AR014975A1 - Compuestos calciliticos, una composicion farmaceutica que los comprende, y el uso de los mismos para la fabricacion de un medicamento - Google Patents
Compuestos calciliticos, una composicion farmaceutica que los comprende, y el uso de los mismos para la fabricacion de un medicamentoInfo
- Publication number
- AR014975A1 AR014975A1 ARP990101555A ARP990101555A AR014975A1 AR 014975 A1 AR014975 A1 AR 014975A1 AR P990101555 A ARP990101555 A AR P990101555A AR P990101555 A ARP990101555 A AR P990101555A AR 014975 A1 AR014975 A1 AR 014975A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- group
- alkylene
- substituted
- riv
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Quinoline Compounds (AREA)
- Pyridine Compounds (AREA)
- Furan Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Un compuesto calcilítico que comprende la formula (I), en la que: Y1 es un enlace covalente, alquileno o alquenileno de hasta 4 átomos de carbono, sinsustituir o sustituido con alquilo de C1-4 u O; Y2 es metileno, sin sustituir o sustituido con alquilo haloalquilo de C1-4; Y3 es un enlace covalenteu O, S, N-RIV o alquileno de C1-4-O, alquileno de C1-4-S, o alquileno de C1-4-N-RIV; RIV se selecciona entre el grupo que consta de H, alquilo de C1-4, ocicloalquilo de C3-6; R3 y R4 son, independientemente, metilo o etilo, o, juntos, forman ciclopropilo; R5 es heteroarilo o heteroarilo fusionado; en elque el anillo heterocíclico contiene N, O o S, y es aromático, dihidro o tetrahidro, sin sustituir o sustituido con cualesquiera sustituyentes seleccionadosentre el grupo que consta de OH, OCH3, (CH3)2, halogeno, alquilo de C1-4, alcoxi de C1-4, cicloalquilo de C3-6, OSO2RIV, CN,NO2, OCF3, CF3, CH2CF3, (CH2)nCO2H,(CH2)nCO2RIV; n es un numero entero de 0 a 3; G es un enlace covalente, CHR6 o C-R6, en cuyas formulas R6 es H, OH u O (formando una cetona); R7 es H, OH,u O-alquilo de C1-4; R8 es H o alquilo de C1-4;o R7 y R8 juntos forman una cetona; A y B se seleccionan independientemente entre el grupo que consta de unenlace, CH2, NH, O, S yC=O, con tal que o bien A o B se seleccione entre CH2 y NH; o A y B juntos forman un enlace; o el resto A-B está representado porCH=CH o C:::C; X se selecciona entre las subformulas (Ia) a (Ie); en las que: W se selecciona entre el grupo que consta de R1, SO2R1, C(O)R1, SO2NR1R1,C(O)NR1R1, C(O)OR1, y SO3R1, en cuyas formulas R1 y R1 se seleccionan independientemente entre el grupo que consta de hidrogeno, alquilo de C1-4,cicloalquilo de C3-6, alquenilo de C2-5, alquinilo de C2-5, heterocicloalquilo, arilo y aril-alquilo de C1-4; o R1 y R1 juntos forman un anillo heterocíclicode 3 a 7 miembros opcionalmente sustituido; en el que cualesquiera sustituyentes se seleccionan entre el grupo que consta de CN, arilo, CO2R, CO2NHR, OH, OR,NH2, halo,CF3, OCF3 y NO2; en cuyas formulas R representa alquilo de C1-4 o cicloalquilo de C3-6; X1 se selecciona entre el grupo que consta de CN, NO2, Cl
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8108798P | 1998-04-08 | 1998-04-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR014975A1 true AR014975A1 (es) | 2001-04-11 |
Family
ID=22162024
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990101555A AR014975A1 (es) | 1998-04-08 | 1999-04-06 | Compuestos calciliticos, una composicion farmaceutica que los comprende, y el uso de los mismos para la fabricacion de un medicamento |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1069901A4 (es) |
| JP (1) | JP2002510636A (es) |
| AR (1) | AR014975A1 (es) |
| AU (1) | AU3551399A (es) |
| CA (1) | CA2327188A1 (es) |
| CO (1) | CO5021223A1 (es) |
| WO (1) | WO1999051241A1 (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CO5180628A1 (es) * | 1999-07-31 | 2002-07-30 | Smithkline Beecham Corp | Compuestos calcioliticos |
| AR030684A1 (es) * | 2000-01-24 | 2003-09-03 | Smithkline Beecham Corp | Compuestos calciliticos, uso de dichos compuestos en la manufactura de medicamentos, e intermediarios utiles en la preparacion de dichos compuestos |
| US20030018203A1 (en) | 2002-07-17 | 2003-01-23 | Largo Maria Amparo | Calcilytic compounds |
| JP2004509077A (ja) * | 2000-07-21 | 2004-03-25 | スミスクライン・ビーチャム・コーポレイション | カルシライティック化合物 |
| FR2812875B1 (fr) | 2000-08-08 | 2003-12-12 | Centre Nat Rech Scient | Nouvelles diamines possedant une activite modulatrice des casr et leur mode de preparation |
| KR100785675B1 (ko) * | 2000-08-11 | 2007-12-14 | 니뽄 다바코 산교 가부시키가이샤 | 칼슘 수용체 길항약 |
| ATE343390T1 (de) * | 2000-10-25 | 2006-11-15 | Smithkline Beecham Corp | Kalzilytische verbindungen |
| US6476046B1 (en) | 2000-12-04 | 2002-11-05 | Sepracor, Inc. | Diazabicyclo[4.3.0]nonanes, and methods of use thereof |
| PL375552A1 (en) | 2002-05-22 | 2005-11-28 | Amgen Inc. | Vanilloid receptor ligands and their medical applications |
| EP2270006A1 (en) | 2002-08-08 | 2011-01-05 | Amgen, Inc | Pyridazine derivatives useful as vanilloid receptor ligands |
| UY28089A1 (es) | 2002-11-26 | 2004-06-30 | Smithkline Beecham Corp | Compuestos calciliticos |
| WO2004069793A2 (en) | 2003-01-28 | 2004-08-19 | Bristol-Myers Squibb Company | Novel 2-substituted cyclic amines as calcium sensing receptor modulators |
| US7205322B2 (en) | 2003-02-12 | 2007-04-17 | Bristol-Myers Squibb Company | Thiazolidine compounds as calcium sensing receptor modulators |
| WO2004094362A1 (ja) | 2003-04-23 | 2004-11-04 | Japan Tobacco Inc. | CaSRアンタゴニスト |
| US7265145B2 (en) | 2003-05-28 | 2007-09-04 | Bristol-Myers Squibb Company | Substituted piperidines and pyrrolidines as calcium sensing receptor modulators and method |
| EP1630157A4 (en) | 2003-05-28 | 2007-05-23 | Japan Tobacco Inc | ANTAGONIST OF CASR |
| MY139645A (en) | 2004-02-11 | 2009-10-30 | Amgen Inc | Vanilloid receptor ligands and their use in treatments |
| EP1745034A1 (en) | 2004-02-11 | 2007-01-24 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
| WO2006089311A1 (en) | 2005-02-15 | 2006-08-24 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
| WO2010103429A1 (en) | 2009-03-10 | 2010-09-16 | Pfizer Inc. | 1,1-(Dimethyl-Ethylamino)-2-Hydroxy-Propoxy]-Ethyl}-3-Methyl-Biphenyl-4- Carboxylic Acid Derivatives As Calcium Receptor Antagonists |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL83966A (en) * | 1986-09-26 | 1992-03-29 | Schering Ag | Amides of aminopolycarboxylic acids and pharmaceutical compositions containing them |
| UY24949A1 (es) * | 1997-04-08 | 2001-04-30 | Smithkline Beecham Corp | Compuestos calcilíticos |
-
1999
- 1999-04-06 AR ARP990101555A patent/AR014975A1/es not_active Application Discontinuation
- 1999-04-08 AU AU35513/99A patent/AU3551399A/en not_active Abandoned
- 1999-04-08 CO CO99020600A patent/CO5021223A1/es unknown
- 1999-04-08 WO PCT/US1999/007760 patent/WO1999051241A1/en not_active Application Discontinuation
- 1999-04-08 CA CA002327188A patent/CA2327188A1/en not_active Abandoned
- 1999-04-08 EP EP99917374A patent/EP1069901A4/en not_active Withdrawn
- 1999-04-08 JP JP2000542012A patent/JP2002510636A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| AU3551399A (en) | 1999-10-25 |
| EP1069901A4 (en) | 2001-06-13 |
| EP1069901A1 (en) | 2001-01-24 |
| CA2327188A1 (en) | 1999-10-14 |
| CO5021223A1 (es) | 2001-03-27 |
| WO1999051241A1 (en) | 1999-10-14 |
| JP2002510636A (ja) | 2002-04-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |