AR049995A1 - Un procedimiento de preparacion de derivados n-piperidino-1,5-difenilpirazol-3-carboxamida - Google Patents
Un procedimiento de preparacion de derivados n-piperidino-1,5-difenilpirazol-3-carboxamidaInfo
- Publication number
- AR049995A1 AR049995A1 ARP050102971A ARP050102971A AR049995A1 AR 049995 A1 AR049995 A1 AR 049995A1 AR P050102971 A ARP050102971 A AR P050102971A AR P050102971 A ARP050102971 A AR P050102971A AR 049995 A1 AR049995 A1 AR 049995A1
- Authority
- AR
- Argentina
- Prior art keywords
- formula
- group
- halogen atom
- alkyl
- difenilpirazol
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- VWOQOMNXHWAQMJ-UHFFFAOYSA-N 1h-pyrazole-5-carbohydrazide Chemical class NNC(=O)C1=CC=NN1 VWOQOMNXHWAQMJ-UHFFFAOYSA-N 0.000 abstract 1
- OFBQJSOFQDEBGM-UHFFFAOYSA-N Pentane Chemical class CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000005010 perfluoroalkyl group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Addiction (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Reivindicacion 1: Procedimiento de preparacion de un compuesto de formula (1), donde: R1 representa un átomo de hidrogeno o de halogeno o un grupo C1-4 alquilo; R2, R3, R4, R5, R6, R7 representan cada uno, independientemente uno del otro, un átomo de hidrogeno o de halogeno o un grupo C1-4 alquilo, C1-4 alcoxi, trifluorometilo; y de sus sales, caracterizado porque: se hace reaccionar un derivado de pentano de formula: X-(CH2)5-X', donde X y X' representan, cada una independientemente, un átomo de halogeno o un grupo YSO2O- donde Y representa un grupo C1-4 alquilo, C1-4 perfluoroalquilo, fenilo no sustituido o sustituido por un grupo metilo, cloro o nitro, sobre un derivado de pirazol-3-carbohidrazida de formula (2), donde R1, R2, R3, R4, R5 R6, R7 son tales como se definieran anteriormente para la formula (1) en presencia de una base, en un solvente y a una temperatura comprendida entre la temperatura ambiente y la temperatura de reflujo del solvente.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0408111A FR2873372B1 (fr) | 2004-07-22 | 2004-07-22 | Procede de preparation de derives n-piperidino-1,5- diphenylpyrazole-3-carboxamide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR049995A1 true AR049995A1 (es) | 2006-09-20 |
Family
ID=34949586
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050102971A AR049995A1 (es) | 2004-07-22 | 2005-07-19 | Un procedimiento de preparacion de derivados n-piperidino-1,5-difenilpirazol-3-carboxamida |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US7462632B2 (es) |
| EP (1) | EP1773783B1 (es) |
| JP (1) | JP4879175B2 (es) |
| KR (1) | KR20070036050A (es) |
| CN (1) | CN100537543C (es) |
| AR (1) | AR049995A1 (es) |
| AT (1) | ATE466843T1 (es) |
| AU (1) | AU2005276350A1 (es) |
| BR (1) | BRPI0510399A (es) |
| CA (1) | CA2564223A1 (es) |
| DE (1) | DE602005021110D1 (es) |
| FR (1) | FR2873372B1 (es) |
| IL (1) | IL179107A0 (es) |
| MA (1) | MA28576B1 (es) |
| MX (1) | MXPA06012954A (es) |
| NO (1) | NO20071008L (es) |
| RU (1) | RU2329252C1 (es) |
| TW (1) | TW200609223A (es) |
| UY (1) | UY29023A1 (es) |
| WO (1) | WO2006021652A1 (es) |
| ZA (1) | ZA200609639B (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1816125A1 (en) * | 2006-02-02 | 2007-08-08 | Ranbaxy Laboratories, Ltd. | Novel crystalline forms of an antagonist of CB1 cannabinoid receptor and preparation method thereof |
| US20100076022A1 (en) * | 2006-09-01 | 2010-03-25 | Hetero Drugs Limited | Novel polymorphs of rimonabant |
| WO2008032330A2 (en) * | 2006-09-11 | 2008-03-20 | Hetero Drugs Limited | Improved process for rimonabant |
| WO2008035023A1 (en) * | 2006-09-19 | 2008-03-27 | Cipla Limited | Polymorphs of rimonabant |
| EP1944297A1 (en) * | 2007-01-09 | 2008-07-16 | Miklós Vértessy | Solid and crystalline rimonabant and processes for preparation, and pharmaceutical composition thereof |
| EP1947090A1 (en) * | 2007-01-17 | 2008-07-23 | Laboratorios del Dr. Esteve S.A. | Method for preparing N-piperidino-1,5-diphenylpyrazole-3-carboxamide and derivatives |
| WO2008088900A2 (en) * | 2007-01-18 | 2008-07-24 | Teva Pharmaceutical Industries Ltd. | Polymorphic forms of rimonabant base and processes for preparation thereof |
| US8431609B2 (en) | 2007-02-19 | 2013-04-30 | Darmesh Mahendrabhai Shah | Process for preparation of pyrazole derivatives |
| FR2913018A1 (fr) * | 2007-02-23 | 2008-08-29 | Sanofi Aventis Sa | Solution solide amorphe contenant un derive de pyrazole-3-carboxamide sous forme amorphe et des excipients stabilisateurs |
| WO2009109222A1 (en) * | 2008-03-04 | 2009-09-11 | Maprimed, S. A. | Process for the preparation of rimonabant |
| WO2010079241A1 (es) | 2009-01-12 | 2010-07-15 | Fundacion Hospital Nacional De Paraplejicos Para La Investigacion Y La Integracion | Uso de antagonistas y/o agonistas inversos de los receptores cb1 para la preparación de medicamentos que incrementen la excitabilidad de las motoneuronas |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2713225B1 (fr) * | 1993-12-02 | 1996-03-01 | Sanofi Sa | N-pipéridino-3-pyrazolecarboxamide substitué. |
| FR2714057B1 (fr) * | 1993-12-17 | 1996-03-08 | Sanofi Elf | Nouveaux dérivés du 3-pyrazolecarboxamide, procédé pour leur préparation et compositions pharmaceutiques les contenant. |
| JP4314339B2 (ja) * | 2002-08-22 | 2009-08-12 | 三井化学アグロ株式会社 | ニコチンアミドラゾン誘導体 |
-
2004
- 2004-07-22 FR FR0408111A patent/FR2873372B1/fr not_active Expired - Fee Related
-
2005
- 2005-07-19 UY UY29023A patent/UY29023A1/es not_active Application Discontinuation
- 2005-07-19 AR ARP050102971A patent/AR049995A1/es unknown
- 2005-07-20 RU RU2006141239/04A patent/RU2329252C1/ru not_active IP Right Cessation
- 2005-07-20 AT AT05790868T patent/ATE466843T1/de not_active IP Right Cessation
- 2005-07-20 BR BRPI0510399-1A patent/BRPI0510399A/pt not_active IP Right Cessation
- 2005-07-20 KR KR1020067024365A patent/KR20070036050A/ko not_active Application Discontinuation
- 2005-07-20 JP JP2007521985A patent/JP4879175B2/ja not_active Expired - Fee Related
- 2005-07-20 MX MXPA06012954A patent/MXPA06012954A/es not_active Application Discontinuation
- 2005-07-20 DE DE602005021110T patent/DE602005021110D1/de active Active
- 2005-07-20 AU AU2005276350A patent/AU2005276350A1/en not_active Abandoned
- 2005-07-20 CN CNB2005800163474A patent/CN100537543C/zh not_active Expired - Fee Related
- 2005-07-20 ZA ZA200609639A patent/ZA200609639B/xx unknown
- 2005-07-20 EP EP05790868A patent/EP1773783B1/fr active Active
- 2005-07-20 WO PCT/FR2005/001850 patent/WO2006021652A1/fr active Application Filing
- 2005-07-20 CA CA002564223A patent/CA2564223A1/fr not_active Abandoned
- 2005-07-21 TW TW094124731A patent/TW200609223A/zh unknown
-
2006
- 2006-11-07 IL IL179107A patent/IL179107A0/en unknown
- 2006-11-10 MA MA29444A patent/MA28576B1/fr unknown
- 2006-11-14 US US11/559,566 patent/US7462632B2/en not_active Expired - Fee Related
-
2007
- 2007-02-21 NO NO20071008A patent/NO20071008L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DE602005021110D1 (de) | 2010-06-17 |
| WO2006021652A1 (fr) | 2006-03-02 |
| ATE466843T1 (de) | 2010-05-15 |
| UY29023A1 (es) | 2006-02-24 |
| EP1773783B1 (fr) | 2010-05-05 |
| RU2329252C1 (ru) | 2008-07-20 |
| CN1956963A (zh) | 2007-05-02 |
| JP4879175B2 (ja) | 2012-02-22 |
| CN100537543C (zh) | 2009-09-09 |
| FR2873372B1 (fr) | 2006-09-08 |
| MA28576B1 (fr) | 2007-05-02 |
| CA2564223A1 (fr) | 2006-03-02 |
| EP1773783A1 (fr) | 2007-04-18 |
| IL179107A0 (en) | 2007-03-08 |
| US7462632B2 (en) | 2008-12-09 |
| FR2873372A1 (fr) | 2006-01-27 |
| NO20071008L (no) | 2007-02-21 |
| KR20070036050A (ko) | 2007-04-02 |
| AU2005276350A1 (en) | 2006-03-02 |
| US20080119653A1 (en) | 2008-05-22 |
| BRPI0510399A (pt) | 2007-11-13 |
| MXPA06012954A (es) | 2007-02-12 |
| TW200609223A (en) | 2006-03-16 |
| JP2008506756A (ja) | 2008-03-06 |
| ZA200609639B (en) | 2008-08-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |