AR054475A1 - Fenilfosfatos sustituidos como profarmacos mutuos de esteroides y (beta)-agonistas para el tratamiento de la inflamacion pulmonar y la broncoconstriccion - Google Patents
Fenilfosfatos sustituidos como profarmacos mutuos de esteroides y (beta)-agonistas para el tratamiento de la inflamacion pulmonar y la broncoconstriccionInfo
- Publication number
- AR054475A1 AR054475A1 ARP060102527A ARP060102527A AR054475A1 AR 054475 A1 AR054475 A1 AR 054475A1 AR P060102527 A ARP060102527 A AR P060102527A AR P060102527 A ARP060102527 A AR P060102527A AR 054475 A1 AR054475 A1 AR 054475A1
- Authority
- AR
- Argentina
- Prior art keywords
- substituted
- alkyl
- propharmaces
- phenylphosphates
- broncoconstriction
- Prior art date
Links
- 206010035664 Pneumonia Diseases 0.000 title 1
- 239000000556 agonist Substances 0.000 title 1
- 150000003431 steroids Chemical class 0.000 title 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 5
- 229910052757 nitrogen Inorganic materials 0.000 abstract 4
- 229910052760 oxygen Inorganic materials 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000004429 atom Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 101500021084 Locusta migratoria 5 kDa peptide Proteins 0.000 abstract 1
- 229910004679 ONO2 Inorganic materials 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000001893 nitrooxy group Chemical group [O-][N+](=O)O* 0.000 abstract 1
- 125000006574 non-aromatic ring group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/12—Esters of phosphoric acids with hydroxyaryl compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Otolaryngology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
Abstract
Reivindicacion 1: Un compuesto de formula (1) o (2) y sales aceptables para uso farmacéutico de las mismas, donde: X es S, N o un heterociclo que nitrogenado, en el cual el átomo de N del heterociclo está unido a R1 y R2; W se selecciona del grupo que incluye Cl, F, OH, ONO2, OCO-alquilo, OCO-arilo, CN, S-alquilo y S-arilo; Cicl es cicloalquilo o cicloalquilo con átomo(s) de C sustituido(s) con S u O; Y está ausente o es -Z(CH2)n, donde n = 0-6 y Z es S, O, N o N-alquilo; R1 y R2 se seleccionan independientemente del grupo que consiste en H, arilo, alquilo inferior y alquilo inferior sustituido, o están ausentes, o se toman conjuntamente para formar un anillo no aromático que posee 2 a 10 átomos seleccionados de C, O, S y N; R3 es como se muestra en el resto de formula (3) donde R6 es un grupo alquilo de 1-12 átomos de C, arilalquilo o arilalquilo sustituido con 1-3 grupos CH2 en la cadena de C sustituida con átomos(s) seleccionado(s) e O, S y N, y R4 y R5 son independientemente H, Cl o F.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69054505P | 2005-06-14 | 2005-06-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR054475A1 true AR054475A1 (es) | 2007-06-27 |
Family
ID=37570763
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060102527A AR054475A1 (es) | 2005-06-14 | 2006-06-14 | Fenilfosfatos sustituidos como profarmacos mutuos de esteroides y (beta)-agonistas para el tratamiento de la inflamacion pulmonar y la broncoconstriccion |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20100209508A1 (es) |
| EP (1) | EP1893220A4 (es) |
| JP (1) | JP2008546694A (es) |
| KR (1) | KR20060130515A (es) |
| CN (1) | CN101227912A (es) |
| AR (1) | AR054475A1 (es) |
| AU (1) | AU2006259604A1 (es) |
| BR (1) | BRPI0611567A2 (es) |
| CA (1) | CA2612364A1 (es) |
| IL (1) | IL187816A0 (es) |
| NO (1) | NO20080182L (es) |
| RU (1) | RU2008100237A (es) |
| TW (1) | TW200718707A (es) |
| WO (1) | WO2006138212A1 (es) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008035066A2 (en) * | 2006-09-19 | 2008-03-27 | Cipla Limited | Processes for the preparation of ciclesonide and its crystal form |
| AR064307A1 (es) * | 2006-12-13 | 2009-03-25 | Gilead Sciences Inc | Monofosfatos utiles para el tratamiento de la inflamacion pulmonar y broncoconstriccion, formulaciones aerosolicas que los contienen, y metodo de preparacion. |
| EP2114972A2 (en) * | 2006-12-13 | 2009-11-11 | Gilead Sciences, Inc. | Monophosphates as mutual prodrugs of muscarinic receptor antagonists and beta-agonists for the treatment of copd and chronic bronchitis |
| PE20091215A1 (es) * | 2007-12-21 | 2009-08-14 | Schering Corp | Tioeteres c-21 como agonistas del receptor de glucocorticoides |
| CL2008003803A1 (es) * | 2007-12-21 | 2010-02-19 | Schering Corp | Compuestos derivados de esteroides c20-21 sustituidos, agonistas del receptor de glucocorticoide; composicion farmaceutica que comprende a dicho compuesto; y uso para tratar o prevenir una enfermedad o afeccion inmune, autoinmune o inflamatoria, tales como colitis inflamatoria y artritis reumatoide. |
| TW201010707A (en) * | 2008-06-10 | 2010-03-16 | Gilead Sciences Inc | Corticosteroid linked beta-agonist compounds for use in therapy |
| WO2010126953A1 (en) * | 2009-04-29 | 2010-11-04 | Gilead Sciences, Inc. | Corticosteroid linked beta-agonist compounds for use in therapy |
| WO2010132743A1 (en) * | 2009-05-15 | 2010-11-18 | Gilead Sciences, Inc. | Corticosteroid beta-agonist compounds for use in therapy |
| AU2010260177A1 (en) * | 2009-06-16 | 2011-12-15 | Merck Sharp & Dohme Corp. | Novel [3,2-c] heteroaryl steroids as glucocorticoid receptor agonists, compositions and uses thereof |
| CA2773594C (en) * | 2009-09-11 | 2018-09-25 | Chiesi Farmaceutici S.P.A. | Isoxazolidine derivatives |
| WO2011081937A1 (en) | 2009-12-15 | 2011-07-07 | Gilead Sciences, Inc. | Corticosteroid-beta-agonist-muscarinic antagonist compounds for use in therapy |
| JP6124176B2 (ja) * | 2013-03-26 | 2017-05-10 | 株式会社伏見製薬所 | 樹脂成形体用組成物 |
| CN104510726A (zh) * | 2013-09-27 | 2015-04-15 | 张金华 | 一种用于清洁呼吸道系统的食盐干粉吸入剂 |
| PT107567B (pt) * | 2014-03-31 | 2019-02-13 | Hovione Farm S A | Secador por atomização com atomizador múltiplo, método para o aumento de escala de pós para inalação secos por dispositivo de atomização múltiplo e uso de vários atomizadores num secador por atomização |
| BR112018074922B1 (pt) | 2016-06-02 | 2022-10-25 | Abbvie Inc | Compostos agonistas de receptores de glucocorticoides, composição farmacêutica compreendendo ditos compostos e uso terapêutico dos mesmos |
| MX2019005330A (es) | 2016-11-08 | 2019-09-11 | Regeneron Pharma | Esteroides y conjugados de proteinas de los mismos. |
| MX2019013690A (es) | 2017-05-18 | 2020-01-27 | Regeneron Pharma | Conjugados de farmaco-proteina con ciclodextrina. |
| KR20200085807A (ko) | 2017-11-07 | 2020-07-15 | 리제너론 파마슈티칼스 인코포레이티드 | 항체 약물 접합제용 친수성 링커 |
| AU2018374634A1 (en) | 2017-12-01 | 2020-05-28 | Abbvie Inc. | Glucocorticoid receptor agonist and immunoconjugates thereof |
| MA54673A1 (fr) | 2018-01-08 | 2022-08-31 | Regeneron Pharma | Stéroïdes et leurs conjugués-anticorps |
| CA3098453A1 (en) | 2018-05-09 | 2019-11-14 | Regeneron Pharmaceuticals, Inc. | Anti-msr1 antibodies and methods of use thereof |
| IT201900014178A1 (it) * | 2019-08-06 | 2021-02-06 | Genetic S P A | Esteri del montelukast e loro formulazioni farmaceutiche |
| CN112592280B (zh) * | 2020-12-09 | 2023-05-23 | 青岛职业技术学院 | 一种消旋沙丁胺醇的制备方法 |
| TW202304462A (zh) | 2021-03-23 | 2023-02-01 | 美商美國禮來大藥廠 | 糖皮質素受體激動劑 |
| AR125079A1 (es) | 2021-03-23 | 2023-06-07 | Lilly Co Eli | Agonistas de receptores de glucocorticoides sustituidos con carboxi |
| EP4365183A1 (en) * | 2021-06-24 | 2024-05-08 | Jiangsu Simcere Pharmaceutical Co., Ltd. | Steroid compound, and pharmaceutical composition thereof and use thereof |
| TW202327620A (zh) * | 2021-09-14 | 2023-07-16 | 大陸商映恩生物製藥（蘇州）有限公司 | 一種抗炎症的化合物及其用途 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE585432A (fr) * | 1958-12-08 | 1960-06-08 | American Cyanamid Co | Stéroïdes fluorés. |
| US4757079A (en) * | 1986-06-24 | 1988-07-12 | Dynamac Corporaton | Anti-hypertensive piperidine compounds |
| GR1001529B (el) * | 1990-09-07 | 1994-03-31 | Elmuquimica Farm Sl | Μέ?οδος για την λήψη νέων 21-εστέρων της 16-17-ακετάλης της πρ να-1,4-διενο-3,20-διόνης. |
| EP0701565B1 (de) * | 1993-04-02 | 1998-10-28 | Byk Gulden Lomberg Chemische Fabrik GmbH | Neue prednisolonderivate |
| US6300326B1 (en) * | 1994-11-02 | 2001-10-09 | Michael R. Dobbs | Composition and method for control and treatment of cutaneous inflammation |
| IT1303671B1 (it) * | 1998-07-28 | 2001-02-23 | Nicox Sa | Sali dell'acido nitrico con farmaci attivi nel trattamento dipatologie del sistema respiratorio |
| AU2004241746A1 (en) * | 2003-05-22 | 2004-12-02 | Nycomed Gmbh | Salmeterol and ciclesonide combination |
| WO2005028495A1 (en) * | 2003-09-24 | 2005-03-31 | Glaxo Group Limited | Anti-inflammatory glucocorticoids |
| WO2005063777A1 (en) * | 2003-12-23 | 2005-07-14 | Corus Pharma | Benzylphosphate and substituted benzylphosphate prodrugs for the treatment of pulmonary inflammation |
-
2006
- 2006-06-12 BR BRPI0611567A patent/BRPI0611567A2/pt not_active IP Right Cessation
- 2006-06-12 US US11/922,258 patent/US20100209508A1/en not_active Abandoned
- 2006-06-12 RU RU2008100237/04A patent/RU2008100237A/ru not_active Application Discontinuation
- 2006-06-12 WO PCT/US2006/022790 patent/WO2006138212A1/en active Application Filing
- 2006-06-12 CA CA002612364A patent/CA2612364A1/en not_active Abandoned
- 2006-06-12 CN CNA2006800213783A patent/CN101227912A/zh active Pending
- 2006-06-12 JP JP2008516976A patent/JP2008546694A/ja active Pending
- 2006-06-12 AU AU2006259604A patent/AU2006259604A1/en not_active Abandoned
- 2006-06-12 EP EP06784777A patent/EP1893220A4/en not_active Withdrawn
- 2006-06-14 TW TW095121230A patent/TW200718707A/zh unknown
- 2006-06-14 AR ARP060102527A patent/AR054475A1/es unknown
- 2006-06-14 KR KR1020060053519A patent/KR20060130515A/ko not_active Application Discontinuation
-
2007
- 2007-12-02 IL IL187816A patent/IL187816A0/en unknown
-
2008
- 2008-01-11 NO NO20080182A patent/NO20080182L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1893220A1 (en) | 2008-03-05 |
| CA2612364A1 (en) | 2006-12-28 |
| JP2008546694A (ja) | 2008-12-25 |
| CN101227912A (zh) | 2008-07-23 |
| EP1893220A4 (en) | 2011-06-15 |
| WO2006138212A1 (en) | 2006-12-28 |
| US20100209508A1 (en) | 2010-08-19 |
| IL187816A0 (en) | 2008-08-07 |
| BRPI0611567A2 (pt) | 2016-11-16 |
| TW200718707A (en) | 2007-05-16 |
| AU2006259604A1 (en) | 2006-12-28 |
| RU2008100237A (ru) | 2009-07-20 |
| NO20080182L (no) | 2008-02-21 |
| KR20060130515A (ko) | 2006-12-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR054475A1 (es) | Fenilfosfatos sustituidos como profarmacos mutuos de esteroides y (beta)-agonistas para el tratamiento de la inflamacion pulmonar y la broncoconstriccion | |
| PA8593001A1 (es) | Derivados de pirimidina para el tratamiento del crecimiento celular anormal | |
| ECSP066985A (es) | Derivados de prolina y su uso como inhibidores de la dipeptidilpeptidasa-iv | |
| AR060749A1 (es) | Uso de bifenilamidas de acido arilcarboxilico para el tratamiento de semillas | |
| ECSP105253A (es) | Derivados de 5-feniltiazol y uso como inhibidores de pi3 cinasa | |
| AR072906A1 (es) | Nucleosidos modificados utiles como antivirales | |
| CY1113538T1 (el) | Παραγωγα της 5-αμινο-2,4,7-τριοξο-3,4,7,8-τετραϋδρο-2η-πυριδο[2,3-d] πυριμιδινης και παρομοιες ενωσεις για την αγωγη του καρκινου | |
| GT200500325A (es) | Pirazolo-pirimidinas 1,4-sustituidas como inhibidores de quinasa | |
| ECSP067120A (es) | 3-aminociclopentanocarboxamidas como moduladores de receptores de quimioquinas | |
| ECSP066717A (es) | Compuestos de quinolina sustituidos | |
| ECSP034642A (es) | Derivados de tetralona como agentes antitumorales | |
| UY29636A1 (es) | 2,4-diamino-pirimidinas como inhibidores de aurora | |
| ECSP088184A (es) | Derivados de benzoquinazolina y su uso en el tratamiento de enfermedades óseas | |
| CU20110129A7 (es) | Piridiloxi-indoles inhibidores del vegf-r2 y uso de los mismos para el tratamiento de enfermedades | |
| AR057148A1 (es) | Combinaciones farmacologicas para el tratamiento de enfermedades de las vias respiratorias | |
| SV2008003032A (es) | Compuestos de tetrahidropiridotienopirimidina y procedimientos de uso de los mismos | |
| UY28700A1 (es) | Compuestos | |
| PE20151892A1 (es) | Compuestos tetraciclicos sustituidos con heterociclo y metodos de uso de los mismos para el tratamiento de enfermedades viricas | |
| ECSP088527A (es) | 3-aminociclopentanocarboxamidas como moduladores de receptores de quimioquinas | |
| PA8573501A1 (es) | Derivados de benzoxazina y su empleo | |
| UY28861A1 (es) | Nuevas combinaciones farmacologicas para el tratamiento de enfermedades de las vias respiratorias | |
| UY27685A1 (es) | Indolil-urea derivados de tienopiridinas útiles como agentes antiangiogénicos, y procedimientos para su uso | |
| MX2022001161A (es) | Derivados de 3,6-diamino-piridazin-3-ilo, composiciones farmaceuticas que los contienen y sus usos como agentes proapoptoticos. | |
| PA8587501A1 (es) | Benzoxazinonas sustituidas y usos de las mismas | |
| UY28356A1 (es) | Derivados de benzimidazol, composiciones que los contienen, preparaciones de los mismos y sus usos |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |