AR058210A1 - Procedimiento para preparar 5-amino-3h-tiazolo[4,5-d]pirimidin-2-ona, un intermediario util para la preparacion de ciertos nucleosidos de tiazolo[4,5-d]pirimidina que actuan como inmunomoduladores. - Google Patents
Procedimiento para preparar 5-amino-3h-tiazolo[4,5-d]pirimidin-2-ona, un intermediario util para la preparacion de ciertos nucleosidos de tiazolo[4,5-d]pirimidina que actuan como inmunomoduladores.Info
- Publication number
- AR058210A1 AR058210A1 ARP060105089A ARP060105089A AR058210A1 AR 058210 A1 AR058210 A1 AR 058210A1 AR P060105089 A ARP060105089 A AR P060105089A AR P060105089 A ARP060105089 A AR P060105089A AR 058210 A1 AR058210 A1 AR 058210A1
- Authority
- AR
- Argentina
- Prior art keywords
- amino
- formula
- thiazolo
- pyrimidin
- tiazolo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Reivindicacion 1: Un procedimiento para la preparacion de 5-amino-3H-tiazolo[4,5-d]pirimidin-2-ona que posee la formula (1) caracterizado porque comprende: (i) halogenacion de una 2,4-diaminopirimidina de formula (2) para formar un 2,4-diamino-5- halo-pirimidina de formula (3) en donde X representa halo seleccionado de F, Cl, Br e I; (ii) ciclocondensacion de 2,4-diamino-5-halo-pirimidina para formar 5-amino-3H-tiazolo[4,5-d]pirimidin-2-tiona de formula (4); y (iii) oxidar la 5-amino-3H- tiazolo[4,5-d]pirimidin-2-tiona para formar 5-amino-3H-tiazolo[4,5-d]pirimidin-2-ona. Reivindicacion 12: Un procedimiento para la ciclocondensacion de 2,4-diamino-5-halo-pirimidina de formula (3) caracterizado porque X es halo seleccionado de F, Cl, Br, e I; para formar 5-amino-3H-tiazolo[4,5-d]pirimidin-2-tiona de formula (4) en donde la ciclocondensacion es realizada en presencia de un compuesto xantogenato que tiene la formula (5) en donde M es un cation de metal y R1es un grupo alquilo; y en donde la reaccion comprende calentar la solucion e los reactivos anteriores en presencia de un solvente inerte. Reivindicacion 17: Un procedimiento para oxidar 5-amino-3H-tiazolo[4,5-d]pirimidin-2-tiona de formula (4) para formar 5-amino-3- tiazolo[4,5-d]pirimidin-2-ona de formula (1) en donde el procedimiento comprende: hacer reaccionar 5-amino-3H-tiazolo[4,5-d]pirimidin-2-tiona con un agente oxidante bajo condiciones básicas y una hidrolisis ácida subsiguiente.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73805505P | 2005-11-21 | 2005-11-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR058210A1 true AR058210A1 (es) | 2008-01-23 |
Family
ID=37908057
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060105089A AR058210A1 (es) | 2005-11-21 | 2006-11-21 | Procedimiento para preparar 5-amino-3h-tiazolo[4,5-d]pirimidin-2-ona, un intermediario util para la preparacion de ciertos nucleosidos de tiazolo[4,5-d]pirimidina que actuan como inmunomoduladores. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7781581B2 (es) |
| EP (1) | EP1973920B1 (es) |
| JP (1) | JP5117391B2 (es) |
| KR (1) | KR20080090400A (es) |
| CN (1) | CN101365705A (es) |
| AR (1) | AR058210A1 (es) |
| AT (1) | ATE474842T1 (es) |
| AU (1) | AU2006318260B2 (es) |
| BR (1) | BRPI0618789A2 (es) |
| CA (1) | CA2630463C (es) |
| DE (1) | DE602006015700D1 (es) |
| EA (1) | EA200801404A1 (es) |
| ES (1) | ES2345904T3 (es) |
| IL (1) | IL191568A0 (es) |
| NO (1) | NO20082365L (es) |
| SG (1) | SG152296A1 (es) |
| TW (1) | TWI383987B (es) |
| WO (1) | WO2007062355A2 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7709448B2 (en) | 2006-06-22 | 2010-05-04 | Anadys Pharmaceuticals, Inc. | Prodrugs of 5-amino-3-(3′-deoxy-β-D-ribofuranosyl)-thiazolo[4,5-d]pyrimidin-2,7-dione |
| WO2012102366A1 (ja) * | 2011-01-28 | 2012-08-02 | 日本たばこ産業株式会社 | 新規ピペラジン化合物の製造方法 |
| CN103012284A (zh) * | 2012-12-26 | 2013-04-03 | 无锡捷化医药科技有限公司 | 一种2-氨基-5-溴嘧啶类化合物的制备方法 |
| US9441008B2 (en) | 2014-12-08 | 2016-09-13 | Hoffmann-La Roche Inc. | 3-substituted 5-amino-6H-thiazolo[4,5-D]pyrimidine-2,7-dione compounds for the treatment and prophylaxis of virus infection |
| CN110139868B (zh) | 2017-01-06 | 2021-07-09 | 豪夫迈·罗氏有限公司 | 制备3-取代的5-氨基-6H-噻唑并[4,5-d]嘧啶-2,7-二酮化合物的方法 |
| CN111635368B (zh) * | 2020-06-12 | 2021-06-29 | 东莞市东阳光仿制药研发有限公司 | 一种胺化合物的制备方法 |
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| US7709448B2 (en) | 2006-06-22 | 2010-05-04 | Anadys Pharmaceuticals, Inc. | Prodrugs of 5-amino-3-(3′-deoxy-β-D-ribofuranosyl)-thiazolo[4,5-d]pyrimidin-2,7-dione |
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-
2006
- 2006-11-20 AT AT06846356T patent/ATE474842T1/de not_active IP Right Cessation
- 2006-11-20 AU AU2006318260A patent/AU2006318260B2/en not_active Ceased
- 2006-11-20 DE DE602006015700T patent/DE602006015700D1/de active Active
- 2006-11-20 EA EA200801404A patent/EA200801404A1/xx unknown
- 2006-11-20 US US11/601,719 patent/US7781581B2/en not_active Expired - Fee Related
- 2006-11-20 SG SG200903039-6A patent/SG152296A1/en unknown
- 2006-11-20 KR KR1020087014973A patent/KR20080090400A/ko not_active Application Discontinuation
- 2006-11-20 ES ES06846356T patent/ES2345904T3/es active Active
- 2006-11-20 BR BRPI0618789A patent/BRPI0618789A2/pt not_active IP Right Cessation
- 2006-11-20 CA CA2630463A patent/CA2630463C/en not_active Expired - Fee Related
- 2006-11-20 JP JP2008541505A patent/JP5117391B2/ja not_active Expired - Fee Related
- 2006-11-20 CN CNA200680050892XA patent/CN101365705A/zh active Pending
- 2006-11-20 EP EP06846356A patent/EP1973920B1/en not_active Not-in-force
- 2006-11-20 WO PCT/US2006/061111 patent/WO2007062355A2/en active Application Filing
- 2006-11-20 TW TW095142739A patent/TWI383987B/zh not_active IP Right Cessation
- 2006-11-21 AR ARP060105089A patent/AR058210A1/es not_active Application Discontinuation
-
2008
- 2008-05-20 IL IL191568A patent/IL191568A0/en unknown
- 2008-05-26 NO NO20082365A patent/NO20082365L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DE602006015700D1 (de) | 2010-09-02 |
| CA2630463A1 (en) | 2007-05-31 |
| KR20080090400A (ko) | 2008-10-08 |
| BRPI0618789A2 (pt) | 2016-08-30 |
| JP5117391B2 (ja) | 2013-01-16 |
| WO2007062355A2 (en) | 2007-05-31 |
| ATE474842T1 (de) | 2010-08-15 |
| NO20082365L (no) | 2008-08-18 |
| EP1973920B1 (en) | 2010-07-21 |
| US7781581B2 (en) | 2010-08-24 |
| EP1973920A2 (en) | 2008-10-01 |
| SG152296A1 (en) | 2009-05-29 |
| CN101365705A (zh) | 2009-02-11 |
| CA2630463C (en) | 2015-01-06 |
| JP2009516709A (ja) | 2009-04-23 |
| EA200801404A1 (ru) | 2008-10-30 |
| WO2007062355A3 (en) | 2007-07-26 |
| TWI383987B (zh) | 2013-02-01 |
| AU2006318260B2 (en) | 2012-05-17 |
| AU2006318260A1 (en) | 2007-05-31 |
| TW200736265A (en) | 2007-10-01 |
| ES2345904T3 (es) | 2010-10-05 |
| US20070117979A1 (en) | 2007-05-24 |
| IL191568A0 (en) | 2008-12-29 |
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