AR036231A1 - Derivados de 4-diarilamino piperidina,procedimiento para su preparacion, empleo de estos derivados para la fabricacion de medicamentos, composicion farmaceutica y compuestos intermediarios - Google Patents
Derivados de 4-diarilamino piperidina,procedimiento para su preparacion, empleo de estos derivados para la fabricacion de medicamentos, composicion farmaceutica y compuestos intermediariosInfo
- Publication number
- AR036231A1 AR036231A1 ARP020101818A ARP020101818A AR036231A1 AR 036231 A1 AR036231 A1 AR 036231A1 AR P020101818 A ARP020101818 A AR P020101818A AR P020101818 A ARP020101818 A AR P020101818A AR 036231 A1 AR036231 A1 AR 036231A1
- Authority
- AR
- Argentina
- Prior art keywords
- derivatives
- medicines
- procedure
- manufacture
- pharmaceutical composition
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- 208000027520 Somatoform disease Diseases 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 125000002883 imidazolyl group Chemical group 0.000 abstract 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 abstract 1
- 208000027753 pain disease Diseases 0.000 abstract 1
- 239000012450 pharmaceutical intermediate Substances 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000000168 pyrrolyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 125000000335 thiazolyl group Chemical group 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
- 125000001425 triazolyl group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Derivados de 4-diarilamino piperidina de la fórmula general (1) donde R1 se selecciona de cualquiera de fenilo, piridinilo, tienilo, furanilo, imidazolilo, pirrolilo, triazolilo, tiazolilo y piridil-N-óxido; en la cual cada anillo de fenilo de R1 y cada anillo heteroaromático de R1 puede estar además opcional e independientemente sustituido con 1, 2 ó 3 sustituyentes independientemente seleccionados de alquilo C1-6 recto y ramificado, NO2, CF3, alcoxilo C1-6, cloro, flúor, bromo y yodo, así como también sales de los mismos. Las sustituciones en el anillo de fenilo y en el anillo heteroaromático pueden tener lugar en cualquier posición en dichos sistemas anulares. Estos compuestos son útiles en terapia, en particular en el control del dolor, ansiedad y trastornos gastrointestinales funcionales. Procedimiento para su preparación, empleo de estos derivados para la fabricación de medicamentos, composición farmacéutica y compuestos intermediarios.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0101773A SE0101773D0 (sv) | 2001-05-18 | 2001-05-18 | Novel compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR036231A1 true AR036231A1 (es) | 2004-08-25 |
Family
ID=20284176
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020101818A AR036231A1 (es) | 2001-05-18 | 2002-05-16 | Derivados de 4-diarilamino piperidina,procedimiento para su preparacion, empleo de estos derivados para la fabricacion de medicamentos, composicion farmaceutica y compuestos intermediarios |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7008952B2 (es) |
| EP (1) | EP1395557A1 (es) |
| JP (1) | JP2005508291A (es) |
| KR (1) | KR20040000472A (es) |
| CN (1) | CN1527818A (es) |
| AR (1) | AR036231A1 (es) |
| BG (1) | BG108334A (es) |
| BR (1) | BR0209665A (es) |
| CA (1) | CA2446516A1 (es) |
| CO (1) | CO5540320A2 (es) |
| CZ (1) | CZ20033093A3 (es) |
| EE (1) | EE200300526A (es) |
| HU (1) | HUP0401610A2 (es) |
| IL (1) | IL158700A0 (es) |
| IS (1) | IS7033A (es) |
| MX (1) | MXPA03010444A (es) |
| NO (1) | NO20035119D0 (es) |
| PL (1) | PL367246A1 (es) |
| RU (1) | RU2003131963A (es) |
| SE (1) | SE0101773D0 (es) |
| SK (1) | SK13992003A3 (es) |
| WO (1) | WO2002094785A1 (es) |
| ZA (1) | ZA200308642B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101255074B1 (ko) | 2003-10-01 | 2013-04-16 | 아돌로 코포레이션 | 스피로시클릭 헤테로시클릭 유도체 및 이의 사용 방법 |
| US7598261B2 (en) | 2005-03-31 | 2009-10-06 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
| US7576207B2 (en) | 2006-04-06 | 2009-08-18 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
| CN113979997A (zh) * | 2021-11-12 | 2022-01-28 | 中国科学院昆明植物研究所 | N,n-(4-哌啶基、芳基)-3-氨基苯酚类衍生物及其药物组合物和其应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4091096A (en) | 1976-03-19 | 1978-05-23 | Eli Lilly And Company | Dinitroanilines for the control of phytopathogens |
| EG12406A (en) | 1976-08-12 | 1979-03-31 | Janssen Pharmaceutica Nv | Process for preparing of novel n-aryl-n-(1-l-4-piperidinyl)-arylacetamides |
| US4252812A (en) | 1977-05-23 | 1981-02-24 | Pfizer Inc. | 2-Substituted-trans-5-aryl-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indoles |
| SE441448B (sv) | 1977-05-23 | 1985-10-07 | Pfizer | Sett att framstella hexahydro-gamma-karbolinforeningar |
| DE3200304A1 (de) | 1981-01-16 | 1982-08-26 | Sandoz-Patent-GmbH, 7850 Lörrach | 3-aminopropoxyaryl-derivate, ihre herstellung und sie enthaltende arzneimittel |
| EP0181793B1 (fr) | 1984-10-16 | 1988-07-27 | Synthelabo | Dérivés de pipéridine, leur préparation et leur application en thérapeutique |
| YU150489A (sh) | 1989-08-10 | 1992-12-21 | W.L. Gore & Co. Gmbh. | Uređaj za ispitivanje odevnih predmeta na nepromočivost |
| KR940003491B1 (ko) | 1989-08-10 | 1994-04-23 | 리히터 게데온 베기에스제티 기아르 알.티 | 4,4-이중 치환된 피페리딘 유도체와 그 제조방법 및 상기 화합물을 함유하는 약제학적 조성물 |
| US5854245A (en) | 1996-06-28 | 1998-12-29 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
| TW548271B (en) * | 1996-12-20 | 2003-08-21 | Astra Pharma Inc | Novel piperidine derivatives having an exocyclic double bond with analgesic effects |
| SE9604786D0 (sv) | 1996-12-20 | 1996-12-20 | Astra Pharma Inc | New compounds |
| AU2009799A (en) | 1997-12-24 | 1999-07-19 | Ortho-Mcneil Pharmaceutical, Inc. | 4-(aryl(piperidin-4-yl)) aminobenzamides which bind to the delta-opioid receptor |
| JP4498602B2 (ja) | 1998-03-10 | 2010-07-07 | リサーチ・トライアングル・インスティチュート | 新規なオピエート化合物、その調製法及び使用法 |
| SE9904675D0 (sv) * | 1999-12-20 | 1999-12-20 | Astra Pharma Inc | Novel compounds |
| CA2402039A1 (en) * | 2000-03-03 | 2001-09-13 | Ortho-Mcneil Pharmaceutical, Inc. | 3-(diarylmethylene)-8-azabicyclo[3.2.1]octane derivatives |
| SE0001207D0 (sv) * | 2000-04-04 | 2000-04-04 | Astrazeneca Canada Inc | Novel compounds |
-
2001
- 2001-05-18 SE SE0101773A patent/SE0101773D0/xx unknown
-
2002
- 2002-05-16 CZ CZ20033093A patent/CZ20033093A3/cs unknown
- 2002-05-16 EP EP02733713A patent/EP1395557A1/en not_active Withdrawn
- 2002-05-16 MX MXPA03010444A patent/MXPA03010444A/es unknown
- 2002-05-16 PL PL02367246A patent/PL367246A1/xx not_active Application Discontinuation
- 2002-05-16 RU RU2003131963/04A patent/RU2003131963A/ru not_active Application Discontinuation
- 2002-05-16 BR BR0209665-0A patent/BR0209665A/pt not_active Application Discontinuation
- 2002-05-16 IL IL15870002A patent/IL158700A0/xx unknown
- 2002-05-16 KR KR10-2003-7014951A patent/KR20040000472A/ko not_active Application Discontinuation
- 2002-05-16 US US10/477,636 patent/US7008952B2/en not_active Expired - Fee Related
- 2002-05-16 EE EEP200300526A patent/EE200300526A/xx unknown
- 2002-05-16 HU HU0401610A patent/HUP0401610A2/hu unknown
- 2002-05-16 SK SK1399-2003A patent/SK13992003A3/sk unknown
- 2002-05-16 WO PCT/SE2002/000957 patent/WO2002094785A1/en not_active Application Discontinuation
- 2002-05-16 AR ARP020101818A patent/AR036231A1/es not_active Application Discontinuation
- 2002-05-16 JP JP2002591458A patent/JP2005508291A/ja active Pending
- 2002-05-16 CN CNA028141687A patent/CN1527818A/zh active Pending
- 2002-05-16 CA CA002446516A patent/CA2446516A1/en not_active Abandoned
-
2003
- 2003-11-05 ZA ZA200308642A patent/ZA200308642B/en unknown
- 2003-11-07 BG BG108334A patent/BG108334A/bg unknown
- 2003-11-12 CO CO03100170A patent/CO5540320A2/es not_active Application Discontinuation
- 2003-11-13 IS IS7033A patent/IS7033A/is unknown
- 2003-11-17 NO NO20035119A patent/NO20035119D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA03010444A (es) | 2004-03-09 |
| IL158700A0 (en) | 2004-05-12 |
| PL367246A1 (en) | 2005-02-21 |
| BR0209665A (pt) | 2004-04-20 |
| BG108334A (bg) | 2004-12-30 |
| ZA200308642B (en) | 2005-02-07 |
| NO20035119D0 (no) | 2003-11-17 |
| CN1527818A (zh) | 2004-09-08 |
| HUP0401610A2 (hu) | 2004-12-28 |
| JP2005508291A (ja) | 2005-03-31 |
| WO2002094785A1 (en) | 2002-11-28 |
| KR20040000472A (ko) | 2004-01-03 |
| RU2003131963A (ru) | 2005-05-10 |
| EE200300526A (et) | 2004-02-16 |
| CO5540320A2 (es) | 2005-07-29 |
| EP1395557A1 (en) | 2004-03-10 |
| CZ20033093A3 (cs) | 2004-07-14 |
| US7008952B2 (en) | 2006-03-07 |
| IS7033A (is) | 2003-11-13 |
| US20040142966A1 (en) | 2004-07-22 |
| CA2446516A1 (en) | 2002-11-28 |
| SK13992003A3 (sk) | 2004-04-06 |
| SE0101773D0 (sv) | 2001-05-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |