AR021137A1 - Derivados de triazina 2,4-disustituida, uso de los mismos para preparar medicamentos, composiciones farmacéuticas que los comprenden, procedimiento para prepararlas, y procedimiento para preparar dichos derivados. - Google Patents
Derivados de triazina 2,4-disustituida, uso de los mismos para preparar medicamentos, composiciones farmacéuticas que los comprenden, procedimiento para prepararlas, y procedimiento para preparar dichos derivados.Info
- Publication number
- AR021137A1 AR021137A1 ARP990105681A ARP990105681A AR021137A1 AR 021137 A1 AR021137 A1 AR 021137A1 AR P990105681 A ARP990105681 A AR P990105681A AR P990105681 A ARP990105681 A AR P990105681A AR 021137 A1 AR021137 A1 AR 021137A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- prepare
- substituted
- derivatives
- procedure
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/14—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom
- C07D251/16—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/14—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom
- C07D251/16—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom
- C07D251/18—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom with nitrogen atoms directly attached to the two other ring carbon atoms, e.g. guanamines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/42—One nitrogen atom
- C07D251/46—One nitrogen atom with oxygen or sulfur atoms attached to the two other ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/48—Two nitrogen atoms
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/773—Nanoparticle, i.e. structure having three dimensions of 100 nm or less
- Y10S977/775—Nanosized powder or flake, e.g. nanosized catalyst
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/915—Therapeutic or pharmaceutical composition
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Esta invencion se refiere al uso de compuesto que tienen la formula (1) a los N-oxidos, a las sales de adicion farmacéuticamente aceptables, las aminascuaternarias y sus formas estereoquímicamente isoméricas en las cuales -a1=a2-a3=a4- forman unfeni lo, piridinilo, pirimidinilo, piridazinilo opirazinilo con el grupo vinilo adherido; n es 0 a 4 y donde es posible 5; R1 es hidrogeno, arilo; formilo; alquilcarbonilo C1-6; alquilo C1-6;alquiloxicarbonilo C1-6; alquilo C1-6 substituido oalquiloxi C1 -6; alquilcarbonilo C1-6 substituido; cada R2 independientemente es hidroxi, halo, alquilo C1-6opcionalmente substituido; alquilo C1-6, alquenilo C2-6 substituido o alquinilo C2-6, cicloalquilo C3-7, alquiloxi C1-6; alquiloxicarboniloC1-6; carboxilo ,ciano, nitro, amino, mono o di(alquilo C1-6) amino, polihalometilo, polihalometiloxi, polihalometiltio, -S(=O)pR4, -NH-S(=O)NHNH2; -NHC(=O)R4, -C(=NH)R4 o unanillo heterocíclico de 5 miembros; p es 1 o 2; L es alquilo C1-10,substituido, alquenilo C 2-10, alquinilo C2-10, cicloalquilo C3-7:0 L es -X-R3 donde R3 esfenilo, piridinilo, pirimidinilo, pirazinilo o piridazinilo opcionalmente substituido, X es -NR1-, -NH-NH-, -N=N-, -O-. -C(=O)-, -CHOH-, -S-, -S(=O)- o -S(=O)2- ; arilo es fenilo substit uido; para la manufactura de un medicamento para el tratamiento de individuos que sufren de infeccion causada por virus de HIV (Virusde Inmunodeficiencia Humana).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10779998P | 1998-11-10 | 1998-11-10 | |
| EP99203128 | 1999-09-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR021137A1 true AR021137A1 (es) | 2002-06-12 |
Family
ID=26153374
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990105681A AR021137A1 (es) | 1998-11-10 | 1999-11-09 | Derivados de triazina 2,4-disustituida, uso de los mismos para preparar medicamentos, composiciones farmacéuticas que los comprenden, procedimiento para prepararlas, y procedimiento para preparar dichos derivados. |
Country Status (35)
| Country | Link |
|---|---|
| US (2) | US6638932B1 (es) |
| EP (1) | EP1129079B1 (es) |
| JP (1) | JP2002529457A (es) |
| KR (1) | KR100620402B1 (es) |
| CN (1) | CN1207290C (es) |
| AP (1) | AP1636A (es) |
| AR (1) | AR021137A1 (es) |
| AT (1) | ATE315031T1 (es) |
| AU (1) | AU764472B2 (es) |
| BG (1) | BG65160B1 (es) |
| BR (1) | BR9915176A (es) |
| CA (1) | CA2351203C (es) |
| CY (1) | CY1105596T1 (es) |
| CZ (1) | CZ20011532A3 (es) |
| DE (1) | DE69929354T2 (es) |
| DK (1) | DK1129079T3 (es) |
| EA (1) | EA004501B1 (es) |
| EE (1) | EE200100253A (es) |
| ES (1) | ES2257081T3 (es) |
| HK (1) | HK1038232A1 (es) |
| HR (1) | HRP20010310A2 (es) |
| HU (1) | HUP0104395A3 (es) |
| ID (1) | ID28545A (es) |
| IL (2) | IL143024A0 (es) |
| MY (1) | MY126781A (es) |
| NO (1) | NO319788B1 (es) |
| NZ (1) | NZ510919A (es) |
| OA (1) | OA11675A (es) |
| PL (1) | PL196523B1 (es) |
| PT (1) | PT1129079E (es) |
| SI (1) | SI1129079T1 (es) |
| SK (1) | SK6022001A3 (es) |
| TR (1) | TR200101319T2 (es) |
| TW (1) | TW541305B (es) |
| WO (1) | WO2000027828A2 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA004501B1 (ru) * | 1998-11-10 | 2004-04-29 | Янссен Фармацевтика Н.В. | Производные 2,4-дизамещенного триазина |
| DE19945982A1 (de) | 1999-09-24 | 2001-03-29 | Knoll Ag | Geschwindigkeitsbestimmte Partikel |
| WO2001085700A2 (en) | 2000-05-08 | 2001-11-15 | Janssen Pharmaceutica N.V. | Hiv replication inhibiting pyrimidines and triazines |
| AR039540A1 (es) * | 2002-05-13 | 2005-02-23 | Tibotec Pharm Ltd | Compuestos microbicidas con contenido de pirimidina o triazina |
| ATE402152T1 (de) * | 2003-02-07 | 2008-08-15 | Janssen Pharmaceutica Nv | Hiv-inhibierende1,2,4-triazine |
| WO2006015985A1 (en) | 2004-08-10 | 2006-02-16 | Janssen Pharmaceutica N.V. | Hiv inhibiting 1,2,4-triazin-6-one derivatives |
| GB201204756D0 (en) * | 2012-03-19 | 2012-05-02 | Lewi Paulus J | Triazines with suitable spacers for treatment and/or prevention of HIV infections |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4927592B1 (es) | 1970-05-13 | 1974-07-18 | ||
| BE754242A (fr) | 1970-07-15 | 1971-02-01 | Geigy Ag J R | Diamino-s-triazines et dinitro-s-triazines |
| US4650867A (en) | 1985-03-26 | 1987-03-17 | Ciba-Geigy Corporation | Process for the preparation of 2,4,6-tris(aminophenylamino)triazines |
| JPH02308248A (ja) * | 1989-05-24 | 1990-12-21 | Fuji Photo Film Co Ltd | アミノピリミジン系色素形成カプラーおよび該カプラーを含有するハロゲン化銀カラー写真感光材料 |
| AU692484B2 (en) | 1993-10-12 | 1998-06-11 | Du Pont Pharmaceuticals Company | 1N-alkyl-N-arylpyrimidinamines and derivatives thereof |
| US5691364A (en) * | 1995-03-10 | 1997-11-25 | Berlex Laboratories, Inc. | Benzamidine derivatives and their use as anti-coagulants |
| NO311614B1 (no) * | 1996-10-01 | 2001-12-17 | Janssen Pharmaceutica Nv | Substituerte diamino-1,3,5-triazinderivater |
| CA2321153A1 (en) * | 1998-02-17 | 1999-08-19 | Timothy D. Cushing | Anti-viral pyrimidine derivatives |
| EA004501B1 (ru) * | 1998-11-10 | 2004-04-29 | Янссен Фармацевтика Н.В. | Производные 2,4-дизамещенного триазина |
-
1999
- 1999-11-04 EA EA200100534A patent/EA004501B1/ru not_active IP Right Cessation
- 1999-11-04 US US09/831,808 patent/US6638932B1/en not_active Expired - Fee Related
- 1999-11-04 NZ NZ510919A patent/NZ510919A/en unknown
- 1999-11-04 SK SK602-2001A patent/SK6022001A3/sk unknown
- 1999-11-04 AU AU10462/00A patent/AU764472B2/en not_active Ceased
- 1999-11-04 CN CNB998130478A patent/CN1207290C/zh not_active Expired - Fee Related
- 1999-11-04 WO PCT/EP1999/008688 patent/WO2000027828A2/en active IP Right Grant
- 1999-11-04 AT AT99953980T patent/ATE315031T1/de not_active IP Right Cessation
- 1999-11-04 PL PL348145A patent/PL196523B1/pl not_active IP Right Cessation
- 1999-11-04 JP JP2000581008A patent/JP2002529457A/ja active Pending
- 1999-11-04 SI SI9930886T patent/SI1129079T1/sl unknown
- 1999-11-04 PT PT99953980T patent/PT1129079E/pt unknown
- 1999-11-04 ES ES99953980T patent/ES2257081T3/es not_active Expired - Lifetime
- 1999-11-04 DE DE69929354T patent/DE69929354T2/de not_active Expired - Fee Related
- 1999-11-04 CZ CZ20011532A patent/CZ20011532A3/cs unknown
- 1999-11-04 EE EEP200100253A patent/EE200100253A/xx unknown
- 1999-11-04 KR KR1020017003574A patent/KR100620402B1/ko not_active IP Right Cessation
- 1999-11-04 ID IDW00200101017A patent/ID28545A/id unknown
- 1999-11-04 EP EP99953980A patent/EP1129079B1/en not_active Expired - Lifetime
- 1999-11-04 AP APAP/P/2001/002155A patent/AP1636A/en active
- 1999-11-04 TR TR2001/01319T patent/TR200101319T2/xx unknown
- 1999-11-04 HU HU0104395A patent/HUP0104395A3/hu unknown
- 1999-11-04 CA CA002351203A patent/CA2351203C/en not_active Expired - Fee Related
- 1999-11-04 DK DK99953980T patent/DK1129079T3/da active
- 1999-11-04 IL IL14302499A patent/IL143024A0/xx active IP Right Grant
- 1999-11-04 BR BR9915176-6A patent/BR9915176A/pt not_active IP Right Cessation
- 1999-11-04 OA OA1200100114A patent/OA11675A/en unknown
- 1999-11-05 MY MYPI99004801A patent/MY126781A/en unknown
- 1999-11-09 AR ARP990105681A patent/AR021137A1/es active IP Right Grant
- 1999-12-23 TW TW088119615A patent/TW541305B/zh not_active IP Right Cessation
-
2001
- 2001-04-06 BG BG105419A patent/BG65160B1/bg unknown
- 2001-04-19 NO NO20011934A patent/NO319788B1/no unknown
- 2001-05-02 HR HR20010310A patent/HRP20010310A2/hr not_active Application Discontinuation
- 2001-05-07 IL IL143024A patent/IL143024A/en not_active IP Right Cessation
- 2001-12-10 HK HK01108632A patent/HK1038232A1/xx not_active IP Right Cessation
-
2003
- 2003-08-27 US US10/649,017 patent/US7015221B2/en not_active Expired - Fee Related
-
2006
- 2006-03-31 CY CY20061100457T patent/CY1105596T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |