AR040993A1 - Procedimiento para la identificacion de sustancias con accion herbicida - Google Patents
Procedimiento para la identificacion de sustancias con accion herbicidaInfo
- Publication number
- AR040993A1 AR040993A1 ARP030102968A ARP030102968A AR040993A1 AR 040993 A1 AR040993 A1 AR 040993A1 AR P030102968 A ARP030102968 A AR P030102968A AR P030102968 A ARP030102968 A AR P030102968A AR 040993 A1 AR040993 A1 AR 040993A1
- Authority
- AR
- Argentina
- Prior art keywords
- seq
- activity
- nucleic acid
- acid sequence
- amino acid
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 239000000126 substance Substances 0.000 title abstract 4
- 230000000694 effects Effects 0.000 abstract 17
- 150000007523 nucleic acids Chemical class 0.000 abstract 14
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 8
- 150000001413 amino acids Chemical group 0.000 abstract 6
- 108020004707 nucleic acids Proteins 0.000 abstract 5
- 102000039446 nucleic acids Human genes 0.000 abstract 5
- 239000012634 fragment Substances 0.000 abstract 4
- 229920001184 polypeptide Polymers 0.000 abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 abstract 3
- 230000004952 protein activity Effects 0.000 abstract 3
- 108020004414 DNA Proteins 0.000 abstract 2
- 108060004795 Methyltransferase Proteins 0.000 abstract 2
- 230000010632 Transcription Factor Activity Effects 0.000 abstract 2
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 abstract 2
- 230000002363 herbicidal effect Effects 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 102000002281 Adenylate kinase Human genes 0.000 abstract 1
- 108020000543 Adenylate kinase Proteins 0.000 abstract 1
- 102000002249 Arginine-tRNA Ligase Human genes 0.000 abstract 1
- 108010014885 Arginine-tRNA ligase Proteins 0.000 abstract 1
- 108010089790 Eukaryotic Initiation Factor-3 Proteins 0.000 abstract 1
- 102100033132 Eukaryotic translation initiation factor 3 subunit E Human genes 0.000 abstract 1
- 108010063907 Glutathione Reductase Proteins 0.000 abstract 1
- 102100036442 Glutathione reductase, mitochondrial Human genes 0.000 abstract 1
- 102000016397 Methyltransferase Human genes 0.000 abstract 1
- 101100261242 Mus musculus Trdmt1 gene Proteins 0.000 abstract 1
- 108090000944 RNA Helicases Proteins 0.000 abstract 1
- 102000004409 RNA Helicases Human genes 0.000 abstract 1
- 230000004570 RNA-binding Effects 0.000 abstract 1
- 101100095302 Streptococcus gordonii secA1 gene Proteins 0.000 abstract 1
- 230000027455 binding Effects 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940104302 cytosine Drugs 0.000 abstract 1
- 230000002068 genetic effect Effects 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 239000003488 releasing hormone Substances 0.000 abstract 1
- 101150108659 secA gene Proteins 0.000 abstract 1
- 230000035939 shock Effects 0.000 abstract 1
- 108040006206 sigma factor activity proteins Proteins 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 230000009261 transgenic effect Effects 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
- C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
- C12N15/8274—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for herbicide resistance
Landscapes
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
La presente se refiere a un procedimiento para la identificación de compuestos con acción herbicida. La presenta se refiere además a constructos de ácidos nucleicos, a vectores que contienen a loa constructos de ácidos nucleicos, a organismos transgénicos y a su uso. La presente se refiere además a sustancias que fueron identificadas con el procedimiento mencionado. Reivindicación 1: Un procedimiento para la identificación de sustancias con acción herbicida, caracterizada porque: a) la expresión o la actividad del producto génico de un ácido nucleico o de un gen que comprende: aa) secuencia de ácidos nucleicos con la secuencia representada en: SEQ ID NO: 1, SEQ ID NO: 3, SEQ ID NO: 5, SEQ ID NO: 7, SEQ ID NO: 9, SEQ ID NO: 11, SEQ ID NO: 13, SEQ ID NO: 15, SEQ ID NO: 17, SEQ ID NO: 19, SEQ ID NO: 21, SEQ ID NO: 23, SEQ ID NO: 25, SEQ ID NO: 27, SEQ ID NO: 29, SEQ ID NO: 31, SEQ ID NO: 33, SEQ ID NO: 35, SEQ ID NO: 37, SEQ ID NO: 39, SEQ ID NO: 41, SEQ ID NO: 43, SEQ ID NO: 45, SEQ ID NO: 47, SEQ ID NO: 49 o SEQ ID NO: 51; bb) secuencia de ácidos nucleicos que se puede derivar, en base al código genético degenerado, de la retrotraducción de las secuencias de aminoácidos representadas en: SEQ ID NO: 2, SEQ ID NO: 4, SEQ ID NO: 6, SEQ ID NO: 8, SEQ ID NO: 10, SEQ ID NO: 12, SEQ ID NO: 14, SEQ ID NO: 16, SEQ ID NO: 18, SEQ ID NO: 20, SEQ ID NO: 22, SEQ ID NO: 24, SEQ ID NO: 26, SEQ ID NO: 28, SEQ ID NO: 30, SEQ ID NO: 32, SEQ ID NO: 34, SEQ ID NO: 36, SEQ ID NO: 38, SEQ ID NO: 40, SEQ ID NO: 42, SEQ ID NO: 44, SEQ ID NO: 46, SEQ ID NO: 48, SEQ ID NO: 50 o SEQ ID NO: 52; cc) secuencia de ácidos nucleicos, que es un derivado o un fragmento de las secuencias de ácidos nucleicos representadas en: SEQ ID NO: 1, SEQ ID NO: 3, SEQ ID NO: 5, SEQ ID NO: 7, SEQ ID NO: 9, SEQ ID NO: 11, SEQ ID NO: 13, SEQ ID NO: 15, SEQ ID NO: 17, SEQ ID NO: 19, SEQ ID NO: 21, SEQ ID NO: 23, SEQ ID NO: 25, SEQ ID NO: 27, SEQ ID NO: 29, SEQ ID NO: 31, SEQ ID NO: 33, SEQ ID NO: 35, SEQ ID NO: 37, SEQ ID NO: 39, SEQ ID NO: 41, SEQ ID NO: 43, SEQ ID NO: 45, SEQ ID NO: 47, SEQ ID NO: 49 o SEQ ID NO: 51, y que presenta una homología de por lo menos 60% en el nivel de los ácidos nucleicos; dd) secuencia de ácidos nucleicos, que codifica para los derivados o fragmentos de los polipéptidos con las secuencias de aminoácidos representadas en: SEQ ID NO: 2, SEQ ID NO: 4, SEQ ID NO: 6, SEQ ID NO: 8, SEQ ID NO: 10, SEQ ID NO: 12, SEQ ID NO: 14, SEQ ID NO: 16, SEQ ID NO: 18, SEQ ID NO: 20, SEQ ID NO: 22, SEQ ID NO: 24, SEQ ID NO: 26, SEQ ID NO: 28, SEQ ID NO: 30, SEQ ID NO: 32, SEQ ID NO: 34, SEQ ID NO: 36, SEQ ID NO: 38, SEQ ID NO: 40, SEQ ID NO: 42, SEQ ID NO: 44, SEQ ID NO: 46, SEQ ID NO: 48, SEQ ID NO: 50 o SEQ ID NO: 52; las que presentan una homología de por lo menos 50% en el nivel de los aminoácidos; ee) secuencia de ácidos nucleicos, que codifica para un fragmento o un epitopo de un polipéptido, el que se liga específicamente a un anticuerpo, ligándose el anticuerpo específicamente a un polipéptido, el que es codificado por la secuencia representada en: SEQ ID NO: 1, SEQ ID NO: 3, SEQ ID NO: 5, SEQ ID NO: 7, SEQ ID NO: 9, SEQ ID NO: 11, SEQ ID NO: 13, SEQ ID NO: 15, SEQ ID NO: 17, SEQ ID NO: 19, SEQ ID NO: 21, SEQ ID NO: 23, SEQ ID NO: 25, SEQ ID NO: 27, SEQ ID NO: 29, SEQ ID NO: 31, SEQ ID NO: 33, SEQ ID NO: 35, SEQ ID NO: 37, SEQ ID NO: 39, SEQ ID NO: 41, SEQ ID NO: 43, SEQ ID NO: 45, SEQ ID NO: 47, SEQ ID NO: 49 o SEQ ID NO: 51, ff) secuencia de ácidos nucleicos, que codifica para un fragmento de un ácido nucleico representado en aa) y que tiene una actividad de "Translation Releasing Factor", una actividad de síntesis de cobalamina, una actividad de arginil-tRna-sintasa, una actividad de RNA-helicasa, una actividad de proteína que liga a GTP, una actividad pseudo uridilato-sintasa, una actividad de adenilatoquinasa, una actividad de proteína precursora de la preproteína-translocasa secA, una actividad de proteína DCL, una actividad de arginina-tRNA-ligasa, una actividad de glutatión reductasa plastidaria, una actividad del factor de transcripción sigma, una actividad de calmudulina, una actividad de INT6, una actividad de helicasa YGL150c, una actividad que liga a RNA, una actividad de factor de transcripción del shock térmico, una actividad que liga a un nucleoide de DNA cloroplastidaria o una actividad citosina DNA metiltransferasa tipo Met2; y / o gg) secuencia de ácidos nucleicos, que codifica para los derivados de los polipéptidos con las secuencias de aminoácidos representadas en: SEQ ID NO: 2, SEQ ID NO: 4, SEQ ID NO: 6, SEQ ID NO: 8, SEQ ID NO: 10, SEQ ID NO: 12, SEQ ID NO: 14, SEQ ID NO: 16, SEQ ID NO: 18, SEQ ID NO: 20, SEQ ID NO: 22, SEQ ID NO: 24, SEQ ID NO: 26, SEQ ID NO: 28, SEQ ID NO: 30, SEQ ID NO: 32, SEQ ID NO: 34, SEQ ID NO: 36, SEQ ID NO: 38, SEQ ID NO: 40, SEQ ID NO: 42, SEQ ID NO: 44, SEQ ID NO: 46, SEQ ID NO: 48, SEQ ID NO: 50 o SEQ ID NO: 52, la que presenta una homología de por lo menos 2'% en el nivel de los aminoácidos y una actividad biológica equivalente; o b) la expresión o actividad de una secuencia de aminoácidos, que se codifica por una secuencia de ácidos nucleicos de acuerdo con aa) a gg), y se seleccionan aquellas sustancias que reducen o bloquean la expresión o la actividad.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10238434A DE10238434A1 (de) | 2002-08-16 | 2002-08-16 | Verfahren zur Identifizierung von Substanzen mit herbizider Wirkung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR040993A1 true AR040993A1 (es) | 2005-04-27 |
Family
ID=31968981
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP030102968A AR040993A1 (es) | 2002-08-16 | 2003-08-15 | Procedimiento para la identificacion de sustancias con accion herbicida |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20060277619A1 (es) |
| EP (1) | EP1530640A2 (es) |
| AR (1) | AR040993A1 (es) |
| AU (1) | AU2003255324A1 (es) |
| CA (1) | CA2495555A1 (es) |
| DE (1) | DE10238434A1 (es) |
| WO (1) | WO2004022780A2 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130145493A1 (en) * | 2010-01-12 | 2013-06-06 | Edwards Allen | Transgenic Plants with Enhanced Agronomic Traits |
| US9612235B2 (en) | 2012-04-05 | 2017-04-04 | Koch Biological Solutions, Llc | Herbicidal compound screening |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5780254A (en) * | 1995-05-04 | 1998-07-14 | Sandoz Ltd | Method for detection of herbicides |
| CN1341151A (zh) * | 1999-01-15 | 2002-03-20 | 辛根塔参与股份公司 | 除草剂的靶基因和方法 |
| US6387637B1 (en) * | 1999-01-15 | 2002-05-14 | Syngenta Participations Ag | Herbicide target genes and method |
| EP1033405A3 (en) * | 1999-02-25 | 2001-08-01 | Ceres Incorporated | Sequence-determined DNA fragments and corresponding polypeptides encoded thereby |
| EP1362059A2 (de) * | 2001-02-16 | 2003-11-19 | Metanomics GmbH & Co. KGaA | Verfahren zur identifizierung von substanzen mit herbizider wirkung |
-
2002
- 2002-08-16 DE DE10238434A patent/DE10238434A1/de not_active Withdrawn
-
2003
- 2003-07-30 CA CA002495555A patent/CA2495555A1/en not_active Abandoned
- 2003-07-30 US US10/524,765 patent/US20060277619A1/en not_active Abandoned
- 2003-07-30 WO PCT/EP2003/008393 patent/WO2004022780A2/de not_active Application Discontinuation
- 2003-07-30 EP EP03793655A patent/EP1530640A2/de not_active Withdrawn
- 2003-07-30 AU AU2003255324A patent/AU2003255324A1/en not_active Abandoned
- 2003-08-15 AR ARP030102968A patent/AR040993A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1530640A2 (de) | 2005-05-18 |
| DE10238434A1 (de) | 2004-04-15 |
| US20060277619A1 (en) | 2006-12-07 |
| AU2003255324A1 (en) | 2004-03-29 |
| CA2495555A1 (en) | 2004-03-18 |
| WO2004022780A2 (de) | 2004-03-18 |
| WO2004022780A3 (de) | 2004-07-01 |
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