodo para tratar un trastorno de tipo cancerigeno

Country Status (44)

Country Link
US (8) US8039469B2 (es)
EP (3) EP2294072B1 (es)
JP (2) JP4948677B2 (es)
KR (1) KR101331341B1 (es)
CN (2) CN104230831B (es)
AP (2) AP2775A (es)
AR (2) AR071909A1 (es)
AU (2) AU2009248993C1 (es)
BR (1) BRPI0912294B8 (es)
CA (2) CA2721710A1 (es)
CL (2) CL2009001274A1 (es)
CO (1) CO6311070A2 (es)
CR (1) CR11757A (es)
CU (1) CU23887B1 (es)
CY (2) CY1118879T1 (es)
DK (2) DK2294072T3 (es)
DO (1) DOP2010000315A (es)
EA (1) EA020317B1 (es)
EC (2) ECSP10010623A (es)
ES (2) ES2625467T3 (es)
GE (1) GEP20125589B (es)
HK (2) HK1157328A1 (es)
HR (2) HRP20170637T1 (es)
HU (1) HUE043331T2 (es)
IL (2) IL209061A0 (es)
LT (2) LT3216793T (es)
MA (1) MA32319B1 (es)
ME (1) ME01111B (es)
MX (1) MX2010012808A (es)
MY (1) MY155653A (es)
NI (1) NI201000198A (es)
NZ (1) NZ588526A (es)
PA (2) PA8828201A1 (es)
PE (2) PE20091943A1 (es)
PL (1) PL3216793T3 (es)
PT (2) PT2294072T (es)
RS (2) RS58724B1 (es)
SA (1) SA109300314B1 (es)
SI (2) SI2294072T1 (es)
TR (1) TR201906123T4 (es)
TW (2) TWI389906B (es)
UA (1) UA99361C2 (es)
WO (2) WO2009143313A1 (es)
ZA (1) ZA201007204B (es)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GEP20125502B (en) 2008-05-23 2012-04-25 Novartis Ag Derivatives of quinolines and quinoxalines as protein tyrosine kinase inhibitors
US10022381B2 (en) * 2008-05-23 2018-07-17 Pfizer Inc. Triazine compounds as PI3 kinase and mTOR inhibitors
RS58724B1 (sr) * 2008-05-23 2019-06-28 Wyeth Llc Jedinjenja triazina kao inhibitori pi3 kinaze i mtor
GB2465405A (en) * 2008-11-10 2010-05-19 Univ Basel Triazine, pyrimidine and pyridine analogues and their use in therapy
WO2010096619A1 (en) * 2009-02-23 2010-08-26 Wyeth Llc Process, purification and crystallization of 1-(4-{[4-(dimethylamino)piperidin-1-yl]carbonyl}phenyl)-3-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]urea
KR20110136880A (ko) 2009-03-27 2011-12-21 패스웨이 테라퓨틱스 인코포레이티드 피리미딘일 및 1,3,5-트라이아진일 벤즈이미다졸 설폰아미드 및 암 치료법에서의 이의 용도
UY32582A (es) 2009-04-28 2010-11-30 Amgen Inc Inhibidores de fosfoinositida 3 cinasa y/u objetivo mamífero
CA2767008C (en) 2009-07-07 2018-01-30 Pathway Therapeutics, Inc. Pyrimidinyl and 1,3,5-triazinyl benzimidazoles and their use in cancer therapy
KR20120059558A (ko) * 2009-08-19 2012-06-08 암비트 바이오사이언시즈 코포레이션 바이아릴 화합물 및 이의 사용 방법
US8697691B2 (en) * 2009-12-21 2014-04-15 Vanderbilt University Alkyl 3-((2-amidoethyl)amino)-8-azabicyclo[3.2.1]octane-8-carboxylate analogs as selective M1 agonists and methods of making and using same
WO2011109833A2 (en) 2010-03-05 2011-09-09 President And Fellows Of Harvard College Induced dendritic cell compositions and uses thereof
GB201004200D0 (en) * 2010-03-15 2010-04-28 Univ Basel Spirocyclic compounds and their use as therapeutic agents and diagnostic probes
US9481670B2 (en) * 2011-01-25 2016-11-01 Sphaera Pharma Pte. Ltd. Triazine compounds
EP2667874A4 (en) * 2011-01-27 2014-07-30 Univ Princeton MTOR KINASE HEMMER AS ANTIVIRUS AGENT
JP5766820B2 (ja) * 2011-02-09 2015-08-19 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ｐｉ３キナーゼ阻害剤としての複素環化合物
WO2012135160A1 (en) 2011-03-28 2012-10-04 Pathway Therapeutics Inc. (alpha- substituted aralkylamino and heteroarylalkylamino) pyrimidinyl and 1,3,5 -triazinyl benzimidazoles, pharmaceutical compositions containing them, and these compounds for use in treating proliferative diseases
CN102250065B (zh) * 2011-05-20 2015-05-13 浙江海正药业股份有限公司 取代的三嗪苯脲衍生物及其用途
CN102887867B (zh) * 2011-07-21 2015-04-15 中国科学院上海药物研究所 一类三嗪类化合物、该化合物的制备方法及其用途
ES2609606T3 (es) 2011-09-21 2017-04-21 Cellzome Limited Derivados de urea y carbamato de 2-morfolino-1,3,5-triazina como inhibidores de mTOR para el tratamiento de enfermedades inmunológicas o proliferativas
WO2013050508A1 (en) 2011-10-07 2013-04-11 Cellzome Limited Morpholino substituted bicyclic pyrimidine urea or carbamate derivatives as mtor inhibitors
CN102659765B (zh) * 2011-12-31 2014-09-10 沈阳药科大学 嘧啶及三嗪类化合物的制备方法和应用
KR20160027218A (ko) 2012-05-23 2016-03-09 에프. 호프만-라 로슈 아게 내배엽 및 간세포를 수득하고 사용하는 조성물 및 방법
WO2014005182A1 (en) * 2012-07-04 2014-01-09 Monash University Phosphoinositide 3-kinase (pi3k) inhibitors
IN2015DN01408A (es) * 2012-07-23 2015-07-03 Sphaera Pharma Pte Ltd
GB201309807D0 (en) 2013-05-31 2013-07-17 Pharma Mar Sau Antibody drug conjugates
US9763992B2 (en) 2014-02-13 2017-09-19 Father Flanagan's Boys' Home Treatment of noise induced hearing loss
TWI636798B (zh) * 2014-03-14 2018-10-01 輝瑞大藥廠 包含治療劑之治療性奈米顆粒及其製造及使用方法
CA2998647A1 (en) * 2014-10-03 2016-04-07 The Royal Institution For The Advancement Of Learning/Mcgill University Urea and bis-urea based compounds and analogues thereof useful in the treatment of androgen receptor mediated diseases or disorders
EP3549583A1 (en) 2014-10-10 2019-10-09 Pfizer Inc Synergistic auristatin combinations
CN107428730B (zh) 2014-11-20 2020-10-16 科学与工业研究会 作为抗癌试剂的1,3,5-三嗪基pi3k抑制剂及其制备方法
KR102016822B1 (ko) * 2014-12-17 2019-08-30 화이자 인코포레이티드 정맥내 투여용 pi3k/mtor-억제제의 제형
CN104725361B (zh) * 2015-04-09 2017-05-31 江苏富比亚化学品有限公司 一种受阻胺类光稳定剂3346的制备方法
KR102379959B1 (ko) 2016-05-12 2022-03-29 난징 스치 파마슈티컬 코포레이션 리미티드 신규 2,4,6-트리치환된-s-트리아진 화합물, 그 제조방법 및 용도
CA3022753A1 (en) * 2016-05-18 2017-11-23 Piqur Therapeutics Ag Use of 4-(difluoro methyl)-pyridin/pyrimidin-2-amine compounds for the treatment of neurological disorders
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام
IT201700047189A1 (it) * 2017-05-02 2018-11-02 Fondazione St Italiano Tecnologia Composti e composizioni per il trattamento di cancro, disordini della retina e cardiomiopatie
CN117860758A (zh) 2017-05-23 2024-04-12 梅制药公司 联合疗法
MX2020001727A (es) 2017-08-14 2020-03-20 Mei Pharma Inc Terapia de combinacion.
SI3672571T1 (sl) 2017-08-25 2022-01-31 Pfizer Inc. Farmacevtska vodna raztopina, ki vsebuje 1-(4-((4-(dimetilamino) piperdin-1-il)karbonil)fenil)-3-(4-(4,6-dimorfolin-4-il-1,3, 5-triazin-2-il)fenil)sečnino
CN108191837A (zh) * 2018-01-10 2018-06-22 贵州医科大学 PI3Kα/mTOR双激酶抑制剂及其药物组合物和应用
US10596165B2 (en) 2018-02-12 2020-03-24 resTORbio, Inc. Combination therapies
KR102022323B1 (ko) * 2018-03-30 2019-09-18 정하윤 트리아진 화합물 및 이의 용도
HUE063493T2 (hu) 2018-06-07 2024-01-28 Pfizer 1-(4-{[4-(dimetilamino)piperidin-1-il]karbonil}fenil)-3-[4-(4,6-dimorfolin-4-il-1,3,5-triazin-2-il)fenil]ureát tartalmazó vizes gyógyszerkészítmény
KR20210021534A (ko) 2018-06-15 2021-02-26 나비토르 파마슈티칼스 인코포레이티드 라파마이신 유사체 및 이의 용도
US20220040324A1 (en) 2018-12-21 2022-02-10 Daiichi Sankyo Company, Limited Combination of antibody-drug conjugate and kinase inhibitor
CN109942562B (zh) * 2019-02-27 2022-02-08 江西科技师范大学 含芳基结构的五元杂环联三嗪类化合物及其制备方法和应用
CN115209897A (zh) 2019-12-05 2022-10-18 安纳库利亚治疗公司 雷帕霉素类似物及其用途
CN115697345A (zh) * 2020-04-07 2023-02-03 梅制药公司 1,3,5-三嗪基苯并咪唑的制备
KR20220138575A (ko) 2021-04-06 2022-10-13 부산대학교병원 전좌 신장암 치료 또는 예방용 약물 스크리닝 방법
CN113200969B (zh) * 2021-05-19 2022-11-25 中国药科大学 一种PI3Kα选择性抑制剂及其制备方法和应用
WO2023009438A1 (en) 2021-07-26 2023-02-02 Celcuity Inc. 1-(4-{[4-(dimethylamino)piperidin-1-yl]carbonyl}phenyl)-3-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]urea (gedatolisib) and its combinations for use in the treatment of cancer
CN115109049B (zh) * 2022-08-12 2023-08-15 江西科技师范大学 含芳基脲结构的三嗪类化合物及其应用
CN115557908B (zh) * 2022-09-28 2024-10-15 九江学院 一种含硫连接键的三嗪类衍生物及其合成方法、用途
CN116102545A (zh) * 2023-02-01 2023-05-12 贵州医科大学 一种二芳基脲类PI3K/mTOR/HDAC多靶点抑制剂及其药物组合物和应用
CN116239580A (zh) * 2023-03-06 2023-06-09 中国药科大学 三嗪类化合物及其制备方法、药物组合物和应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2297326C (en) * 1997-07-24 2007-03-20 Zenyaku Kogyo Kabushiki Kaisha Heterocyclic compound and antitumor agent containing the same as active component
AU1818599A (en) * 1997-12-12 1999-07-05 Abbott Laboratories Triazine angiogenesis inhibitors
EP1389617B1 (en) 2001-04-27 2007-01-03 Zenyaku Kogyo Kabushiki Kaisha Heterocyclic compound and antitumor agent containing the same as active ingredient
GB0512324D0 (en) * 2005-06-16 2005-07-27 Novartis Ag Organic compounds
GB0423653D0 (en) * 2004-10-25 2004-11-24 Piramed Ltd Pharmaceutical compounds
WO2006090167A2 (en) * 2005-02-25 2006-08-31 Kudos Pharmaceuticals Limited Hydrazinomethyl, hydr zonomethyl and 5-membered heterocylic compounds which act as mtor inhibitors and their use as anti cancer agents
MX2009002046A (es) 2006-08-24 2009-03-06 Astrazeneca Ab Derivados de morfolino pirimidina utiles en el tratamiento de trastornos proliferativos.
RS58724B1 (sr) * 2008-05-23 2019-06-28 Wyeth Llc Jedinjenja triazina kao inhibitori pi3 kinaze i mtor

Also Published As

Publication number Publication date
HUE043331T2 (hu) 2019-08-28
PT2294072T (pt) 2017-05-29
EA201071232A1 (ru) 2011-06-30
CA2721692A1 (en) 2009-11-26
MX2010012808A (es) 2010-12-21
CY1118879T1 (el) 2018-01-10
US8039469B2 (en) 2011-10-18
AP2775A (en) 2013-09-30
US20130005723A1 (en) 2013-01-03
ME01111B (me) 2013-03-20
AR071908A1 (es) 2010-07-21
RS55960B1 (sr) 2017-09-29
SI2294072T1 (sl) 2017-05-31
JP2011522802A (ja) 2011-08-04
HRP20190680T1 (hr) 2019-06-14
CN102036995A (zh) 2011-04-27
US20150011752A1 (en) 2015-01-08
CA2721692C (en) 2014-01-14
CU23887B1 (es) 2013-04-19
US8748421B2 (en) 2014-06-10
EP2294072A1 (en) 2011-03-16
CU20100229A7 (es) 2011-11-15
US9174963B2 (en) 2015-11-03
IL209060A (en) 2014-05-28
AU2009248993A1 (en) 2009-11-26
PA8828201A1 (es) 2009-12-16
PT3216793T (pt) 2019-05-30
CY1121699T1 (el) 2020-07-31
DK2294072T3 (en) 2017-05-15
US20110312955A1 (en) 2011-12-22
US20140248239A1 (en) 2014-09-04
US20090291079A1 (en) 2009-11-26
LT2294072T (lt) 2017-06-12
US20130315865A1 (en) 2013-11-28
US8575159B2 (en) 2013-11-05
US8217036B2 (en) 2012-07-10
TW201011010A (en) 2010-03-16
DOP2010000315A (es) 2010-12-15
BRPI0912294A2 (pt) 2015-10-20
CR11757A (es) 2010-11-30
AU2009248993B2 (en) 2011-07-07
TW201008949A (en) 2010-03-01
PE20091957A1 (es) 2009-12-30
ECSP10010623A (es) 2010-12-30
HK1157328A1 (en) 2012-06-29
PA8828101A1 (es) 2009-12-16
ES2728163T3 (es) 2019-10-22
BRPI0912294B1 (pt) 2019-11-12
US20090304692A1 (en) 2009-12-10
BRPI0912294B8 (pt) 2021-05-25
CO6311070A2 (es) 2011-08-22
GEP20125589B (en) 2012-07-25
SA109300314B1 (ar) 2012-09-26
EP3216793A1 (en) 2017-09-13
HK1203199A1 (en) 2015-10-23
IL209061A0 (en) 2011-01-31
JP2011520979A (ja) 2011-07-21
US8445486B2 (en) 2013-05-21
AU2009248997A1 (en) 2009-11-26
HRP20170637T1 (hr) 2017-06-30
US8859542B2 (en) 2014-10-14
AP2010005452A0 (en) 2010-12-31
NI201000198A (es) 2011-05-09
EP2294072B1 (en) 2017-03-29
RS58724B1 (sr) 2019-06-28
CL2009001274A1 (es) 2009-10-16
WO2009143313A1 (en) 2009-11-26
KR101331341B1 (ko) 2013-11-19
ECSP10010624A (es) 2010-12-30
PL3216793T3 (pl) 2019-09-30
TR201906123T4 (tr) 2019-05-21
EP3216793B1 (en) 2019-03-27
ZA201007204B (en) 2011-12-28
NZ588526A (en) 2012-08-31
PE20091943A1 (es) 2009-12-19
LT3216793T (lt) 2019-05-10
CA2721710A1 (en) 2009-11-26
DK3216793T3 (da) 2019-05-06
KR20110002485A (ko) 2011-01-07
US20130109670A1 (en) 2013-05-02
AP2010005453A0 (en) 2010-12-31
CN104230831A (zh) 2014-12-24
CN104230831B (zh) 2016-08-24
AU2009248993C1 (en) 2013-10-03
UA99361C2 (uk) 2012-08-10
SI3216793T1 (sl) 2019-06-28
TWI389906B (zh) 2013-03-21
MY155653A (en) 2015-11-13
WO2009143317A1 (en) 2009-11-26
EA020317B1 (ru) 2014-10-30
EP2300483A1 (en) 2011-03-30
IL209060A0 (en) 2011-01-31
CN102036995B (zh) 2014-09-17
ES2625467T3 (es) 2017-07-19
JP4948677B2 (ja) 2012-06-06
MA32319B1 (fr) 2011-05-02
CL2009001273A1 (es) 2009-11-27

Similar Documents

Publication Publication Date Title
AR071909A1 (es) Compuesto triazina, composicion que lo comprende y metodo para elaborar el compuesto
AR074499A1 (es) Carboxamidas heterobiciclicas como inhibidoras de cinasas
AR071856A1 (es) Derivados de indazoles sustituidos con fenilo o piridinilo, un proceso para su preparacion, una composicion farmaceutica que los comprende y su uso en la fabricacion de un medicamento para el tratamiento de enfermedades mediadas por el receptor de glucocorticoides.
AR087288A1 (es) Compuestos de tetrahidropirido-piridina y tetrahidropirido-pirimidina y su uso como moduladores de receptores de c5a
PE20140293A1 (es) Novedosos derivados heterociclicos
AR085489A1 (es) Derivados de triazolopiridinas, composiciones farmaceuticas que los contienen, proceso para prepararlos, intermediarios de dicho proceso y uso de los mismos para el tratamiento de enfermedades autoinmunes e inflamatorias
AR048032A1 (es) Compuestos de bifenilo utiles como antagonistas de receptores muscarinicos, un proceso para su preparacion, composiciones farmaceuticas que los contienen, su uso en la fabricacion de un medicamento para el tratamiento de afecciones pulmonares y un metodo para estudiar una muestra biologica que los c
AR079689A1 (es) Derivados de imidazo[1,2a]piridina, composiciones farmaceuticas que los comprenden y uso de los mismos en trastornos mieloproliferativos, leucemia y enfermedades inmunologicas e inflamatorias.
AR071717A1 (es) Pirrolo[2,3-b]piridinas inhibidoras de quinasas chk1 y chk2,composiciones farmaceuticas que las contienen,proceso para prepararlas y uso de las mismas en el tratamiento y prevencion del cancer.
BR112012024017A2 (pt) compostos derivados de triazina dissubstituída farmaceuticamemnte ativios, composição farmacêutica, método para a síntese destes e uso dos mesmos
AR075071A1 (es) COMPUESTOS DERIVADOS DE SULFONAMIDAS , USO DE LOS MISMOS PARA LA PREPARACIoN DE MEDICAMENTOS , COMPOSICIONES FARMACÉUTICAS Y PROCESO DE PREPARACIoN DE LOS MISMOS
AR086546A1 (es) Derivados de 7h-purin-8(9h)-ona como inhibidores de jak
AR077974A1 (es) Compuestos de hexahidrooxazinopterina para uso como inhibidores de mtor
AR064353A1 (es) Compuestos y composiciones como inhibidores de la actividad del receptor cannabinoide 1. procesos de obtencion.
BR112016010080A8 (pt) compostos de pirazolopirimidina, composição farmacêutica e seu uso
AR083760A1 (es) Agentes antibacterianos y composiciones farmaceuticas
PE20142366A1 (es) Compuestos triazolo como inhibidores de pde 10
AR086086A1 (es) Derivados glucosidos y usos de los mismos
AR078164A1 (es) Derivados de isoxazolidina, proceso para preparar dichos compuestos y composiciones farmaceuticas que los comprenden
AR090955A1 (es) Aminas biciclicas c-17 de triterpenoides con actividad inhibidora de la maduracion del vih
AR086100A1 (es) Compuestos de cromenona y composiciones farmaceuticas que los contienen
PE20141553A1 (es) Compuestos de triazolopiridina como inhibidores de la ped10a
PE20081368A1 (es) Derivados de azabiciclo[4.1.0]heptano como inhibidores de la recaptacion de serotonina, dopamina y norepinefrina
RU2013136895A (ru) Новое бициклическое соединение или его соль
AR126612A1 (es) Compuestos de heteroarilo para el tratamiento de la enfermedad de huntington

Legal Events

Date Code Title Description
FA Abandonment or withdrawal