AR062737A1 - Composicion farmaceutica que comprende un compuesto derivado de aril-azabiciclo, compuesto correspondiente y su uso para la preparacion de un medicamento - Google Patents
Composicion farmaceutica que comprende un compuesto derivado de aril-azabiciclo, compuesto correspondiente y su uso para la preparacion de un medicamentoInfo
- Publication number
- AR062737A1 AR062737A1 ARP070104006A ARP070104006A AR062737A1 AR 062737 A1 AR062737 A1 AR 062737A1 AR P070104006 A ARP070104006 A AR P070104006A AR P070104006 A ARP070104006 A AR P070104006A AR 062737 A1 AR062737 A1 AR 062737A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- alkyl
- hydrogen
- haloalkyl
- cyano
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Reproductive Health (AREA)
- Pain & Pain Management (AREA)
- Virology (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Anesthesiology (AREA)
- AIDS & HIV (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Pregnancy & Childbirth (AREA)
- Child & Adolescent Psychology (AREA)
- Oncology (AREA)
- Emergency Medicine (AREA)
Abstract
Composicion farmacéutica que comprende un compuesto derivado de aril-azabiciclo de formula (1) o una sal farmacéuticamente aceptable, solvato o profármaco del mismo donde R1 es hidrogeno o alquilo C1-4; R2 es un grupo A, K o W; donde A es como en formula (2), K es un grupo alfa o beta naftilo, opcionalmente sustituido con 1 o 2 grupos R18, siendo cada uno de ellos Igual o diferente; y W es como en formula (3) y donde G es un grupo heteroarilo monociclico de 5 o 6 miembros o un grupo heteroarilo bicíclico de 8 a 11 miembros; de tal forma que G puede estar sustituido con (R15)p, que puede ser igual o diferente; p es un numero entero entre 0 y 5; R3 se selecciona entre el grupo que consiste en: hidrogeno, fluor y alquilo C1-4; o corresponde a un grupo X o X1; R4 se selecciona entre el grupo que consiste en: hidrogeno, fluor y alquilo C1-4; o corresponde a un grupo X o X1; R5 es hidrogeno o alquilo C1-4; R7 es hidrogeno o alquilo C1-4; o es un grupo X, X1, X2, o X3 donde: X es como en formula (4), X1 es formula (5), X2 es formula (6) y X3 es formula (7); R6 es hidrogeno o alquilo C1-4; o es un grupo X o X1; R9 es alquilo C1-4; R10 se selecciona entre un grupo que consiste en: hidrogeno, halogeno, hidroxi, ciano, alquilo C1-4, haloalquilo C1-4, alcoxi C1-4, haloalcoxi C1-4, alcanoílo C1-4 y SF5, o corresponde a un grupo R8; R8 es un grupo heterociclo de 5-6 miembros, que puede estar sustituido con uno o dos sustituyentes seleccionados entre un grupo que consiste en: halogeno, ciano, alquilo C1-4, haloalquilo C1-4, alcoxi C1-4 y alcanoílo C1-4; R11 se selecciona entre un grupo que consiste en hidrogeno, halogeno, hidroxi, ciano, alquilo C1-4, haloalquilo C1-4, alcoxi C1-4, haloalcoxi C1-4, alcanoílo C1-4 y SF5; o corresponde a un grupo R8; R12 se selecciona entre un grupo que consiste en: hidrogeno, halogeno, hidroxi, ciano, alquilo C1-4, haloalquilo C1-4, alcoxi C1-4, haloalcoxi C1-4, alcanoílo C1-4 y SF5; o corresponde a un grupo R8; R13 se selecciona entre un grupo que consiste en hidrogeno, halogeno, hidroxi, ciano, alquilo C1-4, haloalquilo C1-4, alcoxi C1-4, haloalcoxi C1-4, alcanoílo C1-4 y SF5; o corresponde a un grupo R8; R14 se selecciona entre un grupo que consiste en: hidrogeno, halogeno, hidroxi, ciano, alquilo C1-4, haloalquilo C1-4, alcoxi C1-4, haloalcoxi C1-4, alcanoílo C1-4 y SF5; o corresponde a un grupo R8; R15 se selecciona entre un grupo que consiste en halogeno, hidroxi, ciano, alquilo C1-4, haloalquilo C1-4, alcoxi C1-4, haloalcoxi C1-4, alcanoílo C1-4 y SF5; o corresponde a un grupo R8; R16 es H, alquilo C1-4, cicloalquilo C3-6 o cicloalquil C3-6-alquilo C1-3; R17 es hidrogeno o alquilo C1-4; R18 se selecciona entre un grupo que consiste en halogeno, ciano, alquilo C1-4; R19 es haloalquilo C1-2 n es 1 o 2; y un vehiculo farmacéuticamente aceptable. El compuesto correspondiente. Uso para la preparacion de un medicamento util para el tratamiento de una afeccion en la que es beneficiosa la inhibicion de serotonina (5-HT), dopamina (DA) y norepinefrina (NE), tal como para la depresion.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0617868A GB0617868D0 (en) | 2006-09-11 | 2006-09-11 | Chemical compounds |
| GB0617863A GB0617863D0 (en) | 2006-09-11 | 2006-09-11 | Chemical compounds |
| GB0716371A GB0716371D0 (en) | 2007-08-22 | 2007-08-22 | Chemical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR062737A1 true AR062737A1 (es) | 2008-11-26 |
Family
ID=38561834
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070104006A AR062737A1 (es) | 2006-09-11 | 2007-09-11 | Composicion farmaceutica que comprende un compuesto derivado de aril-azabiciclo, compuesto correspondiente y su uso para la preparacion de un medicamento |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US20100035914A1 (es) |
| EP (1) | EP2064186A1 (es) |
| JP (1) | JP4448198B2 (es) |
| KR (1) | KR20090064447A (es) |
| AR (1) | AR062737A1 (es) |
| AU (1) | AU2007296301A1 (es) |
| BR (1) | BRPI0716532A2 (es) |
| CA (1) | CA2662538A1 (es) |
| CL (1) | CL2007002619A1 (es) |
| CO (1) | CO6150149A2 (es) |
| CR (1) | CR10671A (es) |
| EA (1) | EA200970266A1 (es) |
| IL (1) | IL197297A0 (es) |
| MA (1) | MA30767B1 (es) |
| MX (1) | MX2009002625A (es) |
| NO (1) | NO20091099L (es) |
| PE (1) | PE20081368A1 (es) |
| TW (1) | TW200826934A (es) |
| WO (1) | WO2008031772A1 (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100035914A1 (en) | 2006-09-11 | 2010-02-11 | Barbara Bertani | Azabicyclic compounds as inhibitors of monoamines reuptake |
| GB0716573D0 (en) * | 2007-08-24 | 2007-10-03 | Glaxo Group Ltd | Chemical compounds |
| GB0804326D0 (en) * | 2008-03-07 | 2008-04-16 | Glaxo Group Ltd | Novel compounds |
| WO2010125033A1 (en) * | 2009-04-29 | 2010-11-04 | Glaxo Group Limited | Azabicyclo[4.1.0]heptane derivatives |
| WO2010130672A1 (en) * | 2009-05-12 | 2010-11-18 | Glaxo Group Limited | Azabicyclo [4.1.0] heptane derivatives and their use as monoamine reuptake inhibitors |
| WO2010133569A1 (en) * | 2009-05-20 | 2010-11-25 | Glaxo Group Limited | Azabicyclo[4.1.0]heptane derivatives |
| WO2010146025A1 (en) * | 2009-06-17 | 2010-12-23 | Glaxo Group Limited | Tricyclic azabicyclo [4.1.0] heptane derivatives as inhibitors of serotonin, dopamine and norepinephrine re-uptake |
| MY160969A (en) | 2010-09-22 | 2017-03-31 | Eisai R&D Man Co Ltd | Cyclopropane compounds |
| DE102011100831A1 (de) | 2011-05-07 | 2012-11-08 | Studiengesellschaft Kohle Mbh | Verfahren zur Herstellung von GSK 1360707 und verwandter Verbindungen mit 6-Aryl-1-[(alkyloxy) alkyl]-3-azabicyclo[4.1.0]heptan Grundgerüst |
| US10188652B2 (en) | 2014-10-23 | 2019-01-29 | Eisai R&D Management Co., Ltd. | Compositions and methods for treating insomnia |
| KR20230051247A (ko) | 2020-08-13 | 2023-04-17 | 베링거 인겔하임 인터내셔날 게엠베하 | 정신분열병과 연관된 인지 손상의 치료 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2008A (en) * | 1841-03-18 | Gas-lamp eok conducting gas pkom ah elevated buhner to one below it | ||
| US2004A (en) * | 1841-03-12 | Improvement in the manner of constructing and propelling steam-vessels | ||
| US4131611A (en) * | 1975-07-31 | 1978-12-26 | American Cyanamid Company | Azabicyclohexanes |
| US4435419A (en) * | 1981-07-01 | 1984-03-06 | American Cyanamid Company | Method of treating depression using azabicyclohexanes |
| AU672644B2 (en) * | 1992-12-23 | 1996-10-10 | Neurosearch A/S | Aryl substituted heterocyclic compounds |
| US6288079B1 (en) * | 1996-02-22 | 2001-09-11 | Neurosearch A/S | Tropane-derivatives, their preparation and use |
| ATE433959T1 (de) * | 1997-04-07 | 2009-07-15 | Univ Georgetown | Analoge von kokain |
| US6303627B1 (en) * | 1998-06-19 | 2001-10-16 | Eli Lilly And Company | Inhibitors of serotonin reuptake |
| US6372919B1 (en) * | 2001-01-11 | 2002-04-16 | Dov Pharmaceutical, Inc. | (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as an anti-depressant agent |
| US20060173064A1 (en) | 2001-08-24 | 2006-08-03 | Lippa Arnold S | (-)-1-(3,4-Dichlorophenyl)-3-azabi cyclo[3.1.0]hexane, compositions thereof, and uses for treating alcohol-related disorders |
| US6569887B2 (en) * | 2001-08-24 | 2003-05-27 | Dov Pharmaceuticals Inc. | (−)-1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as a dopamine-reuptake |
| DE10306250A1 (de) * | 2003-02-14 | 2004-09-09 | Aventis Pharma Deutschland Gmbh | Substituierte N-Arylheterozyklen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| US7223788B2 (en) * | 2003-02-14 | 2007-05-29 | Sanofi-Aventis Deutschland Gmbh | Substituted N-aryl heterocycles, process for their preparation and their use as medicaments |
| WO2005092885A1 (en) * | 2004-02-27 | 2005-10-06 | Eli Lilly And Company | 4-amino-piperidine derivatives as monoamine uptake inhibitors |
| US20100035914A1 (en) | 2006-09-11 | 2010-02-11 | Barbara Bertani | Azabicyclic compounds as inhibitors of monoamines reuptake |
-
2007
- 2007-09-07 US US12/440,852 patent/US20100035914A1/en not_active Abandoned
- 2007-09-07 AU AU2007296301A patent/AU2007296301A1/en not_active Abandoned
- 2007-09-07 EP EP07803326A patent/EP2064186A1/en not_active Withdrawn
- 2007-09-07 WO PCT/EP2007/059381 patent/WO2008031772A1/en active Application Filing
- 2007-09-07 JP JP2009527793A patent/JP4448198B2/ja not_active Expired - Fee Related
- 2007-09-07 PE PE2007001202A patent/PE20081368A1/es not_active Application Discontinuation
- 2007-09-07 MX MX2009002625A patent/MX2009002625A/es unknown
- 2007-09-07 EA EA200970266A patent/EA200970266A1/ru unknown
- 2007-09-07 KR KR1020097007365A patent/KR20090064447A/ko not_active Application Discontinuation
- 2007-09-07 US US11/851,459 patent/US7691893B2/en not_active Expired - Fee Related
- 2007-09-07 CA CA002662538A patent/CA2662538A1/en not_active Abandoned
- 2007-09-07 BR BRPI0716532-3A2A patent/BRPI0716532A2/pt not_active IP Right Cessation
- 2007-09-10 TW TW096133638A patent/TW200826934A/zh unknown
- 2007-09-10 CL CL200702619A patent/CL2007002619A1/es unknown
- 2007-09-11 AR ARP070104006A patent/AR062737A1/es not_active Application Discontinuation
-
2009
- 2009-02-26 IL IL197297A patent/IL197297A0/en unknown
- 2009-03-10 CO CO09024346A patent/CO6150149A2/es unknown
- 2009-03-13 NO NO20091099A patent/NO20091099L/no not_active Application Discontinuation
- 2009-03-19 CR CR10671A patent/CR10671A/es not_active Application Discontinuation
- 2009-03-30 MA MA31737A patent/MA30767B1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2064186A1 (en) | 2009-06-03 |
| TW200826934A (en) | 2008-07-01 |
| NO20091099L (no) | 2009-04-03 |
| EA200970266A1 (ru) | 2009-08-28 |
| CA2662538A1 (en) | 2008-03-20 |
| MX2009002625A (es) | 2009-03-24 |
| US20080114049A1 (en) | 2008-05-15 |
| US20100035914A1 (en) | 2010-02-11 |
| KR20090064447A (ko) | 2009-06-18 |
| CO6150149A2 (es) | 2010-04-20 |
| CL2007002619A1 (es) | 2008-04-18 |
| IL197297A0 (en) | 2009-12-24 |
| PE20081368A1 (es) | 2008-11-19 |
| US7691893B2 (en) | 2010-04-06 |
| CR10671A (es) | 2009-04-29 |
| BRPI0716532A2 (pt) | 2013-09-24 |
| MA30767B1 (fr) | 2009-10-01 |
| AU2007296301A1 (en) | 2008-03-20 |
| JP4448198B2 (ja) | 2010-04-07 |
| WO2008031772A1 (en) | 2008-03-20 |
| JP2010502761A (ja) | 2010-01-28 |
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