AR054109A1 - Derivados de 2-metil-4-fenil-5-oxo-1,4,5,6,7,8-hexahidroquinolina, composiciones farmaceuticas que los contienen y su uso en la preparacion de medicamentos para el tratamiento de la infertilidad - Google Patents
Derivados de 2-metil-4-fenil-5-oxo-1,4,5,6,7,8-hexahidroquinolina, composiciones farmaceuticas que los contienen y su uso en la preparacion de medicamentos para el tratamiento de la infertilidadInfo
- Publication number
- AR054109A1 AR054109A1 ARP060101781A ARP060101781A AR054109A1 AR 054109 A1 AR054109 A1 AR 054109A1 AR P060101781 A ARP060101781 A AR P060101781A AR P060101781 A ARP060101781 A AR P060101781A AR 054109 A1 AR054109 A1 AR 054109A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- alkoxy
- phenyl
- derivatives
- oxo
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Derivados de 2-metil-4-fenil-5-oxo-1,4,5,6,7,8-hexahidroquinolina de la formula general (1), donde R1 es alquilo C1-6, alquenilo C2-6 o alquinilo C2-6; R2 es halogeno; R3 es SO2NR5R6 o alcoxilo c1-4, opcionalmente sustituido por uno o más átomos de fluor; es O o NR7; R4 es R8-alquiloC2-8, R8-alqueniloC3-8, R8-alquiniloC3-8- o R8-alcoxiC2-4-alquiloC2-4; Z es CN o NO2; R5 y R6 son independientemente H o alquilo C1-4; o R5 junto con R6 y el N, al cual están ligados, forman un anillo saturado de 3 a 8 miembros, conteniendo opcionalmente otro heteroátomos seleccionado entre O y S; R8 es OH, alcoxilo C1-4, NH2; NR9C(O)R11, NR9SO2R11 o C(O)NR9R10; R7 y R9 son independientemente H o alquilo C1-4; R10 es alquilo C1-4, alcoxiC1-4-alquiloC1-4, o fenil-alquiloC1-4 o heteroarilC2-5-alquiloC1-4, ambos opcionalmente sustituidos en el anillo (hetero)aromático por uno o más sustituyentes seleccionados entre OH, NH2, halogeno, NO2, CF3, CN, alquilo C1-4, alcoxilo C1-4 y di-alquilaminoC1-4; R11 es alquilo C1-4, alquenilo C2-4, alquinilo C2-4, alcoxiC1-4-alquiloC1-4, cicloalquilo C3-6, alcoxilo C1-4 di-alquilaminoC1-4, o fenilo o heteroarilo C2-5, ambos opcionalmente sustituidos en el anillo (hetero)aromático por uno o más sustituyentes seleccionados entre OH, NH2, halogeno, NO2, CF3, CN, alquilo C1-4, alcoxilo C1-4 y di-alquilaminoC1-4; o su sal farmacéuticamente aceptable. Composiciones farmacéuticas que comprenden dichos derivados, así como la utilizacion de estos derivados de 2- metil-4-fenil-5-oxo-1,4,5,6,7,8-hexahidroquinolina en la terapia, más específicamente, para el tratamiento de los trastornos de la fertilidad y su uso en la preparacion de un medicamento para el tratamiento de esta ultima disfuncion.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05103741 | 2005-05-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR054109A1 true AR054109A1 (es) | 2007-06-06 |
Family
ID=34939698
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060101781A AR054109A1 (es) | 2005-05-04 | 2006-05-03 | Derivados de 2-metil-4-fenil-5-oxo-1,4,5,6,7,8-hexahidroquinolina, composiciones farmaceuticas que los contienen y su uso en la preparacion de medicamentos para el tratamiento de la infertilidad |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US8017782B2 (es) |
| EP (1) | EP1879581B1 (es) |
| JP (1) | JP5118631B2 (es) |
| KR (1) | KR20080010445A (es) |
| CN (1) | CN101212971B (es) |
| AR (1) | AR054109A1 (es) |
| AT (1) | ATE406895T1 (es) |
| AU (1) | AU2006243194B2 (es) |
| BR (1) | BRPI0611124A2 (es) |
| CA (1) | CA2607106C (es) |
| CY (1) | CY1108584T1 (es) |
| DE (1) | DE602006002608D1 (es) |
| DK (1) | DK1879581T3 (es) |
| ES (1) | ES2313667T3 (es) |
| HK (1) | HK1110782A1 (es) |
| HR (1) | HRP20080488T3 (es) |
| IL (1) | IL186831A (es) |
| MX (1) | MX2007013754A (es) |
| MY (1) | MY144609A (es) |
| NO (1) | NO20075637L (es) |
| NZ (1) | NZ562804A (es) |
| PE (1) | PE20061371A1 (es) |
| PL (1) | PL1879581T3 (es) |
| PT (1) | PT1879581E (es) |
| RS (1) | RS50614B (es) |
| RU (1) | RU2403249C2 (es) |
| SI (1) | SI1879581T1 (es) |
| TW (1) | TW200716553A (es) |
| UA (1) | UA92009C2 (es) |
| WO (1) | WO2006117371A1 (es) |
| ZA (1) | ZA200709096B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA92007C2 (ru) * | 2005-05-04 | 2010-09-27 | Н.В. Органон | Производные 4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолина для лечения бесплодности |
| BRPI0520259A2 (pt) * | 2005-05-04 | 2009-09-15 | Organon Nv | composto derivado de diidropiridina ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, uso do composto |
| UA92008C2 (en) * | 2005-05-04 | 2010-09-27 | Н.В. Органон | 4-PHENYL-5-OXO-l,4,5,6,7,8-HEXAHYDROQUINOLINE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF INFERTILITY |
| TW200944523A (en) | 2008-02-08 | 2009-11-01 | Organon Nv | (Dihydro)pyrrolo[2,1-a]isoquinolines |
| US8071587B2 (en) | 2009-05-27 | 2011-12-06 | N. V. Organon | (Dihydro)imidazoiso[5,1-A]quinolines |
| TW201116531A (en) | 2009-07-29 | 2011-05-16 | Organon Nv | Ring-annulated dihydropyrrolo[2,1-a]isoquinolines |
| US8431564B2 (en) | 2009-07-29 | 2013-04-30 | Merck Sharp & Dohme B.V. | Ring-annulated dihydropyrrolo[2,1-α]isoquinolines |
| TW201116515A (en) | 2009-07-31 | 2011-05-16 | Organon Nv | Dihydrobenzoindazoles |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1070162B (de) | 1959-12-03 | Farbwerke Hoechst Aktiengesellschaft vormals Meister Lucius &. Brüning, Frankfurt/M | Verfahren zur Herstellung von 5 - Brom - 3 - nitro - 4 - hydroxybenzaldehyd bzw. 5 - Chlor - 3 - nitro - 4 - hydroxybenzaldehyd | |
| GB9318935D0 (en) | 1992-10-20 | 1993-10-27 | Zeneca Ltd | Heterocyclic derivatives |
| US5455253A (en) * | 1992-10-20 | 1995-10-03 | Zeneca Limited | Heterocyclic derivatives |
| DE4430639A1 (de) * | 1994-08-29 | 1996-03-07 | Bayer Ag | Verwendung von 5-substituierten Pyridin- und Hexahydrochinolin-3-carbonsäurederivaten |
| GB9515445D0 (en) | 1995-07-27 | 1995-09-27 | Pharmacia Spa | Dihydropyridine and pyridine derivatives and process for their preparation |
| EP0876349B1 (en) * | 1995-10-19 | 2002-09-11 | Takeda Chemical Industries, Ltd. | Quinoline derivatives as gnrh antagonists |
| US6593335B1 (en) * | 1997-12-18 | 2003-07-15 | Abbott Laboratories | Potassium channel openers |
| ATE279407T1 (de) | 1998-08-07 | 2004-10-15 | Applied Research Systems | Fsh mimetika zur behandlung von infertilität |
| AU2001278006A1 (en) | 2000-07-27 | 2002-02-13 | Smithkline Beecham Corporation | Agonists of follicle stimulating hormone activity |
| BR0210645A (pt) | 2001-07-02 | 2004-10-05 | Akzo Nobel Nv | Composto derivado de tetraidroquinolina, composição farmacêutica, e, uso do composto. |
| JP2003026630A (ja) | 2001-07-13 | 2003-01-29 | Taoka Chem Co Ltd | カラーカプラー中間体用カルボン酸クロリド類の製造法 |
| TWI322012B (en) * | 2002-12-20 | 2010-03-21 | Organon Nv | Tetrahydroquinoline derivatives |
| UA92007C2 (ru) * | 2005-05-04 | 2010-09-27 | Н.В. Органон | Производные 4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолина для лечения бесплодности |
| BRPI0520259A2 (pt) * | 2005-05-04 | 2009-09-15 | Organon Nv | composto derivado de diidropiridina ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, uso do composto |
| UA92008C2 (en) * | 2005-05-04 | 2010-09-27 | Н.В. Органон | 4-PHENYL-5-OXO-l,4,5,6,7,8-HEXAHYDROQUINOLINE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF INFERTILITY |
-
2006
- 2006-02-05 UA UAA200711804A patent/UA92009C2/ru unknown
- 2006-05-02 AU AU2006243194A patent/AU2006243194B2/en not_active Ceased
- 2006-05-02 RS RSP-2008/0457A patent/RS50614B/sr unknown
- 2006-05-02 RU RU2007144984/04A patent/RU2403249C2/ru not_active IP Right Cessation
- 2006-05-02 US US11/912,756 patent/US8017782B2/en active Active
- 2006-05-02 SI SI200630120T patent/SI1879581T1/sl unknown
- 2006-05-02 CA CA2607106A patent/CA2607106C/en not_active Expired - Fee Related
- 2006-05-02 PL PL06754954T patent/PL1879581T3/pl unknown
- 2006-05-02 BR BRPI0611124-6A patent/BRPI0611124A2/pt not_active IP Right Cessation
- 2006-05-02 KR KR1020077027874A patent/KR20080010445A/ko not_active Application Discontinuation
- 2006-05-02 JP JP2008509437A patent/JP5118631B2/ja not_active Expired - Fee Related
- 2006-05-02 ES ES06754954T patent/ES2313667T3/es active Active
- 2006-05-02 DK DK06754954T patent/DK1879581T3/da active
- 2006-05-02 PT PT06754954T patent/PT1879581E/pt unknown
- 2006-05-02 DE DE602006002608T patent/DE602006002608D1/de active Active
- 2006-05-02 AT AT06754954T patent/ATE406895T1/de active
- 2006-05-02 NZ NZ562804A patent/NZ562804A/en not_active IP Right Cessation
- 2006-05-02 MX MX2007013754A patent/MX2007013754A/es active IP Right Grant
- 2006-05-02 EP EP06754954A patent/EP1879581B1/en active Active
- 2006-05-02 CN CN2006800235439A patent/CN101212971B/zh not_active Expired - Fee Related
- 2006-05-02 WO PCT/EP2006/061978 patent/WO2006117371A1/en active Application Filing
- 2006-05-03 AR ARP060101781A patent/AR054109A1/es unknown
- 2006-05-03 TW TW095115776A patent/TW200716553A/zh unknown
- 2006-05-03 MY MYPI20062028A patent/MY144609A/en unknown
- 2006-05-03 PE PE2006000466A patent/PE20061371A1/es not_active Application Discontinuation
-
2007
- 2007-10-22 IL IL186831A patent/IL186831A/en not_active IP Right Cessation
- 2007-10-22 ZA ZA200709096A patent/ZA200709096B/xx unknown
- 2007-11-06 NO NO20075637A patent/NO20075637L/no not_active Application Discontinuation
-
2008
- 2008-05-08 HK HK08105174A patent/HK1110782A1/xx not_active IP Right Cessation
- 2008-09-30 HR HR20080488T patent/HRP20080488T3/xx unknown
- 2008-11-20 CY CY20081101342T patent/CY1108584T1/el unknown
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