AR046170A1 - Derivados de pirimidin-2-amina y su uso como antagonistas del receptor de adenosina a 2b - Google Patents
Derivados de pirimidin-2-amina y su uso como antagonistas del receptor de adenosina a 2bInfo
- Publication number
- AR046170A1 AR046170A1 ARP040103547A ARP040103547A AR046170A1 AR 046170 A1 AR046170 A1 AR 046170A1 AR P040103547 A ARP040103547 A AR P040103547A AR P040103547 A ARP040103547 A AR P040103547A AR 046170 A1 AR046170 A1 AR 046170A1
- Authority
- AR
- Argentina
- Prior art keywords
- optionally substituted
- branched
- group
- linear
- substituted linear
- Prior art date
Links
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 title 2
- 239000002126 C01EB10 - Adenosine Substances 0.000 title 1
- 229960005305 adenosine Drugs 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000004429 atom Chemical group 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000004414 alkyl thio group Chemical group 0.000 abstract 3
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 3
- 125000004122 cyclic group Chemical group 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000002950 monocyclic group Chemical group 0.000 abstract 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 3
- 125000001424 substituent group Chemical group 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000003367 polycyclic group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
El presente se refiere a procesos para su preparación; a composiciones farmacéuticas que los comprenden y a su uso en terapia. Reivindicación 1: Un compuesto de fórmula (1), en la que: R1 representa un grupo arilo o heteroarilo monocíclico o policíclico opcionalmente sustituido con uno, dos o tres sustituyentes seleccionados del grupo constituido por átomos de halógeno, alquilo inferior lineal o ramificado opcionalmente sustituido, hidroxi, alcoxi inferior lineal o ramificado opcionalmente sustituido, -SH, alquiltio inferior lineal o ramificado opcionalmente sustituido, nitro, ciano, -NR'R'', -CO2R', -C(O)-NR'R'', -N(R''')C(O)-R', -N(R''')-C(O)NR'R'', representando cada R', R'' y R''' independientemente un átomo de hidrógeno o un grupo alquilo inferior lineal o ramificado opcionalmente sustituido o R' y R'' junto con el átomo al que están unidos forman un grupo cíclico; R2 representa un grupo heteroarilo monocíclico que contiene N seleccionado del grupo de fórmulas (2), estando los grupos de fórmulas (2) opcionalmente sustituidos con uno, dos o tres sustituyentes seleccionados del grupo formado por átomos de halógeno, alquilo inferior opcionalmente sustituido lineal o ramificado, hidroxi, alcoxi opcionalmente sustituido lineal o ramificado, -SH, alquiltio opcionalmente sustituido lineal o ramificado, nitro, ciano, -NR'R'', -CO2R', -C(O)-NR'R'', -N(R''')C(O)-R', -N(R''')-C(O)NR'R'', en los que cada uno de R', R'' y R''' representa independientemente un átomo de hidrógeno o un grupo alquilo inferior opcionalmente sustituido lineal o ramificado o R' y R'' junto con el átomo al que están unidos forman un grupo cíclico; R3 representa un grupo heteroarilo monocíclico o policíclico que está opcionalmente sustituido con uno, dos o tres sustituyentes seleccionados del grupo de halógeno, alquilo inferior lineal o ramificado opcionalmente sustituido, hidroxi, oxo, alcoxi inferior lineal o ramificado opcionalmente sustituido, -SH, alquiltio inferior lineal o ramificado opcionalmente sustituido, nitro, ciano, -NR'R'', -CO2R', -C(O)-NR'R'', -N(R''')C(O)-R', -N(R''')-C(O)NR'R'', representando cada R', R'' y R''' independientemente un átomo de hidrógeno o un grupo alquilo lineal o ramificado opcionalmente sustituido o R' y R'' junto con el átomo al que están unidos forman un grupo cíclico; o un N-óxido o una sal farmacéuticamente aceptable del mismo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200302275A ES2229928B1 (es) | 2003-10-02 | 2003-10-02 | Nuevos derivados de pirimidin-2-amina. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR046170A1 true AR046170A1 (es) | 2005-11-30 |
Family
ID=34507890
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040103547A AR046170A1 (es) | 2003-10-02 | 2004-09-30 | Derivados de pirimidin-2-amina y su uso como antagonistas del receptor de adenosina a 2b |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US20070265273A1 (es) |
| EP (1) | EP1668000A1 (es) |
| JP (1) | JP2007507443A (es) |
| KR (1) | KR20060097010A (es) |
| CN (1) | CN1886402A (es) |
| AR (1) | AR046170A1 (es) |
| AU (1) | AU2004283800B8 (es) |
| BR (1) | BRPI0415324A (es) |
| CA (1) | CA2540765A1 (es) |
| CO (1) | CO5690593A2 (es) |
| EC (1) | ECSP066426A (es) |
| ES (1) | ES2229928B1 (es) |
| IL (1) | IL174771A0 (es) |
| MX (1) | MXPA06003525A (es) |
| NO (1) | NO20061952L (es) |
| NZ (1) | NZ546266A (es) |
| PE (1) | PE20050473A1 (es) |
| RU (1) | RU2006114746A (es) |
| SG (1) | SG149077A1 (es) |
| TW (1) | TW200526645A (es) |
| UA (1) | UA82563C2 (es) |
| UY (1) | UY28529A1 (es) |
| WO (1) | WO2005040155A1 (es) |
| ZA (1) | ZA200602139B (es) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ554485A (en) | 2004-10-15 | 2010-12-24 | Gilead Palo Alto Inc | Method of preventing and treating airway remodeling and pulmonary inflammation using A2B adenosine receptor antagonists |
| ES2270715B1 (es) * | 2005-07-29 | 2008-04-01 | Laboratorios Almirall S.A. | Nuevos derivados de pirazina. |
| ES2274712B1 (es) | 2005-10-06 | 2008-03-01 | Laboratorios Almirall S.A. | Nuevos derivados imidazopiridina. |
| DE102006046410A1 (de) * | 2006-09-20 | 2008-03-27 | Eberhard-Karls-Universität Tübingen Universitätsklinikum | Arzneimittel zur Prophylaxe oder Behandlung oder Diagnostik von ischämischen Krankheiten |
| ES2303776B1 (es) * | 2006-12-29 | 2009-08-07 | Laboratorios Almirall S.A. | Derivados de 5-fenil-6-piridin-4-il-1,3-dihidro-2h-imidazo(4,5-b)piridin-2-ona utiles como antagonistas del receptor de adenosina a2b. |
| ES2320955B1 (es) | 2007-03-02 | 2010-03-16 | Laboratorios Almirall S.A. | Nuevos derivados de 3-((1,2,4)triazolo(4,3-a)piridin-7-il)benzamida. |
| KR20100020454A (ko) * | 2007-06-08 | 2010-02-22 | 바이엘 크롭사이언스 소시에떼아노님 | 살진균제 헤테로사이클릴-피리미디닐-아미노 유도체 |
| ES2394126T3 (es) * | 2007-07-26 | 2013-01-22 | Novartis Ag | Derivados de pirimidina útiles para el tratamiento de estados inflamatorios o alérgicos |
| ATE520682T1 (de) | 2007-08-22 | 2011-09-15 | Irm Llc | 2-heteroarylaminopyrimidinderivate als kinaseinhibitoren |
| JP5599312B2 (ja) | 2007-08-22 | 2014-10-01 | アイアールエム・リミテッド・ライアビリティ・カンパニー | ５−（４−（ハロアルコキシ）フェニル）ピリミジン−２−アミン化合物およびキナーゼ阻害剤としての組成物 |
| EP2108641A1 (en) | 2008-04-11 | 2009-10-14 | Laboratorios Almirall, S.A. | New substituted spiro[cycloalkyl-1,3'-indo]-2'(1'H)-one derivatives and their use as p38 mitogen-activated kinase inhibitors |
| EP2113503A1 (en) | 2008-04-28 | 2009-11-04 | Laboratorios Almirall, S.A. | New substituted indolin-2-one derivatives and their use as p39 mitogen-activated kinase inhibitors |
| EP2308866A1 (de) | 2009-10-09 | 2011-04-13 | Bayer CropScience AG | Phenylpyri(mi)dinylpyrazole und ihre Verwendung als Fungizide |
| EP2322176A1 (en) | 2009-11-11 | 2011-05-18 | Almirall, S.A. | New 7-phenyl-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one derivatives |
| BR112012018358A2 (pt) | 2009-12-21 | 2016-08-09 | Bayer Cropscience Ag | tienilpiri(mi)dinilazol e seu uso para controlar fungos fitopatogênicos |
| SG183146A1 (en) * | 2010-02-05 | 2012-09-27 | Heptares Therapeutics Ltd | 1,2,4-triazine-4-amine derivatives |
| KR20130130030A (ko) | 2010-12-21 | 2013-11-29 | 노파르티스 아게 | Vps34 억제제로서의 비-헤테로아릴 화합물 |
| SG11202106963YA (en) | 2019-01-11 | 2021-07-29 | Omeros Corp | Methods and compositions for treating cancer |
| CN111825698B (zh) | 2019-07-30 | 2021-10-15 | 杭州阿诺生物医药科技有限公司 | 腺苷受体拮抗剂 |
| CN112500416B (zh) | 2019-07-30 | 2021-12-17 | 厦门宝太生物科技股份有限公司 | 一种吡唑并三嗪类化合物中间体的制备方法 |
| CN115477653B (zh) * | 2022-10-11 | 2024-04-09 | 安徽省庆云医药股份有限公司 | 一种曲拉西利关键中间体及曲拉西利的制备方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US23763A (en) * | 1859-04-26 | Method of adjusting the knives of rotary cutter-heads for planing wood | ||
| US176399A (en) * | 1876-04-18 | Improvement in boxes for packing crackers | ||
| US22106A (en) * | 1858-11-23 | Truss-bridge | ||
| US275038A (en) * | 1883-04-03 | Ors to themselves | ||
| US42891A (en) * | 1864-05-24 | Improvement in water-engines | ||
| GB9309573D0 (en) * | 1993-05-10 | 1993-06-23 | Merck Sharp & Dohme | Therapeutic agents |
| US5686470A (en) * | 1995-02-10 | 1997-11-11 | Weier; Richard M. | 2, 3-substituted pyridines for the treatment of inflammation |
| IL152023A0 (en) * | 2000-04-26 | 2003-04-10 | Eisai Co Ltd | Compounds having adenosine a2 receptor antagonism and pharmaceutical compositions containing the same |
| US6641549B2 (en) * | 2001-02-05 | 2003-11-04 | Bsn Medical, Inc. | Custom-moldable support for patellar tendinitis |
| TWI330183B (es) * | 2001-10-22 | 2010-09-11 | Eisai R&D Man Co Ltd | |
| US20050043315A1 (en) * | 2002-01-02 | 2005-02-24 | Hideo Tsutsumi | Aminopyrimidine compounds, processes for their preparation and pharmaceutical compositions containing them |
-
2003
- 2003-10-02 ES ES200302275A patent/ES2229928B1/es not_active Expired - Fee Related
-
2004
- 2004-09-21 UY UY28529A patent/UY28529A1/es not_active Application Discontinuation
- 2004-09-22 AU AU2004283800A patent/AU2004283800B8/en not_active Ceased
- 2004-09-22 UA UAA200604615A patent/UA82563C2/uk unknown
- 2004-09-22 CA CA002540765A patent/CA2540765A1/en not_active Abandoned
- 2004-09-22 BR BRPI0415324-3A patent/BRPI0415324A/pt not_active IP Right Cessation
- 2004-09-22 WO PCT/EP2004/010644 patent/WO2005040155A1/en active Application Filing
- 2004-09-22 JP JP2006530007A patent/JP2007507443A/ja active Pending
- 2004-09-22 KR KR1020067006384A patent/KR20060097010A/ko not_active Application Discontinuation
- 2004-09-22 SG SG200809684-4A patent/SG149077A1/en unknown
- 2004-09-22 NZ NZ546266A patent/NZ546266A/en unknown
- 2004-09-22 EP EP04765506A patent/EP1668000A1/en not_active Withdrawn
- 2004-09-22 RU RU2006114746/04A patent/RU2006114746A/ru not_active Application Discontinuation
- 2004-09-22 ZA ZA200602139A patent/ZA200602139B/en unknown
- 2004-09-22 CN CNA2004800346926A patent/CN1886402A/zh active Pending
- 2004-09-22 US US10/574,101 patent/US20070265273A1/en not_active Abandoned
- 2004-09-22 MX MXPA06003525A patent/MXPA06003525A/es unknown
- 2004-09-28 PE PE2004000948A patent/PE20050473A1/es not_active Application Discontinuation
- 2004-09-30 AR ARP040103547A patent/AR046170A1/es unknown
- 2004-09-30 TW TW093129574A patent/TW200526645A/zh unknown
-
2006
- 2006-03-16 EC EC2006006426A patent/ECSP066426A/es unknown
- 2006-03-31 CO CO06032147A patent/CO5690593A2/es not_active Application Discontinuation
- 2006-04-03 IL IL174771A patent/IL174771A0/en unknown
- 2006-05-02 NO NO20061952A patent/NO20061952L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2004283800A1 (en) | 2005-05-06 |
| AU2004283800B2 (en) | 2009-05-07 |
| KR20060097010A (ko) | 2006-09-13 |
| US20070265273A1 (en) | 2007-11-15 |
| TW200526645A (en) | 2005-08-16 |
| UA82563C2 (uk) | 2008-04-25 |
| CO5690593A2 (es) | 2006-10-31 |
| WO2005040155A1 (en) | 2005-05-06 |
| WO2005040155A8 (en) | 2006-04-20 |
| ES2229928B1 (es) | 2006-07-01 |
| UY28529A1 (es) | 2005-04-29 |
| MXPA06003525A (es) | 2006-06-08 |
| JP2007507443A (ja) | 2007-03-29 |
| BRPI0415324A (pt) | 2006-12-05 |
| AU2004283800B8 (en) | 2009-06-18 |
| IL174771A0 (en) | 2006-08-20 |
| ECSP066426A (es) | 2006-10-17 |
| CN1886402A (zh) | 2006-12-27 |
| NZ546266A (en) | 2008-10-31 |
| ES2229928A1 (es) | 2005-04-16 |
| PE20050473A1 (es) | 2005-08-24 |
| SG149077A1 (en) | 2009-01-29 |
| RU2006114746A (ru) | 2007-11-20 |
| CA2540765A1 (en) | 2005-05-06 |
| ZA200602139B (en) | 2007-06-27 |
| EP1668000A1 (en) | 2006-06-14 |
| NO20061952L (no) | 2006-06-26 |
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