AR070329A1 - Procedimiento para la preparacion de derivados de 3, 6-dihidro-1, 3, 5-triazina - Google Patents
Procedimiento para la preparacion de derivados de 3, 6-dihidro-1, 3, 5-triazinaInfo
- Publication number
- AR070329A1 AR070329A1 ARP090100299A ARP090100299A AR070329A1 AR 070329 A1 AR070329 A1 AR 070329A1 AR P090100299 A ARP090100299 A AR P090100299A AR P090100299 A ARP090100299 A AR P090100299A AR 070329 A1 AR070329 A1 AR 070329A1
- Authority
- AR
- Argentina
- Prior art keywords
- hal
- mono
- replaced
- formula
- case independently
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/10—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Cephalosporin Compounds (AREA)
Abstract
Reivindicacion 1: Procedimiento para preparar compuestos de la formula (1) en donde R1, R2 son, en cada caso de modo independiente entre si H o A, R3, R4 son, en cada caso de modo independiente entre sí, H, A, alquenilo C2-6, alquinilo C2-6, Ar o Het, R5 y R6 también son juntos alquileno con C2-5, R5, R6 son, en cada caso de modo independiente entre sí, H, A, (CH2)nAr, (CH2)mOAr, (CH2)mOA o (CH2)mOH, R5 y R6 también son juntos alquileno C2-5, en donde un grupo CH2 puede estar reemplazad por O, NH o NA y/o en donde 1 átomo de H puede estar reemplazado por OH, Ar es fenilo; naftilo o bifenilo no sustituido o mono-, di- o trisustituido con Hal, A, OA, OH, CO-OH, COOA, CN, NH2, NHA, NA2, SO2A y/o COA, Het es un heterociclo saturado, insaturado o aromático mono-, bi- o tricíclico con 1 a 4 átomos de N, O y/o S, que puede no estar sustituido o que puede estar mono-, di- o trisustituido con Hal, A, OH, OA, NH2, (CH2)nAr, NHA, NA2, COOH, COOA y/u =O (oxígeno del carbonilo), A es alquilo no ramificado o ramificado C1-10, en donde 1-7 átomos de H pueden estar reemplazados por F o alquilo cíclico C3-7, Hal es F, Cl, Br o I, m es 1, 2, 3, 4, 5 o 6, n es 0, 1 o 2, así como sus sales por adicion de ácidos, que comprende la reaccion de un compuesto de la formula 2 en donde R1, R2, R3, R4 tienen los significados indicados con anterioridad, con un compuesto de la formula 3 en donde R5, R6 tienen los significados indicados con anterioridad.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102008007314A DE102008007314A1 (de) | 2008-02-02 | 2008-02-02 | Verfahren zur Herstellung von 3,6-Dihydro-1,3,5-triazinderivaten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR070329A1 true AR070329A1 (es) | 2010-03-31 |
Family
ID=40459622
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090100299A AR070329A1 (es) | 2008-02-02 | 2009-01-30 | Procedimiento para la preparacion de derivados de 3, 6-dihidro-1, 3, 5-triazina |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US8461331B2 (es) |
| EP (1) | EP2240456B1 (es) |
| JP (1) | JP5542066B2 (es) |
| KR (1) | KR101553568B1 (es) |
| CN (1) | CN101932566B (es) |
| AR (1) | AR070329A1 (es) |
| AT (1) | ATE519752T1 (es) |
| AU (1) | AU2009210293B2 (es) |
| BR (1) | BRPI0907052B8 (es) |
| CA (1) | CA2713236C (es) |
| CY (1) | CY1111837T1 (es) |
| DE (1) | DE102008007314A1 (es) |
| DK (1) | DK2240456T3 (es) |
| EA (1) | EA017062B1 (es) |
| ES (1) | ES2368116T3 (es) |
| HR (1) | HRP20110644T1 (es) |
| IL (1) | IL206816A (es) |
| MX (1) | MX2010008282A (es) |
| PL (1) | PL2240456T3 (es) |
| PT (1) | PT2240456E (es) |
| RS (1) | RS51968B (es) |
| SI (1) | SI2240456T1 (es) |
| WO (1) | WO2009095159A1 (es) |
| ZA (1) | ZA201006211B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2646422T3 (en) | 2010-12-01 | 2015-10-05 | Poxel | SEPARATION OF TRIAZINE DERIVATIVE ENANTIOMES USING TIN ACID ACID |
| EP3691650A1 (en) | 2017-10-02 | 2020-08-12 | Poxel | Methods of treating heart failure with preserved ejection fraction |
| KR20200130281A (ko) | 2018-06-06 | 2020-11-18 | 메타반트 사이언시스 게엠베하 | 당뇨병과 만성 신장 질환을 갖는 대상체를 치료하는 방법 |
| JP7266616B2 (ja) | 2018-06-14 | 2023-04-28 | ポクセル | 糖尿病の治療において使用するためのトリアジン誘導体を含むフィルムコーティング錠剤 |
| CN109655544B (zh) * | 2018-12-25 | 2022-08-12 | 广东华南药业集团有限公司 | 一种盐酸二甲双胍及其制剂的质量控制方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1537604A (fr) | 1966-09-26 | 1968-08-23 | Sandoz Sa | Procédé de préparation de biguanides |
| GB1250531A (es) * | 1969-01-01 | 1971-10-20 | ||
| DE2117015A1 (de) | 1971-04-02 | 1972-10-26 | Schering Ag | 1,2-Biguanide |
| SU458538A1 (ru) * | 1973-06-14 | 1975-01-30 | Уфимский Нефтяной Институт | Способ совместного получени 1,3диеновых углеводородов и гексаметилентетрамина |
| JPH061779A (ja) * | 1992-02-06 | 1994-01-11 | Wakamoto Pharmaceut Co Ltd | ベンズオキサジノン誘導体 |
| US5767294A (en) * | 1993-02-17 | 1998-06-16 | Hoechst Celanese Corporation | Process for the production of trioxane from formaldehyde |
| US5627282A (en) * | 1996-01-03 | 1997-05-06 | Yukong Limited | Process for the preparation of optically pure 1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid and its derivatives |
| FR2804113B1 (fr) * | 2000-01-26 | 2004-06-18 | Lipha | Derives animes de dihydro-1,3,5-triazine et leurs applications en therapeutique |
| CN100551916C (zh) * | 2002-12-17 | 2009-10-21 | 浜理药品工业株式会社 | 新的2,4-二氨基-1,3,5-三嗪衍生物 |
| WO2004054989A1 (ja) | 2002-12-17 | 2004-07-01 | Hamari Chemicals, Ltd. | 新規２，４−ジアミノ−１，３，５−トリアジン誘導体 |
| FR2853650B1 (fr) * | 2003-04-10 | 2006-07-07 | Merck Sante Sas | Procede de dedoublement d'amines utiles pour le traitement de desordres associes au syndrome d'insulino-resistance |
| TWI410413B (zh) * | 2006-04-26 | 2013-10-01 | Sumitomo Seika Chemicals | Preparation method of methylene disulfonate compound |
-
2008
- 2008-02-02 DE DE102008007314A patent/DE102008007314A1/de not_active Withdrawn
-
2009
- 2009-01-15 PL PL09705420T patent/PL2240456T3/pl unknown
- 2009-01-15 CN CN2009801039472A patent/CN101932566B/zh active Active
- 2009-01-15 EP EP09705420A patent/EP2240456B1/de active Active
- 2009-01-15 EA EA201001252A patent/EA017062B1/ru not_active IP Right Cessation
- 2009-01-15 KR KR1020107018199A patent/KR101553568B1/ko active Active
- 2009-01-15 JP JP2010544612A patent/JP5542066B2/ja active Active
- 2009-01-15 AT AT09705420T patent/ATE519752T1/de active
- 2009-01-15 WO PCT/EP2009/000212 patent/WO2009095159A1/de active Application Filing
- 2009-01-15 DK DK09705420.9T patent/DK2240456T3/da active
- 2009-01-15 AU AU2009210293A patent/AU2009210293B2/en not_active Ceased
- 2009-01-15 ES ES09705420T patent/ES2368116T3/es active Active
- 2009-01-15 US US12/735,608 patent/US8461331B2/en active Active
- 2009-01-15 PT PT09705420T patent/PT2240456E/pt unknown
- 2009-01-15 BR BRPI0907052A patent/BRPI0907052B8/pt not_active IP Right Cessation
- 2009-01-15 SI SI200930069T patent/SI2240456T1/sl unknown
- 2009-01-15 MX MX2010008282A patent/MX2010008282A/es active IP Right Grant
- 2009-01-15 CA CA2713236A patent/CA2713236C/en active Active
- 2009-01-15 RS RS20110409A patent/RS51968B/en unknown
- 2009-01-30 AR ARP090100299A patent/AR070329A1/es unknown
-
2010
- 2010-07-05 IL IL206816A patent/IL206816A/en active IP Right Grant
- 2010-08-31 ZA ZA2010/06211A patent/ZA201006211B/en unknown
-
2011
- 2011-09-07 HR HR20110644T patent/HRP20110644T1/hr unknown
- 2011-09-13 CY CY20111100879T patent/CY1111837T1/el unknown
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Legal Events
| Date | Code | Title | Description |
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| FB | Suspension of granting procedure |